Amino acid dipepetide frequency for Streptococcus phage Javan273

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.799AlaAla: 3.799 ± 0.872
0.086AlaCys: 0.086 ± 0.1
4.144AlaAsp: 4.144 ± 0.595
7.166AlaGlu: 7.166 ± 1.131
2.59AlaPhe: 2.59 ± 0.755
3.712AlaGly: 3.712 ± 0.929
1.122AlaHis: 1.122 ± 0.371
6.389AlaIle: 6.389 ± 0.915
5.612AlaLys: 5.612 ± 0.682
5.871AlaLeu: 5.871 ± 0.922
2.331AlaMet: 2.331 ± 0.645
5.871AlaAsn: 5.871 ± 0.784
2.331AlaPro: 2.331 ± 0.494
3.108AlaGln: 3.108 ± 0.612
2.676AlaArg: 2.676 ± 0.521
5.957AlaSer: 5.957 ± 1.847
6.475AlaThr: 6.475 ± 0.896
4.489AlaVal: 4.489 ± 0.935
0.777AlaTrp: 0.777 ± 0.275
2.245AlaTyr: 2.245 ± 0.633
0.0AlaXaa: 0.0 ± 0.0
Cys
0.259CysAla: 0.259 ± 0.174
0.086CysCys: 0.086 ± 0.092
0.173CysAsp: 0.173 ± 0.11
0.345CysGlu: 0.345 ± 0.212
0.086CysPhe: 0.086 ± 0.079
0.518CysGly: 0.518 ± 0.276
0.086CysHis: 0.086 ± 0.079
0.173CysIle: 0.173 ± 0.13
0.518CysLys: 0.518 ± 0.209
0.0CysLeu: 0.0 ± 0.0
0.173CysMet: 0.173 ± 0.143
0.432CysAsn: 0.432 ± 0.276
0.345CysPro: 0.345 ± 0.149
0.0CysGln: 0.0 ± 0.0
0.432CysArg: 0.432 ± 0.233
0.432CysSer: 0.432 ± 0.215
0.0CysThr: 0.0 ± 0.0
0.173CysVal: 0.173 ± 0.124
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.317AspAla: 4.317 ± 0.759
0.432AspCys: 0.432 ± 0.196
3.281AspAsp: 3.281 ± 0.462
4.662AspGlu: 4.662 ± 0.682
3.799AspPhe: 3.799 ± 0.59
5.525AspGly: 5.525 ± 1.172
0.604AspHis: 0.604 ± 0.287
4.489AspIle: 4.489 ± 0.57
4.748AspLys: 4.748 ± 0.624
4.748AspLeu: 4.748 ± 0.786
1.295AspMet: 1.295 ± 0.294
4.144AspAsn: 4.144 ± 0.774
1.468AspPro: 1.468 ± 0.395
1.554AspGln: 1.554 ± 0.424
2.331AspArg: 2.331 ± 0.594
3.367AspSer: 3.367 ± 0.573
3.54AspThr: 3.54 ± 0.574
3.453AspVal: 3.453 ± 0.493
0.95AspTrp: 0.95 ± 0.244
3.799AspTyr: 3.799 ± 0.681
0.0AspXaa: 0.0 ± 0.0
Glu
4.317GluAla: 4.317 ± 0.686
0.259GluCys: 0.259 ± 0.199
3.453GluAsp: 3.453 ± 0.677
5.007GluGlu: 5.007 ± 1.122
2.849GluPhe: 2.849 ± 0.522
3.108GluGly: 3.108 ± 0.644
0.432GluHis: 0.432 ± 0.2
5.18GluIle: 5.18 ± 0.613
5.698GluLys: 5.698 ± 0.834
7.943GluLeu: 7.943 ± 1.103
1.813GluMet: 1.813 ± 0.452
3.367GluAsn: 3.367 ± 0.682
2.158GluPro: 2.158 ± 0.426
3.626GluGln: 3.626 ± 0.738
3.367GluArg: 3.367 ± 0.681
4.23GluSer: 4.23 ± 0.686
3.885GluThr: 3.885 ± 0.789
4.144GluVal: 4.144 ± 0.676
1.295GluTrp: 1.295 ± 0.393
3.54GluTyr: 3.54 ± 0.549
0.0GluXaa: 0.0 ± 0.0
Phe
3.885PheAla: 3.885 ± 0.713
0.0PheCys: 0.0 ± 0.0
2.59PheAsp: 2.59 ± 0.503
2.59PheGlu: 2.59 ± 0.556
0.95PhePhe: 0.95 ± 0.312
3.367PheGly: 3.367 ± 0.578
0.345PheHis: 0.345 ± 0.167
2.331PheIle: 2.331 ± 0.454
2.935PheLys: 2.935 ± 0.69
2.072PheLeu: 2.072 ± 0.473
1.036PheMet: 1.036 ± 0.302
3.281PheAsn: 3.281 ± 0.626
0.95PhePro: 0.95 ± 0.385
0.604PheGln: 0.604 ± 0.208
1.036PheArg: 1.036 ± 0.284
1.813PheSer: 1.813 ± 0.479
2.417PheThr: 2.417 ± 0.351
2.245PheVal: 2.245 ± 0.339
0.345PheTrp: 0.345 ± 0.238
1.468PheTyr: 1.468 ± 0.357
0.0PheXaa: 0.0 ± 0.0
Gly
4.23GlyAla: 4.23 ± 0.938
0.432GlyCys: 0.432 ± 0.207
2.245GlyAsp: 2.245 ± 0.44
3.626GlyGlu: 3.626 ± 0.461
2.417GlyPhe: 2.417 ± 0.66
2.849GlyGly: 2.849 ± 0.465
1.209GlyHis: 1.209 ± 0.424
4.144GlyIle: 4.144 ± 1.17
6.648GlyLys: 6.648 ± 0.582
5.007GlyLeu: 5.007 ± 0.929
2.417GlyMet: 2.417 ± 0.802
3.022GlyAsn: 3.022 ± 0.436
0.604GlyPro: 0.604 ± 0.202
2.245GlyGln: 2.245 ± 0.392
3.022GlyArg: 3.022 ± 0.71
4.748GlySer: 4.748 ± 0.695
4.576GlyThr: 4.576 ± 0.723
4.662GlyVal: 4.662 ± 0.623
1.468GlyTrp: 1.468 ± 0.465
2.59GlyTyr: 2.59 ± 0.579
0.0GlyXaa: 0.0 ± 0.0
His
1.036HisAla: 1.036 ± 0.263
0.086HisCys: 0.086 ± 0.089
0.345HisAsp: 0.345 ± 0.158
0.777HisGlu: 0.777 ± 0.317
0.95HisPhe: 0.95 ± 0.276
1.122HisGly: 1.122 ± 0.412
0.345HisHis: 0.345 ± 0.204
0.691HisIle: 0.691 ± 0.327
0.691HisLys: 0.691 ± 0.288
0.95HisLeu: 0.95 ± 0.304
0.0HisMet: 0.0 ± 0.0
0.691HisAsn: 0.691 ± 0.272
0.173HisPro: 0.173 ± 0.118
0.345HisGln: 0.345 ± 0.146
0.345HisArg: 0.345 ± 0.152
1.295HisSer: 1.295 ± 0.261
1.036HisThr: 1.036 ± 0.251
0.173HisVal: 0.173 ± 0.119
0.0HisTrp: 0.0 ± 0.0
0.432HisTyr: 0.432 ± 0.189
0.0HisXaa: 0.0 ± 0.0
Ile
7.597IleAla: 7.597 ± 1.273
0.345IleCys: 0.345 ± 0.16
7.684IleAsp: 7.684 ± 0.708
5.525IleGlu: 5.525 ± 0.924
1.727IlePhe: 1.727 ± 0.298
4.058IleGly: 4.058 ± 0.774
0.259IleHis: 0.259 ± 0.167
4.403IleIle: 4.403 ± 0.736
5.353IleLys: 5.353 ± 0.696
4.058IleLeu: 4.058 ± 0.531
1.295IleMet: 1.295 ± 0.367
4.835IleAsn: 4.835 ± 0.751
1.899IlePro: 1.899 ± 0.422
2.417IleGln: 2.417 ± 0.626
1.986IleArg: 1.986 ± 0.35
4.489IleSer: 4.489 ± 0.749
5.525IleThr: 5.525 ± 0.708
4.403IleVal: 4.403 ± 0.563
0.691IleTrp: 0.691 ± 0.236
2.417IleTyr: 2.417 ± 0.534
0.0IleXaa: 0.0 ± 0.0
Lys
6.302LysAla: 6.302 ± 0.777
0.086LysCys: 0.086 ± 0.089
4.23LysAsp: 4.23 ± 0.662
6.216LysGlu: 6.216 ± 0.903
2.245LysPhe: 2.245 ± 0.458
4.144LysGly: 4.144 ± 0.43
1.122LysHis: 1.122 ± 0.35
5.957LysIle: 5.957 ± 0.967
6.907LysLys: 6.907 ± 1.047
5.612LysLeu: 5.612 ± 0.7
2.417LysMet: 2.417 ± 0.536
5.266LysAsn: 5.266 ± 0.771
2.245LysPro: 2.245 ± 0.428
3.971LysGln: 3.971 ± 0.684
4.489LysArg: 4.489 ± 0.825
4.835LysSer: 4.835 ± 0.753
5.871LysThr: 5.871 ± 0.729
5.353LysVal: 5.353 ± 0.919
1.036LysTrp: 1.036 ± 0.272
2.763LysTyr: 2.763 ± 0.644
0.0LysXaa: 0.0 ± 0.0
Leu
6.13LeuAla: 6.13 ± 0.558
0.173LeuCys: 0.173 ± 0.158
6.82LeuAsp: 6.82 ± 1.078
5.612LeuGlu: 5.612 ± 0.701
2.417LeuPhe: 2.417 ± 0.407
5.007LeuGly: 5.007 ± 0.946
0.691LeuHis: 0.691 ± 0.297
4.921LeuIle: 4.921 ± 0.908
7.856LeuLys: 7.856 ± 0.958
5.007LeuLeu: 5.007 ± 0.832
1.554LeuMet: 1.554 ± 0.39
4.403LeuAsn: 4.403 ± 0.721
3.54LeuPro: 3.54 ± 0.718
2.935LeuGln: 2.935 ± 0.42
3.108LeuArg: 3.108 ± 0.571
6.13LeuSer: 6.13 ± 0.888
4.576LeuThr: 4.576 ± 0.612
5.784LeuVal: 5.784 ± 0.743
0.345LeuTrp: 0.345 ± 0.15
2.072LeuTyr: 2.072 ± 0.521
0.0LeuXaa: 0.0 ± 0.0
Met
2.935MetAla: 2.935 ± 0.789
0.086MetCys: 0.086 ± 0.09
2.072MetAsp: 2.072 ± 0.514
1.899MetGlu: 1.899 ± 0.367
0.777MetPhe: 0.777 ± 0.243
1.295MetGly: 1.295 ± 0.302
0.173MetHis: 0.173 ± 0.101
2.072MetIle: 2.072 ± 0.419
1.554MetLys: 1.554 ± 0.502
1.727MetLeu: 1.727 ± 0.432
0.432MetMet: 0.432 ± 0.19
1.468MetAsn: 1.468 ± 0.579
0.604MetPro: 0.604 ± 0.172
1.468MetGln: 1.468 ± 0.399
1.122MetArg: 1.122 ± 0.34
2.676MetSer: 2.676 ± 0.932
1.899MetThr: 1.899 ± 0.295
1.122MetVal: 1.122 ± 0.305
0.432MetTrp: 0.432 ± 0.168
0.345MetTyr: 0.345 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
5.353AsnAla: 5.353 ± 1.158
0.173AsnCys: 0.173 ± 0.122
3.108AsnAsp: 3.108 ± 0.658
3.194AsnGlu: 3.194 ± 0.712
2.504AsnPhe: 2.504 ± 0.446
4.921AsnGly: 4.921 ± 0.628
0.691AsnHis: 0.691 ± 0.314
4.144AsnIle: 4.144 ± 0.504
3.367AsnLys: 3.367 ± 0.367
5.094AsnLeu: 5.094 ± 0.736
2.245AsnMet: 2.245 ± 0.438
3.712AsnAsn: 3.712 ± 0.554
2.676AsnPro: 2.676 ± 0.559
2.158AsnGln: 2.158 ± 0.373
2.676AsnArg: 2.676 ± 0.4
4.403AsnSer: 4.403 ± 1.233
3.281AsnThr: 3.281 ± 0.499
3.885AsnVal: 3.885 ± 0.562
0.863AsnTrp: 0.863 ± 0.338
2.158AsnTyr: 2.158 ± 0.481
0.0AsnXaa: 0.0 ± 0.0
Pro
2.331ProAla: 2.331 ± 0.531
0.086ProCys: 0.086 ± 0.095
1.727ProAsp: 1.727 ± 0.418
2.331ProGlu: 2.331 ± 0.509
1.381ProPhe: 1.381 ± 0.437
1.295ProGly: 1.295 ± 0.371
0.0ProHis: 0.0 ± 0.0
1.813ProIle: 1.813 ± 0.42
2.158ProLys: 2.158 ± 0.523
2.59ProLeu: 2.59 ± 0.461
0.604ProMet: 0.604 ± 0.259
1.468ProAsn: 1.468 ± 0.316
0.691ProPro: 0.691 ± 0.313
1.727ProGln: 1.727 ± 0.628
1.209ProArg: 1.209 ± 0.34
1.468ProSer: 1.468 ± 0.306
2.158ProThr: 2.158 ± 0.451
2.072ProVal: 2.072 ± 0.394
0.086ProTrp: 0.086 ± 0.079
1.036ProTyr: 1.036 ± 0.243
0.0ProXaa: 0.0 ± 0.0
Gln
3.281GlnAla: 3.281 ± 0.67
0.259GlnCys: 0.259 ± 0.149
2.331GlnAsp: 2.331 ± 0.431
2.417GlnGlu: 2.417 ± 0.603
1.64GlnPhe: 1.64 ± 0.339
2.072GlnGly: 2.072 ± 0.546
0.777GlnHis: 0.777 ± 0.319
2.245GlnIle: 2.245 ± 0.57
3.54GlnLys: 3.54 ± 0.569
3.54GlnLeu: 3.54 ± 0.458
1.209GlnMet: 1.209 ± 0.317
1.986GlnAsn: 1.986 ± 0.402
1.554GlnPro: 1.554 ± 0.512
3.194GlnGln: 3.194 ± 0.874
2.158GlnArg: 2.158 ± 0.391
4.058GlnSer: 4.058 ± 0.513
3.194GlnThr: 3.194 ± 0.482
2.072GlnVal: 2.072 ± 0.468
0.432GlnTrp: 0.432 ± 0.164
0.777GlnTyr: 0.777 ± 0.194
0.0GlnXaa: 0.0 ± 0.0
Arg
2.849ArgAla: 2.849 ± 0.676
0.432ArgCys: 0.432 ± 0.246
1.468ArgAsp: 1.468 ± 0.41
2.158ArgGlu: 2.158 ± 0.445
1.468ArgPhe: 1.468 ± 0.337
1.986ArgGly: 1.986 ± 0.575
0.777ArgHis: 0.777 ± 0.292
2.245ArgIle: 2.245 ± 0.433
3.367ArgLys: 3.367 ± 0.79
5.18ArgLeu: 5.18 ± 0.836
1.727ArgMet: 1.727 ± 0.343
2.504ArgAsn: 2.504 ± 0.487
1.036ArgPro: 1.036 ± 0.281
2.072ArgGln: 2.072 ± 0.422
2.158ArgArg: 2.158 ± 0.583
1.381ArgSer: 1.381 ± 0.284
2.504ArgThr: 2.504 ± 0.523
2.849ArgVal: 2.849 ± 0.499
1.209ArgTrp: 1.209 ± 0.419
2.676ArgTyr: 2.676 ± 0.588
0.0ArgXaa: 0.0 ± 0.0
Ser
5.871SerAla: 5.871 ± 2.066
0.259SerCys: 0.259 ± 0.219
4.576SerAsp: 4.576 ± 0.805
4.317SerGlu: 4.317 ± 0.588
2.59SerPhe: 2.59 ± 0.617
5.353SerGly: 5.353 ± 1.2
0.518SerHis: 0.518 ± 0.212
6.043SerIle: 6.043 ± 1.598
5.698SerLys: 5.698 ± 0.643
6.13SerLeu: 6.13 ± 1.157
1.727SerMet: 1.727 ± 0.446
3.54SerAsn: 3.54 ± 0.627
1.468SerPro: 1.468 ± 0.308
3.108SerGln: 3.108 ± 0.675
2.072SerArg: 2.072 ± 0.558
5.266SerSer: 5.266 ± 2.158
3.799SerThr: 3.799 ± 0.594
4.489SerVal: 4.489 ± 0.812
0.518SerTrp: 0.518 ± 0.225
1.209SerTyr: 1.209 ± 0.327
0.0SerXaa: 0.0 ± 0.0
Thr
4.835ThrAla: 4.835 ± 0.907
0.259ThrCys: 0.259 ± 0.146
4.058ThrAsp: 4.058 ± 0.406
3.885ThrGlu: 3.885 ± 0.76
2.072ThrPhe: 2.072 ± 0.43
4.576ThrGly: 4.576 ± 0.62
0.604ThrHis: 0.604 ± 0.213
5.784ThrIle: 5.784 ± 0.637
4.921ThrLys: 4.921 ± 0.848
5.266ThrLeu: 5.266 ± 0.735
1.813ThrMet: 1.813 ± 0.442
3.281ThrAsn: 3.281 ± 0.642
2.158ThrPro: 2.158 ± 0.498
3.022ThrGln: 3.022 ± 0.589
2.763ThrArg: 2.763 ± 0.482
5.353ThrSer: 5.353 ± 1.341
3.54ThrThr: 3.54 ± 0.753
5.007ThrVal: 5.007 ± 0.654
0.432ThrTrp: 0.432 ± 0.175
3.108ThrTyr: 3.108 ± 0.699
0.0ThrXaa: 0.0 ± 0.0
Val
4.317ValAla: 4.317 ± 0.642
0.604ValCys: 0.604 ± 0.239
4.748ValAsp: 4.748 ± 0.725
4.921ValGlu: 4.921 ± 1.05
1.727ValPhe: 1.727 ± 0.414
4.144ValGly: 4.144 ± 0.627
0.691ValHis: 0.691 ± 0.19
4.144ValIle: 4.144 ± 0.516
5.957ValLys: 5.957 ± 0.59
4.576ValLeu: 4.576 ± 0.852
1.209ValMet: 1.209 ± 0.389
4.23ValAsn: 4.23 ± 0.529
1.381ValPro: 1.381 ± 0.346
2.331ValGln: 2.331 ± 0.663
2.849ValArg: 2.849 ± 0.55
3.367ValSer: 3.367 ± 0.83
5.094ValThr: 5.094 ± 0.606
3.712ValVal: 3.712 ± 0.723
0.518ValTrp: 0.518 ± 0.175
2.072ValTyr: 2.072 ± 0.456
0.0ValXaa: 0.0 ± 0.0
Trp
1.209TrpAla: 1.209 ± 0.322
0.0TrpCys: 0.0 ± 0.0
1.295TrpAsp: 1.295 ± 0.35
1.122TrpGlu: 1.122 ± 0.367
0.345TrpPhe: 0.345 ± 0.174
0.691TrpGly: 0.691 ± 0.237
0.345TrpHis: 0.345 ± 0.17
1.036TrpIle: 1.036 ± 0.368
0.95TrpLys: 0.95 ± 0.262
0.95TrpLeu: 0.95 ± 0.261
0.173TrpMet: 0.173 ± 0.111
0.432TrpAsn: 0.432 ± 0.198
0.086TrpPro: 0.086 ± 0.082
0.432TrpGln: 0.432 ± 0.199
0.432TrpArg: 0.432 ± 0.149
0.863TrpSer: 0.863 ± 0.315
0.518TrpThr: 0.518 ± 0.247
0.691TrpVal: 0.691 ± 0.279
0.086TrpTrp: 0.086 ± 0.09
0.173TrpTyr: 0.173 ± 0.112
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.899TyrAla: 1.899 ± 0.414
0.086TyrCys: 0.086 ± 0.079
2.245TyrAsp: 2.245 ± 0.517
1.899TyrGlu: 1.899 ± 0.41
1.727TyrPhe: 1.727 ± 0.359
2.417TyrGly: 2.417 ± 0.546
0.691TyrHis: 0.691 ± 0.276
2.763TyrIle: 2.763 ± 0.6
2.59TyrLys: 2.59 ± 0.545
2.763TyrLeu: 2.763 ± 0.603
0.604TyrMet: 0.604 ± 0.329
2.676TyrAsn: 2.676 ± 0.647
0.863TyrPro: 0.863 ± 0.314
2.417TyrGln: 2.417 ± 0.647
1.813TyrArg: 1.813 ± 0.675
2.417TyrSer: 2.417 ± 0.413
2.849TyrThr: 2.849 ± 0.526
1.813TyrVal: 1.813 ± 0.414
0.345TyrTrp: 0.345 ± 0.165
1.468TyrTyr: 1.468 ± 0.376
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (11584 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski