Amino acid dipepetide frequency for Corynebacterium phage Cruella

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.136AlaAla: 10.136 ± 1.283
0.494AlaCys: 0.494 ± 0.162
5.735AlaAsp: 5.735 ± 0.705
7.07AlaGlu: 7.07 ± 0.588
2.769AlaPhe: 2.769 ± 0.368
7.07AlaGly: 7.07 ± 0.742
1.78AlaHis: 1.78 ± 0.451
4.697AlaIle: 4.697 ± 0.532
5.637AlaLys: 5.637 ± 0.562
7.96AlaLeu: 7.96 ± 1.059
2.027AlaMet: 2.027 ± 0.27
3.708AlaAsn: 3.708 ± 0.497
3.313AlaPro: 3.313 ± 0.385
3.362AlaGln: 3.362 ± 0.482
4.203AlaArg: 4.203 ± 0.519
5.983AlaSer: 5.983 ± 0.858
3.412AlaThr: 3.412 ± 0.669
5.735AlaVal: 5.735 ± 0.649
1.286AlaTrp: 1.286 ± 0.246
3.461AlaTyr: 3.461 ± 0.419
0.0AlaXaa: 0.0 ± 0.0
Cys
0.494CysAla: 0.494 ± 0.197
0.099CysCys: 0.099 ± 0.065
0.593CysAsp: 0.593 ± 0.184
0.396CysGlu: 0.396 ± 0.154
0.099CysPhe: 0.099 ± 0.07
0.445CysGly: 0.445 ± 0.13
0.148CysHis: 0.148 ± 0.086
0.247CysIle: 0.247 ± 0.101
0.247CysLys: 0.247 ± 0.108
0.544CysLeu: 0.544 ± 0.155
0.247CysMet: 0.247 ± 0.108
0.396CysAsn: 0.396 ± 0.109
0.396CysPro: 0.396 ± 0.166
0.247CysGln: 0.247 ± 0.127
0.346CysArg: 0.346 ± 0.123
0.89CysSer: 0.89 ± 0.257
0.297CysThr: 0.297 ± 0.113
0.494CysVal: 0.494 ± 0.142
0.148CysTrp: 0.148 ± 0.077
0.297CysTyr: 0.297 ± 0.115
0.0CysXaa: 0.0 ± 0.0
Asp
4.944AspAla: 4.944 ± 0.588
0.445AspCys: 0.445 ± 0.152
4.747AspAsp: 4.747 ± 0.521
5.686AspGlu: 5.686 ± 0.613
3.214AspPhe: 3.214 ± 0.498
5.538AspGly: 5.538 ± 0.456
1.434AspHis: 1.434 ± 0.194
3.758AspIle: 3.758 ± 0.465
2.967AspLys: 2.967 ± 0.331
6.428AspLeu: 6.428 ± 0.485
2.522AspMet: 2.522 ± 0.337
2.67AspAsn: 2.67 ± 0.295
4.153AspPro: 4.153 ± 0.482
2.077AspGln: 2.077 ± 0.275
4.104AspArg: 4.104 ± 0.45
3.708AspSer: 3.708 ± 0.29
3.412AspThr: 3.412 ± 0.402
3.412AspVal: 3.412 ± 0.408
1.038AspTrp: 1.038 ± 0.196
2.126AspTyr: 2.126 ± 0.28
0.0AspXaa: 0.0 ± 0.0
Glu
8.208GluAla: 8.208 ± 0.807
0.494GluCys: 0.494 ± 0.182
5.538GluAsp: 5.538 ± 0.649
6.774GluGlu: 6.774 ± 0.66
2.967GluPhe: 2.967 ± 0.415
5.834GluGly: 5.834 ± 0.607
0.989GluHis: 0.989 ± 0.24
5.785GluIle: 5.785 ± 0.665
3.066GluLys: 3.066 ± 0.416
5.983GluLeu: 5.983 ± 0.661
1.879GluMet: 1.879 ± 0.317
2.225GluAsn: 2.225 ± 0.332
2.67GluPro: 2.67 ± 0.34
2.373GluGln: 2.373 ± 0.372
4.697GluArg: 4.697 ± 0.691
4.153GluSer: 4.153 ± 0.454
4.747GluThr: 4.747 ± 0.378
5.834GluVal: 5.834 ± 0.662
1.236GluTrp: 1.236 ± 0.251
