Amino acid dipepetide frequency for Desulfovibrio mexicanus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.423AlaAla: 16.423 ± 0.249
1.847AlaCys: 1.847 ± 0.044
6.176AlaAsp: 6.176 ± 0.09
7.935AlaGlu: 7.935 ± 0.111
4.107AlaPhe: 4.107 ± 0.067
10.142AlaGly: 10.142 ± 0.144
2.376AlaHis: 2.376 ± 0.051
4.245AlaIle: 4.245 ± 0.075
4.87AlaLys: 4.87 ± 0.096
15.118AlaLeu: 15.118 ± 0.179
3.377AlaMet: 3.377 ± 0.055
2.425AlaAsn: 2.425 ± 0.051
6.052AlaPro: 6.052 ± 0.104
4.931AlaGln: 4.931 ± 0.074
9.248AlaArg: 9.248 ± 0.119
6.026AlaSer: 6.026 ± 0.097
4.974AlaThr: 4.974 ± 0.087
8.47AlaVal: 8.47 ± 0.097
1.655AlaTrp: 1.655 ± 0.044
2.515AlaTyr: 2.515 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
1.772CysAla: 1.772 ± 0.04
0.274CysCys: 0.274 ± 0.018
0.595CysAsp: 0.595 ± 0.028
0.673CysGlu: 0.673 ± 0.027
0.465CysPhe: 0.465 ± 0.02
1.642CysGly: 1.642 ± 0.047
0.395CysHis: 0.395 ± 0.031
0.528CysIle: 0.528 ± 0.025
0.383CysLys: 0.383 ± 0.022
1.527CysLeu: 1.527 ± 0.045
0.281CysMet: 0.281 ± 0.017
0.296CysAsn: 0.296 ± 0.02
1.002CysPro: 1.002 ± 0.036
0.431CysGln: 0.431 ± 0.019
1.02CysArg: 1.02 ± 0.03
0.764CysSer: 0.764 ± 0.027
0.615CysThr: 0.615 ± 0.024
1.038CysVal: 1.038 ± 0.032
0.181CysTrp: 0.181 ± 0.011
0.285CysTyr: 0.285 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.624AspAla: 6.624 ± 0.087
0.7AspCys: 0.7 ± 0.024
2.457AspAsp: 2.457 ± 0.055
3.444AspGlu: 3.444 ± 0.067
2.215AspPhe: 2.215 ± 0.047
4.317AspGly: 4.317 ± 0.083
0.995AspHis: 0.995 ± 0.037
2.998AspIle: 2.998 ± 0.064
2.084AspLys: 2.084 ± 0.051
5.642AspLeu: 5.642 ± 0.063
1.655AspMet: 1.655 ± 0.039
1.163AspAsn: 1.163 ± 0.036
3.099AspPro: 3.099 ± 0.059
1.535AspGln: 1.535 ± 0.037
3.262AspArg: 3.262 ± 0.065
2.349AspSer: 2.349 ± 0.051
2.332AspThr: 2.332 ± 0.061
3.467AspVal: 3.467 ± 0.059
0.745AspTrp: 0.745 ± 0.028
1.348AspTyr: 1.348 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
8.124GluAla: 8.124 ± 0.099
0.629GluCys: 0.629 ± 0.027
3.046GluAsp: 3.046 ± 0.053
3.79GluGlu: 3.79 ± 0.075
2.007GluPhe: 2.007 ± 0.044
4.35GluGly: 4.35 ± 0.066
1.494GluHis: 1.494 ± 0.04
2.861GluIle: 2.861 ± 0.061
2.62GluLys: 2.62 ± 0.059
7.033GluLeu: 7.033 ± 0.099
1.541GluMet: 1.541 ± 0.035
1.722GluAsn: 1.722 ± 0.043
2.737GluPro: 2.737 ± 0.057
2.338GluGln: 2.338 ± 0.056
5.325GluArg: 5.325 ± 0.084
2.794GluSer: 2.794 ± 0.053
3.015GluThr: 3.015 ± 0.058
4.12GluVal: 4.12 ± 0.07
0.519GluTrp: 0.519 ± 0.022
1.324GluTyr: 1.324 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.038PheAla: 4.038 ± 0.058
0.657PheCys: 0.657 ± 0.029
2.217PheAsp: 2.217 ± 0.045
2.114PheGlu: 2.114 ± 0.045
1.561PhePhe: 1.561 ± 0.044
3.278PheGly: 3.278 ± 0.067
0.774PheHis: 0.774 ± 0.024
1.426PheIle: 1.426 ± 0.044
1.22PheLys: 1.22 ± 0.036
4.144PheLeu: 4.144 ± 0.073
0.907PheMet: 0.907 ± 0.028
0.991PheAsn: 0.991 ± 0.034
1.698PhePro: 1.698 ± 0.036
1.123PheGln: 1.123 ± 0.036
2.236PheArg: 2.236 ± 0.051
2.367PheSer: 2.367 ± 0.056
1.883PheThr: 1.883 ± 0.042
2.601PheVal: 2.601 ± 0.049
0.542PheTrp: 0.542 ± 0.023
0.872PheTyr: 0.872 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.193GlyAla: 9.193 ± 0.117
1.41GlyCys: 1.41 ± 0.037
3.973GlyAsp: 3.973 ± 0.073
5.034GlyGlu: 5.034 ± 0.076
3.655GlyPhe: 3.655 ± 0.059
7.812GlyGly: 7.812 ± 0.152
1.86GlyHis: 1.86 ± 0.044
3.674GlyIle: 3.674 ± 0.068
3.721GlyLys: 3.721 ± 0.07
10.308GlyLeu: 10.308 ± 0.122
2.477GlyMet: 2.477 ± 0.059
1.884GlyAsn: 1.884 ± 0.055
3.737GlyPro: 3.737 ± 0.077
3.566GlyGln: 3.566 ± 0.071
6.459GlyArg: 6.459 ± 0.092
4.066GlySer: 4.066 ± 0.079
3.763GlyThr: 3.763 ± 0.067
6.771GlyVal: 6.771 ± 0.092
1.124GlyTrp: 1.124 ± 0.036
2.211GlyTyr: 2.211 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.277HisAla: 2.277 ± 0.049
0.341HisCys: 0.341 ± 0.019
1.0HisAsp: 1.0 ± 0.03
1.144HisGlu: 1.144 ± 0.033
0.876HisPhe: 0.876 ± 0.034
1.954HisGly: 1.954 ± 0.043
0.51HisHis: 0.51 ± 0.024
0.853HisIle: 0.853 ± 0.033
0.79HisLys: 0.79 ± 0.028
2.24HisLeu: 2.24 ± 0.05
0.572HisMet: 0.572 ± 0.022
0.535HisAsn: 0.535 ± 0.021
1.411HisPro: 1.411 ± 0.043
0.644HisGln: 0.644 ± 0.028
1.198HisArg: 1.198 ± 0.032
0.998HisSer: 0.998 ± 0.034
0.965HisThr: 0.965 ± 0.03
1.448HisVal: 1.448 ± 0.038
0.274HisTrp: 0.274 ± 0.018
0.545HisTyr: 0.545 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
4.573IleAla: 4.573 ± 0.076
0.578IleCys: 0.578 ± 0.023
2.186IleAsp: 2.186 ± 0.051
2.56IleGlu: 2.56 ± 0.059
1.412IlePhe: 1.412 ± 0.038
3.482IleGly: 3.482 ± 0.067
0.85IleHis: 0.85 ± 0.029
1.902IleIle: 1.902 ± 0.051
1.657IleLys: 1.657 ± 0.048
4.382IleLeu: 4.382 ± 0.073
1.053IleMet: 1.053 ± 0.04
1.138IleAsn: 1.138 ± 0.034
2.191IlePro: 2.191 ± 0.047
1.206IleGln: 1.206 ± 0.036
2.759IleArg: 2.759 ± 0.056
2.321IleSer: 2.321 ± 0.055
2.195IleThr: 2.195 ± 0.054
3.177IleVal: 3.177 ± 0.067
0.391IleTrp: 0.391 ± 0.02
0.867IleTyr: 0.867 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.972LysAla: 4.972 ± 0.086
0.388LysCys: 0.388 ± 0.021
2.219LysAsp: 2.219 ± 0.058
2.186LysGlu: 2.186 ± 0.055
0.882LysPhe: 0.882 ± 0.031
3.264LysGly: 3.264 ± 0.062
0.765LysHis: 0.765 ± 0.027
1.751LysIle: 1.751 ± 0.048
2.016LysLys: 2.016 ± 0.065
3.475LysLeu: 3.475 ± 0.065
0.949LysMet: 0.949 ± 0.033
1.368LysAsn: 1.368 ± 0.04
2.18LysPro: 2.18 ± 0.049
1.14LysGln: 1.14 ± 0.035
2.62LysArg: 2.62 ± 0.056
2.114LysSer: 2.114 ± 0.045
2.176LysThr: 2.176 ± 0.042
2.602LysVal: 2.602 ± 0.058
0.352LysTrp: 0.352 ± 0.018
0.828LysTyr: 0.828 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
16.275LeuAla: 16.275 ± 0.203
1.839LeuCys: 1.839 ± 0.048
6.747LeuAsp: 6.747 ± 0.094
6.709LeuGlu: 6.709 ± 0.1
4.067LeuPhe: 4.067 ± 0.067
9.771LeuGly: 9.771 ± 0.116
2.111LeuHis: 2.111 ± 0.047
3.518LeuIle: 3.518 ± 0.075
4.284LeuLys: 4.284 ± 0.072
12.241LeuLeu: 12.241 ± 0.178
2.312LeuMet: 2.312 ± 0.049
2.503LeuAsn: 2.503 ± 0.05
6.455LeuPro: 6.455 ± 0.105
2.338LeuGln: 2.338 ± 0.047
8.384LeuArg: 8.384 ± 0.122
6.989LeuSer: 6.989 ± 0.087
5.3LeuThr: 5.3 ± 0.071
7.87LeuVal: 7.87 ± 0.103
1.247LeuTrp: 1.247 ± 0.04
2.214LeuTyr: 2.214 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
3.322MetAla: 3.322 ± 0.058
0.27MetCys: 0.27 ± 0.016
1.556MetAsp: 1.556 ± 0.041
1.435MetGlu: 1.435 ± 0.036
0.684MetPhe: 0.684 ± 0.026
2.198MetGly: 2.198 ± 0.054
0.461MetHis: 0.461 ± 0.02
0.813MetIle: 0.813 ± 0.029
0.961MetLys: 0.961 ± 0.035
2.655MetLeu: 2.655 ± 0.057
0.386MetMet: 0.386 ± 0.02
0.829MetAsn: 0.829 ± 0.027
1.46MetPro: 1.46 ± 0.041
0.792MetGln: 0.792 ± 0.029
1.925MetArg: 1.925 ± 0.043
1.602MetSer: 1.602 ± 0.039
1.455MetThr: 1.455 ± 0.037
1.651MetVal: 1.651 ± 0.038
0.177MetTrp: 0.177 ± 0.013
0.393MetTyr: 0.393 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.989AsnAla: 2.989 ± 0.06
0.342AsnCys: 0.342 ± 0.02
1.064AsnAsp: 1.064 ± 0.039
1.079AsnGlu: 1.079 ± 0.035
0.888AsnPhe: 0.888 ± 0.032
1.843AsnGly: 1.843 ± 0.047
0.473AsnHis: 0.473 ± 0.021
1.368AsnIle: 1.368 ± 0.042
0.837AsnLys: 0.837 ± 0.029
2.722AsnLeu: 2.722 ± 0.055
0.698AsnMet: 0.698 ± 0.025
0.586AsnAsn: 0.586 ± 0.029
1.809AsnPro: 1.809 ± 0.035
0.696AsnGln: 0.696 ± 0.025
1.6AsnArg: 1.6 ± 0.042
1.195AsnSer: 1.195 ± 0.039
1.262AsnThr: 1.262 ± 0.041
1.872AsnVal: 1.872 ± 0.044
0.352AsnTrp: 0.352 ± 0.02
0.659AsnTyr: 0.659 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.318ProAla: 6.318 ± 0.105
0.697ProCys: 0.697 ± 0.026
3.449ProAsp: 3.449 ± 0.064
4.578ProGlu: 4.578 ± 0.066
1.89ProPhe: 1.89 ± 0.042
5.657ProGly: 5.657 ± 0.082
1.054ProHis: 1.054 ± 0.032
1.52ProIle: 1.52 ± 0.038
1.915ProLys: 1.915 ± 0.047
5.435ProLeu: 5.435 ± 0.08
1.206ProMet: 1.206 ± 0.033
1.084ProAsn: 1.084 ± 0.031
2.788ProPro: 2.788 ± 0.062
1.949ProGln: 1.949 ± 0.049
3.188ProArg: 3.188 ± 0.071
2.485ProSer: 2.485 ± 0.048
2.135ProThr: 2.135 ± 0.045
4.17ProVal: 4.17 ± 0.067
0.745ProTrp: 0.745 ± 0.025
1.082ProTyr: 1.082 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.059GlnAla: 5.059 ± 0.081
0.372GlnCys: 0.372 ± 0.019
1.847GlnAsp: 1.847 ± 0.043
2.118GlnGlu: 2.118 ± 0.041
0.907GlnPhe: 0.907 ± 0.026
3.166GlnGly: 3.166 ± 0.066
0.668GlnHis: 0.668 ± 0.028
1.237GlnIle: 1.237 ± 0.035
1.306GlnLys: 1.306 ± 0.037
2.917GlnLeu: 2.917 ± 0.061
0.818GlnMet: 0.818 ± 0.027
0.996GlnAsn: 0.996 ± 0.037
1.645GlnPro: 1.645 ± 0.047
1.107GlnGln: 1.107 ± 0.043
2.241GlnArg: 2.241 ± 0.05
1.746GlnSer: 1.746 ± 0.043
1.588GlnThr: 1.588 ± 0.038
2.374GlnVal: 2.374 ± 0.047
0.419GlnTrp: 0.419 ± 0.018
0.705GlnTyr: 0.705 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.866ArgAla: 7.866 ± 0.103
0.884ArgCys: 0.884 ± 0.033
3.465ArgAsp: 3.465 ± 0.057
5.184ArgGlu: 5.184 ± 0.078
2.924ArgPhe: 2.924 ± 0.061
4.885ArgGly: 4.885 ± 0.078
1.791ArgHis: 1.791 ± 0.041
3.489ArgIle: 3.489 ± 0.06
2.835ArgLys: 2.835 ± 0.056
9.023ArgLeu: 9.023 ± 0.113
1.99ArgMet: 1.99 ± 0.044
1.63ArgAsn: 1.63 ± 0.041
3.736ArgPro: 3.736 ± 0.079
3.029ArgGln: 3.029 ± 0.059
5.445ArgArg: 5.445 ± 0.094
3.239ArgSer: 3.239 ± 0.062
3.179ArgThr: 3.179 ± 0.054
5.056ArgVal: 5.056 ± 0.079
0.75ArgTrp: 0.75 ± 0.027
1.645ArgTyr: 1.645 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.911SerAla: 5.911 ± 0.078
0.727SerCys: 0.727 ± 0.031
2.247SerAsp: 2.247 ± 0.046
2.687SerGlu: 2.687 ± 0.052
2.196SerPhe: 2.196 ± 0.05
5.766SerGly: 5.766 ± 0.087
1.035SerHis: 1.035 ± 0.033
2.361SerIle: 2.361 ± 0.058
1.564SerLys: 1.564 ± 0.04
6.117SerLeu: 6.117 ± 0.086
1.348SerMet: 1.348 ± 0.033
1.044SerAsn: 1.044 ± 0.032
2.902SerPro: 2.902 ± 0.054
1.743SerGln: 1.743 ± 0.047
3.814SerArg: 3.814 ± 0.063
2.708SerSer: 2.708 ± 0.067
2.405SerThr: 2.405 ± 0.044
3.79SerVal: 3.79 ± 0.058
0.667SerTrp: 0.667 ± 0.027
1.168SerTyr: 1.168 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
5.445ThrAla: 5.445 ± 0.083
0.598ThrCys: 0.598 ± 0.027
2.295ThrAsp: 2.295 ± 0.046
2.354ThrGlu: 2.354 ± 0.046
1.575ThrPhe: 1.575 ± 0.043
4.893ThrGly: 4.893 ± 0.075
0.905ThrHis: 0.905 ± 0.027
2.043ThrIle: 2.043 ± 0.052
1.484ThrLys: 1.484 ± 0.041
5.421ThrLeu: 5.421 ± 0.072
1.059ThrMet: 1.059 ± 0.035
1.151ThrAsn: 1.151 ± 0.043
3.246ThrPro: 3.246 ± 0.061
1.356ThrGln: 1.356 ± 0.036
3.14ThrArg: 3.14 ± 0.051
2.416ThrSer: 2.416 ± 0.061
2.217ThrThr: 2.217 ± 0.06
3.56ThrVal: 3.56 ± 0.067
0.509ThrTrp: 0.509 ± 0.021
1.081ThrTyr: 1.081 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
7.927ValAla: 7.927 ± 0.107
1.106ValCys: 1.106 ± 0.034
4.022ValAsp: 4.022 ± 0.057
4.49ValGlu: 4.49 ± 0.06
2.975ValPhe: 2.975 ± 0.063
5.334ValGly: 5.334 ± 0.081
1.36ValHis: 1.36 ± 0.036
3.047ValIle: 3.047 ± 0.059
2.514ValLys: 2.514 ± 0.05
8.931ValLeu: 8.931 ± 0.122
1.615ValMet: 1.615 ± 0.04
2.037ValAsn: 2.037 ± 0.052
3.367ValPro: 3.367 ± 0.064
2.238ValGln: 2.238 ± 0.044
5.469ValArg: 5.469 ± 0.07
4.174ValSer: 4.174 ± 0.068
3.463ValThr: 3.463 ± 0.061
5.603ValVal: 5.603 ± 0.081
0.745ValTrp: 0.745 ± 0.024
1.511ValTyr: 1.511 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.246TrpAla: 1.246 ± 0.037
0.133TrpCys: 0.133 ± 0.011
0.615TrpAsp: 0.615 ± 0.023
0.722TrpGlu: 0.722 ± 0.027
0.443TrpPhe: 0.443 ± 0.02
0.896TrpGly: 0.896 ± 0.029
0.265TrpHis: 0.265 ± 0.015
0.46TrpIle: 0.46 ± 0.02
0.427TrpLys: 0.427 ± 0.022
1.466TrpLeu: 1.466 ± 0.042
0.295TrpMet: 0.295 ± 0.015
0.337TrpAsn: 0.337 ± 0.019
0.69TrpPro: 0.69 ± 0.028
0.347TrpGln: 0.347 ± 0.018
1.174TrpArg: 1.174 ± 0.037
0.621TrpSer: 0.621 ± 0.027
0.723TrpThr: 0.723 ± 0.028
0.66TrpVal: 0.66 ± 0.028
0.216TrpTrp: 0.216 ± 0.015
0.206TrpTyr: 0.206 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.56TyrAla: 2.56 ± 0.052
0.372TyrCys: 0.372 ± 0.018
1.255TyrAsp: 1.255 ± 0.041
1.155TyrGlu: 1.155 ± 0.033
0.918TyrPhe: 0.918 ± 0.034
2.048TyrGly: 2.048 ± 0.048
0.434TyrHis: 0.434 ± 0.02
0.789TyrIle: 0.789 ± 0.029
0.759TyrLys: 0.759 ± 0.028
2.378TyrLeu: 2.378 ± 0.049
0.485TyrMet: 0.485 ± 0.022
0.614TyrAsn: 0.614 ± 0.027
1.14TyrPro: 1.14 ± 0.036
0.729TyrGln: 0.729 ± 0.027
1.539TyrArg: 1.539 ± 0.039
1.223TyrSer: 1.223 ± 0.035
1.104TyrThr: 1.104 ± 0.033
1.627TyrVal: 1.627 ± 0.038
0.332TyrTrp: 0.332 ± 0.017
0.615TyrTyr: 0.615 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3215 proteins (1069092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski