Amino acid dipepetide frequency for Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.852AlaAla: 8.852 ± 0.121	0.999AlaCys: 0.999 ± 0.034	4.286AlaAsp: 4.286 ± 0.069	5.251AlaGlu: 5.251 ± 0.093	2.971AlaPhe: 2.971 ± 0.066	7.03AlaGly: 7.03 ± 0.104	1.828AlaHis: 1.828 ± 0.046	5.873AlaIle: 5.873 ± 0.091	2.989AlaLys: 2.989 ± 0.055	10.489AlaLeu: 10.489 ± 0.132	2.25AlaMet: 2.25 ± 0.047	2.34AlaAsn: 2.34 ± 0.052	3.431AlaPro: 3.431 ± 0.062	3.123AlaGln: 3.123 ± 0.057	6.315AlaArg: 6.315 ± 0.09	5.895AlaSer: 5.895 ± 0.088	4.303AlaThr: 4.303 ± 0.075	6.821AlaVal: 6.821 ± 0.105	1.345AlaTrp: 1.345 ± 0.037	2.661AlaTyr: 2.661 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.719CysAla: 0.719 ± 0.026	0.157CysCys: 0.157 ± 0.012	0.426CysAsp: 0.426 ± 0.023	0.526CysGlu: 0.526 ± 0.023	0.28CysPhe: 0.28 ± 0.019	0.968CysGly: 0.968 ± 0.037	0.216CysHis: 0.216 ± 0.017	0.449CysIle: 0.449 ± 0.021	0.31CysLys: 0.31 ± 0.021	0.873CysLeu: 0.873 ± 0.031	0.198CysMet: 0.198 ± 0.014	0.26CysAsn: 0.26 ± 0.014	0.602CysPro: 0.602 ± 0.027	0.272CysGln: 0.272 ± 0.017	0.617CysArg: 0.617 ± 0.03	0.573CysSer: 0.573 ± 0.028	0.432CysThr: 0.432 ± 0.023	0.592CysVal: 0.592 ± 0.02	0.141CysTrp: 0.141 ± 0.011	0.298CysTyr: 0.298 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.185AspAla: 4.185 ± 0.081	0.395AspCys: 0.395 ± 0.022	2.406AspAsp: 2.406 ± 0.062	3.365AspGlu: 3.365 ± 0.066	1.73AspPhe: 1.73 ± 0.045	3.891AspGly: 3.891 ± 0.086	1.104AspHis: 1.104 ± 0.038	3.371AspIle: 3.371 ± 0.064	2.081AspLys: 2.081 ± 0.053	6.155AspLeu: 6.155 ± 0.086	1.099AspMet: 1.099 ± 0.034	1.515AspAsn: 1.515 ± 0.04	3.562AspPro: 3.562 ± 0.07	1.596AspGln: 1.596 ± 0.047	3.526AspArg: 3.526 ± 0.058	2.803AspSer: 2.803 ± 0.059	2.431AspThr: 2.431 ± 0.049	4.182AspVal: 4.182 ± 0.072	0.927AspTrp: 0.927 ± 0.035	1.801AspTyr: 1.801 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.36GluAla: 6.36 ± 0.104	0.463GluCys: 0.463 ± 0.023	3.644GluAsp: 3.644 ± 0.072	5.189GluGlu: 5.189 ± 0.109	1.901GluPhe: 1.901 ± 0.044	4.877GluGly: 4.877 ± 0.08	1.607GluHis: 1.607 ± 0.043	4.069GluIle: 4.069 ± 0.078	2.397GluLys: 2.397 ± 0.059	6.922GluLeu: 6.922 ± 0.106	1.554GluMet: 1.554 ± 0.042	1.704GluAsn: 1.704 ± 0.048	2.754GluPro: 2.754 ± 0.056	2.545GluGln: 2.545 ± 0.06	4.719GluArg: 4.719 ± 0.095	3.531GluSer: 3.531 ± 0.07	2.431GluThr: 2.431 ± 0.06	5.426GluVal: 5.426 ± 0.092	0.92GluTrp: 0.92 ± 0.034	1.907GluTyr: 1.907 