2.472GluTyr: 2.472 ± 0.426
0.0GluXaa: 0.0 ± 0.0
Phe
2.967PheAla: 2.967 ± 0.335
0.148PheCys: 0.148 ± 0.1
3.461PheAsp: 3.461 ± 0.517
3.066PheGlu: 3.066 ± 0.393
1.483PhePhe: 1.483 ± 0.264
3.066PheGly: 3.066 ± 0.405
0.791PheHis: 0.791 ± 0.183
1.533PheIle: 1.533 ± 0.251
1.533PheLys: 1.533 ± 0.264
2.719PheLeu: 2.719 ± 0.402
1.187PheMet: 1.187 ± 0.233
1.582PheAsn: 1.582 ± 0.295
1.137PhePro: 1.137 ± 0.212
1.483PheGln: 1.483 ± 0.229
2.423PheArg: 2.423 ± 0.288
3.412PheSer: 3.412 ± 0.441
2.274PheThr: 2.274 ± 0.328
2.126PheVal: 2.126 ± 0.347
0.346PheTrp: 0.346 ± 0.109
1.286PheTyr: 1.286 ± 0.231
0.0PheXaa: 0.0 ± 0.0
Gly
5.587GlyAla: 5.587 ± 0.867
0.396GlyCys: 0.396 ± 0.175
5.34GlyAsp: 5.34 ± 0.461
4.549GlyGlu: 4.549 ± 0.404
3.066GlyPhe: 3.066 ± 0.387
5.983GlyGly: 5.983 ± 1.02
1.335GlyHis: 1.335 ± 0.303
4.747GlyIle: 4.747 ± 0.482
3.56GlyLys: 3.56 ± 0.456
6.477GlyLeu: 6.477 ± 1.067
2.274GlyMet: 2.274 ± 0.291
3.412GlyAsn: 3.412 ± 0.408
2.868GlyPro: 2.868 ± 0.39
1.78GlyGln: 1.78 ± 0.288
4.994GlyArg: 4.994 ± 0.571
4.697GlySer: 4.697 ± 0.679
4.252GlyThr: 4.252 ± 0.504
5.439GlyVal: 5.439 ± 0.63
1.483GlyTrp: 1.483 ± 0.178
2.769GlyTyr: 2.769 ± 0.478
0.0GlyXaa: 0.0 ± 0.0
His
1.533HisAla: 1.533 ± 0.252
0.148HisCys: 0.148 ± 0.091
1.038HisAsp: 1.038 ± 0.277
0.989HisGlu: 0.989 ± 0.274
0.544HisPhe: 0.544 ± 0.181
1.384HisGly: 1.384 ± 0.293
0.544HisHis: 0.544 ± 0.194
1.137HisIle: 1.137 ± 0.221
1.038HisLys: 1.038 ± 0.211
0.939HisLeu: 0.939 ± 0.214
0.247HisMet: 0.247 ± 0.089
0.593HisAsn: 0.593 ± 0.174
1.434HisPro: 1.434 ± 0.245
0.692HisGln: 0.692 ± 0.2
0.989HisArg: 0.989 ± 0.285
0.89HisSer: 0.89 ± 0.251
1.286HisThr: 1.286 ± 0.343
1.038HisVal: 1.038 ± 0.265
0.198HisTrp: 0.198 ± 0.101
1.088HisTyr: 1.088 ± 0.32
0.0HisXaa: 0.0 ± 0.0
Ile
5.142IleAla: 5.142 ± 0.508
0.445IleCys: 0.445 ± 0.182
4.994IleAsp: 4.994 ± 0.479
4.796IleGlu: 4.796 ± 0.626
2.176IlePhe: 2.176 ± 0.336
3.708IleGly: 3.708 ± 0.536
1.286IleHis: 1.286 ± 0.267
2.967IleIle: 2.967 ± 0.343
3.115IleLys: 3.115 ± 0.35
3.857IleLeu: 3.857 ± 0.462
1.038IleMet: 1.038 ± 0.241
2.423IleAsn: 2.423 ± 0.298
2.769IlePro: 2.769 ± 0.363
1.632IleGln: 1.632 ± 0.315
2.423IleArg: 2.423 ± 0.4
4.45IleSer: 4.45 ± 0.438
3.164IleThr: 3.164 ± 0.522
4.104IleVal: 4.104 ± 0.485
0.89IleTrp: 0.89 ± 0.185
1.533IleTyr: 1.533 ± 0.32
0.0IleXaa: 0.0 ± 0.0
Lys
5.884LysAla: 5.884 ± 0.595
0.198LysCys: 0.198 ± 0.088
3.066LysAsp: 3.066 ± 0.42
3.807LysGlu: 3.807 ± 0.449
2.126LysPhe: 2.126 ± 0.328
3.164LysGly: 3.164 ± 0.323
0.989LysHis: 0.989 ± 0.231
3.412LysIle: 3.412 ± 0.38
2.967LysLys: 2.967 ± 0.522
2.719LysLeu: 2.719 ± 0.359
1.286LysMet: 1.286 ± 0.197
2.274LysAsn: 2.274 ± 0.351
1.434LysPro: 1.434 ± 0.207
1.681LysGln: 1.681 ± 0.35
2.769LysArg: 2.769 ± 0.397
2.967LysSer: 2.967 ± 0.351
3.362LysThr: 3.362 ± 0.431
4.203LysVal: 4.203 ± 0.451
1.236LysTrp: 1.236 ± 0.323
1.137LysTyr: 1.137 ± 0.245
0.0LysXaa: 0.0 ± 0.0
Leu
7.169LeuAla: 7.169 ± 0.75
0.643LeuCys: 0.643 ± 0.178
5.093LeuAsp: 5.093 ± 0.441
6.279LeuGlu: 6.279 ± 0.621
3.115LeuPhe: 3.115 ± 0.427
5.587LeuGly: 5.587 ± 0.743
0.989LeuHis: 0.989 ± 0.221
3.511LeuIle: 3.511 ± 0.385
4.104LeuLys: 4.104 ± 0.405
5.043LeuLeu: 5.043 ± 0.638
1.978LeuMet: 1.978 ± 0.427
3.461LeuAsn: 3.461 ± 0.333
3.708LeuPro: 3.708 ± 0.402
2.522LeuGln: 2.522 ± 0.374
5.735LeuArg: 5.735 ± 0.618
5.389LeuSer: 5.389 ± 0.455
5.834LeuThr: 5.834 ± 0.488
4.944LeuVal: 4.944 ± 0.551
1.286LeuTrp: 1.286 ± 0.37
2.027LeuTyr: 2.027 ± 0.291
0.0LeuXaa: 0.0 ± 0.0
Met
2.373MetAla: 2.373 ± 0.355
0.049MetCys: 0.049 ± 0.045
1.681MetAsp: 1.681 ± 0.38
2.225MetGlu: 2.225 ± 0.347
0.742MetPhe: 0.742 ± 0.209
1.829MetGly: 1.829 ± 0.493
0.148MetHis: 0.148 ± 0.086
1.384MetIle: 1.384 ± 0.294
1.038MetLys: 1.038 ± 0.249
1.978MetLeu: 1.978 ± 0.313
0.593MetMet: 0.593 ± 0.21
1.434MetAsn: 1.434 ± 0.244
1.434MetPro: 1.434 ± 0.264
1.137MetGln: 1.137 ± 0.228
1.533MetArg: 1.533 ± 0.295
2.176MetSer: 2.176 ± 0.312
1.978MetThr: 1.978 ± 0.304
1.286MetVal: 1.286 ± 0.254
0.494MetTrp: 0.494 ± 0.168
0.643MetTyr: 0.643 ± 0.136
0.0MetXaa: 0.0 ± 0.0
Asn
3.857AsnAla: 3.857 ± 0.458
0.297AsnCys: 0.297 ± 0.126
2.621AsnAsp: 2.621 ± 0.351
2.324AsnGlu: 2.324 ± 0.399
1.434AsnPhe: 1.434 ± 0.253
4.005AsnGly: 4.005 ± 0.325
0.89AsnHis: 0.89 ± 0.236
2.225AsnIle: 2.225 ± 0.424
1.978AsnLys: 1.978 ± 0.312
4.697AsnLeu: 4.697 ± 0.627
0.692AsnMet: 0.692 ± 0.175
2.818AsnAsn: 2.818 ± 0.41
2.868AsnPro: 2.868 ± 0.379
1.384AsnGln: 1.384 ± 0.303
2.274AsnArg: 2.274 ± 0.307
1.632AsnSer: 1.632 ± 0.301
2.077AsnThr: 2.077 ± 0.266
2.571AsnVal: 2.571 ± 0.279
0.643AsnTrp: 0.643 ± 0.167
1.533AsnTyr: 1.533 ± 0.3
0.0AsnXaa: 0.0 ± 0.0
Pro
3.313ProAla: 3.313 ± 0.416
0.346ProCys: 0.346 ± 0.149
3.412ProAsp: 3.412 ± 0.411
3.906ProGlu: 3.906 ± 0.49
1.78ProPhe: 1.78 ± 0.277
3.066ProGly: 3.066 ± 0.516
0.89ProHis: 0.89 ± 0.217
2.126ProIle: 2.126 ± 0.423
1.978ProLys: 1.978 ± 0.305
2.868ProLeu: 2.868 ± 0.432
1.434ProMet: 1.434 ± 0.238
1.928ProAsn: 1.928 ± 0.309
2.077ProPro: 2.077 ± 0.359
1.088ProGln: 1.088 ± 0.202
2.274ProArg: 2.274 ± 0.407
3.066ProSer: 3.066 ± 0.399
3.412ProThr: 3.412 ± 0.516
2.868ProVal: 2.868 ± 0.345
0.297ProTrp: 0.297 ± 0.132
1.681ProTyr: 1.681 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
3.511GlnAla: 3.511 ± 0.483
0.198GlnCys: 0.198 ± 0.111
1.483GlnAsp: 1.483 ± 0.328
2.522GlnGlu: 2.522 ± 0.461
0.939GlnPhe: 0.939 ± 0.244
1.731GlnGly: 1.731 ± 0.262
0.544GlnHis: 0.544 ± 0.152
2.126GlnIle: 2.126 ± 0.32
1.731GlnLys: 1.731 ± 0.311
2.373GlnLeu: 2.373 ± 0.344
1.038GlnMet: 1.038 ± 0.197
1.187GlnAsn: 1.187 ± 0.215
1.286GlnPro: 1.286 ± 0.269
0.841GlnGln: 0.841 ± 0.24
2.077GlnArg: 2.077 ± 0.374
1.928GlnSer: 1.928 ± 0.339
1.483GlnThr: 1.483 ± 0.262
2.027GlnVal: 2.027 ± 0.306
0.643GlnTrp: 0.643 ± 0.158
0.989GlnTyr: 0.989 ± 0.19
0.0GlnXaa: 0.0 ± 0.0
Arg
4.648ArgAla: 4.648 ± 0.582
0.445ArgCys: 0.445 ± 0.169
4.549ArgAsp: 4.549 ± 0.418
4.648ArgGlu: 4.648 ± 0.465
2.324ArgPhe: 2.324 ± 0.297
3.956ArgGly: 3.956 ± 0.385
1.236ArgHis: 1.236 ± 0.3
2.818ArgIle: 2.818 ± 0.321
4.351ArgLys: 4.351 ± 0.46
4.45ArgLeu: 4.45 ± 0.533
2.077ArgMet: 2.077 ± 0.366
2.324ArgAsn: 2.324 ± 0.379
1.829ArgPro: 1.829 ± 0.3
1.879ArgGln: 1.879 ± 0.278
4.005ArgArg: 4.005 ± 0.592
3.461ArgSer: 3.461 ± 0.372
2.522ArgThr: 2.522 ± 0.451
3.56ArgVal: 3.56 ± 0.447
1.187ArgTrp: 1.187 ± 0.307
2.225ArgTyr: 2.225 ± 0.304
0.0ArgXaa: 0.0 ± 0.0
Ser
5.241SerAla: 5.241 ± 0.626
0.692SerCys: 0.692 ± 0.243
4.252SerAsp: 4.252 ± 0.537
5.488SerGlu: 5.488 ± 0.434
2.225SerPhe: 2.225 ± 0.347
4.944SerGly: 4.944 ± 0.582
0.939SerHis: 0.939 ± 0.249
4.302SerIle: 4.302 ± 0.475
3.164SerLys: 3.164 ± 0.323
5.34SerLeu: 5.34 ± 0.585
1.236SerMet: 1.236 ± 0.272
2.769SerAsn: 2.769 ± 0.386
2.571SerPro: 2.571 ± 0.394
1.879SerGln: 1.879 ± 0.323
3.56SerArg: 3.56 ± 0.395
4.499SerSer: 4.499 ± 0.448
3.708SerThr: 3.708 ± 0.551
4.648SerVal: 4.648 ± 0.494
1.038SerTrp: 1.038 ± 0.188
2.126SerTyr: 2.126 ± 0.29
0.0SerXaa: 0.0 ± 0.0
Thr
5.142ThrAla: 5.142 ± 0.558
0.544ThrCys: 0.544 ± 0.165
2.67ThrAsp: 2.67 ± 0.439
3.164ThrGlu: 3.164 ± 0.304
2.917ThrPhe: 2.917 ± 0.451
4.697ThrGly: 4.697 ± 0.505
1.088ThrHis: 1.088 ± 0.298
3.263ThrIle: 3.263 ± 0.462
2.621ThrLys: 2.621 ± 0.39
4.351ThrLeu: 4.351 ± 0.542
1.582ThrMet: 1.582 ± 0.371
2.769ThrAsn: 2.769 ± 0.32
3.115ThrPro: 3.115 ± 0.353
1.187ThrGln: 1.187 ± 0.22
3.659ThrArg: 3.659 ± 0.355
3.956ThrSer: 3.956 ± 0.348
3.263ThrThr: 3.263 ± 0.616
3.511ThrVal: 3.511 ± 0.361
0.841ThrTrp: 0.841 ± 0.206
2.126ThrTyr: 2.126 ± 0.331
0.0ThrXaa: 0.0 ± 0.0
Val
5.587ValAla: 5.587 ± 0.482
0.396ValCys: 0.396 ± 0.171
4.45ValAsp: 4.45 ± 0.442
5.983ValGlu: 5.983 ± 0.616
2.719ValPhe: 2.719 ± 0.355
4.697ValGly: 4.697 ± 0.515
1.038ValHis: 1.038 ± 0.207
4.45ValIle: 4.45 ± 0.434
3.313ValLys: 3.313 ± 0.422
5.587ValLeu: 5.587 ± 0.607
1.879ValMet: 1.879 ± 0.292
2.719ValAsn: 2.719 ± 0.395
2.373ValPro: 2.373 ± 0.332
1.632ValGln: 1.632 ± 0.291
3.263ValArg: 3.263 ± 0.502
4.499ValSer: 4.499 ± 0.432
3.758ValThr: 3.758 ± 0.448
4.845ValVal: 4.845 ± 0.561
1.137ValTrp: 1.137 ± 0.255
2.274ValTyr: 2.274 ± 0.365
0.0ValXaa: 0.0 ± 0.0
Trp
1.632TrpAla: 1.632 ± 0.382
0.247TrpCys: 0.247 ± 0.114
1.434TrpAsp: 1.434 ± 0.246
1.582TrpGlu: 1.582 ± 0.262
0.445TrpPhe: 0.445 ± 0.136
1.137TrpGly: 1.137 ± 0.295
0.148TrpHis: 0.148 ± 0.087
0.742TrpIle: 0.742 ± 0.177
0.643TrpLys: 0.643 ± 0.163
1.286TrpLeu: 1.286 ± 0.302
0.445TrpMet: 0.445 ± 0.144
0.791TrpAsn: 0.791 ± 0.2
0.89TrpPro: 0.89 ± 0.21
0.742TrpGln: 0.742 ± 0.209
0.544TrpArg: 0.544 ± 0.147
0.791TrpSer: 0.791 ± 0.184
0.643TrpThr: 0.643 ± 0.167
1.533TrpVal: 1.533 ± 0.245
0.247TrpTrp: 0.247 ± 0.098
0.544TrpTyr: 0.544 ± 0.17
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.472TyrAla: 2.472 ± 0.325
0.346TyrCys: 0.346 ± 0.13
2.225TyrAsp: 2.225 ± 0.287
2.67TyrGlu: 2.67 ± 0.444
0.939TyrPhe: 0.939 ± 0.171
3.164TyrGly: 3.164 ± 0.478
0.544TyrHis: 0.544 ± 0.173
1.681TyrIle: 1.681 ± 0.281
1.632TyrLys: 1.632 ± 0.284
2.818TyrLeu: 2.818 ± 0.365
0.445TyrMet: 0.445 ± 0.153
1.335TyrAsn: 1.335 ± 0.318
1.483TyrPro: 1.483 ± 0.378
1.038TyrGln: 1.038 ± 0.251
2.67TyrArg: 2.67 ± 0.335
2.077TyrSer: 2.077 ± 0.37
1.582TyrThr: 1.582 ± 0.313
2.423TyrVal: 2.423 ± 0.415
0.791TyrTrp: 0.791 ± 0.161
1.582TyrTyr: 1.582 ± 0.239
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 92 proteins (20226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski