Amino acid dipepetide frequency for McMurdo Ice Shelf pond-associated circular DNA virus-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.217AlaAla: 6.217 ± 0.191
0.888AlaCys: 0.888 ± 0.796
4.44AlaAsp: 4.44 ± 0.572
7.105AlaGlu: 7.105 ± 3.541
1.776AlaPhe: 1.776 ± 0.645
6.217AlaGly: 6.217 ± 3.17
0.888AlaHis: 0.888 ± 0.796
3.552AlaIle: 3.552 ± 1.29
6.217AlaLys: 6.217 ± 3.388
8.881AlaLeu: 8.881 ± 2.579
0.0AlaMet: 0.0 ± 0.0
2.664AlaAsn: 2.664 ± 1.908
4.44AlaPro: 4.44 ± 1.891
0.0AlaGln: 0.0 ± 0.0
6.217AlaArg: 6.217 ± 2.298
6.217AlaSer: 6.217 ± 0.191
0.888AlaThr: 0.888 ± 0.794
5.329AlaVal: 5.329 ± 1.5
1.776AlaTrp: 1.776 ± 0.645
4.44AlaTyr: 4.44 ± 2.151
0.0AlaXaa: 0.0 ± 0.0
Cys
0.888CysAla: 0.888 ± 0.796
0.0CysCys: 0.0 ± 0.0
0.888CysAsp: 0.888 ± 0.796
0.888CysGlu: 0.888 ± 0.796
0.0CysPhe: 0.0 ± 0.0
1.776CysGly: 1.776 ± 0.885
0.0CysHis: 0.0 ± 0.0
0.888CysIle: 0.888 ± 0.796
0.888CysLys: 0.888 ± 0.636
2.664CysLeu: 2.664 ± 2.389
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.888CysPro: 0.888 ± 0.796
0.0CysGln: 0.0 ± 0.0
1.776CysArg: 1.776 ± 0.731
0.0CysSer: 0.0 ± 0.0
0.888CysThr: 0.888 ± 0.636
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.888CysTyr: 0.888 ± 0.636
0.0CysXaa: 0.0 ± 0.0
Asp
4.44AspAla: 4.44 ± 2.83
0.0AspCys: 0.0 ± 0.0
3.552AspAsp: 3.552 ± 0.925
0.888AspGlu: 0.888 ± 0.794
1.776AspPhe: 1.776 ± 0.731
5.329AspGly: 5.329 ± 2.868
0.0AspHis: 0.0 ± 0.0
2.664AspIle: 2.664 ± 1.005
4.44AspLys: 4.44 ± 1.137
4.44AspLeu: 4.44 ± 1.78
1.776AspMet: 1.776 ± 0.645
0.0AspAsn: 0.0 ± 0.0
4.44AspPro: 4.44 ± 1.891
1.776AspGln: 1.776 ± 0.645
2.664AspArg: 2.664 ± 2.381
6.217AspSer: 6.217 ± 2.444
0.888AspThr: 0.888 ± 0.796
8.881AspVal: 8.881 ± 4.655
0.0AspTrp: 0.0 ± 0.0
3.552AspTyr: 3.552 ± 1.29
0.0AspXaa: 0.0 ± 0.0
Glu
2.664GluAla: 2.664 ± 1.481
0.888GluCys: 0.888 ± 0.796
4.44GluAsp: 4.44 ± 0.572
2.664GluGlu: 2.664 ± 0.255
0.888GluPhe: 0.888 ± 0.796
3.552GluGly: 3.552 ± 1.77
0.0GluHis: 0.0 ± 0.0
2.664GluIle: 2.664 ± 1.481
1.776GluLys: 1.776 ± 1.587
3.552GluLeu: 3.552 ± 0.991
0.0GluMet: 0.0 ± 0.0
3.552GluAsn: 3.552 ± 1.662
3.552GluPro: 3.552 ± 2.054
2.664GluGln: 2.664 ± 1.39
2.664GluArg: 2.664 ± 1.485
2.664GluSer: 2.664 ± 1.481
2.664GluThr: 2.664 ± 1.485
3.552GluVal: 3.552 ± 0.991
0.888GluTrp: 0.888 ± 0.794
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
0.888PheAla: 0.888 ± 0.636
0.0PheCys: 0.0 ± 0.0
2.664PheAsp: 2.664 ± 0.255
0.888PheGlu: 0.888 ± 0.636
0.888PhePhe: 0.888 ± 0.636
1.776PheGly: 1.776 ± 1.272
1.776PheHis: 1.776 ± 1.593
0.0PheIle: 0.0 ± 0.0
2.664PheLys: 2.664 ± 1.005
1.776PheLeu: 1.776 ± 0.731
0.0PheMet: 0.0 ± 0.0
1.776PheAsn: 1.776 ± 0.645
0.0PhePro: 0.0 ± 0.0
0.888PheGln: 0.888 ± 0.636
0.888PheArg: 0.888 ± 0.636
0.888PheSer: 0.888 ± 0.636
2.664PheThr: 2.664 ± 1.299
2.664PheVal: 2.664 ± 1.115
0.0PheTrp: 0.0 ± 0.0
1.776PheTyr: 1.776 ± 0.645
0.0PheXaa: 0.0 ± 0.0
Gly
7.993GlyAla: 7.993 ± 1.98
0.0GlyCys: 0.0 ± 0.0
4.44GlyAsp: 4.44 ± 2.922
0.888GlyGlu: 0.888 ± 0.794
1.776GlyPhe: 1.776 ± 1.272
8.881GlyGly: 8.881 ± 2.828
1.776GlyHis: 1.776 ± 0.645
1.776GlyIle: 1.776 ± 1.593
4.44GlyLys: 4.44 ± 1.705
6.217GlyLeu: 6.217 ± 1.464
0.888GlyMet: 0.888 ± 0.636
3.552GlyAsn: 3.552 ± 0.394
1.776GlyPro: 1.776 ± 0.645
4.44GlyGln: 4.44 ± 2.151
5.329GlyArg: 5.329 ± 0.51
10.657GlySer: 10.657 ± 3.325
4.44GlyThr: 4.44 ± 0.572
5.329GlyVal: 5.329 ± 1.5
0.888GlyTrp: 0.888 ± 0.636
4.44GlyTyr: 4.44 ± 0.572
0.0GlyXaa: 0.0 ± 0.0
His
2.664HisAla: 2.664 ± 0.255
0.0HisCys: 0.0 ± 0.0
0.888HisAsp: 0.888 ± 0.796
0.0HisGlu: 0.0 ± 0.0
1.776HisPhe: 1.776 ± 0.645
1.776HisGly: 1.776 ± 1.587
0.888HisHis: 0.888 ± 0.636
2.664HisIle: 2.664 ± 1.115
0.0HisLys: 0.0 ± 0.0
0.888HisLeu: 0.888 ± 0.796
1.776HisMet: 1.776 ± 0.645
0.888HisAsn: 0.888 ± 0.636
0.888HisPro: 0.888 ± 0.794
1.776HisGln: 1.776 ± 1.593
1.776HisArg: 1.776 ± 1.593
1.776HisSer: 1.776 ± 1.593
2.664HisThr: 2.664 ± 1.481
3.552HisVal: 3.552 ± 0.991
0.0HisTrp: 0.0 ± 0.0
2.664HisTyr: 2.664 ± 1.299
0.0HisXaa: 0.0 ± 0.0
Ile
3.552IleAla: 3.552 ± 1.554
0.0IleCys: 0.0 ± 0.0
2.664IleAsp: 2.664 ± 1.39
2.664IleGlu: 2.664 ± 1.39
0.0IlePhe: 0.0 ± 0.0
0.888IleGly: 0.888 ± 0.636
0.0IleHis: 0.0 ± 0.0
0.0IleIle: 0.0 ± 0.0
0.888IleLys: 0.888 ± 0.636
1.776IleLeu: 1.776 ± 0.645
0.0IleMet: 0.0 ± 0.0
1.776IleAsn: 1.776 ± 0.645
3.552IlePro: 3.552 ± 0.394
1.776IleGln: 1.776 ± 0.645
1.776IleArg: 1.776 ± 0.731
1.776IleSer: 1.776 ± 0.885
2.664IleThr: 2.664 ± 1.299
4.44IleVal: 4.44 ± 1.027
0.888IleTrp: 0.888 ± 0.794
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
2.664LysAla: 2.664 ± 0.255
0.0LysCys: 0.0 ± 0.0
4.44LysAsp: 4.44 ± 2.83
1.776LysGlu: 1.776 ± 0.645
2.664LysPhe: 2.664 ± 1.005
3.552LysGly: 3.552 ± 2.054
4.44LysHis: 4.44 ± 0.572
1.776LysIle: 1.776 ± 0.645
0.888LysLys: 0.888 ± 0.636
3.552LysLeu: 3.552 ± 1.462
0.0LysMet: 0.0 ± 0.0
0.888LysAsn: 0.888 ± 0.636
0.888LysPro: 0.888 ± 0.636
0.0LysGln: 0.0 ± 0.0
8.881LysArg: 8.881 ± 3.129
3.552LysSer: 3.552 ± 1.554
4.44LysThr: 4.44 ± 1.565
4.44LysVal: 4.44 ± 1.775
0.0LysTrp: 0.0 ± 0.0
2.664LysTyr: 2.664 ± 2.381
0.0LysXaa: 0.0 ± 0.0
Leu
9.769LeuAla: 9.769 ± 1.014
0.0LeuCys: 0.0 ± 0.0
4.44LeuAsp: 4.44 ± 2.307
3.552LeuGlu: 3.552 ± 3.186
3.552LeuPhe: 3.552 ± 0.394
7.993LeuGly: 7.993 ± 3.19
1.776LeuHis: 1.776 ± 1.593
0.888LeuIle: 0.888 ± 0.796
1.776LeuLys: 1.776 ± 0.885
3.552LeuLeu: 3.552 ± 2.054
0.888LeuMet: 0.888 ± 0.636
2.664LeuAsn: 2.664 ± 1.115
3.552LeuPro: 3.552 ± 3.175
3.552LeuGln: 3.552 ± 0.394
0.888LeuArg: 0.888 ± 0.794
5.329LeuSer: 5.329 ± 2.193
6.217LeuThr: 6.217 ± 1.209
9.769LeuVal: 9.769 ± 5.449
0.888LeuTrp: 0.888 ± 0.794
3.552LeuTyr: 3.552 ± 0.394
0.0LeuXaa: 0.0 ± 0.0
Met
0.888MetAla: 0.888 ± 0.636
0.0MetCys: 0.0 ± 0.0
0.888MetAsp: 0.888 ± 0.794
1.776MetGlu: 1.776 ± 0.645
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.888MetHis: 0.888 ± 0.794
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
1.776MetMet: 1.776 ± 1.587
0.888MetAsn: 0.888 ± 0.636
0.888MetPro: 0.888 ± 0.636
0.0MetGln: 0.0 ± 0.0
1.776MetArg: 1.776 ± 1.587
2.664MetSer: 2.664 ± 0.255
0.0MetThr: 0.0 ± 0.0
0.888MetVal: 0.888 ± 0.796
0.0MetTrp: 0.0 ± 0.0
0.888MetTyr: 0.888 ± 0.636
0.0MetXaa: 0.0 ± 0.0
Asn
3.552AsnAla: 3.552 ± 0.394
0.888AsnCys: 0.888 ± 0.636
2.664AsnAsp: 2.664 ± 1.005
0.0AsnGlu: 0.0 ± 0.0
0.888AsnPhe: 0.888 ± 0.636
1.776AsnGly: 1.776 ± 1.272
0.888AsnHis: 0.888 ± 0.636
0.888AsnIle: 0.888 ± 0.636
0.888AsnLys: 0.888 ± 0.794
4.44AsnLeu: 4.44 ± 0.572
0.888AsnMet: 0.888 ± 0.636
3.552AsnAsn: 3.552 ± 1.662
1.776AsnPro: 1.776 ± 1.272
4.44AsnGln: 4.44 ± 3.18
3.552AsnArg: 3.552 ± 0.925
0.0AsnSer: 0.0 ± 0.0
1.776AsnThr: 1.776 ± 0.645
4.44AsnVal: 4.44 ± 2.256
0.0AsnTrp: 0.0 ± 0.0
1.776AsnTyr: 1.776 ± 0.645
0.0AsnXaa: 0.0 ± 0.0
Pro
5.329ProAla: 5.329 ± 2.01
0.888ProCys: 0.888 ± 0.796
2.664ProAsp: 2.664 ± 1.299
1.776ProGlu: 1.776 ± 1.587
0.0ProPhe: 0.0 ± 0.0
5.329ProGly: 5.329 ± 1.326
1.776ProHis: 1.776 ± 0.645
1.776ProIle: 1.776 ± 1.272
1.776ProLys: 1.776 ± 1.587
2.664ProLeu: 2.664 ± 1.005
0.888ProMet: 0.888 ± 0.794
0.888ProAsn: 0.888 ± 0.794
1.776ProPro: 1.776 ± 0.645
2.664ProGln: 2.664 ± 1.299
3.552ProArg: 3.552 ± 0.394
0.888ProSer: 0.888 ± 0.794
3.552ProThr: 3.552 ± 1.554
3.552ProVal: 3.552 ± 0.925
0.888ProTrp: 0.888 ± 0.794
0.888ProTyr: 0.888 ± 0.794
0.0ProXaa: 0.0 ± 0.0
Gln
5.329GlnAla: 5.329 ± 2.766
0.888GlnCys: 0.888 ± 0.796
0.0GlnAsp: 0.0 ± 0.0
0.888GlnGlu: 0.888 ± 0.636
1.776GlnPhe: 1.776 ± 0.645
4.44GlnGly: 4.44 ± 0.572
0.888GlnHis: 0.888 ± 0.636
0.0GlnIle: 0.0 ± 0.0
0.888GlnLys: 0.888 ± 0.796
2.664GlnLeu: 2.664 ± 0.255
1.776GlnMet: 1.776 ± 1.457
2.664GlnAsn: 2.664 ± 1.115
0.888GlnPro: 0.888 ± 0.794
0.888GlnGln: 0.888 ± 0.796
0.888GlnArg: 0.888 ± 0.636
1.776GlnSer: 1.776 ± 0.645
3.552GlnThr: 3.552 ± 0.394
7.105GlnVal: 7.105 ± 0.607
0.0GlnTrp: 0.0 ± 0.0
2.664GlnTyr: 2.664 ± 1.005
0.0GlnXaa: 0.0 ± 0.0
Arg
6.217ArgAla: 6.217 ± 1.192
3.552ArgCys: 3.552 ± 2.145
0.888ArgAsp: 0.888 ± 0.794
4.44ArgGlu: 4.44 ± 1.137
0.0ArgPhe: 0.0 ± 0.0
4.44ArgGly: 4.44 ± 1.027
4.44ArgHis: 4.44 ± 2.307
4.44ArgIle: 4.44 ± 0.572
6.217ArgLys: 6.217 ± 1.192
6.217ArgLeu: 6.217 ± 2.782
0.0ArgMet: 0.0 ± 0.0
1.776ArgAsn: 1.776 ± 0.645
3.552ArgPro: 3.552 ± 1.554
1.776ArgGln: 1.776 ± 0.731
7.105ArgArg: 7.105 ± 2.045
7.993ArgSer: 7.993 ± 2.086
8.881ArgThr: 8.881 ± 1.144
5.329ArgVal: 5.329 ± 2.23
0.0ArgTrp: 0.0 ± 0.0
3.552ArgTyr: 3.552 ± 1.29
0.0ArgXaa: 0.0 ± 0.0
Ser
4.44SerAla: 4.44 ± 2.976
1.776SerCys: 1.776 ± 0.731
5.329SerAsp: 5.329 ± 2.493
3.552SerGlu: 3.552 ± 2.213
0.888SerPhe: 0.888 ± 0.636
5.329SerGly: 5.329 ± 2.23
0.0SerHis: 0.0 ± 0.0
2.664SerIle: 2.664 ± 1.115
4.44SerLys: 4.44 ± 1.565
2.664SerLeu: 2.664 ± 1.115
1.776SerMet: 1.776 ± 0.869
2.664SerAsn: 2.664 ± 1.005
3.552SerPro: 3.552 ± 0.394
2.664SerGln: 2.664 ± 1.115
5.329SerArg: 5.329 ± 2.766
11.545SerSer: 11.545 ± 3.76
7.105SerThr: 7.105 ± 1.896
6.217SerVal: 6.217 ± 2.444
0.888SerTrp: 0.888 ± 0.796
1.776SerTyr: 1.776 ± 0.731
0.0SerXaa: 0.0 ± 0.0
Thr
4.44ThrAla: 4.44 ± 1.565
0.0ThrCys: 0.0 ± 0.0
2.664ThrAsp: 2.664 ± 1.115
2.664ThrGlu: 2.664 ± 1.481
0.888ThrPhe: 0.888 ± 0.636
7.993ThrGly: 7.993 ± 1.42
0.888ThrHis: 0.888 ± 0.636
2.664ThrIle: 2.664 ± 1.005
4.44ThrLys: 4.44 ± 1.565
4.44ThrLeu: 4.44 ± 1.705
0.888ThrMet: 0.888 ± 0.635
6.217ThrAsn: 6.217 ± 2.539
1.776ThrPro: 1.776 ± 1.587
3.552ThrGln: 3.552 ± 3.175
10.657ThrArg: 10.657 ± 2.256
3.552ThrSer: 3.552 ± 0.991
4.44ThrThr: 4.44 ± 2.151
3.552ThrVal: 3.552 ± 2.145
2.664ThrTrp: 2.664 ± 1.299
0.888ThrTyr: 0.888 ± 0.636
0.0ThrXaa: 0.0 ± 0.0
Val
3.552ValAla: 3.552 ± 1.77
2.664ValCys: 2.664 ± 1.39
7.105ValAsp: 7.105 ± 2.874
5.329ValGlu: 5.329 ± 0.51
3.552ValPhe: 3.552 ± 0.394
6.217ValGly: 6.217 ± 3.526
5.329ValHis: 5.329 ± 2.574
1.776ValIle: 1.776 ± 0.645
2.664ValLys: 2.664 ± 1.908
9.769ValLeu: 9.769 ± 5.449
0.0ValMet: 0.0 ± 0.0
0.888ValAsn: 0.888 ± 0.636
2.664ValPro: 2.664 ± 1.115
6.217ValGln: 6.217 ± 1.303
12.433ValArg: 12.433 ± 6.942
4.44ValSer: 4.44 ± 0.754
2.664ValThr: 2.664 ± 1.115
15.098ValVal: 15.098 ± 7.168
0.888ValTrp: 0.888 ± 0.794
4.44ValTyr: 4.44 ± 1.705
0.0ValXaa: 0.0 ± 0.0
Trp
0.888TrpAla: 0.888 ± 0.636
0.888TrpCys: 0.888 ± 0.794
0.888TrpAsp: 0.888 ± 0.794
0.0TrpGlu: 0.0 ± 0.0
0.888TrpPhe: 0.888 ± 0.796
0.888TrpGly: 0.888 ± 0.794
0.888TrpHis: 0.888 ± 0.794
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.888TrpAsn: 0.888 ± 0.794
1.776TrpPro: 1.776 ± 1.587
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.888TrpSer: 0.888 ± 0.636
1.776TrpThr: 1.776 ± 0.645
0.888TrpVal: 0.888 ± 0.794
0.888TrpTrp: 0.888 ± 0.794
0.888TrpTyr: 0.888 ± 0.794
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.776TyrAla: 1.776 ± 0.645
0.0TyrCys: 0.0 ± 0.0
1.776TyrAsp: 1.776 ± 0.731
3.552TyrGlu: 3.552 ± 2.054
0.888TyrPhe: 0.888 ± 0.636
1.776TyrGly: 1.776 ± 0.645
1.776TyrHis: 1.776 ± 0.885
0.0TyrIle: 0.0 ± 0.0
6.217TyrLys: 6.217 ± 2.172
4.44TyrLeu: 4.44 ± 1.137
0.0TyrMet: 0.0 ± 0.0
0.888TyrAsn: 0.888 ± 0.636
0.888TyrPro: 0.888 ± 0.794
1.776TyrGln: 1.776 ± 1.587
2.664TyrArg: 2.664 ± 1.908
1.776TyrSer: 1.776 ± 1.272
7.105TyrThr: 7.105 ± 3.108
2.664TyrVal: 2.664 ± 2.381
1.776TyrTrp: 1.776 ± 1.587
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1127 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski