Amino acid dipepetide frequency for Roseomonas cervicalis ATCC 49957

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.448AlaAla: 25.448 ± 0.181	1.242AlaCys: 1.242 ± 0.031	6.163AlaAsp: 6.163 ± 0.076	10.608AlaGlu: 10.608 ± 0.102	4.149AlaPhe: 4.149 ± 0.057	13.802AlaGly: 13.802 ± 0.105	2.418AlaHis: 2.418 ± 0.044	5.632AlaIle: 5.632 ± 0.079	2.692AlaLys: 2.692 ± 0.062	19.216AlaLeu: 19.216 ± 0.155	4.254AlaMet: 4.254 ± 0.061	2.313AlaAsn: 2.313 ± 0.047	8.427AlaPro: 8.427 ± 0.086	4.889AlaGln: 4.889 ± 0.071	12.574AlaArg: 12.574 ± 0.101	5.989AlaSer: 5.989 ± 0.063	6.586AlaThr: 6.586 ± 0.078	9.518AlaVal: 9.518 ± 0.102	2.127AlaTrp: 2.127 ± 0.038	2.289AlaTyr: 2.289 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.123CysAla: 1.123 ± 0.033	0.125CysCys: 0.125 ± 0.01	0.482CysAsp: 0.482 ± 0.019	0.35CysGlu: 0.35 ± 0.018	0.289CysPhe: 0.289 ± 0.015	0.94CysGly: 0.94 ± 0.029	0.219CysHis: 0.219 ± 0.011	0.33CysIle: 0.33 ± 0.016	0.099CysLys: 0.099 ± 0.009	0.824CysLeu: 0.824 ± 0.026	0.144CysMet: 0.144 ± 0.011	0.15CysAsn: 0.15 ± 0.011	0.5CysPro: 0.5 ± 0.02	0.213CysGln: 0.213 ± 0.012	0.769CysArg: 0.769 ± 0.027	0.336CysSer: 0.336 ± 0.016	0.405CysThr: 0.405 ± 0.019	0.554CysVal: 0.554 ± 0.02	0.13CysTrp: 0.13 ± 0.009	0.167CysTyr: 0.167 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.91AspAla: 6.91 ± 0.078	0.362AspCys: 0.362 ± 0.016	1.913AspAsp: 1.913 ± 0.049	2.468AspGlu: 2.468 ± 0.048	1.749AspPhe: 1.749 ± 0.037	4.728AspGly: 4.728 ± 0.071	0.951AspHis: 0.951 ± 0.027	2.081AspIle: 2.081 ± 0.04	0.87AspLys: 0.87 ± 0.03	5.235AspLeu: 5.235 ± 0.068	1.011AspMet: 1.011 ± 0.027	0.775AspAsn: 0.775 ± 0.026	3.719AspPro: 3.719 ± 0.061	1.374AspGln: 1.374 ± 0.029	4.052AspArg: 4.052 ± 0.054	2.016AspSer: 2.016 ± 0.04	2.217AspThr: 2.217 ± 0.049	2.991AspVal: 2.991 ± 0.052	0.946AspTrp: 0.946 ± 0.027	1.105AspTyr: 1.105 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	10.259GluAla: 10.259 ± 0.11	0.305GluCys: 0.305 ± 0.017	2.555GluAsp: 2.555 ± 0.049	3.495GluGlu: 3.495 ± 0.061	1.518GluPhe: 1.518 ± 0.036	5.547GluGly: 5.547 ± 0.069	1.06GluHis: 1.06 ± 0.029	2.756GluIle: 2.756 ± 0.045	1.459GluLys: 1.459 ± 0.041	5.378GluLeu: 5.378 ± 0.064	1.439GluMet: 1.439 ± 0.031	1.109GluAsn: 1.109 ± 0.031	2.763GluPro: 2.763 ± 0.046	2.153GluGln: 2.153 ± 0.042	5.149GluArg: 5.149 ± 0.075	2.143GluSer: 2.143 ± 0.037	2.785GluThr: 2.785 ± 0.047	3.875GluVal: 3.875 ± 0.057	0.732GluTrp: 