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.789PheAla: 2.789 ± 0.066	0.33PheCys: 0.33 ± 0.018	1.946PheAsp: 1.946 ± 0.048	2.033PheGlu: 2.033 ± 0.049	1.281PhePhe: 1.281 ± 0.041	2.888PheGly: 2.888 ± 0.065	0.679PheHis: 0.679 ± 0.028	2.016PheIle: 2.016 ± 0.053	1.05PheLys: 1.05 ± 0.037	3.615PheLeu: 3.615 ± 0.092	0.736PheMet: 0.736 ± 0.029	0.928PheAsn: 0.928 ± 0.03	1.627PhePro: 1.627 ± 0.048	1.004PheGln: 1.004 ± 0.035	2.032PheArg: 2.032 ± 0.05	2.073PheSer: 2.073 ± 0.043	1.813PheThr: 1.813 ± 0.046	2.624PheVal: 2.624 ± 0.052	0.62PheTrp: 0.62 ± 0.028	1.128PheTyr: 1.128 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.583GlyAla: 6.583 ± 0.11	0.792GlyCys: 0.792 ± 0.033	3.987GlyAsp: 3.987 ± 0.077	4.689GlyGlu: 4.689 ± 0.083	2.845GlyPhe: 2.845 ± 0.06	6.2GlyGly: 6.2 ± 0.105	1.65GlyHis: 1.65 ± 0.041	5.051GlyIle: 5.051 ± 0.086	3.694GlyLys: 3.694 ± 0.076	7.907GlyLeu: 7.907 ± 0.122	1.976GlyMet: 1.976 ± 0.042	2.341GlyAsn: 2.341 ± 0.046	3.077GlyPro: 3.077 ± 0.052	2.658GlyGln: 2.658 ± 0.054	5.397GlyArg: 5.397 ± 0.079	4.843GlySer: 4.843 ± 0.081	4.107GlyThr: 4.107 ± 0.074	6.304GlyVal: 6.304 ± 0.102	1.493GlyTrp: 1.493 ± 0.045	2.973GlyTyr: 2.973 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.618HisAla: 1.618 ± 0.045	0.2HisCys: 0.2 ± 0.013	1.048HisAsp: 1.048 ± 0.035	1.183HisGlu: 1.183 ± 0.042	0.7HisPhe: 0.7 ± 0.031	1.695HisGly: 1.695 ± 0.045	0.546HisHis: 0.546 ± 0.025	1.391HisIle: 1.391 ± 0.042	0.794HisLys: 0.794 ± 0.025	2.178HisLeu: 2.178 ± 0.047	0.505HisMet: 0.505 ± 0.022	0.66HisAsn: 0.66 ± 0.024	1.563HisPro: 1.563 ± 0.047	0.643HisGln: 0.643 ± 0.03	1.477HisArg: 1.477 ± 0.04	1.113HisSer: 1.113 ± 0.035	1.141HisThr: 1.141 ± 0.034	1.556HisVal: 1.556 ± 0.039	0.325HisTrp: 0.325 ± 0.019	0.655HisTyr: 0.655 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.003IleAla: 6.003 ± 0.071	0.629IleCys: 0.629 ± 0.024	3.583IleAsp: 3.583 ± 0.06	3.915IleGlu: 3.915 ± 0.071	2.062IlePhe: 2.062 ± 0.056	4.607IleGly: 4.607 ± 0.074	1.177IleHis: 1.177 ± 0.036	3.442IleIle: 3.442 ± 0.062	2.349IleLys: 2.349 ± 0.058	5.799IleLeu: 5.799 ± 0.095	1.186IleMet: 1.186 ± 0.037	1.999IleAsn: 1.999 ± 0.045	3.319IlePro: 3.319 ± 0.067	1.859IleGln: 1.859 ± 0.048	3.973IleArg: 3.973 ± 0.073	4.314IleSer: 4.314 ± 0.073	3.41IleThr: 3.41 ± 0.063	4.628IleVal: 4.628 ± 0.077	0.853IleTrp: 0.853 ± 0.033	1.963IleTyr: 1.963 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	3.267LysAla: 3.267 ± 0.065	0.217LysCys: 0.217 ± 0.015	1.913LysAsp: 1.913 ± 0.056	2.434LysGlu: 2.434 ± 0.061	1.053LysPhe: 1.053 ± 0.037	2.628LysGly: 2.628 ± 0.062	0.852LysHis: 0.852 ± 0.031	2.449LysIle: 2.449 ± 0.055	1.314LysLys: 1.314 ± 0.039	4.143LysLeu: 4.143 ± 0.071	0.868LysMet: 0.868 ± 0.031	1.091LysAsn: 1.091 ± 0.044	1.878LysPro: 1.878 ± 0.048	1.363LysGln: 1.363 ± 0.044	2.077LysArg: 2.077 ± 0.049	2.03LysSer: 2.03 ± 0.05	1.657LysThr: 1.657 ± 0.046	3.214LysVal: 3.214 ± 0.069	0.507LysTrp: 0.507 ± 0.026	1.265LysTyr: 1.265 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	10.655LeuAla: 10.655 ± 0.124	0.979LeuCys: 0.979 ± 0.034	5.471LeuAsp: 5.471 ± 0.085	7.303LeuGlu: 7.303 ± 0.109	3.326LeuPhe: 3.326 ± 0.078	9.109LeuGly: 9.109 ± 0.145	2.019LeuHis: 2.019 ± 0.047	5.99LeuIle: 5.99 ± 0.115	3.147LeuLys: 3.147 ± 0.062	12.483LeuLeu: 12.483 ± 0.216	2.237LeuMet: 2.237 ± 0.053	2.569LeuAsn: 2.569 ± 0.053	5.725LeuPro: 5.725 ± 0.093	3.821LeuGln: 3.821 ± 0.076	7.917LeuArg: 7.917 ± 0.104	7.122LeuSer: 7.122 ± 0.09	4.936LeuThr: 4.936 ± 0.075	8.586LeuVal: 8.586 ± 0.106	1.588LeuTrp: 1.588 ± 0.041	2.995LeuTyr: 2.995 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.32MetAla: 2.32 ± 0.055	0.145MetCys: 0.145 ± 0.011	1.09MetAsp: 1.09 ± 0.036	1.333MetGlu: 1.333 ± 0.036	0.692MetPhe: 0.692 ± 0.035	1.803MetGly: 1.803 ± 0.048	0.512MetHis: 0.512 ± 0.022	1.255MetIle: 1.255 ± 0.04	0.789MetLys: 0.789 ± 0.028	2.673MetLeu: 2.673 ± 0.058	0.521MetMet: 0.521 ± 0.027	0.67MetAsn: 0.67 ± 0.027	1.298MetPro: 1.298 ± 0.035	0.833MetGln: 0.833 ± 0.027	1.616MetArg: 1.616 ± 0.04	1.645MetSer: 1.645 ± 0.043	1.143MetThr: 1.143 ± 0.036	1.675MetVal: 1.675 ± 0.043	0.284MetTrp: 0.284 ± 0.017	0.615MetTyr: 0.615 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.385AsnAla: 2.385 ± 0.055	0.242AsnCys: 0.242 ± 0.016	1.313AsnAsp: 1.313 ± 0.04	1.461AsnGlu: 1.461 ± 0.039	1.03AsnPhe: 1.03 ± 0.039	2.178AsnGly: 2.178 ± 0.056	0.586AsnHis: 0.586 ± 0.023	1.908AsnIle: 1.908 ± 0.042	1.197AsnLys: 1.197 ± 0.039	3.199AsnLeu: 3.199 ± 0.064	0.627AsnMet: 0.627 ± 0.03	1.102AsnAsn: 1.102 ± 0.039	2.217AsnPro: 2.217 ± 0.053	0.964AsnGln: 0.964 ± 0.036	1.806AsnArg: 1.806 ± 0.045	1.796AsnSer: 1.796 ± 0.049	1.676AsnThr: 1.676 ± 0.045	1.981AsnVal: 1.981 ± 0.048	0.477AsnTrp: 0.477 ± 0.022	1.128AsnTyr: 1.128 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.957ProAla: 3.957 ± 0.065	0.382ProCys: 0.382 ± 0.02	3.35ProAsp: 3.35 ± 0.055	4.363ProGlu: 4.363 ± 0.074	1.707ProPhe: 1.707 ± 0.043	4.14ProGly: 4.14 ± 0.077	1.064ProHis: 1.064 ± 0.035	2.855ProIle: 2.855 ± 0.057	1.887ProLys: 1.887 ± 0.052	4.635ProLeu: 4.635 ± 0.067	1.081ProMet: 1.081 ± 0.027	1.828ProAsn: 1.828 ± 0.042	2.656ProPro: 2.656 ± 0.067	1.971ProGln: 1.971 ± 0.049	2.934ProArg: 2.934 ± 0.054	3.799ProSer: 3.799 ± 0.119	2.913ProThr: 2.913 ± 0.084	3.927ProVal: 3.927 ± 0.07	0.867ProTrp: 0.867 ± 0.031	1.706ProTyr: 1.706 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.322GlnAla: 3.322 ± 0.066	0.187GlnCys: 0.187 ± 0.014	1.85GlnAsp: 1.85 ± 0.049	2.732GlnGlu: 2.732 ± 0.062	0.933GlnPhe: 0.933 ± 0.035	2.627GlnGly: 2.627 ± 0.051	0.765GlnHis: 0.765 ± 0.029	2.23GlnIle: 2.23 ± 0.048	1.383GlnLys: 1.383 ± 0.046	3.549GlnLeu: 3.549 ± 0.064	0.874GlnMet: 0.874 ± 0.034	0.897GlnAsn: 0.897 ± 0.031	1.678GlnPro: 1.678 ± 0.04	1.631GlnGln: 1.631 ± 0.057	2.347GlnArg: 2.347 ± 0.059	1.893GlnSer: 1.893 ± 0.049	1.463GlnThr: 1.463 ± 0.04	3.022GlnVal: 3.022 ± 0.063	0.481GlnTrp: 0.481 ± 0.021	0.972GlnTyr: 0.972 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.036ArgAla: 6.036 ± 0.1	0.588ArgCys: 0.588 ± 0.025	3.563ArgAsp: 3.563 ± 0.063	5.136ArgGlu: 5.136 ± 0.1	2.423ArgPhe: 2.423 ± 0.052	4.512ArgGly: 4.512 ± 0.073	1.39ArgHis: 1.39 ± 0.039	4.035ArgIle: 4.035 ± 0.068	2.479ArgLys: 2.479 ± 0.049	7.261ArgLeu: 7.261 ± 0.101	1.726ArgMet: 1.726 ± 0.046	1.963ArgAsn: 1.963 ± 0.045	2.836ArgPro: 2.836 ± 0.05	2.622ArgGln: 2.622 ± 0.063	5.369ArgArg: 5.369 ± 0.095	4.178ArgSer: 4.178 ± 0.072	3.162ArgThr: 3.162 ± 0.06	5.24ArgVal: 5.24 ± 0.092	1.236ArgTrp: 1.236 ± 0.038	2.544ArgTyr: 2.544 ± 0.067	0.0ArgXaa: 0.0 ± 0.0
Ser	4.937SerAla: 4.937 ± 0.074	0.548SerCys: 0.548 ± 0.025	2.959SerAsp: 2.959 ± 0.068	3.639SerGlu: 3.639 ± 0.066	2.178SerPhe: 2.178 ± 0.054	5.225SerGly: 5.225 ± 0.086	1.27SerHis: 1.27 ± 0.033	3.858SerIle: 3.858 ± 0.076	2.513SerLys: 2.513 ± 0.052	6.62SerLeu: 6.62 ± 0.084	1.617SerMet: 1.617 ± 0.039	2.036SerAsn: 2.036 ± 0.054	3.925SerPro: 3.925 ± 0.109	2.341SerGln: 2.341 ± 0.051	4.293SerArg: 4.293 ± 0.072	4.601SerSer: 4.601 ± 0.094	3.412SerThr: 3.412 ± 0.065	4.262SerVal: 4.262 ± 0.068	1.199SerTrp: 1.199 ± 0.038	1.999SerTyr: 1.999 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.013ThrAla: 4.013 ± 0.069	0.475ThrCys: 0.475 ± 0.029	2.389ThrAsp: 2.389 ± 0.047	2.399ThrGlu: 2.399 ± 0.053	1.933ThrPhe: 1.933 ± 0.054	4.396ThrGly: 4.396 ± 0.08	1.098ThrHis: 1.098 ± 0.035	3.176ThrIle: 3.176 ± 0.062	1.606ThrLys: 1.606 ± 0.048	5.478ThrLeu: 5.478 ± 0.093	0.975ThrMet: 0.975 ± 0.031	1.578ThrAsn: 1.578 ± 0.043	3.477ThrPro: 3.477 ± 0.081	1.439ThrGln: 1.439 ± 0.041	2.869ThrArg: 2.869 ± 0.054	3.365ThrSer: 3.365 ± 0.063	2.777ThrThr: 2.777 ± 0.061	3.711ThrVal: 3.711 ± 0.065	0.82ThrTrp: 0.82 ± 0.033	1.658ThrTyr: 1.658 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.227ValAla: 7.227 ± 0.104	0.698ValCys: 0.698 ± 0.029	4.271ValAsp: 4.271 ± 0.076	5.089ValGlu: 5.089 ± 0.081	2.521ValPhe: 2.521 ± 0.053	5.955ValGly: 5.955 ± 0.098	1.564ValHis: 1.564 ± 0.041	4.877ValIle: 4.877 ± 0.08	2.444ValLys: 2.444 ± 0.057	8.593ValLeu: 8.593 ± 0.125	1.765ValMet: 1.765 ± 0.048	2.224ValAsn: 2.224 ± 0.058	4.07ValPro: 4.07 ± 0.066	2.351ValGln: 2.351 ± 0.053	5.401ValArg: 5.401 ± 0.089	4.879ValSer: 4.879 ± 0.07	4.098ValThr: 4.098 ± 0.068	6.871ValVal: 6.871 ± 0.107	1.084ValTrp: 1.084 ± 0.034	2.26ValTyr: 2.26 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.23TrpAla: 1.23 ± 0.036	0.165TrpCys: 0.165 ± 0.013	0.848TrpAsp: 0.848 ± 0.034	0.997TrpGlu: 0.997 ± 0.041	0.506TrpPhe: 0.506 ± 0.026	1.2TrpGly: 1.2 ± 0.037	0.387TrpHis: 0.387 ± 0.02	0.914TrpIle: 0.914 ± 0.041	0.557TrpLys: 0.557 ± 0.025	1.839TrpLeu: 1.839 ± 0.053	0.447TrpMet: 0.447 ± 0.023	0.505TrpAsn: 0.505 ± 0.023	0.688TrpPro: 0.688 ± 0.025	0.767TrpGln: 0.767 ± 0.033	1.254TrpArg: 1.254 ± 0.038	0.956TrpSer: 0.956 ± 0.032	0.717TrpThr: 0.717 ± 0.031	1.222TrpVal: 1.222 ± 0.039	0.347TrpTrp: 0.347 ± 0.022	0.538TrpTyr: 0.538 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.594TyrAla: 2.594 ± 0.053	0.319TyrCys: 0.319 ± 0.02	1.78TyrAsp: 1.78 ± 0.05	1.881TyrGlu: 1.881 ± 0.041	1.141TyrPhe: 1.141 ± 0.036	2.637TyrGly: 2.637 ± 0.055	0.679TyrHis: 0.679 ± 0.03	1.862TyrIle: 1.862 ± 0.05	1.241TyrLys: 1.241 ± 0.036	3.568TyrLeu: 3.568 ± 0.073	0.667TyrMet: 0.667 ± 0.027	1.066TyrAsn: 1.066 ± 0.034	1.638TyrPro: 1.638 ± 0.042	1.035TyrGln: 1.035 ± 0.034	2.357TyrArg: 2.357 ± 0.053	2.025TyrSer: 2.025 ± 0.053	1.609TyrThr: 1.609 ± 0.042	2.398TyrVal: 2.398 ± 0.053	0.569TyrTrp: 0.569 ± 0.026	1.166TyrTyr: 1.166 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2827 proteins (935529 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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