Amino acid dipepetide frequency for Hanseniaspora valbyensis NRRL Y-1626

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.86AlaAla: 2.86 ± 0.065	0.563AlaCys: 0.563 ± 0.017	2.116AlaAsp: 2.116 ± 0.04	2.454AlaGlu: 2.454 ± 0.043	1.863AlaPhe: 1.863 ± 0.034	2.103AlaGly: 2.103 ± 0.043	0.717AlaHis: 0.717 ± 0.02	3.39AlaIle: 3.39 ± 0.042	3.483AlaLys: 3.483 ± 0.051	4.12AlaLeu: 4.12 ± 0.056	0.985AlaMet: 0.985 ± 0.023	2.832AlaAsn: 2.832 ± 0.035	1.443AlaPro: 1.443 ± 0.029	1.378AlaGln: 1.378 ± 0.03	1.332AlaArg: 1.332 ± 0.029	3.652AlaSer: 3.652 ± 0.058	2.843AlaThr: 2.843 ± 0.051	2.439AlaVal: 2.439 ± 0.044	0.327AlaTrp: 0.327 ± 0.013	1.36AlaTyr: 1.36 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.444CysAla: 0.444 ± 0.015	0.301CysCys: 0.301 ± 0.013	0.702CysAsp: 0.702 ± 0.016	0.636CysGlu: 0.636 ± 0.017	0.78CysPhe: 0.78 ± 0.019	0.707CysGly: 0.707 ± 0.021	0.246CysHis: 0.246 ± 0.01	1.051CysIle: 1.051 ± 0.025	0.993CysLys: 0.993 ± 0.025	1.374CysLeu: 1.374 ± 0.027	0.248CysMet: 0.248 ± 0.011	0.738CysAsn: 0.738 ± 0.02	0.378CysPro: 0.378 ± 0.014	0.39CysGln: 0.39 ± 0.014	0.353CysArg: 0.353 ± 0.013	0.976CysSer: 0.976 ± 0.023	0.473CysThr: 0.473 ± 0.018	0.698CysVal: 0.698 ± 0.018	0.133CysTrp: 0.133 ± 0.008	0.533CysTyr: 0.533 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.322AspAla: 2.322 ± 0.037	0.769AspCys: 0.769 ± 0.02	5.164AspAsp: 5.164 ± 0.079	5.191AspGlu: 5.191 ± 0.068	3.241AspPhe: 3.241 ± 0.041	2.523AspGly: 2.523 ± 0.037	0.941AspHis: 0.941 ± 0.023	5.231AspIle: 5.231 ± 0.05	4.44AspLys: 4.44 ± 0.048	6.382AspLeu: 6.382 ± 0.049	1.141AspMet: 1.141 ± 0.024	4.394AspAsn: 4.394 ± 0.049	1.977AspPro: 1.977 ± 0.036	1.596AspGln: 1.596 ± 0.029	1.476AspArg: 1.476 ± 0.029	5.18AspSer: 5.18 ± 0.058	2.954AspThr: 2.954 ± 0.038	3.112AspVal: 3.112 ± 0.036	0.549AspTrp: 0.549 ± 0.019	2.61AspTyr: 2.61 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	2.707GluAla: 2.707 ± 0.045	0.645GluCys: 0.645 ± 0.019	4.828GluAsp: 4.828 ± 0.065	7.652GluGlu: 7.652 ± 0.146	3.077GluPhe: 3.077 ± 0.038	2.306GluGly: 2.306 ± 0.036	1.13GluHis: 1.13 ± 0.026	5.041GluIle: 5.041 ± 0.055	6.399GluLys: 6.399 ± 0.083	6.422GluLeu: 6.422 ± 0.057	1.467GluMet: 1.467 ± 0.028	6.108GluAsn: 6.108 ± 0.063	1.594GluPro: 1.594 ± 0.028	2.852GluGln: 2.852 ± 0.043	2.365GluArg: 2.365 ± 0.037	4.688GluSer: 4.688 ± 0.048	3.918GluThr: 3.918 ± 0.053	3.168GluVal: 3.168 ± 0.041	0.529GluTrp: 0.529 ± 0.015	2.674GluTyr: 2.674 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.223PheAla: 2.223 ± 0.039	0.552PheCys: 0.552 ± 0.016	3.277PheAsp: 3.277 ± 0.042	3.306PheGlu: 3.306 ± 0.041	2.617PhePhe: 2.617 ± 0.042	2.526PheGly: 2.526 ± 0.042	0.81PheHis: 0.81 ± 0.017	3.974PheIle: 3.974 ± 0.051	4.535PheLys: 4.535 ± 0.049	4.755PheLeu: 4.755 ± 0.056	1.02PheMet: 1.02 ± 0.022	3.904PheAsn: 3.904 ± 0.053	1.428PhePro: 1.428 ± 0.025	1.844PheGln: 1.844 ± 0.03	1.209PheArg: 1.209 ± 0.023	3.622PheSer: 3.622 ± 0.048	2.518PheThr: 2.518 ± 0.035	2.742PheVal: 2.742 ± 0.039	0.445PheTrp: 0.445 ± 0.014	1.858PheTyr: 1.858 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	2.007GlyAla: 2.007 ± 0.047	0.721GlyCys: 0.721 ± 0.018	2.533GlyAsp: 2.533 ± 0.041	2.637GlyGlu: 2.637 ± 0.041	2.417GlyPhe: 2.417 ± 0.041	2.625GlyGly: 2.625 ± 0.055	0.809GlyHis: 0.809 ± 0.023	3.308GlyIle: 3.308 ± 0.045	3.634GlyLys: 3.634 ± 0.042	4.16GlyLeu: 4.16 ± 0.054	0.928GlyMet: 0.928 ± 0.022	3.089GlyAsn: 3.089 ± 0.044	1.019GlyPro: 1.019 ± 0.023	1.189GlyGln: 1.189 ± 0.026	1.474GlyArg: 1.474 ± 0.03	3.815GlySer: 3.815 ± 0.056	2.39GlyThr: 2.39 ± 0.042	2.652GlyVal: 2.652 ± 0.043	0.427GlyTrp: 0.427 ± 0.016	1.761GlyTyr: 1.761 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	0.574HisAla: 0.574 ± 0.019	0.264HisCys: 0.264 ± 0.011	0.917HisAsp: 0.917 ± 0.02	0.975HisGlu: 0.975 ± 0.024	0.934HisPhe: 0.934 ± 0.021	0.8HisGly: 0.8 ± 0.022	0.415HisHis: 0.415 ± 0.015	1.345HisIle: 1.345 ± 0.031	1.345HisLys: 1.345 ± 0.026	1.96HisLeu: 1.96 ± 0.033	0.366HisMet: 0.366 ± 0.014	1.208HisAsn: 1.208 ± 0.024	0.731HisPro: 0.731 ± 0.021	0.686HisGln: 0.686 ± 0.02	0.583HisArg: 0.583 ± 0.017	1.465HisSer: 1.465 ± 0.03	0.823HisThr: 0.823 ± 0.019	0.817HisVal: 0.817 ± 0.021	0.197HisTrp: 0.197 ± 0.011	0.751HisTyr: 0.751 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.309IleAla: 3.309 ± 0.047	0.952IleCys: 0.952 ± 0.023	5.082IleAsp: 5.082 ± 0.06	5.074IleGlu: 5.074 ± 0.059	3.757IlePhe: 3.757 ± 0.051	3.21IleGly: 3.21 ± 0.05	1.299IleHis: 1.299 ± 0.026	5.864IleIle: 5.864 ± 0.066	6.536IleLys: 6.536 ± 0.065	7.587IleLeu: 7.587 ± 0.068	1.533IleMet: 1.533 ± 0.031	6.506IleAsn: 6.506 ± 0.068	3.136IlePro: 3.136 ± 0.048	2.676IleGln: 2.676 ± 0.04	2.144IleArg: 2.144 ± 0.033	6.602IleSer: 6.602 ± 0.064	4.301IleThr: 4.301 ± 0.047	4.048IleVal: 4.048 ± 0.05	0.665IleTrp: 0.665 ± 0.019	2.741IleTyr: 2.741 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.126LysAla: 3.126 ± 0.045	0.893LysCys: 0.893 ± 0.023	5.162LysAsp: 5.162 ± 0.063	6.911LysGlu: 6.911 ± 0.077	4.098LysPhe: 4.098 ± 0.054	2.917LysGly: 2.917 ± 0.043	1.645LysHis: 1.645 ± 0.028	6.976LysIle: 6.976 ± 0.064	9.183LysLys: 9.183 ± 0.108	8.741LysLeu: 8.741 ± 0.078	1.832LysMet: 1.832 ± 0.029	7.535LysAsn: 7.535 ± 0.077	2.815LysPro: 2.815 ± 0.038	4.145LysGln: 4.145 ± 0.045	3.398LysArg: 3.398 ± 0.047	5.793LysSer: 5.793 ± 0.061	4.934LysThr: 4.934 ± 0.056	3.875LysVal: 3.875 ± 0.042	0.78LysTrp: 0.78 ± 0.017	3.648LysTyr: 3.648 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	4.44LeuAla: 4.44 ± 0.053	1.114LeuCys: 1.114 ± 0.024	5.615LeuAsp: 5.615 ± 0.06	6.513LeuGlu: 6.513 ± 0.07	4.478LeuPhe: 4.478 ± 0.052	4.006LeuGly: 4.006 ± 0.054	1.643LeuHis: 1.643 ± 0.03	7.364LeuIle: 7.364 ± 0.082	9.796LeuLys: 9.796 ± 0.081	9.991LeuLeu: 9.991 ± 0.1	2.014LeuMet: 2.014 ± 0.032	7.864LeuAsn: 7.864 ± 0.084	3.876LeuPro: 3.876 ± 0.05	4.342LeuGln: 4.342 ± 0.049	3.17LeuArg: 3.17 ± 0.041	7.943LeuSer: 7.943 ± 0.066	5.289LeuThr: 5.289 ± 0.043	4.77LeuVal: 4.77 ± 0.055	0.675LeuTrp: 0.675 ± 0.019	3.305LeuTyr: 3.305 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.077MetAla: 1.077 ± 0.025	0.261MetCys: 0.261 ± 0.012	1.208MetAsp: 1.208 ± 0.023	1.313MetGlu: 1.313 ± 0.026	1.013MetPhe: 1.013 ± 0.021	1.006MetGly: 1.006 ± 0.022	0.302MetHis: 0.302 ± 0.012	1.544MetIle: 1.544 ± 0.029	1.801MetLys: 1.801 ± 0.031	1.697MetLeu: 1.697 ± 0.031	0.498MetMet: 0.498 ± 0.018	1.692MetAsn: 1.692 ± 0.032	0.622MetPro: 0.622 ± 0.017	0.659MetGln: 0.659 ± 0.019	0.622MetArg: 0.622 ± 0.019	1.967MetSer: 1.967 ± 0.034	1.093MetThr: 1.093 ± 0.026	1.022MetVal: 1.022 ± 0.023	0.148MetTrp: 0.148 ± 0.009	0.573MetTyr: 0.573 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.597AsnAla: 2.597 ± 0.034	0.919AsnCys: 0.919 ± 0.021	5.397AsnAsp: 5.397 ± 0.057	5.38AsnGlu: 5.38 ± 0.052	3.652AsnPhe: 3.652 ± 0.047	3.855AsnGly: 3.855 ± 0.044	1.291AsnHis: 1.291 ± 0.026	6.564AsnIle: 6.564 ± 0.069	7.615AsnLys: 7.615 ± 0.078	7.098AsnLeu: 7.098 ± 0.063	1.477AsnMet: 1.477 ± 0.031	10.463AsnAsn: 10.463 ± 0.181	2.31AsnPro: 2.31 ± 0.033	2.429AsnGln: 2.429 ± 0.042	2.008AsnArg: 2.008 ± 0.03	7.317AsnSer: 7.317 ± 0.094	4.393AsnThr: 4.393 ± 0.054	3.738AsnVal: 3.738 ± 0.04	0.696AsnTrp: 0.696 ± 0.019	2.951AsnTyr: 2.951 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	1.454ProAla: 1.454 ± 0.03	0.281ProCys: 0.281 ± 0.013	1.664ProAsp: 1.664 ± 0.034	2.411ProGlu: 2.411 ± 0.04	1.798ProPhe: 1.798 ± 0.032	1.274ProGly: 1.274 ± 0.029	0.572ProHis: 0.572 ± 0.018	2.748ProIle: 2.748 ± 0.038	2.754ProLys: 2.754 ± 0.038	3.46ProLeu: 3.46 ± 0.044	0.673ProMet: 0.673 ± 0.019	2.187ProAsn: 2.187 ± 0.034	1.428ProPro: 1.428 ± 0.04	1.318ProGln: 1.318 ± 0.033	0.957ProArg: 0.957 ± 0.024	2.886ProSer: 2.886 ± 0.043	2.064ProThr: 2.064 ± 0.037	2.072ProVal: 2.072 ± 0.039	0.3ProTrp: 0.3 ± 0.012	1.186ProTyr: 1.186 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	1.426GlnAla: 1.426 ± 0.03	0.388GlnCys: 0.388 ± 0.014	1.838GlnAsp: 1.838 ± 0.031	2.603GlnGlu: 2.603 ± 0.038	1.95GlnPhe: 1.95 ± 0.031	1.271GlnGly: 1.271 ± 0.029	0.776GlnHis: 0.776 ± 0.02	2.664GlnIle: 2.664 ± 0.036	3.251GlnLys: 3.251 ± 0.046	4.013GlnLeu: 4.013 ± 0.053	0.831GlnMet: 0.831 ± 0.021	2.667GlnAsn: 2.667 ± 0.044	1.365GlnPro: 1.365 ± 0.034	3.353GlnGln: 3.353 ± 0.111	1.449GlnArg: 1.449 ± 0.029	2.611GlnSer: 2.611 ± 0.036	1.882GlnThr: 1.882 ± 0.035	1.751GlnVal: 1.751 ± 0.027	0.295GlnTrp: 0.295 ± 0.011	1.455GlnTyr: 1.455 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	1.36ArgAla: 1.36 ± 0.028	0.396ArgCys: 0.396 ± 0.014	1.785ArgAsp: 1.785 ± 0.029	2.06ArgGlu: 2.06 ± 0.037	1.661ArgPhe: 1.661 ± 0.03	1.36ArgGly: 1.36 ± 0.032	0.617ArgHis: 0.617 ± 0.016	2.201ArgIle: 2.201 ± 0.035	2.787ArgLys: 2.787 ± 0.045	3.176ArgLeu: 3.176 ± 0.039	0.66ArgMet: 0.66 ± 0.018	2.143ArgAsn: 2.143 ± 0.033	0.936ArgPro: 0.936 ± 0.023	1.245ArgGln: 1.245 ± 0.026	1.518ArgArg: 1.518 ± 0.038	2.31ArgSer: 2.31 ± 0.039	1.514ArgThr: 1.514 ± 0.028	1.62ArgVal: 1.62 ± 0.029	0.266ArgTrp: 0.266 ± 0.011	1.237ArgTyr: 1.237 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	3.346SerAla: 3.346 ± 0.053	0.981SerCys: 0.981 ± 0.024	4.755SerAsp: 4.755 ± 0.058	4.763SerGlu: 4.763 ± 0.05	4.291SerPhe: 4.291 ± 0.056	3.724SerGly: 3.724 ± 0.055	1.348SerHis: 1.348 ± 0.027	6.292SerIle: 6.292 ± 0.061	7.067SerLys: 7.067 ± 0.07	8.328SerLeu: 8.328 ± 0.072	1.55SerMet: 1.55 ± 0.031	7.288SerAsn: 7.288 ± 0.089	2.571SerPro: 2.571 ± 0.048	2.703SerGln: 2.703 ± 0.041	2.365SerArg: 2.365 ± 0.041	9.532SerSer: 9.532 ± 0.171	5.263SerThr: 5.263 ± 0.114	4.076SerVal: 4.076 ± 0.043	0.64SerTrp: 0.64 ± 0.021	2.826SerTyr: 2.826 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	2.628ThrAla: 2.628 ± 0.044	0.691ThrCys: 0.691 ± 0.017	2.937ThrAsp: 2.937 ± 0.043	3.21ThrGlu: 3.21 ± 0.044	2.727ThrPhe: 2.727 ± 0.037	2.817ThrGly: 2.817 ± 0.05	0.925ThrHis: 0.925 ± 0.02	4.325ThrIle: 4.325 ± 0.049	4.52ThrLys: 4.52 ± 0.055	5.223ThrLeu: 5.223 ± 0.054	0.908ThrMet: 0.908 ± 0.022	4.51ThrAsn: 4.51 ± 0.056	2.437ThrPro: 2.437 ± 0.04	1.718ThrGln: 1.718 ± 0.03	1.519ThrArg: 1.519 ± 0.026	5.42ThrSer: 5.42 ± 0.115	4.386ThrThr: 4.386 ± 0.105	3.027ThrVal: 3.027 ± 0.048	0.466ThrTrp: 0.466 ± 0.015	1.847ThrTyr: 1.847 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	2.574ValAla: 2.574 ± 0.042	0.669ValCys: 0.669 ± 0.019	3.222ValAsp: 3.222 ± 0.039	3.589ValGlu: 3.589 ± 0.048	2.578ValPhe: 2.578 ± 0.04	2.386ValGly: 2.386 ± 0.04	0.783ValHis: 0.783 ± 0.019	3.806ValIle: 3.806 ± 0.046	4.099ValLys: 4.099 ± 0.049	5.077ValLeu: 5.077 ± 0.056	1.002ValMet: 1.002 ± 0.022	3.51ValAsn: 3.51 ± 0.043	1.929ValPro: 1.929 ± 0.033	1.529ValGln: 1.529 ± 0.027	1.406ValArg: 1.406 ± 0.032	4.412ValSer: 4.412 ± 0.048	2.877ValThr: 2.877 ± 0.046	3.122ValVal: 3.122 ± 0.045	0.453ValTrp: 0.453 ± 0.016	1.942ValTyr: 1.942 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.394TrpAla: 0.394 ± 0.016	0.193TrpCys: 0.193 ± 0.01	0.546TrpAsp: 0.546 ± 0.019	0.559TrpGlu: 0.559 ± 0.016	0.474TrpPhe: 0.474 ± 0.016	0.416TrpGly: 0.416 ± 0.017	0.137TrpHis: 0.137 ± 0.008	0.612TrpIle: 0.612 ± 0.017	0.758TrpLys: 0.758 ± 0.02	0.804TrpLeu: 0.804 ± 0.023	0.189TrpMet: 0.189 ± 0.01	0.582TrpAsn: 0.582 ± 0.019	0.244TrpPro: 0.244 ± 0.012	0.287TrpGln: 0.287 ± 0.012	0.38TrpArg: 0.38 ± 0.014	0.639TrpSer: 0.639 ± 0.02	0.408TrpThr: 0.408 ± 0.016	0.47TrpVal: 0.47 ± 0.016	0.105TrpTrp: 0.105 ± 0.008	0.316TrpTyr: 0.316 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.391TyrAla: 1.391 ± 0.031	0.602TyrCys: 0.602 ± 0.017	2.445TyrAsp: 2.445 ± 0.036	2.331TyrGlu: 2.331 ± 0.038	1.762TyrPhe: 1.762 ± 0.031	1.764TyrGly: 1.764 ± 0.032	0.753TyrHis: 0.753 ± 0.019	2.72TyrIle: 2.72 ± 0.041	3.413TyrLys: 3.413 ± 0.041	3.843TyrLeu: 3.843 ± 0.051	0.796TyrMet: 0.796 ± 0.02	2.93TyrAsn: 2.93 ± 0.041	1.246TyrPro: 1.246 ± 0.026	1.499TyrGln: 1.499 ± 0.03	1.123TyrArg: 1.123 ± 0.024	2.878TyrSer: 2.878 ± 0.042	1.918TyrThr: 1.918 ± 0.033	1.746TyrVal: 1.746 ± 0.031	0.414TyrTrp: 0.414 ± 0.017	1.822TyrTyr: 1.822 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4754 proteins (2108114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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