Amino acid dipepetide frequency for Candidatus Methylopumilus turicensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.39AlaAla: 9.39 ± 0.19
0.993AlaCys: 0.993 ± 0.041
5.38AlaAsp: 5.38 ± 0.122
6.306AlaGlu: 6.306 ± 0.136
3.758AlaPhe: 3.758 ± 0.099
7.048AlaGly: 7.048 ± 0.147
2.111AlaHis: 2.111 ± 0.059
6.319AlaIle: 6.319 ± 0.106
6.223AlaLys: 6.223 ± 0.12
11.133AlaLeu: 11.133 ± 0.183
2.954AlaMet: 2.954 ± 0.073
4.219AlaAsn: 4.219 ± 0.084
3.475AlaPro: 3.475 ± 0.09
4.075AlaGln: 4.075 ± 0.089
4.431AlaArg: 4.431 ± 0.106
6.137AlaSer: 6.137 ± 0.112
4.732AlaThr: 4.732 ± 0.102
6.139AlaVal: 6.139 ± 0.119
1.284AlaTrp: 1.284 ± 0.059
2.724AlaTyr: 2.724 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.819CysAla: 0.819 ± 0.043
0.125CysCys: 0.125 ± 0.015
0.529CysAsp: 0.529 ± 0.031
0.546CysGlu: 0.546 ± 0.03
0.365CysPhe: 0.365 ± 0.025
0.854CysGly: 0.854 ± 0.049
0.301CysHis: 0.301 ± 0.023
0.497CysIle: 0.497 ± 0.03
0.4CysLys: 0.4 ± 0.028
0.867CysLeu: 0.867 ± 0.043
0.251CysMet: 0.251 ± 0.021
0.312CysAsn: 0.312 ± 0.022
0.51CysPro: 0.51 ± 0.035
0.295CysGln: 0.295 ± 0.024
0.389CysArg: 0.389 ± 0.028
0.488CysSer: 0.488 ± 0.033
0.475CysThr: 0.475 ± 0.027
0.637CysVal: 0.637 ± 0.038
0.084CysTrp: 0.084 ± 0.013
0.273CysTyr: 0.273 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
5.739AspAla: 5.739 ± 0.109
0.475AspCys: 0.475 ± 0.032
2.829AspAsp: 2.829 ± 0.084
3.545AspGlu: 3.545 ± 0.088
2.447AspPhe: 2.447 ± 0.077
4.01AspGly: 4.01 ± 0.087
1.028AspHis: 1.028 ± 0.042
3.537AspIle: 3.537 ± 0.094
2.907AspLys: 2.907 ± 0.077
5.676AspLeu: 5.676 ± 0.112
1.425AspMet: 1.425 ± 0.05
1.632AspAsn: 1.632 ± 0.063
2.04AspPro: 2.04 ± 0.054
1.918AspGln: 1.918 ± 0.067
2.389AspArg: 2.389 ± 0.072
2.703AspSer: 2.703 ± 0.081
2.546AspThr: 2.546 ± 0.069
4.105AspVal: 4.105 ± 0.108
0.838AspTrp: 0.838 ± 0.038
1.83AspTyr: 1.83 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
6.354GluAla: 6.354 ± 0.128
0.445GluCys: 0.445 ± 0.03
2.746GluAsp: 2.746 ± 0.081
3.025GluGlu: 3.025 ± 0.092
2.202GluPhe: 2.202 ± 0.066
3.419GluGly: 3.419 ± 0.088
1.344GluHis: 1.344 ± 0.054
4.324GluIle: 4.324 ± 0.096
3.76GluLys: 3.76 ± 0.107
5.676GluLeu: 5.676 ± 0.123
1.847GluMet: 1.847 ± 0.06
2.415GluAsn: 2.415 ± 0.069
1.808GluPro: 1.808 ± 0.054
2.746GluGln: 2.746 ± 0.087
3.268GluArg: 3.268 ± 0.089
3.21GluSer: 3.21 ± 0.077
3.1GluThr: 3.1 ± 0.08
4.451GluVal: 4.451 ± 0.111
0.671GluTrp: 0.671 ± 0.036
1.535GluTyr: 1.535 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.679PheAla: 3.679 ± 0.088
0.447PheCys: 0.447 ± 0.03
2.645PheAsp: 2.645 ± 0.074
2.406PheGlu: 2.406 ± 0.065
1.787PhePhe: 1.787 ± 0.071
3.374PheGly: 3.374 ± 0.085
0.77PheHis: 0.77 ± 0.04
2.546PheIle: 2.546 ± 0.091
2.156PheLys: 2.156 ± 0.07
3.457PheLeu: 3.457 ± 0.105
1.002PheMet: 1.002 ± 0.05
2.041PheAsn: 2.041 ± 0.071
1.494PhePro: 1.494 ± 0.052
1.187PheGln: 1.187 ± 0.052
1.503PheArg: 1.503 ± 0.061
2.795PheSer: 2.795 ± 0.073
2.006PheThr: 2.006 ± 0.064
2.943PheVal: 2.943 ± 0.096
0.505PheTrp: 0.505 ± 0.036
1.282PheTyr: 1.282 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
6.123GlyAla: 6.123 ± 0.127
0.757GlyCys: 0.757 ± 0.043
3.874GlyAsp: 3.874 ± 0.107
4.133GlyGlu: 4.133 ± 0.1
3.225GlyPhe: 3.225 ± 0.094
5.192GlyGly: 5.192 ± 0.132
1.709GlyHis: 1.709 ± 0.055
4.827GlyIle: 4.827 ± 0.104
4.425GlyLys: 4.425 ± 0.099
7.717GlyLeu: 7.717 ± 0.129
2.191GlyMet: 2.191 ± 0.076
2.632GlyAsn: 2.632 ± 0.084
1.677GlyPro: 1.677 ± 0.057
2.509GlyGln: 2.509 ± 0.068
3.404GlyArg: 3.404 ± 0.086
3.954GlySer: 3.954 ± 0.111
3.365GlyThr: 3.365 ± 0.096
5.56GlyVal: 5.56 ± 0.116
0.946GlyTrp: 0.946 ± 0.054
2.215GlyTyr: 2.215 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
2.322HisAla: 2.322 ± 0.069
0.284HisCys: 0.284 ± 0.025
1.125HisAsp: 1.125 ± 0.041
1.241HisGlu: 1.241 ± 0.047
1.112HisPhe: 1.112 ± 0.047
1.641HisGly: 1.641 ± 0.054
0.787HisHis: 0.787 ± 0.035
1.454HisIle: 1.454 ± 0.054
0.953HisLys: 0.953 ± 0.044
2.442HisLeu: 2.442 ± 0.074
0.574HisMet: 0.574 ± 0.03
0.763HisAsn: 0.763 ± 0.042
1.355HisPro: 1.355 ± 0.054
1.281HisGln: 1.281 ± 0.051
0.95HisArg: 0.95 ± 0.043
1.193HisSer: 1.193 ± 0.045
1.135HisThr: 1.135 ± 0.045
1.439HisVal: 1.439 ± 0.056
0.333HisTrp: 0.333 ± 0.027
0.867HisTyr: 0.867 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
7.055IleAla: 7.055 ± 0.131
0.576IleCys: 0.576 ± 0.038
3.911IleAsp: 3.911 ± 0.095
4.391IleGlu: 4.391 ± 0.078
2.206IlePhe: 2.206 ± 0.071
4.76IleGly: 4.76 ± 0.113
1.395IleHis: 1.395 ± 0.059
3.436IleIle: 3.436 ± 0.09
4.01IleLys: 4.01 ± 0.1
5.463IleLeu: 5.463 ± 0.112
1.301IleMet: 1.301 ± 0.051
2.986IleAsn: 2.986 ± 0.085
2.731IlePro: 2.731 ± 0.077
2.393IleGln: 2.393 ± 0.077
2.696IleArg: 2.696 ± 0.073
4.457IleSer: 4.457 ± 0.094
3.773IleThr: 3.773 ± 0.091
4.337IleVal: 4.337 ± 0.102
0.608IleTrp: 0.608 ± 0.035
1.729IleTyr: 1.729 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.797LysAla: 5.797 ± 0.119
0.284LysCys: 0.284 ± 0.024
2.784LysAsp: 2.784 ± 0.074
3.085LysGlu: 3.085 ± 0.085
1.896LysPhe: 1.896 ± 0.061
3.395LysGly: 3.395 ± 0.099
1.419LysHis: 1.419 ± 0.052
3.717LysIle: 3.717 ± 0.09
3.359LysLys: 3.359 ± 0.091
6.102LysLeu: 6.102 ± 0.124
1.55LysMet: 1.55 ± 0.06
2.473LysAsn: 2.473 ± 0.068
2.806LysPro: 2.806 ± 0.087
2.815LysGln: 2.815 ± 0.08
2.958LysArg: 2.958 ± 0.079
3.668LysSer: 3.668 ± 0.086
3.397LysThr: 3.397 ± 0.083
4.014LysVal: 4.014 ± 0.078
0.465LysTrp: 0.465 ± 0.032
1.318LysTyr: 1.318 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
10.811LeuAla: 10.811 ± 0.164
0.895LeuCys: 0.895 ± 0.046
5.665LeuAsp: 5.665 ± 0.12
5.782LeuGlu: 5.782 ± 0.12
3.862LeuPhe: 3.862 ± 0.105
7.36LeuGly: 7.36 ± 0.126
2.118LeuHis: 2.118 ± 0.074
6.517LeuIle: 6.517 ± 0.138
6.061LeuLys: 6.061 ± 0.114
10.144LeuLeu: 10.144 ± 0.187
2.944LeuMet: 2.944 ± 0.082
4.737LeuAsn: 4.737 ± 0.105
4.891LeuPro: 4.891 ± 0.105
3.645LeuGln: 3.645 ± 0.082
4.943LeuArg: 4.943 ± 0.106
7.244LeuSer: 7.244 ± 0.129
5.45LeuThr: 5.45 ± 0.099
7.009LeuVal: 7.009 ± 0.139
1.004LeuTrp: 1.004 ± 0.054
2.357LeuTyr: 2.357 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.743MetAla: 2.743 ± 0.074
0.155MetCys: 0.155 ± 0.016
1.305MetAsp: 1.305 ± 0.049
1.318MetGlu: 1.318 ± 0.055
0.901MetPhe: 0.901 ± 0.045
1.836MetGly: 1.836 ± 0.067
0.675MetHis: 0.675 ± 0.039
1.552MetIle: 1.552 ± 0.055
1.597MetLys: 1.597 ± 0.062
2.948MetLeu: 2.948 ± 0.074
0.839MetMet: 0.839 ± 0.049
1.142MetAsn: 1.142 ± 0.045
1.354MetPro: 1.354 ± 0.043
1.514MetGln: 1.514 ± 0.053
1.694MetArg: 1.694 ± 0.052
1.871MetSer: 1.871 ± 0.063
1.675MetThr: 1.675 ± 0.061
1.868MetVal: 1.868 ± 0.061
0.193MetTrp: 0.193 ± 0.017
0.479MetTyr: 0.479 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
4.193AsnAla: 4.193 ± 0.101
0.38AsnCys: 0.38 ± 0.027
2.019AsnAsp: 2.019 ± 0.069
2.135AsnGlu: 2.135 ± 0.057
1.593AsnPhe: 1.593 ± 0.051
2.963AsnGly: 2.963 ± 0.083
0.978AsnHis: 0.978 ± 0.044
2.956AsnIle: 2.956 ± 0.089
2.43AsnLys: 2.43 ± 0.074
4.117AsnLeu: 4.117 ± 0.09
1.028AsnMet: 1.028 ± 0.045
1.684AsnAsn: 1.684 ± 0.067
2.294AsnPro: 2.294 ± 0.072
2.07AsnGln: 2.07 ± 0.071
1.877AsnArg: 1.877 ± 0.063
2.028AsnSer: 2.028 ± 0.074
2.354AsnThr: 2.354 ± 0.058
2.778AsnVal: 2.778 ± 0.076
0.465AsnTrp: 0.465 ± 0.029
1.099AsnTyr: 1.099 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
3.797ProAla: 3.797 ± 0.084
0.365ProCys: 0.365 ± 0.024
2.352ProAsp: 2.352 ± 0.066
2.931ProGlu: 2.931 ± 0.078
1.726ProPhe: 1.726 ± 0.054
2.453ProGly: 2.453 ± 0.078
1.047ProHis: 1.047 ± 0.047
2.711ProIle: 2.711 ± 0.064
2.427ProLys: 2.427 ± 0.078
3.924ProLeu: 3.924 ± 0.09
1.11ProMet: 1.11 ± 0.049
2.071ProAsn: 2.071 ± 0.058
1.402ProPro: 1.402 ± 0.075
1.681ProGln: 1.681 ± 0.049
1.518ProArg: 1.518 ± 0.059
2.675ProSer: 2.675 ± 0.075
2.264ProThr: 2.264 ± 0.062
3.064ProVal: 3.064 ± 0.076
0.482ProTrp: 0.482 ± 0.031
1.258ProTyr: 1.258 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
4.823GlnAla: 4.823 ± 0.104
0.312GlnCys: 0.312 ± 0.025
2.094GlnAsp: 2.094 ± 0.059
2.133GlnGlu: 2.133 ± 0.064
1.58GlnPhe: 1.58 ± 0.051
2.559GlnGly: 2.559 ± 0.067
1.196GlnHis: 1.196 ± 0.046
2.557GlnIle: 2.557 ± 0.073
2.189GlnLys: 2.189 ± 0.071
4.206GlnLeu: 4.206 ± 0.099
1.133GlnMet: 1.133 ± 0.049
1.598GlnAsn: 1.598 ± 0.07
1.542GlnPro: 1.542 ± 0.06
2.015GlnGln: 2.015 ± 0.073
2.064GlnArg: 2.064 ± 0.076
2.584GlnSer: 2.584 ± 0.073
2.099GlnThr: 2.099 ± 0.065
3.021GlnVal: 3.021 ± 0.08
0.445GlnTrp: 0.445 ± 0.028
1.23GlnTyr: 1.23 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
4.227ArgAla: 4.227 ± 0.093
0.413ArgCys: 0.413 ± 0.03
2.628ArgAsp: 2.628 ± 0.078
3.12ArgGlu: 3.12 ± 0.085
2.163ArgPhe: 2.163 ± 0.062
2.963ArgGly: 2.963 ± 0.087
1.153ArgHis: 1.153 ± 0.046
3.214ArgIle: 3.214 ± 0.08
2.299ArgLys: 2.299 ± 0.064
5.063ArgLeu: 5.063 ± 0.115
1.484ArgMet: 1.484 ± 0.056
1.912ArgAsn: 1.912 ± 0.07
1.851ArgPro: 1.851 ± 0.074
1.987ArgGln: 1.987 ± 0.067
2.344ArgArg: 2.344 ± 0.075
2.378ArgSer: 2.378 ± 0.069
2.111ArgThr: 2.111 ± 0.066
3.488ArgVal: 3.488 ± 0.08
0.594ArgTrp: 0.594 ± 0.037
1.653ArgTyr: 1.653 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.022SerAla: 6.022 ± 0.108
0.54SerCys: 0.54 ± 0.035
3.107SerAsp: 3.107 ± 0.077
3.193SerGlu: 3.193 ± 0.067
2.511SerPhe: 2.511 ± 0.073
4.691SerGly: 4.691 ± 0.102
1.623SerHis: 1.623 ± 0.054
3.879SerIle: 3.879 ± 0.098
3.419SerLys: 3.419 ± 0.092
6.796SerLeu: 6.796 ± 0.133
1.645SerMet: 1.645 ± 0.05
2.572SerAsn: 2.572 ± 0.081
2.649SerPro: 2.649 ± 0.07
2.47SerGln: 2.47 ± 0.081
2.782SerArg: 2.782 ± 0.078
3.754SerSer: 3.754 ± 0.108
3.012SerThr: 3.012 ± 0.085
3.999SerVal: 3.999 ± 0.094
0.709SerTrp: 0.709 ± 0.036
1.649SerTyr: 1.649 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
4.552ThrAla: 4.552 ± 0.096
0.436ThrCys: 0.436 ± 0.031
2.565ThrAsp: 2.565 ± 0.065
2.873ThrGlu: 2.873 ± 0.078
2.075ThrPhe: 2.075 ± 0.064
4.255ThrGly: 4.255 ± 0.109
1.288ThrHis: 1.288 ± 0.049
3.221ThrIle: 3.221 ± 0.082
2.714ThrLys: 2.714 ± 0.065
5.906ThrLeu: 5.906 ± 0.117
1.153ThrMet: 1.153 ± 0.058
2.075ThrAsn: 2.075 ± 0.063
2.999ThrPro: 2.999 ± 0.09
2.212ThrGln: 2.212 ± 0.065
2.277ThrArg: 2.277 ± 0.069
3.122ThrSer: 3.122 ± 0.088
2.759ThrThr: 2.759 ± 0.098
3.552ThrVal: 3.552 ± 0.087
0.54ThrTrp: 0.54 ± 0.032
1.425ThrTyr: 1.425 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
6.872ValAla: 6.872 ± 0.133
0.656ValCys: 0.656 ± 0.039
3.943ValAsp: 3.943 ± 0.092
4.178ValGlu: 4.178 ± 0.083
2.772ValPhe: 2.772 ± 0.08
4.851ValGly: 4.851 ± 0.103
1.297ValHis: 1.297 ± 0.049
4.82ValIle: 4.82 ± 0.094
4.075ValLys: 4.075 ± 0.112
7.171ValLeu: 7.171 ± 0.124
2.266ValMet: 2.266 ± 0.068
2.829ValAsn: 2.829 ± 0.07
2.713ValPro: 2.713 ± 0.063
2.346ValGln: 2.346 ± 0.075
3.294ValArg: 3.294 ± 0.08
4.554ValSer: 4.554 ± 0.093
3.887ValThr: 3.887 ± 0.091
5.347ValVal: 5.347 ± 0.098
0.768ValTrp: 0.768 ± 0.047
1.759ValTyr: 1.759 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.901TrpAla: 0.901 ± 0.046
0.146TrpCys: 0.146 ± 0.017
0.568TrpAsp: 0.568 ± 0.038
0.538TrpGlu: 0.538 ± 0.034
0.499TrpPhe: 0.499 ± 0.03
0.716TrpGly: 0.716 ± 0.035
0.299TrpHis: 0.299 ± 0.027
0.664TrpIle: 0.664 ± 0.036
0.587TrpLys: 0.587 ± 0.033
1.641TrpLeu: 1.641 ± 0.064
0.35TrpMet: 0.35 ± 0.027
0.391TrpAsn: 0.391 ± 0.027
0.394TrpPro: 0.394 ± 0.026
0.684TrpGln: 0.684 ± 0.035
0.742TrpArg: 0.742 ± 0.045
0.593TrpSer: 0.593 ± 0.034
0.48TrpThr: 0.48 ± 0.029
0.86TrpVal: 0.86 ± 0.043
0.196TrpTrp: 0.196 ± 0.022
0.307TrpTyr: 0.307 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.612TyrAla: 2.612 ± 0.07
0.335TyrCys: 0.335 ± 0.025
1.55TyrAsp: 1.55 ± 0.055
1.466TyrGlu: 1.466 ± 0.055
1.346TyrPhe: 1.346 ± 0.057
2.094TyrGly: 2.094 ± 0.073
0.714TyrHis: 0.714 ± 0.036
1.466TyrIle: 1.466 ± 0.059
1.311TyrLys: 1.311 ± 0.056
2.993TyrLeu: 2.993 ± 0.075
0.608TyrMet: 0.608 ± 0.035
0.953TyrAsn: 0.953 ± 0.051
1.273TyrPro: 1.273 ± 0.054
1.539TyrGln: 1.539 ± 0.053
1.525TyrArg: 1.525 ± 0.056
1.611TyrSer: 1.611 ± 0.058
1.382TyrThr: 1.382 ± 0.051
1.787TyrVal: 1.787 ± 0.059
0.426TyrTrp: 0.426 ± 0.027
0.768TyrTyr: 0.768 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1739 proteins (534910 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski