Amino acid dipepetide frequency for Sulfitobacter sp. HI0023

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.431AlaAla: 16.431 ± 0.18	1.069AlaCys: 1.069 ± 0.033	6.896AlaAsp: 6.896 ± 0.086	8.795AlaGlu: 8.795 ± 0.107	4.252AlaPhe: 4.252 ± 0.062	10.408AlaGly: 10.408 ± 0.1	2.322AlaHis: 2.322 ± 0.051	5.703AlaIle: 5.703 ± 0.071	3.729AlaLys: 3.729 ± 0.071	13.469AlaLeu: 13.469 ± 0.124	3.752AlaMet: 3.752 ± 0.057	2.631AlaAsn: 2.631 ± 0.052	5.779AlaPro: 5.779 ± 0.08	4.566AlaGln: 4.566 ± 0.069	9.203AlaArg: 9.203 ± 0.093	5.445AlaSer: 5.445 ± 0.063	5.828AlaThr: 5.828 ± 0.076	8.175AlaVal: 8.175 ± 0.104	1.364AlaTrp: 1.364 ± 0.038	2.532AlaTyr: 2.532 ± 0.048	0.002AlaXaa: 0.002 ± 0.001
Cys	1.066CysAla: 1.066 ± 0.033	0.116CysCys: 0.116 ± 0.01	0.612CysAsp: 0.612 ± 0.023	0.491CysGlu: 0.491 ± 0.022	0.327CysPhe: 0.327 ± 0.015	0.944CysGly: 0.944 ± 0.03	0.255CysHis: 0.255 ± 0.014	0.452CysIle: 0.452 ± 0.02	0.217CysLys: 0.217 ± 0.011	0.784CysLeu: 0.784 ± 0.024	0.179CysMet: 0.179 ± 0.012	0.22CysAsn: 0.22 ± 0.012	0.511CysPro: 0.511 ± 0.022	0.217CysGln: 0.217 ± 0.014	0.536CysArg: 0.536 ± 0.022	0.433CysSer: 0.433 ± 0.02	0.453CysThr: 0.453 ± 0.021	0.613CysVal: 0.613 ± 0.024	0.113CysTrp: 0.113 ± 0.011	0.218CysTyr: 0.218 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.603AspAla: 7.603 ± 0.108	0.545AspCys: 0.545 ± 0.022	3.583AspAsp: 3.583 ± 0.07	3.62AspGlu: 3.62 ± 0.056	2.211AspPhe: 2.211 ± 0.045	5.468AspGly: 5.468 ± 0.068	1.369AspHis: 1.369 ± 0.034	3.231AspIle: 3.231 ± 0.049	1.738AspLys: 1.738 ± 0.046	6.349AspLeu: 6.349 ± 0.076	1.775AspMet: 1.775 ± 0.038	1.296AspAsn: 1.296 ± 0.033	3.694AspPro: 3.694 ± 0.055	1.703AspGln: 1.703 ± 0.042	4.692AspArg: 4.692 ± 0.071	2.319AspSer: 2.319 ± 0.045	3.1AspThr: 3.1 ± 0.055	4.377AspVal: 4.377 ± 0.057	1.207AspTrp: 1.207 ± 0.036	1.596AspTyr: 1.596 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.248GluAla: 8.248 ± 0.099	0.376GluCys: 0.376 ± 0.02	3.767GluAsp: 3.767 ± 0.058	4.159GluGlu: 4.159 ± 0.069	1.82GluPhe: 1.82 ± 0.041	5.403GluGly: 5.403 ± 0.078	1.195GluHis: 1.195 ± 0.029	3.475GluIle: 3.475 ± 0.057	2.357GluLys: 2.357 ± 0.055	5.344GluLeu: 5.344 ± 0.082	1.957GluMet: 1.957 ± 0.042	1.843GluAsn: 1.843 ± 0.039	2.626GluPro: 2.626 ± 0.049	2.092GluGln: 2.092 ± 0.048	4.65GluArg: 4.65 ± 0.064	2.311GluSer: 2.311 ± 0.042	3.988GluThr: 3.988 ± 0.056	4.63GluVal: 4.63 ± 0.062	0.786GluTrp: 0.786 ± 0.03	1.089GluTyr: 1.089 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.641PheAla: 4.641 ± 0.075	0.43PheCys: 0.43 ± 0.018	3.008PheAsp: 3.008 ± 0.053	2.306PheGlu: 2.306 ± 0.045	1.407PhePhe: 1.407 ± 0.04	3.746PheGly: 3.746 ± 0.063	0.716PheHis: 0.716 ± 0.025	1.628PheIle: 1.628 ± 0.04	0.938PheLys: 0.938 ± 0.028	3.268PheLeu: 3.268 ± 0.056	0.884PheMet: 0.884 ± 0.027	1.009PheAsn: 1.009 ± 0.029	1.491PhePro: 1.491 ± 0.034	0.951PheGln: 0.951 ± 0.027	2.16PheArg: 2.16 ± 0.042	1.943PheSer: 1.943 ± 0.045	2.059PheThr: 2.059 ± 0.039	2.625PheVal: 2.625 ± 0.052	0.555PheTrp: 0.555 ± 0.024	0.926PheTyr: 0.926 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.81GlyAla: 9.81 ± 0.105	0.842GlyCys: 0.842 ± 0.028	4.742GlyAsp: 4.742 ± 0.067	4.846GlyGlu: 4.846 ± 0.07	3.655GlyPhe: 3.655 ± 0.063	7.616GlyGly: 7.616 ± 0.116	1.931GlyHis: 1.931 ± 0.042	4.598GlyIle: 4.598 ± 0.067	3.23GlyLys: 3.23 ± 0.059	9.078GlyLeu: 9.078 ± 0.091	2.679GlyMet: 2.679 ± 0.055	2.164GlyAsn: 2.164 ± 0.047	3.835GlyPro: 3.835 ± 0.059	3.086GlyGln: 3.086 ± 0.05	5.928GlyArg: 5.928 ± 0.079	4.456GlySer: 4.456 ± 0.082	4.687GlyThr: 4.687 ± 0.074	6.391GlyVal: 6.391 ± 0.093	1.477GlyTrp: 1.477 ± 0.04	2.3GlyTyr: 2.3 ± 0.043	0.001GlyXaa: 0.001 ± 0.001
His	2.352HisAla: 2.352 ± 0.054	0.235HisCys: 0.235 ± 0.016	1.322HisAsp: 1.322 ± 0.039	1.149HisGlu: 1.149 ± 0.035	0.797HisPhe: 0.797 ± 0.031	1.99HisGly: 1.99 ± 0.045	0.565HisHis: 0.565 ± 0.024	0.97HisIle: 0.97 ± 0.03	0.502HisLys: 0.502 ± 0.021	2.054HisLeu: 2.054 ± 0.04	0.584HisMet: 0.584 ± 0.021	0.419HisAsn: 0.419 ± 0.018	1.357HisPro: 1.357 ± 0.041	0.534HisGln: 0.534 ± 0.025	1.433HisArg: 1.433 ± 0.033	0.913HisSer: 0.913 ± 0.027	0.855HisThr: 0.855 ± 0.025	1.594HisVal: 1.594 ± 0.037	0.33HisTrp: 0.33 ± 0.016	0.58HisTyr: 0.58 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.875IleAla: 6.875 ± 0.072	0.623IleCys: 0.623 ± 0.021	3.532IleAsp: 3.532 ± 0.053	3.652IleGlu: 3.652 ± 0.066	1.796IlePhe: 1.796 ± 0.045	4.662IleGly: 4.662 ± 0.072	0.918IleHis: 0.918 ± 0.026	2.2IleIle: 2.2 ± 0.046	1.344IleLys: 1.344 ± 0.042	4.581IleLeu: 4.581 ± 0.068	1.093IleMet: 1.093 ± 0.03	1.352IleAsn: 1.352 ± 0.035	2.332IlePro: 2.332 ± 0.042	1.212IleGln: 1.212 ± 0.035	3.179IleArg: 3.179 ± 0.057	2.767IleSer: 2.767 ± 0.045	2.886IleThr: 2.886 ± 0.052	3.922IleVal: 3.922 ± 0.058	0.714IleTrp: 0.714 ± 0.027	1.186IleTyr: 1.186 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.899LysAla: 3.899 ± 0.067	0.169LysCys: 0.169 ± 0.013	1.821LysAsp: 1.821 ± 0.045	1.701LysGlu: 1.701 ± 0.047	0.931LysPhe: 0.931 ± 0.031	2.726LysGly: 2.726 ± 0.054	0.575LysHis: 0.575 ± 0.022	1.595LysIle: 1.595 ± 0.04	1.222LysLys: 1.222 ± 0.038	2.986LysLeu: 2.986 ± 0.054	0.859LysMet: 0.859 ± 0.025	0.776LysAsn: 0.776 ± 0.027	1.742LysPro: 1.742 ± 0.044	0.914LysGln: 0.914 ± 0.025	2.3LysArg: 2.3 ± 0.05	1.765LysSer: 1.765 ± 0.046	1.976LysThr: 1.976 ± 0.044	2.364LysVal: 2.364 ± 0.05	0.366LysTrp: 0.366 ± 0.015	0.645LysTyr: 0.645 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.47LeuAla: 12.47 ± 0.12	0.965LeuCys: 0.965 ± 0.03	5.965LeuAsp: 5.965 ± 0.079	5.515LeuGlu: 5.515 ± 0.075	3.474LeuPhe: 3.474 ± 0.07	8.369LeuGly: 8.369 ± 0.111	1.94LeuHis: 1.94 ± 0.044	5.022LeuIle: 5.022 ± 0.067	3.176LeuLys: 3.176 ± 0.063	9.188LeuLeu: 9.188 ± 0.132	2.629LeuMet: 2.629 ± 0.048	2.657LeuAsn: 2.657 ± 0.041	5.564LeuPro: 5.564 ± 0.087	2.835LeuGln: 2.835 ± 0.047	7.503LeuArg: 7.503 ± 0.075	6.54LeuSer: 6.54 ± 0.084	5.819LeuThr: 5.819 ± 0.066	6.623LeuVal: 6.623 ± 0.078	1.259LeuTrp: 1.259 ± 0.039	1.932LeuTyr: 1.932 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.509MetAla: 3.509 ± 0.051	0.187MetCys: 0.187 ± 0.012	1.418MetAsp: 1.418 ± 0.033	1.559MetGlu: 1.559 ± 0.035	0.806MetPhe: 0.806 ± 0.026	2.348MetGly: 2.348 ± 0.05	0.481MetHis: 0.481 ± 0.02	1.515MetIle: 1.515 ± 0.034	1.134MetLys: 1.134 ± 0.031	2.659MetLeu: 2.659 ± 0.051	0.831MetMet: 0.831 ± 0.032	0.94MetAsn: 0.94 ± 0.027	1.549MetPro: 1.549 ± 0.037	1.033MetGln: 1.033 ± 0.03	2.014MetArg: 2.014 ± 0.039	1.742MetSer: 1.742 ± 0.04	2.053MetThr: 2.053 ± 0.041	1.812MetVal: 1.812 ± 0.039	0.237MetTrp: 0.237 ± 0.015	0.379MetTyr: 0.379 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.197AsnAla: 3.197 ± 0.057	0.26AsnCys: 0.26 ± 0.016	1.493AsnAsp: 1.493 ± 0.041	1.309AsnGlu: 1.309 ± 0.04	0.956AsnPhe: 0.956 ± 0.03	2.303AsnGly: 2.303 ± 0.051	0.505AsnHis: 0.505 ± 0.022	1.329AsnIle: 1.329 ± 0.037	0.651AsnLys: 0.651 ± 0.025	2.492AsnLeu: 2.492 ± 0.05	0.723AsnMet: 0.723 ± 0.027	0.639AsnAsn: 0.639 ± 0.025	1.767AsnPro: 1.767 ± 0.043	0.692AsnGln: 0.692 ± 0.023	1.854AsnArg: 1.854 ± 0.039	1.139AsnSer: 1.139 ± 0.034	1.324AsnThr: 1.324 ± 0.032	1.801AsnVal: 1.801 ± 0.038	0.411AsnTrp: 0.411 ± 0.021	0.657AsnTyr: 0.657 ± 0.024	0.001AsnXaa: 0.001 ± 0.001
Pro	5.762ProAla: 5.762 ± 0.078	0.358ProCys: 0.358 ± 0.017	3.907ProAsp: 3.907 ± 0.064	4.321ProGlu: 4.321 ± 0.066	2.017ProPhe: 2.017 ± 0.046	4.53ProGly: 4.53 ± 0.066	1.096ProHis: 1.096 ± 0.033	2.198ProIle: 2.198 ± 0.041	1.584ProLys: 1.584 ± 0.041	4.708ProLeu: 4.708 ± 0.065	1.241ProMet: 1.241 ± 0.034	1.239ProAsn: 1.239 ± 0.035	2.414ProPro: 2.414 ± 0.051	1.672ProGln: 1.672 ± 0.036	3.1ProArg: 3.1 ± 0.057	2.41ProSer: 2.41 ± 0.04	2.298ProThr: 2.298 ± 0.05	4.178ProVal: 4.178 ± 0.066	0.637ProTrp: 0.637 ± 0.027	1.204ProTyr: 1.204 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.881GlnAla: 3.881 ± 0.062	0.204GlnCys: 0.204 ± 0.013	1.784GlnAsp: 1.784 ± 0.039	1.726GlnGlu: 1.726 ± 0.043	1.07GlnPhe: 1.07 ± 0.031	2.512GlnGly: 2.512 ± 0.047	0.597GlnHis: 0.597 ± 0.024	1.936GlnIle: 1.936 ± 0.039	1.138GlnLys: 1.138 ± 0.032	2.804GlnLeu: 2.804 ± 0.055	1.101GlnMet: 1.101 ± 0.029	0.933GlnAsn: 0.933 ± 0.029	1.591GlnPro: 1.591 ± 0.041	1.133GlnGln: 1.133 ± 0.038	2.264GlnArg: 2.264 ± 0.048	1.768GlnSer: 1.768 ± 0.039	1.83GlnThr: 1.83 ± 0.039	2.328GlnVal: 2.328 ± 0.042	0.399GlnTrp: 0.399 ± 0.016	0.574GlnTyr: 0.574 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.376ArgAla: 8.376 ± 0.095	0.485ArgCys: 0.485 ± 0.021	4.618ArgAsp: 4.618 ± 0.06	4.224ArgGlu: 4.224 ± 0.06	2.778ArgPhe: 2.778 ± 0.055	4.835ArgGly: 4.835 ± 0.061	1.65ArgHis: 1.65 ± 0.04	4.041ArgIle: 4.041 ± 0.06	2.452ArgLys: 2.452 ± 0.049	7.498ArgLeu: 7.498 ± 0.084	2.087ArgMet: 2.087 ± 0.036	1.851ArgAsn: 1.851 ± 0.039	3.353ArgPro: 3.353 ± 0.061	2.474ArgGln: 2.474 ± 0.054	5.392ArgArg: 5.392 ± 0.082	3.391ArgSer: 3.391 ± 0.052	3.21ArgThr: 3.21 ± 0.046	4.829ArgVal: 4.829 ± 0.068	0.949ArgTrp: 0.949 ± 0.029	1.722ArgTyr: 1.722 ± 0.043	0.001ArgXaa: 0.001 ± 0.001
Ser	5.736SerAla: 5.736 ± 0.068	0.399SerCys: 0.399 ± 0.018	3.443SerAsp: 3.443 ± 0.055	2.974SerGlu: 2.974 ± 0.058	2.19SerPhe: 2.19 ± 0.037	5.302SerGly: 5.302 ± 0.087	1.056SerHis: 1.056 ± 0.029	2.483SerIle: 2.483 ± 0.044	1.431SerLys: 1.431 ± 0.039	4.825SerLeu: 4.825 ± 0.064	1.444SerMet: 1.444 ± 0.037	1.36SerAsn: 1.36 ± 0.032	2.445SerPro: 2.445 ± 0.045	1.496SerGln: 1.496 ± 0.033	3.31SerArg: 3.31 ± 0.052	2.494SerSer: 2.494 ± 0.05	2.392SerThr: 2.392 ± 0.042	3.748SerVal: 3.748 ± 0.056	0.635SerTrp: 0.635 ± 0.022	1.353SerTyr: 1.353 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.181ThrAla: 6.181 ± 0.08	0.497ThrCys: 0.497 ± 0.023	3.115ThrAsp: 3.115 ± 0.052	3.1ThrGlu: 3.1 ± 0.053	1.975ThrPhe: 1.975 ± 0.041	5.518ThrGly: 5.518 ± 0.086	1.066ThrHis: 1.066 ± 0.031	2.653ThrIle: 2.653 ± 0.048	1.36ThrLys: 1.36 ± 0.035	5.988ThrLeu: 5.988 ± 0.07	1.366ThrMet: 1.366 ± 0.032	1.272ThrAsn: 1.272 ± 0.031	3.419ThrPro: 3.419 ± 0.055	1.636ThrGln: 1.636 ± 0.04	3.573ThrArg: 3.573 ± 0.054	2.621ThrSer: 2.621 ± 0.044	2.782ThrThr: 2.782 ± 0.053	4.051ThrVal: 4.051 ± 0.058	0.643ThrTrp: 0.643 ± 0.02	1.251ThrTyr: 1.251 ± 0.035	0.001ThrXaa: 0.001 ± 0.001
Val	8.471ValAla: 8.471 ± 0.1	0.637ValCys: 0.637 ± 0.021	4.052ValAsp: 4.052 ± 0.058	4.694ValGlu: 4.694 ± 0.065	2.764ValPhe: 2.764 ± 0.054	5.347ValGly: 5.347 ± 0.071	1.408ValHis: 1.408 ± 0.038	4.117ValIle: 4.117 ± 0.075	2.09ValLys: 2.09 ± 0.048	7.456ValLeu: 7.456 ± 0.091	2.097ValMet: 2.097 ± 0.042	1.869ValAsn: 1.869 ± 0.041	3.673ValPro: 3.673 ± 0.059	2.131ValGln: 2.131 ± 0.046	4.32ValArg: 4.32 ± 0.064	4.219ValSer: 4.219 ± 0.057	4.656ValThr: 4.656 ± 0.064	5.513ValVal: 5.513 ± 0.074	0.945ValTrp: 0.945 ± 0.027	1.542ValTyr: 1.542 ± 0.039	0.001ValXaa: 0.001 ± 0.001
Trp	1.286TrpAla: 1.286 ± 0.034	0.144TrpCys: 0.144 ± 0.01	0.731TrpAsp: 0.731 ± 0.024	0.655TrpGlu: 0.655 ± 0.029	0.565TrpPhe: 0.565 ± 0.025	1.081TrpGly: 1.081 ± 0.036	0.348TrpHis: 0.348 ± 0.018	0.7TrpIle: 0.7 ± 0.026	0.469TrpLys: 0.469 ± 0.019	1.581TrpLeu: 1.581 ± 0.036	0.428TrpMet: 0.428 ± 0.023	0.446TrpAsn: 0.446 ± 0.023	0.649TrpPro: 0.649 ± 0.024	0.585TrpGln: 0.585 ± 0.024	1.11TrpArg: 1.11 ± 0.031	0.763TrpSer: 0.763 ± 0.027	0.736TrpThr: 0.736 ± 0.024	0.857TrpVal: 0.857 ± 0.028	0.216TrpTrp: 0.216 ± 0.013	0.274TrpTyr: 0.274 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.554TyrAla: 2.554 ± 0.047	0.216TyrCys: 0.216 ± 0.012	1.665TyrAsp: 1.665 ± 0.041	1.318TyrGlu: 1.318 ± 0.039	0.898TyrPhe: 0.898 ± 0.028	2.244TyrGly: 2.244 ± 0.043	0.542TyrHis: 0.542 ± 0.023	0.981TyrIle: 0.981 ± 0.026	0.571TyrLys: 0.571 ± 0.023	2.334TyrLeu: 2.334 ± 0.043	0.496TyrMet: 0.496 ± 0.023	0.589TyrAsn: 0.589 ± 0.022	1.083TyrPro: 1.083 ± 0.031	0.612TyrGln: 0.612 ± 0.02	1.695TyrArg: 1.695 ± 0.039	1.077TyrSer: 1.077 ± 0.031	1.135TyrThr: 1.135 ± 0.027	1.572TyrVal: 1.572 ± 0.038	0.376TyrTrp: 0.376 ± 0.019	0.58TyrTyr: 0.58 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3900 proteins (1190183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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