0.732 ± 0.022	0.801GluTyr: 0.801 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.507PheAla: 4.507 ± 0.055	0.364PheCys: 0.364 ± 0.013	1.998PheAsp: 1.998 ± 0.044	1.602PheGlu: 1.602 ± 0.038	1.108PhePhe: 1.108 ± 0.029	3.501PheGly: 3.501 ± 0.057	0.662PheHis: 0.662 ± 0.024	1.18PheIle: 1.18 ± 0.033	0.504PheLys: 0.504 ± 0.02	3.407PheLeu: 3.407 ± 0.052	0.579PheMet: 0.579 ± 0.02	0.751PheAsn: 0.751 ± 0.022	1.673PhePro: 1.673 ± 0.037	0.937PheGln: 0.937 ± 0.022	2.514PheArg: 2.514 ± 0.041	1.68PheSer: 1.68 ± 0.038	1.759PheThr: 1.759 ± 0.033	2.095PheVal: 2.095 ± 0.041	0.501PheTrp: 0.501 ± 0.021	0.657PheTyr: 0.657 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	12.156GlyAla: 12.156 ± 0.104	0.9GlyCys: 0.9 ± 0.028	3.788GlyAsp: 3.788 ± 0.068	5.176GlyGlu: 5.176 ± 0.064	3.866GlyPhe: 3.866 ± 0.06	8.985GlyGly: 8.985 ± 0.135	2.16GlyHis: 2.16 ± 0.041	4.171GlyIle: 4.171 ± 0.065	2.183GlyLys: 2.183 ± 0.048	11.363GlyLeu: 11.363 ± 0.122	2.597GlyMet: 2.597 ± 0.042	1.862GlyAsn: 1.862 ± 0.055	4.559GlyPro: 4.559 ± 0.061	3.74GlyGln: 3.74 ± 0.055	8.224GlyArg: 8.224 ± 0.081	4.313GlySer: 4.313 ± 0.06	4.488GlyThr: 4.488 ± 0.07	6.179GlyVal: 6.179 ± 0.079	1.741GlyTrp: 1.741 ± 0.036	1.984GlyTyr: 1.984 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.796HisAla: 2.796 ± 0.06	0.222HisCys: 0.222 ± 0.014	1.032HisAsp: 1.032 ± 0.029	0.879HisGlu: 0.879 ± 0.027	0.705HisPhe: 0.705 ± 0.021	2.169HisGly: 2.169 ± 0.042	0.553HisHis: 0.553 ± 0.02	0.657HisIle: 0.657 ± 0.024	0.317HisLys: 0.317 ± 0.016	2.134HisLeu: 2.134 ± 0.037	0.377HisMet: 0.377 ± 0.016	0.398HisAsn: 0.398 ± 0.019	1.548HisPro: 1.548 ± 0.035	0.534HisGln: 0.534 ± 0.022	1.73HisArg: 1.73 ± 0.04	0.816HisSer: 0.816 ± 0.025	0.734HisThr: 0.734 ± 0.024	1.34HisVal: 1.34 ± 0.031	0.399HisTrp: 0.399 ± 0.017	0.472HisTyr: 0.472 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.492IleAla: 6.492 ± 0.073	0.368IleCys: 0.368 ± 0.018	2.233IleAsp: 2.233 ± 0.042	2.523IleGlu: 2.523 ± 0.043	1.115IlePhe: 1.115 ± 0.033	4.418IleGly: 4.418 ± 0.058	0.732IleHis: 0.732 ± 0.023	1.401IleIle: 1.401 ± 0.036	0.642IleLys: 0.642 ± 0.024	3.96IleLeu: 3.96 ± 0.067	0.656IleMet: 0.656 ± 0.023	0.842IleAsn: 0.842 ± 0.025	2.172IlePro: 2.172 ± 0.038	1.029IleGln: 1.029 ± 0.025	3.052IleArg: 3.052 ± 0.046	1.765IleSer: 1.765 ± 0.036	2.053IleThr: 2.053 ± 0.036	2.75IleVal: 2.75 ± 0.047	0.454IleTrp: 0.454 ± 0.019	0.675IleTyr: 0.675 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.635LysAla: 2.635 ± 0.049	0.081LysCys: 0.081 ± 0.009	0.876LysAsp: 0.876 ± 0.027	0.938LysGlu: 0.938 ± 0.033	0.481LysPhe: 0.481 ± 0.019	1.753LysGly: 1.753 ± 0.045	0.368LysHis: 0.368 ± 0.018	0.841LysIle: 0.841 ± 0.031	0.643LysLys: 0.643 ± 0.032	2.407LysLeu: 2.407 ± 0.052	0.376LysMet: 0.376 ± 0.016	0.426LysAsn: 0.426 ± 0.019	1.444LysPro: 1.444 ± 0.036	0.66LysGln: 0.66 ± 0.024	1.694LysArg: 1.694 ± 0.04	0.95LysSer: 0.95 ± 0.027	0.945LysThr: 0.945 ± 0.027	1.521LysVal: 1.521 ± 0.042	0.176LysTrp: 0.176 ± 0.01	0.302LysTyr: 0.302 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	18.765LeuAla: 18.765 ± 0.151	1.056LeuCys: 1.056 ± 0.031	5.99LeuAsp: 5.99 ± 0.071	5.806LeuGlu: 5.806 ± 0.072	3.389LeuPhe: 3.389 ± 0.058	10.334LeuGly: 10.334 ± 0.099	2.242LeuHis: 2.242 ± 0.041	3.633LeuIle: 3.633 ± 0.06	2.212LeuLys: 2.212 ± 0.045	13.741LeuLeu: 13.741 ± 0.166	2.205LeuMet: 2.205 ± 0.042	2.031LeuAsn: 2.031 ± 0.039	8.316LeuPro: 8.316 ± 0.09	3.187LeuGln: 3.187 ± 0.052	10.711LeuArg: 10.711 ± 0.105	6.144LeuSer: 6.144 ± 0.072	5.187LeuThr: 5.187 ± 0.064	8.004LeuVal: 8.004 ± 0.09	1.489LeuTrp: 1.489 ± 0.034	1.839LeuTyr: 1.839 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.608MetAla: 3.608 ± 0.051	0.121MetCys: 0.121 ± 0.01	1.019MetAsp: 1.019 ± 0.027	1.018MetGlu: 1.018 ± 0.026	0.53MetPhe: 0.53 ± 0.018	1.784MetGly: 1.784 ± 0.035	0.344MetHis: 0.344 ± 0.016	0.902MetIle: 0.902 ± 0.027	0.53MetLys: 0.53 ± 0.019	2.727MetLeu: 2.727 ± 0.046	0.543MetMet: 0.543 ± 0.023	0.56MetAsn: 0.56 ± 0.02	1.616MetPro: 1.616 ± 0.038	0.954MetGln: 0.954 ± 0.029	1.914MetArg: 1.914 ± 0.035	1.405MetSer: 1.405 ± 0.031	1.464MetThr: 1.464 ± 0.032	1.622MetVal: 1.622 ± 0.04	0.191MetTrp: 0.191 ± 0.012	0.223MetTyr: 0.223 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.659AsnAla: 2.659 ± 0.051	0.167AsnCys: 0.167 ± 0.01	0.892AsnAsp: 0.892 ± 0.039	0.789AsnGlu: 0.789 ± 0.027	0.695AsnPhe: 0.695 ± 0.022	1.698AsnGly: 1.698 ± 0.039	0.384AsnHis: 0.384 ± 0.016	0.915AsnIle: 0.915 ± 0.027	0.361AsnLys: 0.361 ± 0.017	2.166AsnLeu: 2.166 ± 0.043	0.389AsnMet: 0.389 ± 0.017	0.473AsnAsn: 0.473 ± 0.022	1.606AsnPro: 1.606 ± 0.038	0.56AsnGln: 0.56 ± 0.023	1.629AsnArg: 1.629 ± 0.036	0.856AsnSer: 0.856 ± 0.026	0.997AsnThr: 0.997 ± 0.027	1.315AsnVal: 1.315 ± 0.031	0.295AsnTrp: 0.295 ± 0.014	0.444AsnTyr: 0.444 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	9.469ProAla: 9.469 ± 0.094	0.439ProCys: 0.439 ± 0.017	3.581ProAsp: 3.581 ± 0.052	4.754ProGlu: 4.754 ± 0.065	1.991ProPhe: 1.991 ± 0.036	6.925ProGly: 6.925 ± 0.086	1.236ProHis: 1.236 ± 0.035	1.798ProIle: 1.798 ± 0.042	1.045ProLys: 1.045 ± 0.034	6.362ProLeu: 6.362 ± 0.077	1.3ProMet: 1.3 ± 0.031	1.16ProAsn: 1.16 ± 0.034	4.587ProPro: 4.587 ± 0.075	1.955ProGln: 1.955 ± 0.04	4.766ProArg: 4.766 ± 0.069	2.588ProSer: 2.588 ± 0.043	2.239ProThr: 2.239 ± 0.042	4.725ProVal: 4.725 ± 0.057	0.985ProTrp: 0.985 ± 0.026	1.117ProTyr: 1.117 ± 0.03	0.001ProXaa: 0.001 ± 0.001
Gln	5.532GlnAla: 5.532 ± 0.072	0.182GlnCys: 0.182 ± 0.011	1.656GlnAsp: 1.656 ± 0.036	1.774GlnGlu: 1.774 ± 0.043	0.786GlnPhe: 0.786 ± 0.024	3.524GlnGly: 3.524 ± 0.048	0.688GlnHis: 0.688 ± 0.024	1.361GlnIle: 1.361 ± 0.032	0.723GlnLys: 0.723 ± 0.024	2.983GlnLeu: 2.983 ± 0.052	0.789GlnMet: 0.789 ± 0.027	0.644GlnAsn: 0.644 ± 0.026	2.265GlnPro: 2.265 ± 0.042	1.441GlnGln: 1.441 ± 0.04	3.179GlnArg: 3.179 ± 0.059	1.482GlnSer: 1.482 ± 0.029	1.261GlnThr: 1.261 ± 0.032	2.304GlnVal: 2.304 ± 0.046	0.388GlnTrp: 0.388 ± 0.016	0.43GlnTyr: 0.43 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.721ArgAla: 11.721 ± 0.107	0.677ArgCys: 0.677 ± 0.024	4.365ArgAsp: 4.365 ± 0.058	4.596ArgGlu: 4.596 ± 0.055	3.15ArgPhe: 3.15 ± 0.053	6.747ArgGly: 6.747 ± 0.08	2.199ArgHis: 2.199 ± 0.045	4.036ArgIle: 4.036 ± 0.061	1.479ArgLys: 1.479 ± 0.041	10.759ArgLeu: 10.759 ± 0.098	2.11ArgMet: 2.11 ± 0.041	1.699ArgAsn: 1.699 ± 0.037	5.392ArgPro: 5.392 ± 0.077	3.564ArgGln: 3.564 ± 0.061	8.352ArgArg: 8.352 ± 0.115	3.396ArgSer: 3.396 ± 0.059	2.901ArgThr: 2.901 ± 0.051	5.339ArgVal: 5.339 ± 0.072	1.254ArgTrp: 1.254 ± 0.032	1.566ArgTyr: 1.566 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.999SerAla: 5.999 ± 0.074	0.41SerCys: 0.41 ± 0.019	1.97SerAsp: 1.97 ± 0.037	2.042SerGlu: 2.042 ± 0.039	1.822SerPhe: 1.822 ± 0.035	4.998SerGly: 4.998 ± 0.064	0.886SerHis: 0.886 ± 0.026	1.921SerIle: 1.921 ± 0.038	0.798SerLys: 0.798 ± 0.024	5.241SerLeu: 5.241 ± 0.082	1.001SerMet: 1.001 ± 0.026	0.879SerAsn: 0.879 ± 0.029	2.817SerPro: 2.817 ± 0.045	1.297SerGln: 1.297 ± 0.034	3.538SerArg: 3.538 ± 0.053	2.034SerSer: 2.034 ± 0.045	2.083SerThr: 2.083 ± 0.049	3.217SerVal: 3.217 ± 0.053	0.789SerTrp: 0.789 ± 0.028	0.924SerTyr: 0.924 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.076ThrAla: 6.076 ± 0.067	0.301ThrCys: 0.301 ± 0.016	2.205ThrAsp: 2.205 ± 0.041	2.467ThrGlu: 2.467 ± 0.045	1.255ThrPhe: 1.255 ± 0.03	4.757ThrGly: 4.757 ± 0.066	0.873ThrHis: 0.873 ± 0.028	1.897ThrIle: 1.897 ± 0.041	0.778ThrLys: 0.778 ± 0.026	6.222ThrLeu: 6.222 ± 0.079	0.909ThrMet: 0.909 ± 0.028	0.869ThrAsn: 0.869 ± 0.024	3.554ThrPro: 3.554 ± 0.057	1.313ThrGln: 1.313 ± 0.032	3.382ThrArg: 3.382 ± 0.048	1.93ThrSer: 1.93 ± 0.04	2.329ThrThr: 2.329 ± 0.051	3.526ThrVal: 3.526 ± 0.057	0.508ThrTrp: 0.508 ± 0.02	0.874ThrTyr: 0.874 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.002ValAla: 10.002 ± 0.103	0.497ValCys: 0.497 ± 0.019	3.067ValAsp: 3.067 ± 0.051	4.468ValGlu: 4.468 ± 0.059	2.279ValPhe: 2.279 ± 0.043	4.974ValGly: 4.974 ± 0.071	1.11ValHis: 1.11 ± 0.031	2.743ValIle: 2.743 ± 0.052	1.545ValLys: 1.545 ± 0.036	8.366ValLeu: 8.366 ± 0.096	1.722ValMet: 1.722 ± 0.039	1.595ValAsn: 1.595 ± 0.042	4.216ValPro: 4.216 ± 0.064	2.322ValGln: 2.322 ± 0.048	4.797ValArg: 4.797 ± 0.061	3.287ValSer: 3.287 ± 0.052	4.03ValThr: 4.03 ± 0.06	5.676ValVal: 5.676 ± 0.08	0.847ValTrp: 0.847 ± 0.028	1.047ValTyr: 1.047 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.655TrpAla: 1.655 ± 0.037	0.148TrpCys: 0.148 ± 0.01	0.61TrpAsp: 0.61 ± 0.022	0.621TrpGlu: 0.621 ± 0.024	0.49TrpPhe: 0.49 ± 0.019	1.076TrpGly: 1.076 ± 0.029	0.356TrpHis: 0.356 ± 0.019	0.526TrpIle: 0.526 ± 0.019	0.328TrpLys: 0.328 ± 0.017	1.971TrpLeu: 1.971 ± 0.04	0.365TrpMet: 0.365 ± 0.017	0.34TrpAsn: 0.34 ± 0.015	0.925TrpPro: 0.925 ± 0.028	0.716TrpGln: 0.716 ± 0.022	1.619TrpArg: 1.619 ± 0.036	0.727TrpSer: 0.727 ± 0.02	0.694TrpThr: 0.694 ± 0.024	0.821TrpVal: 0.821 ± 0.023	0.24TrpTrp: 0.24 ± 0.015	0.246TrpTyr: 0.246 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.043	0.185TyrCys: 0.185 ± 0.012	1.077TyrAsp: 1.077 ± 0.029	0.906TyrGlu: 0.906 ± 0.026	0.614TyrPhe: 0.614 ± 0.025	1.777TyrGly: 1.777 ± 0.039	0.371TyrHis: 0.371 ± 0.017	0.552TyrIle: 0.552 ± 0.02	0.311TyrLys: 0.311 ± 0.016	1.817TyrLeu: 1.817 ± 0.038	0.308TyrMet: 0.308 ± 0.016	0.414TyrAsn: 0.414 ± 0.019	0.92TyrPro: 0.92 ± 0.025	0.555TyrGln: 0.555 ± 0.022	1.655TyrArg: 1.655 ± 0.04	0.807TyrSer: 0.807 ± 0.027	0.869TyrThr: 0.869 ± 0.026	1.213TyrVal: 1.213 ± 0.033	0.283TyrTrp: 0.283 ± 0.015	0.414TyrTyr: 0.414 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4774 proteins (1327154 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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