Amino acid dipepetide frequency for Circoviridae 10 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.822AlaAla: 3.822 ± 1.047
1.274AlaCys: 1.274 ± 0.918
3.822AlaAsp: 3.822 ± 1.029
5.096AlaGlu: 5.096 ± 3.21
2.548AlaPhe: 2.548 ± 0.59
6.369AlaGly: 6.369 ± 4.341
0.0AlaHis: 0.0 ± 0.0
2.548AlaIle: 2.548 ± 0.59
5.096AlaLys: 5.096 ± 1.757
5.096AlaLeu: 5.096 ± 0.885
0.0AlaMet: 0.0 ± 0.0
2.548AlaAsn: 2.548 ± 1.448
1.274AlaPro: 1.274 ± 1.581
2.548AlaGln: 2.548 ± 1.835
6.369AlaArg: 6.369 ± 1.323
5.096AlaSer: 5.096 ± 3.152
3.822AlaThr: 3.822 ± 1.047
3.822AlaVal: 3.822 ± 1.326
0.0AlaTrp: 0.0 ± 0.0
3.822AlaTyr: 3.822 ± 1.029
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.274CysAsp: 1.274 ± 0.788
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
3.822CysPro: 3.822 ± 1.326
1.274CysGln: 1.274 ± 0.918
1.274CysArg: 1.274 ± 0.918
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.548AspAla: 2.548 ± 1.448
1.274AspCys: 1.274 ± 0.788
2.548AspAsp: 2.548 ± 1.835
3.822AspGlu: 3.822 ± 1.714
5.096AspPhe: 5.096 ± 0.885
5.096AspGly: 5.096 ± 1.757
0.0AspHis: 0.0 ± 0.0
1.274AspIle: 1.274 ± 0.788
0.0AspLys: 0.0 ± 0.0
7.643AspLeu: 7.643 ± 2.094
2.548AspMet: 2.548 ± 1.576
0.0AspAsn: 0.0 ± 0.0
10.191AspPro: 10.191 ± 7.176
5.096AspGln: 5.096 ± 0.885
2.548AspArg: 2.548 ± 1.835
5.096AspSer: 5.096 ± 2.897
5.096AspThr: 5.096 ± 1.757
1.274AspVal: 1.274 ± 0.918
1.274AspTrp: 1.274 ± 0.918
2.548AspTyr: 2.548 ± 1.835
0.0AspXaa: 0.0 ± 0.0
Glu
5.096GluAla: 5.096 ± 1.18
0.0GluCys: 0.0 ± 0.0
3.822GluAsp: 3.822 ± 2.928
1.274GluGlu: 1.274 ± 0.918
2.548GluPhe: 2.548 ± 1.576
1.274GluGly: 1.274 ± 1.581
0.0GluHis: 0.0 ± 0.0
2.548GluIle: 2.548 ± 1.835
3.822GluLys: 3.822 ± 1.047
5.096GluLeu: 5.096 ± 2.602
0.0GluMet: 0.0 ± 0.0
1.274GluAsn: 1.274 ± 0.788
6.369GluPro: 6.369 ± 1.323
1.274GluGln: 1.274 ± 1.581
3.822GluArg: 3.822 ± 2.082
5.096GluSer: 5.096 ± 1.18
3.822GluThr: 3.822 ± 1.326
3.822GluVal: 3.822 ± 1.047
0.0GluTrp: 0.0 ± 0.0
2.548GluTyr: 2.548 ± 1.576
0.0GluXaa: 0.0 ± 0.0
Phe
3.822PheAla: 3.822 ± 2.364
0.0PheCys: 0.0 ± 0.0
3.822PheAsp: 3.822 ± 1.029
2.548PheGlu: 2.548 ± 1.835
2.548PhePhe: 2.548 ± 0.59
3.822PheGly: 3.822 ± 1.714
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
1.274PheLys: 1.274 ± 0.918
3.822PheLeu: 3.822 ± 1.326
0.0PheMet: 0.0 ± 0.0
2.548PheAsn: 2.548 ± 0.59
1.274PhePro: 1.274 ± 0.788
1.274PheGln: 1.274 ± 0.788
1.274PheArg: 1.274 ± 0.788
2.548PheSer: 2.548 ± 1.835
5.096PheThr: 5.096 ± 1.757
3.822PheVal: 3.822 ± 2.364
0.0PheTrp: 0.0 ± 0.0
3.822PheTyr: 3.822 ± 1.326
0.0PheXaa: 0.0 ± 0.0
Gly
6.369GlyAla: 6.369 ± 2.514
1.274GlyCys: 1.274 ± 0.788
7.643GlyAsp: 7.643 ± 1.989
7.643GlyGlu: 7.643 ± 3.593
1.274GlyPhe: 1.274 ± 0.918
5.096GlyGly: 5.096 ± 2.24
2.548GlyHis: 2.548 ± 1.576
2.548GlyIle: 2.548 ± 1.576
3.822GlyLys: 3.822 ± 1.326
5.096GlyLeu: 5.096 ± 2.789
0.0GlyMet: 0.0 ± 0.0
2.548GlyAsn: 2.548 ± 1.835
7.643GlyPro: 7.643 ± 0.405
3.822GlyGln: 3.822 ± 1.326
6.369GlyArg: 6.369 ± 2.579
7.643GlySer: 7.643 ± 2.836
5.096GlyThr: 5.096 ± 1.18
5.096GlyVal: 5.096 ± 0.885
2.548GlyTrp: 2.548 ± 1.576
5.096GlyTyr: 5.096 ± 2.789
0.0GlyXaa: 0.0 ± 0.0
His
1.274HisAla: 1.274 ± 0.918
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.274HisPhe: 1.274 ± 0.918
2.548HisGly: 2.548 ± 0.59
0.0HisHis: 0.0 ± 0.0
2.548HisIle: 2.548 ± 0.59
2.548HisLys: 2.548 ± 0.59
1.274HisLeu: 1.274 ± 0.788
1.274HisMet: 1.274 ± 0.918
1.274HisAsn: 1.274 ± 1.581
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
5.096HisThr: 5.096 ± 1.757
0.0HisVal: 0.0 ± 0.0
1.274HisTrp: 1.274 ± 0.918
1.274HisTyr: 1.274 ± 0.788
0.0HisXaa: 0.0 ± 0.0
Ile
1.274IleAla: 1.274 ± 0.918
1.274IleCys: 1.274 ± 0.918
3.822IleAsp: 3.822 ± 2.364
6.369IleGlu: 6.369 ± 0.559
1.274IlePhe: 1.274 ± 0.918
3.822IleGly: 3.822 ± 1.029
2.548IleHis: 2.548 ± 0.59
2.548IleIle: 2.548 ± 1.576
2.548IleLys: 2.548 ± 0.59
3.822IleLeu: 3.822 ± 2.082
1.274IleMet: 1.274 ± 0.788
2.548IleAsn: 2.548 ± 1.576
1.274IlePro: 1.274 ± 0.788
3.822IleGln: 3.822 ± 1.714
1.274IleArg: 1.274 ± 0.918
1.274IleSer: 1.274 ± 0.788
0.0IleThr: 0.0 ± 0.0
0.0IleVal: 0.0 ± 0.0
0.0IleTrp: 0.0 ± 0.0
2.548IleTyr: 2.548 ± 1.835
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
1.274LysCys: 1.274 ± 0.918
1.274LysAsp: 1.274 ± 0.918
5.096LysGlu: 5.096 ± 2.203
2.548LysPhe: 2.548 ± 1.576
6.369LysGly: 6.369 ± 2.514
3.822LysHis: 3.822 ± 1.047
1.274LysIle: 1.274 ± 0.918
1.274LysLys: 1.274 ± 0.918
1.274LysLeu: 1.274 ± 0.918
2.548LysMet: 2.548 ± 1.576
0.0LysAsn: 0.0 ± 0.0
2.548LysPro: 2.548 ± 1.835
1.274LysGln: 1.274 ± 0.788
3.822LysArg: 3.822 ± 1.326
3.822LysSer: 3.822 ± 2.364
3.822LysThr: 3.822 ± 1.029
5.096LysVal: 5.096 ± 3.152
1.274LysTrp: 1.274 ± 0.918
1.274LysTyr: 1.274 ± 1.581
0.0LysXaa: 0.0 ± 0.0
Leu
5.096LeuAla: 5.096 ± 2.602
0.0LeuCys: 0.0 ± 0.0
3.822LeuAsp: 3.822 ± 1.326
2.548LeuGlu: 2.548 ± 1.576
1.274LeuPhe: 1.274 ± 1.581
3.822LeuGly: 3.822 ± 2.753
0.0LeuHis: 0.0 ± 0.0
6.369LeuIle: 6.369 ± 2.339
3.822LeuLys: 3.822 ± 1.09
6.369LeuLeu: 6.369 ± 2.008
0.0LeuMet: 0.0 ± 0.695
2.548LeuAsn: 2.548 ± 1.448
7.643LeuPro: 7.643 ± 2.866
2.548LeuGln: 2.548 ± 1.835
0.0LeuArg: 0.0 ± 0.0
5.096LeuSer: 5.096 ± 1.757
2.548LeuThr: 2.548 ± 1.576
10.191LeuVal: 10.191 ± 1.548
0.0LeuTrp: 0.0 ± 0.0
1.274LeuTyr: 1.274 ± 0.788
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
1.274MetAsp: 1.274 ± 1.581
1.274MetGlu: 1.274 ± 0.788
3.822MetPhe: 3.822 ± 2.364
1.274MetGly: 1.274 ± 0.918
0.0MetHis: 0.0 ± 0.0
1.274MetIle: 1.274 ± 0.788
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
3.822MetVal: 3.822 ± 2.364
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.548AsnAla: 2.548 ± 1.576
0.0AsnCys: 0.0 ± 0.0
3.822AsnAsp: 3.822 ± 1.047
3.822AsnGlu: 3.822 ± 1.047
0.0AsnPhe: 0.0 ± 0.0
2.548AsnGly: 2.548 ± 1.576
1.274AsnHis: 1.274 ± 0.918
2.548AsnIle: 2.548 ± 1.576
1.274AsnLys: 1.274 ± 0.788
2.548AsnLeu: 2.548 ± 1.448
0.0AsnMet: 0.0 ± 0.0
1.274AsnAsn: 1.274 ± 0.788
6.369AsnPro: 6.369 ± 2.514
1.274AsnGln: 1.274 ± 1.581
0.0AsnArg: 0.0 ± 0.0
1.274AsnSer: 1.274 ± 0.788
3.822AsnThr: 3.822 ± 2.082
5.096AsnVal: 5.096 ± 2.897
1.274AsnTrp: 1.274 ± 0.918
2.548AsnTyr: 2.548 ± 1.576
0.0AsnXaa: 0.0 ± 0.0
Pro
8.917ProAla: 8.917 ± 3.627
0.0ProCys: 0.0 ± 0.0
7.643ProAsp: 7.643 ± 0.405
1.274ProGlu: 1.274 ± 0.788
5.096ProPhe: 5.096 ± 1.757
12.739ProGly: 12.739 ± 1.806
2.548ProHis: 2.548 ± 1.448
5.096ProIle: 5.096 ± 2.789
2.548ProLys: 2.548 ± 1.576
2.548ProLeu: 2.548 ± 1.448
0.0ProMet: 0.0 ± 0.0
1.274ProAsn: 1.274 ± 0.788
8.917ProPro: 8.917 ± 5.616
1.274ProGln: 1.274 ± 0.918
2.548ProArg: 2.548 ± 0.59
1.274ProSer: 1.274 ± 1.581
5.096ProThr: 5.096 ± 1.305
5.096ProVal: 5.096 ± 2.203
2.548ProTrp: 2.548 ± 1.835
5.096ProTyr: 5.096 ± 2.602
0.0ProXaa: 0.0 ± 0.0
Gln
2.548GlnAla: 2.548 ± 1.605
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
1.274GlnGlu: 1.274 ± 0.918
1.274GlnPhe: 1.274 ± 0.918
6.369GlnGly: 6.369 ± 0.559
1.274GlnHis: 1.274 ± 0.788
1.274GlnIle: 1.274 ± 1.581
1.274GlnLys: 1.274 ± 1.581
1.274GlnLeu: 1.274 ± 0.788
1.274GlnMet: 1.274 ± 0.788
0.0GlnAsn: 0.0 ± 0.0
2.548GlnPro: 2.548 ± 1.835
1.274GlnGln: 1.274 ± 0.918
1.274GlnArg: 1.274 ± 0.918
1.274GlnSer: 1.274 ± 0.788
0.0GlnThr: 0.0 ± 0.0
0.0GlnVal: 0.0 ± 0.0
2.548GlnTrp: 2.548 ± 0.59
6.369GlnTyr: 6.369 ± 2.579
0.0GlnXaa: 0.0 ± 0.0
Arg
6.369ArgAla: 6.369 ± 2.579
0.0ArgCys: 0.0 ± 0.0
1.274ArgAsp: 1.274 ± 0.788
2.548ArgGlu: 2.548 ± 1.605
3.822ArgPhe: 3.822 ± 1.326
6.369ArgGly: 6.369 ± 3.104
1.274ArgHis: 1.274 ± 0.788
2.548ArgIle: 2.548 ± 1.576
1.274ArgLys: 1.274 ± 0.918
1.274ArgLeu: 1.274 ± 1.581
0.0ArgMet: 0.0 ± 0.0
3.822ArgAsn: 3.822 ± 1.029
2.548ArgPro: 2.548 ± 1.835
2.548ArgGln: 2.548 ± 1.605
5.096ArgArg: 5.096 ± 2.203
1.274ArgSer: 1.274 ± 0.788
2.548ArgThr: 2.548 ± 1.835
3.822ArgVal: 3.822 ± 2.753
1.274ArgTrp: 1.274 ± 0.788
3.822ArgTyr: 3.822 ± 2.753
0.0ArgXaa: 0.0 ± 0.0
Ser
1.274SerAla: 1.274 ± 0.788
0.0SerCys: 0.0 ± 0.0
3.822SerAsp: 3.822 ± 2.928
5.096SerGlu: 5.096 ± 2.24
1.274SerPhe: 1.274 ± 0.788
6.369SerGly: 6.369 ± 1.506
1.274SerHis: 1.274 ± 0.918
0.0SerIle: 0.0 ± 0.0
6.369SerLys: 6.369 ± 2.976
3.822SerLeu: 3.822 ± 1.326
2.548SerMet: 2.548 ± 1.721
8.917SerAsn: 8.917 ± 4.063
3.822SerPro: 3.822 ± 1.029
0.0SerGln: 0.0 ± 0.0
5.096SerArg: 5.096 ± 1.18
14.013SerSer: 14.013 ± 6.226
3.822SerThr: 3.822 ± 1.047
3.822SerVal: 3.822 ± 1.047
0.0SerTrp: 0.0 ± 0.0
3.822SerTyr: 3.822 ± 1.047
0.0SerXaa: 0.0 ± 0.0
Thr
5.096ThrAla: 5.096 ± 1.757
0.0ThrCys: 0.0 ± 0.0
7.643ThrAsp: 7.643 ± 0.405
0.0ThrGlu: 0.0 ± 0.0
2.548ThrPhe: 2.548 ± 1.576
2.548ThrGly: 2.548 ± 1.835
0.0ThrHis: 0.0 ± 0.0
3.822ThrIle: 3.822 ± 1.326
1.274ThrLys: 1.274 ± 0.918
3.822ThrLeu: 3.822 ± 1.326
0.0ThrMet: 0.0 ± 0.0
5.096ThrAsn: 5.096 ± 1.757
2.548ThrPro: 2.548 ± 0.59
0.0ThrGln: 0.0 ± 0.0
2.548ThrArg: 2.548 ± 0.59
6.369ThrSer: 6.369 ± 2.008
5.096ThrThr: 5.096 ± 0.885
6.369ThrVal: 6.369 ± 0.559
0.0ThrTrp: 0.0 ± 0.0
5.096ThrTyr: 5.096 ± 3.152
0.0ThrXaa: 0.0 ± 0.0
Val
2.548ValAla: 2.548 ± 1.576
0.0ValCys: 0.0 ± 0.0
3.822ValAsp: 3.822 ± 1.326
2.548ValGlu: 2.548 ± 1.605
1.274ValPhe: 1.274 ± 0.788
8.917ValGly: 8.917 ± 1.122
3.822ValHis: 3.822 ± 2.753
2.548ValIle: 2.548 ± 0.59
2.548ValLys: 2.548 ± 0.59
2.548ValLeu: 2.548 ± 1.576
0.0ValMet: 0.0 ± 0.0
5.096ValAsn: 5.096 ± 2.24
6.369ValPro: 6.369 ± 1.836
1.274ValGln: 1.274 ± 1.581
5.096ValArg: 5.096 ± 3.21
6.369ValSer: 6.369 ± 3.94
5.096ValThr: 5.096 ± 1.18
0.0ValVal: 0.0 ± 0.0
1.274ValTrp: 1.274 ± 0.918
3.822ValTyr: 3.822 ± 1.047
0.0ValXaa: 0.0 ± 0.0
Trp
1.274TrpAla: 1.274 ± 0.918
0.0TrpCys: 0.0 ± 0.0
1.274TrpAsp: 1.274 ± 0.788
1.274TrpGlu: 1.274 ± 0.918
2.548TrpPhe: 2.548 ± 1.835
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.274TrpIle: 1.274 ± 0.918
0.0TrpLys: 0.0 ± 0.0
1.274TrpLeu: 1.274 ± 0.788
0.0TrpMet: 0.0 ± 0.0
1.274TrpAsn: 1.274 ± 0.918
1.274TrpPro: 1.274 ± 0.918
1.274TrpGln: 1.274 ± 0.918
0.0TrpArg: 0.0 ± 0.0
2.548TrpSer: 2.548 ± 1.576
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.096TyrAla: 5.096 ± 3.21
1.274TyrCys: 1.274 ± 0.918
2.548TyrAsp: 2.548 ± 1.605
0.0TyrGlu: 0.0 ± 0.0
1.274TyrPhe: 1.274 ± 0.918
3.822TyrGly: 3.822 ± 1.047
1.274TyrHis: 1.274 ± 0.918
1.274TyrIle: 1.274 ± 0.788
7.643TyrLys: 7.643 ± 0.405
7.643TyrLeu: 7.643 ± 2.058
0.0TyrMet: 0.0 ± 0.0
1.274TyrAsn: 1.274 ± 0.788
5.096TyrPro: 5.096 ± 2.24
1.274TyrGln: 1.274 ± 0.788
5.096TyrArg: 5.096 ± 3.67
5.096TyrSer: 5.096 ± 3.152
0.0TyrThr: 0.0 ± 0.0
3.822TyrVal: 3.822 ± 1.326
0.0TyrTrp: 0.0 ± 0.0
1.274TyrTyr: 1.274 ± 0.918
1.274TyrXaa: 1.274 ± 0.918
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
1.274XaaLys: 1.274 ± 0.918
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski