Amino acid dipepetide frequency for Natrarchaeobius chitinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.583AlaAla: 10.583 ± 0.139	0.683AlaCys: 0.683 ± 0.022	9.095AlaAsp: 9.095 ± 0.118	7.794AlaGlu: 7.794 ± 0.086	3.689AlaPhe: 3.689 ± 0.059	8.426AlaGly: 8.426 ± 0.097	1.651AlaHis: 1.651 ± 0.036	5.591AlaIle: 5.591 ± 0.08	1.667AlaLys: 1.667 ± 0.039	9.285AlaLeu: 9.285 ± 0.102	1.838AlaMet: 1.838 ± 0.038	2.418AlaAsn: 2.418 ± 0.036	3.271AlaPro: 3.271 ± 0.052	1.977AlaGln: 1.977 ± 0.045	5.596AlaArg: 5.596 ± 0.075	5.275AlaSer: 5.275 ± 0.074	6.71AlaThr: 6.71 ± 0.099	9.453AlaVal: 9.453 ± 0.099	0.944AlaTrp: 0.944 ± 0.028	2.538AlaTyr: 2.538 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.575CysAla: 0.575 ± 0.022	0.095CysCys: 0.095 ± 0.01	0.631CysAsp: 0.631 ± 0.024	0.685CysGlu: 0.685 ± 0.026	0.211CysPhe: 0.211 ± 0.013	0.837CysGly: 0.837 ± 0.031	0.22CysHis: 0.22 ± 0.014	0.301CysIle: 0.301 ± 0.015	0.141CysLys: 0.141 ± 0.01	0.636CysLeu: 0.636 ± 0.024	0.106CysMet: 0.106 ± 0.009	0.213CysAsn: 0.213 ± 0.014	0.538CysPro: 0.538 ± 0.023	0.168CysGln: 0.168 ± 0.013	0.566CysArg: 0.566 ± 0.023	0.467CysSer: 0.467 ± 0.021	0.453CysThr: 0.453 ± 0.019	0.495CysVal: 0.495 ± 0.023	0.104CysTrp: 0.104 ± 0.007	0.211CysTyr: 0.211 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.044AspAla: 9.044 ± 0.101	0.688AspCys: 0.688 ± 0.026	9.127AspAsp: 9.127 ± 0.183	8.985AspGlu: 8.985 ± 0.126	1.804AspPhe: 1.804 ± 0.039	8.708AspGly: 8.708 ± 0.124	2.058AspHis: 2.058 ± 0.042	2.609AspIle: 2.609 ± 0.053	0.802AspLys: 0.802 ± 0.028	7.076AspLeu: 7.076 ± 0.093	1.051AspMet: 1.051 ± 0.032	1.248AspAsn: 1.248 ± 0.042	4.962AspPro: 4.962 ± 0.073	1.743AspGln: 1.743 ± 0.039	7.332AspArg: 7.332 ± 0.1	4.023AspSer: 4.023 ± 0.069	3.698AspThr: 3.698 ± 0.06	8.796AspVal: 8.796 ± 0.104	0.949AspTrp: 0.949 ± 0.028	1.652AspTyr: 1.652 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.283GluAla: 8.283 ± 0.107	0.646GluCys: 0.646 ± 0.027	6.386GluAsp: 6.386 ± 0.091	7.527GluGlu: 7.527 ± 0.107	3.41GluPhe: 3.41 ± 0.056	5.555GluGly: 5.555 ± 0.073	1.972GluHis: 1.972 ± 0.041	4.842GluIle: 4.842 ± 0.07	1.933GluLys: 1.933 ± 0.05	8.04GluLeu: 8.04 ± 0.089	2.006GluMet: 2.006 ± 0.038	2.693GluAsn: 2.693 ± 0.049	4.622GluPro: 4.622 ± 0.075	2.642GluGln: 2.642 ± 0.053	7.972GluArg: 7.972 ± 0.108	6.027GluSer: 6.027 ± 0.078	7.543GluThr: 7.543 ± 0.101	5.361GluVal: 5.361 ± 0.084	1.222GluTrp: 1.222 ± 0.036	3.313GluTyr: 3.313 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.483PheAla: 3.483 ± 0.062	0.288PheCys: 0.288 ± 0.015	3.482PheAsp: 3.482 ± 0.058	3.369PheGlu: 3.369 ± 0.065	1.075PhePhe: 1.075 ± 0.033	3.051PheGly: 3.051 ± 0.06	0.686PheHis: 0.686 ± 0.028	1.028PheIle: 1.028 ± 0.033	0.429PheLys: 0.429 ± 0.02	2.868PheLeu: 2.868 ± 0.053	0.456PheMet: 0.456 ± 0.02	0.66PheAsn: 0.66 ± 0.022	1.35PhePro: 1.35 ± 0.035	0.786PheGln: 0.786 ± 0.024	1.841PheArg: 1.841 ± 0.042	1.754PheSer: 1.754 ± 0.045	1.823PheThr: 1.823 ± 0.044	3.465PheVal: 3.465 ± 0.06	0.42PheTrp: 0.42 ± 0.021	0.845PheTyr: 0.845 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	6.802GlyAla: 6.802 ± 0.093	0.788GlyCys: 0.788 ± 0.027	6.751GlyAsp: 6.751 ± 0.097	7.217GlyGlu: 7.217 ± 0.093	3.083GlyPhe: 3.083 ± 0.055	6.917GlyGly: 6.917 ± 0.103	1.649GlyHis: 1.649 ± 0.038	4.597GlyIle: 4.597 ± 0.066	1.754GlyLys: 1.754 ± 0.043	6.878GlyLeu: 6.878 ± 0.085	1.656GlyMet: 1.656 ± 0.037	2.019GlyAsn: 2.019 ± 0.043	3.32GlyPro: 3.32 ± 0.059	1.896GlyGln: 1.896 ± 0.037	4.897GlyArg: 4.897 ± 0.06	5.342GlySer: 5.342 ± 0.072	6.004GlyThr: 6.004 ± 0.085	7.2GlyVal: 7.2 ± 0.087	1.107GlyTrp: 1.107 ± 0.026	2.739GlyTyr: 2.739 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.991HisAla: 1.991 ± 0.047	0.237HisCys: 0.237 ± 0.015	1.916HisAsp: 1.916 ± 0.042	1.822HisGlu: 1.822 ± 0.039	0.537HisPhe: 0.537 ± 0.021	1.975HisGly: 1.975 ± 0.042	0.588HisHis: 0.588 ± 0.022	0.605HisIle: 0.605 ± 0.023	0.246HisLys: 0.246 ± 0.015	1.742HisLeu: 1.742 ± 0.036	0.275HisMet: 0.275 ± 0.015	0.461HisAsn: 0.461 ± 0.021	1.24HisPro: 1.24 ± 0.033	0.512HisGln: 0.512 ± 0.019	1.396HisArg: 1.396 ± 0.036	0.963HisSer: 0.963 ± 0.031	1.065HisThr: 1.065 ± 0.033	1.992HisVal: 1.992 ± 0.043	0.25HisTrp: 0.25 ± 0.015	0.562HisTyr: 0.562 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.205IleAla: 5.205 ± 0.074	0.328IleCys: 0.328 ± 0.016	4.913IleAsp: 4.913 ± 0.058	4.692IleGlu: 4.692 ± 0.059	1.115IlePhe: 1.115 ± 0.031	4.325IleGly: 4.325 ± 0.074	0.91IleHis: 0.91 ± 0.029	1.377IleIle: 1.377 ± 0.044	0.711IleLys: 0.711 ± 0.026	3.299IleLeu: 3.299 ± 0.073	0.562IleMet: 0.562 ± 0.025	0.981IleAsn: 0.981 ± 0.031	2.111IlePro: 2.111 ± 0.049	1.153IleGln: 1.153 ± 0.035	2.785IleArg: 2.785 ± 0.046	2.485IleSer: 2.485 ± 0.049	2.675IleThr: 2.675 ± 0.048	4.597IleVal: 4.597 ± 0.071	0.4IleTrp: 0.4 ± 0.018	1.062IleTyr: 1.062 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	1.561LysAla: 1.561 ± 0.039	0.132LysCys: 0.132 ± 0.01	0.988LysAsp: 0.988 ± 0.033	1.231LysGlu: 1.231 ± 0.04	0.461LysPhe: 0.461 ± 0.021	1.247LysGly: 1.247 ± 0.032	0.475LysHis: 0.475 ± 0.019	0.858LysIle: 0.858 ± 0.03	0.514LysLys: 0.514 ± 0.026	1.6LysLeu: 1.6 ± 0.04	0.371LysMet: 0.371 ± 0.017	0.531LysAsn: 0.531 ± 0.022	0.964LysPro: 0.964 ± 0.033	0.63LysGln: 0.63 ± 0.028	1.707LysArg: 1.707 ± 0.038	1.144LysSer: 1.144 ± 0.031	1.292LysThr: 1.292 ± 0.035	1.04LysVal: 1.04 ± 0.032	0.222LysTrp: 0.222 ± 0.013	0.517LysTyr: 0.517 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	10.021LeuAla: 10.021 ± 0.117	0.651LeuCys: 0.651 ± 0.023	5.953LeuAsp: 5.953 ± 0.085	11.802LeuGlu: 11.802 ± 0.112	3.06LeuPhe: 3.06 ± 0.07	6.866LeuGly: 6.866 ± 0.086	1.451LeuHis: 1.451 ± 0.038	3.356LeuIle: 3.356 ± 0.067	1.373LeuLys: 1.373 ± 0.036	8.066LeuLeu: 8.066 ± 0.109	1.174LeuMet: 1.174 ± 0.032	1.673LeuAsn: 1.673 ± 0.045	3.735LeuPro: 3.735 ± 0.059	1.918LeuGln: 1.918 ± 0.045	4.844LeuArg: 4.844 ± 0.07	5.688LeuSer: 5.688 ± 0.072	4.941LeuThr: 4.941 ± 0.072	7.905LeuVal: 7.905 ± 0.1	0.854LeuTrp: 0.854 ± 0.027	2.136LeuTyr: 2.136 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.74MetAla: 1.74 ± 0.041	0.124MetCys: 0.124 ± 0.012	1.212MetAsp: 1.212 ± 0.033	1.085MetGlu: 1.085 ± 0.033	0.511MetPhe: 0.511 ± 0.025	1.365MetGly: 1.365 ± 0.037	0.322MetHis: 0.322 ± 0.016	0.84MetIle: 0.84 ± 0.028	0.446MetLys: 0.446 ± 0.02	1.447MetLeu: 1.447 ± 0.036	0.328MetMet: 0.328 ± 0.017	0.607MetAsn: 0.607 ± 0.023	0.74MetPro: 0.74 ± 0.026	0.443MetGln: 0.443 ± 0.02	0.972MetArg: 0.972 ± 0.028	1.42MetSer: 1.42 ± 0.035	1.562MetThr: 1.562 ± 0.038	1.253MetVal: 1.253 ± 0.035	0.159MetTrp: 0.159 ± 0.012	0.447MetTyr: 0.447 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.649AsnAla: 2.649 ± 0.044	0.228AsnCys: 0.228 ± 0.013	1.802AsnAsp: 1.802 ± 0.038	1.982AsnGlu: 1.982 ± 0.048	0.623AsnPhe: 0.623 ± 0.023	2.189AsnGly: 2.189 ± 0.049	0.535AsnHis: 0.535 ± 0.021	0.823AsnIle: 0.823 ± 0.027	0.405AsnLys: 0.405 ± 0.02	1.898AsnLeu: 1.898 ± 0.036	0.379AsnMet: 0.379 ± 0.016	0.482AsnAsn: 0.482 ± 0.025	1.487AsnPro: 1.487 ± 0.033	0.618AsnGln: 0.618 ± 0.024	1.85AsnArg: 1.85 ± 0.041	1.039AsnSer: 1.039 ± 0.032	1.201AsnThr: 1.201 ± 0.029	2.362AsnVal: 2.362 ± 0.05	0.342AsnTrp: 0.342 ± 0.018	0.672AsnTyr: 0.672 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.325ProAla: 4.325 ± 0.059	0.249ProCys: 0.249 ± 0.012	5.082ProAsp: 5.082 ± 0.07	4.495ProGlu: 4.495 ± 0.065	1.56ProPhe: 1.56 ± 0.034	3.697ProGly: 3.697 ± 0.07	0.895ProHis: 0.895 ± 0.026	2.35ProIle: 2.35 ± 0.04	0.833ProLys: 0.833 ± 0.028	3.643ProLeu: 3.643 ± 0.05	0.834ProMet: 0.834 ± 0.029	1.179ProAsn: 1.179 ± 0.032	2.272ProPro: 2.272 ± 0.047	0.968ProGln: 0.968 ± 0.03	2.381ProArg: 2.381 ± 0.047	2.821ProSer: 2.821 ± 0.052	3.218ProThr: 3.218 ± 0.052	3.987ProVal: 3.987 ± 0.058	0.526ProTrp: 0.526 ± 0.021	1.146ProTyr: 1.146 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.053GlnAla: 2.053 ± 0.036	0.165GlnCys: 0.165 ± 0.013	1.269GlnAsp: 1.269 ± 0.037	1.706GlnGlu: 1.706 ± 0.043	1.078GlnPhe: 1.078 ± 0.03	1.469GlnGly: 1.469 ± 0.038	0.493GlnHis: 0.493 ± 0.02	1.218GlnIle: 1.218 ± 0.031	0.548GlnLys: 0.548 ± 0.023	2.469GlnLeu: 2.469 ± 0.048	0.485GlnMet: 0.485 ± 0.02	0.704GlnAsn: 0.704 ± 0.024	1.171GlnPro: 1.171 ± 0.035	0.915GlnGln: 0.915 ± 0.035	1.979GlnArg: 1.979 ± 0.046	1.518GlnSer: 1.518 ± 0.042	1.634GlnThr: 1.634 ± 0.037	1.639GlnVal: 1.639 ± 0.038	0.359GlnTrp: 0.359 ± 0.016	0.842GlnTyr: 0.842 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	5.855ArgAla: 5.855 ± 0.081	0.532ArgCys: 0.532 ± 0.022	4.973ArgAsp: 4.973 ± 0.068	6.633ArgGlu: 6.633 ± 0.094	2.447ArgPhe: 2.447 ± 0.055	4.396ArgGly: 4.396 ± 0.062	1.284ArgHis: 1.284 ± 0.035	3.614ArgIle: 3.614 ± 0.054	1.427ArgLys: 1.427 ± 0.038	6.129ArgLeu: 6.129 ± 0.087	1.365ArgMet: 1.365 ± 0.03	1.783ArgAsn: 1.783 ± 0.038	2.729ArgPro: 2.729 ± 0.058	1.772ArgGln: 1.772 ± 0.042	5.365ArgArg: 5.365 ± 0.095	4.24ArgSer: 4.24 ± 0.069	4.531ArgThr: 4.531 ± 0.071	4.904ArgVal: 4.904 ± 0.067	0.84ArgTrp: 0.84 ± 0.028	2.011ArgTyr: 2.011 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.221SerAla: 5.221 ± 0.069	0.367SerCys: 0.367 ± 0.019	4.801SerAsp: 4.801 ± 0.08	4.824SerGlu: 4.824 ± 0.068	1.974SerPhe: 1.974 ± 0.036	5.301SerGly: 5.301 ± 0.076	1.203SerHis: 1.203 ± 0.029	3.07SerIle: 3.07 ± 0.051	1.222SerLys: 1.222 ± 0.033	4.931SerLeu: 4.931 ± 0.065	1.19SerMet: 1.19 ± 0.031	1.488SerAsn: 1.488 ± 0.037	2.795SerPro: 2.795 ± 0.047	1.376SerGln: 1.376 ± 0.03	3.704SerArg: 3.704 ± 0.061	3.807SerSer: 3.807 ± 0.06	3.836SerThr: 3.836 ± 0.066	5.326SerVal: 5.326 ± 0.065	0.629SerTrp: 0.629 ± 0.022	1.489SerTyr: 1.489 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.563ThrAla: 6.563 ± 0.082	0.418ThrCys: 0.418 ± 0.019	6.088ThrAsp: 6.088 ± 0.085	4.878ThrGlu: 4.878 ± 0.075	2.152ThrPhe: 2.152 ± 0.049	5.686ThrGly: 5.686 ± 0.078	1.28ThrHis: 1.28 ± 0.035	3.66ThrIle: 3.66 ± 0.053	1.05ThrLys: 1.05 ± 0.027	5.674ThrLeu: 5.674 ± 0.066	1.054ThrMet: 1.054 ± 0.029	1.563ThrAsn: 1.563 ± 0.038	3.115ThrPro: 3.115 ± 0.049	1.34ThrGln: 1.34 ± 0.037	3.364ThrArg: 3.364 ± 0.056	3.166ThrSer: 3.166 ± 0.052	4.234ThrThr: 4.234 ± 0.08	7.1ThrVal: 7.1 ± 0.094	0.62ThrTrp: 0.62 ± 0.023	1.79ThrTyr: 1.79 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.95ValAla: 8.95 ± 0.104	0.663ValCys: 0.663 ± 0.024	8.248ValAsp: 8.248 ± 0.1	7.677ValGlu: 7.677 ± 0.093	3.001ValPhe: 3.001 ± 0.055	7.448ValGly: 7.448 ± 0.098	1.789ValHis: 1.789 ± 0.04	3.607ValIle: 3.607 ± 0.066	1.294ValLys: 1.294 ± 0.032	8.113ValLeu: 8.113 ± 0.091	1.296ValMet: 1.296 ± 0.034	1.85ValAsn: 1.85 ± 0.042	4.327ValPro: 4.327 ± 0.056	1.799ValGln: 1.799 ± 0.038	5.398ValArg: 5.398 ± 0.075	5.459ValSer: 5.459 ± 0.071	6.119ValThr: 6.119 ± 0.088	8.941ValVal: 8.941 ± 0.111	0.869ValTrp: 0.869 ± 0.031	2.219ValTyr: 2.219 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.872TrpAla: 0.872 ± 0.028	0.117TrpCys: 0.117 ± 0.009	0.797TrpAsp: 0.797 ± 0.029	0.915TrpGlu: 0.915 ± 0.033	0.465TrpPhe: 0.465 ± 0.02	0.813TrpGly: 0.813 ± 0.029	0.279TrpHis: 0.279 ± 0.016	0.64TrpIle: 0.64 ± 0.024	0.283TrpLys: 0.283 ± 0.016	1.171TrpLeu: 1.171 ± 0.036	0.244TrpMet: 0.244 ± 0.013	0.42TrpAsn: 0.42 ± 0.017	0.426TrpPro: 0.426 ± 0.019	0.355TrpGln: 0.355 ± 0.018	0.814TrpArg: 0.814 ± 0.031	0.66TrpSer: 0.66 ± 0.025	0.771TrpThr: 0.771 ± 0.028	0.745TrpVal: 0.745 ± 0.025	0.183TrpTrp: 0.183 ± 0.012	0.359TrpTyr: 0.359 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.705TyrAla: 2.705 ± 0.05	0.254TyrCys: 0.254 ± 0.014	2.837TyrAsp: 2.837 ± 0.052	2.674TyrGlu: 2.674 ± 0.047	0.903TyrPhe: 0.903 ± 0.026	2.345TyrGly: 2.345 ± 0.043	0.635TyrHis: 0.635 ± 0.027	0.699TyrIle: 0.699 ± 0.025	0.41TyrLys: 0.41 ± 0.018	2.501TyrLeu: 2.501 ± 0.051	0.355TyrMet: 0.355 ± 0.017	0.594TyrAsn: 0.594 ± 0.023	1.287TyrPro: 1.287 ± 0.035	0.707TyrGln: 0.707 ± 0.027	2.065TyrArg: 2.065 ± 0.044	1.257TyrSer: 1.257 ± 0.037	1.484TyrThr: 1.484 ± 0.035	2.506TyrVal: 2.506 ± 0.043	0.33TyrTrp: 0.33 ± 0.018	0.83TyrTyr: 0.83 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4237 proteins (1218109 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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