Amino acid dipepetide frequency for Alteromonadaceae bacterium M269

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.474AlaAla: 6.474 ± 0.09	0.9AlaCys: 0.9 ± 0.026	4.576AlaAsp: 4.576 ± 0.058	5.151AlaGlu: 5.151 ± 0.071	3.566AlaPhe: 3.566 ± 0.053	5.363AlaGly: 5.363 ± 0.072	1.492AlaHis: 1.492 ± 0.027	5.589AlaIle: 5.589 ± 0.066	4.491AlaLys: 4.491 ± 0.063	8.821AlaLeu: 8.821 ± 0.085	2.097AlaMet: 2.097 ± 0.05	3.725AlaAsn: 3.725 ± 0.051	2.681AlaPro: 2.681 ± 0.041	3.419AlaGln: 3.419 ± 0.052	3.293AlaArg: 3.293 ± 0.044	5.355AlaSer: 5.355 ± 0.051	4.272AlaThr: 4.272 ± 0.061	5.274AlaVal: 5.274 ± 0.065	0.904AlaTrp: 0.904 ± 0.023	2.446AlaTyr: 2.446 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.689CysAla: 0.689 ± 0.025	0.157CysCys: 0.157 ± 0.01	0.569CysAsp: 0.569 ± 0.021	0.567CysGlu: 0.567 ± 0.02	0.439CysPhe: 0.439 ± 0.015	0.728CysGly: 0.728 ± 0.022	0.314CysHis: 0.314 ± 0.016	0.588CysIle: 0.588 ± 0.019	0.41CysLys: 0.41 ± 0.019	0.93CysLeu: 0.93 ± 0.024	0.193CysMet: 0.193 ± 0.011	0.353CysAsn: 0.353 ± 0.017	0.395CysPro: 0.395 ± 0.016	0.438CysGln: 0.438 ± 0.02	0.457CysArg: 0.457 ± 0.019	0.705CysSer: 0.705 ± 0.021	0.414CysThr: 0.414 ± 0.015	0.587CysVal: 0.587 ± 0.019	0.13CysTrp: 0.13 ± 0.01	0.306CysTyr: 0.306 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.36AspAla: 4.36 ± 0.054	0.478AspCys: 0.478 ± 0.02	3.492AspAsp: 3.492 ± 0.065	4.346AspGlu: 4.346 ± 0.088	2.827AspPhe: 2.827 ± 0.046	4.154AspGly: 4.154 ± 0.083	0.925AspHis: 0.925 ± 0.021	4.623AspIle: 4.623 ± 0.06	3.506AspLys: 3.506 ± 0.044	5.431AspLeu: 5.431 ± 0.062	1.411AspMet: 1.411 ± 0.032	2.912AspAsn: 2.912 ± 0.046	2.097AspPro: 2.097 ± 0.042	1.899AspGln: 1.899 ± 0.035	2.355AspArg: 2.355 ± 0.039	3.697AspSer: 3.697 ± 0.054	2.878AspThr: 2.878 ± 0.04	4.081AspVal: 4.081 ± 0.05	0.893AspTrp: 0.893 ± 0.022	2.101AspTyr: 2.101 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.103GluAla: 5.103 ± 0.073	0.492GluCys: 0.492 ± 0.017	3.299GluAsp: 3.299 ± 0.061	4.305GluGlu: 4.305 ± 0.079	2.661GluPhe: 2.661 ± 0.045	3.766GluGly: 3.766 ± 0.053	1.61GluHis: 1.61 ± 0.034	3.795GluIle: 3.795 ± 0.053	4.07GluLys: 4.07 ± 0.062	7.314GluLeu: 7.314 ± 0.112	1.477GluMet: 1.477 ± 0.035	3.168GluAsn: 3.168 ± 0.046	2.207GluPro: 2.207 ± 0.039	4.156GluGln: 4.156 ± 0.063	3.371GluArg: 3.371 ± 0.049	4.494GluSer: 4.494 ± 0.056	3.354GluThr: 3.354 ± 0.044	4.345GluVal: 4.345 ± 0.058	0.752GluTrp: 0.752 ± 0.021	1.884GluTyr: 1.884 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.388PheAla: 3.388 ± 0.053	0.473PheCys: 0.473 ± 0.017	3.29PheAsp: 3.29 ± 0.047	2.973PheGlu: 2.973 ± 0.041	1.994PhePhe: 1.994 ± 0.043	3.303PheGly: 3.303 ± 0.048	0.8PheHis: 0.8 ± 0.026	2.908PheIle: 2.908 ± 0.052	2.091PheLys: 2.091 ± 0.04	3.644PheLeu: 3.644 ± 0.049	0.946PheMet: 0.946 ± 0.024	2.345PheAsn: 2.345 ± 0.045	1.527PhePro: 1.527 ± 0.032	1.304PheGln: 1.304 ± 0.03	1.753PheArg: 1.753 ± 0.035	3.711PheSer: 3.711 ± 0.055	2.42PheThr: 2.42 ± 0.041	3.145PheVal: 3.145 ± 0.046	0.56PheTrp: 0.56 ± 0.02	1.476PheTyr: 1.476 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	4.976GlyAla: 4.976 ± 0.064	0.769GlyCys: 0.769 ± 0.023	3.893GlyAsp: 3.893 ± 0.06	4.233GlyGlu: 4.233 ± 0.058	3.404GlyPhe: 3.404 ± 0.055	4.732GlyGly: 4.732 ± 0.073	1.449GlyHis: 1.449 ± 0.03	4.499GlyIle: 4.499 ± 0.057	3.708GlyLys: 3.708 ± 0.052	6.667GlyLeu: 6.667 ± 0.078	1.661GlyMet: 1.661 ± 0.035	2.923GlyAsn: 2.923 ± 0.047	1.695GlyPro: 1.695 ± 0.038	2.867GlyGln: 2.867 ± 0.046	2.999GlyArg: 2.999 ± 0.047	4.199GlySer: 4.199 ± 0.052	3.529GlyThr: 3.529 ± 0.058	4.84GlyVal: 4.84 ± 0.053	0.907GlyTrp: 0.907 ± 0.026	2.448GlyTyr: 2.448 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.509HisAla: 1.509 ± 0.032	0.299HisCys: 0.299 ± 0.014	1.045HisAsp: 1.045 ± 0.031	1.185HisGlu: 1.185 ± 0.031	1.118HisPhe: 1.118 ± 0.028	1.343HisGly: 1.343 ± 0.028	0.621HisHis: 0.621 ± 0.022	1.45HisIle: 1.45 ± 0.035	1.065HisLys: 1.065 ± 0.028	2.15HisLeu: 2.15 ± 0.038	0.498HisMet: 0.498 ± 0.014	0.845HisAsn: 0.845 ± 0.022	0.997HisPro: 0.997 ± 0.024	1.1HisGln: 1.1 ± 0.029	1.004HisArg: 1.004 ± 0.026	1.368HisSer: 1.368 ± 0.036	0.977HisThr: 0.977 ± 0.024	1.225HisVal: 1.225 ± 0.024	0.392HisTrp: 0.392 ± 0.017	0.886HisTyr: 0.886 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.759IleAla: 5.759 ± 0.05	0.621IleCys: 0.621 ± 0.019	4.479IleAsp: 4.479 ± 0.058	5.036IleGlu: 5.036 ± 0.057	2.361IlePhe: 2.361 ± 0.047	4.584IleGly: 4.584 ± 0.053	1.272IleHis: 1.272 ± 0.035	3.441IleIle: 3.441 ± 0.051	3.502IleLys: 3.502 ± 0.049	5.164IleLeu: 5.164 ± 0.063	1.206IleMet: 1.206 ± 0.03	3.425IleAsn: 3.425 ± 0.052	2.668IlePro: 2.668 ± 0.045	2.58IleGln: 2.58 ± 0.04	2.901IleArg: 2.901 ± 0.042	4.848IleSer: 4.848 ± 0.057	3.622IleThr: 3.622 ± 0.046	4.211IleVal: 4.211 ± 0.052	0.684IleTrp: 0.684 ± 0.021	1.769IleTyr: 1.769 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.717LysAla: 4.717 ± 0.062	0.317LysCys: 0.317 ± 0.016	2.821LysAsp: 2.821 ± 0.045	3.582LysGlu: 3.582 ± 0.053	1.655LysPhe: 1.655 ± 0.035	3.296LysGly: 3.296 ± 0.049	1.371LysHis: 1.371 ± 0.033	2.951LysIle: 2.951 ± 0.05	3.172LysLys: 3.172 ± 0.058	5.6LysLeu: 5.6 ± 0.067	1.203LysMet: 1.203 ± 0.03	2.311LysAsn: 2.311 ± 0.04	2.419LysPro: 2.419 ± 0.038	2.995LysGln: 2.995 ± 0.048	2.866LysArg: 2.866 ± 0.046	3.557LysSer: 3.557 ± 0.051	3.041LysThr: 3.041 ± 0.052	3.845LysVal: 3.845 ± 0.047	0.588LysTrp: 0.588 ± 0.019	1.449LysTyr: 1.449 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	8.773LeuAla: 8.773 ± 0.089	1.009LeuCys: 1.009 ± 0.027	5.889LeuAsp: 5.889 ± 0.075	6.236LeuGlu: 6.236 ± 0.07	4.438LeuPhe: 4.438 ± 0.056	6.563LeuGly: 6.563 ± 0.069	1.873LeuHis: 1.873 ± 0.037	6.295LeuIle: 6.295 ± 0.067	5.505LeuLys: 5.505 ± 0.069	10.19LeuLeu: 10.19 ± 0.112	2.342LeuMet: 2.342 ± 0.041	5.055LeuAsn: 5.055 ± 0.066	4.455LeuPro: 4.455 ± 0.057	3.571LeuGln: 3.571 ± 0.047	4.267LeuArg: 4.267 ± 0.05	8.682LeuSer: 8.682 ± 0.093	5.85LeuThr: 5.85 ± 0.066	6.736LeuVal: 6.736 ± 0.077	1.063LeuTrp: 1.063 ± 0.028	2.814LeuTyr: 2.814 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.015MetAla: 2.015 ± 0.04	0.184MetCys: 0.184 ± 0.011	1.112MetAsp: 1.112 ± 0.028	1.136MetGlu: 1.136 ± 0.026	0.824MetPhe: 0.824 ± 0.022	1.481MetGly: 1.481 ± 0.026	0.497MetHis: 0.497 ± 0.017	1.269MetIle: 1.269 ± 0.032	1.404MetLys: 1.404 ± 0.033	2.443MetLeu: 2.443 ± 0.041	0.639MetMet: 0.639 ± 0.024	1.042MetAsn: 1.042 ± 0.025	1.134MetPro: 1.134 ± 0.027	1.173MetGln: 1.173 ± 0.031	1.152MetArg: 1.152 ± 0.023	1.92MetSer: 1.92 ± 0.035	1.437MetThr: 1.437 ± 0.032	1.358MetVal: 1.358 ± 0.034	0.195MetTrp: 0.195 ± 0.012	0.462MetTyr: 0.462 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.678AsnAla: 3.678 ± 0.057	0.405AsnCys: 0.405 ± 0.018	2.771AsnAsp: 2.771 ± 0.054	2.971AsnGlu: 2.971 ± 0.043	1.884AsnPhe: 1.884 ± 0.037	3.295AsnGly: 3.295 ± 0.063	0.994AsnHis: 0.994 ± 0.025	3.165AsnIle: 3.165 ± 0.051	2.53AsnLys: 2.53 ± 0.047	4.346AsnLeu: 4.346 ± 0.052	1.057AsnMet: 1.057 ± 0.024	2.473AsnAsn: 2.473 ± 0.052	2.128AsnPro: 2.128 ± 0.041	2.375AsnGln: 2.375 ± 0.038	2.292AsnArg: 2.292 ± 0.042	2.978AsnSer: 2.978 ± 0.051	2.576AsnThr: 2.576 ± 0.048	3.006AsnVal: 3.006 ± 0.043	0.651AsnTrp: 0.651 ± 0.023	1.486AsnTyr: 1.486 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.79ProAla: 2.79 ± 0.052	0.272ProCys: 0.272 ± 0.013	2.555ProAsp: 2.555 ± 0.043	3.195ProGlu: 3.195 ± 0.045	1.782ProPhe: 1.782 ± 0.032	2.392ProGly: 2.392 ± 0.041	0.728ProHis: 0.728 ± 0.024	2.593ProIle: 2.593 ± 0.041	2.008ProLys: 2.008 ± 0.04	3.771ProLeu: 3.771 ± 0.051	0.888ProMet: 0.888 ± 0.023	2.031ProAsn: 2.031 ± 0.039	1.24ProPro: 1.24 ± 0.031	1.589ProGln: 1.589 ± 0.034	1.36ProArg: 1.36 ± 0.033	2.725ProSer: 2.725 ± 0.042	2.118ProThr: 2.118 ± 0.036	2.787ProVal: 2.787 ± 0.041	0.489ProTrp: 0.489 ± 0.018	1.231ProTyr: 1.231 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.983GlnAla: 3.983 ± 0.056	0.371GlnCys: 0.371 ± 0.018	2.102GlnAsp: 2.102 ± 0.036	2.718GlnGlu: 2.718 ± 0.042	1.871GlnPhe: 1.871 ± 0.031	2.816GlnGly: 2.816 ± 0.044	1.088GlnHis: 1.088 ± 0.026	2.639GlnIle: 2.639 ± 0.043	2.322GlnLys: 2.322 ± 0.038	5.035GlnLeu: 5.035 ± 0.069	0.997GlnMet: 0.997 ± 0.027	1.819GlnAsn: 1.819 ± 0.035	1.665GlnPro: 1.665 ± 0.036	2.903GlnGln: 2.903 ± 0.058	2.316GlnArg: 2.316 ± 0.036	3.142GlnSer: 3.142 ± 0.05	2.353GlnThr: 2.353 ± 0.04	3.028GlnVal: 3.028 ± 0.044	0.66GlnTrp: 0.66 ± 0.017	1.395GlnTyr: 1.395 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.34ArgAla: 3.34 ± 0.051	0.368ArgCys: 0.368 ± 0.015	2.501ArgAsp: 2.501 ± 0.039	2.996ArgGlu: 2.996 ± 0.046	2.304ArgPhe: 2.304 ± 0.045	2.603ArgGly: 2.603 ± 0.047	1.022ArgHis: 1.022 ± 0.024	3.161ArgIle: 3.161 ± 0.038	2.392ArgLys: 2.392 ± 0.04	4.949ArgLeu: 4.949 ± 0.055	1.089ArgMet: 1.089 ± 0.028	2.09ArgAsn: 2.09 ± 0.041	1.533ArgPro: 1.533 ± 0.032	2.193ArgGln: 2.193 ± 0.041	2.303ArgArg: 2.303 ± 0.044	2.768ArgSer: 2.768 ± 0.044	2.232ArgThr: 2.232 ± 0.041	3.246ArgVal: 3.246 ± 0.044	0.647ArgTrp: 0.647 ± 0.021	1.731ArgTyr: 1.731 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.416SerAla: 5.416 ± 0.059	0.689SerCys: 0.689 ± 0.022	4.273SerAsp: 4.273 ± 0.061	4.59SerGlu: 4.59 ± 0.053	3.352SerPhe: 3.352 ± 0.045	4.957SerGly: 4.957 ± 0.06	1.567SerHis: 1.567 ± 0.031	4.78SerIle: 4.78 ± 0.051	3.411SerLys: 3.411 ± 0.044	7.528SerLeu: 7.528 ± 0.075	1.624SerMet: 1.624 ± 0.034	3.222SerAsn: 3.222 ± 0.053	2.681SerPro: 2.681 ± 0.041	3.165SerGln: 3.165 ± 0.042	3.197SerArg: 3.197 ± 0.047	5.071SerSer: 5.071 ± 0.063	3.615SerThr: 3.615 ± 0.051	4.956SerVal: 4.956 ± 0.06	0.898SerTrp: 0.898 ± 0.028	2.202SerTyr: 2.202 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.117ThrAla: 4.117 ± 0.056	0.419ThrCys: 0.419 ± 0.017	3.111ThrAsp: 3.111 ± 0.056	3.318ThrGlu: 3.318 ± 0.047	2.328ThrPhe: 2.328 ± 0.041	3.789ThrGly: 3.789 ± 0.056	1.225ThrHis: 1.225 ± 0.028	3.307ThrIle: 3.307 ± 0.045	2.541ThrLys: 2.541 ± 0.042	6.171ThrLeu: 6.171 ± 0.057	1.016ThrMet: 1.016 ± 0.027	2.328ThrAsn: 2.328 ± 0.047	2.703ThrPro: 2.703 ± 0.044	2.61ThrGln: 2.61 ± 0.038	2.248ThrArg: 2.248 ± 0.041	3.689ThrSer: 3.689 ± 0.048	3.034ThrThr: 3.034 ± 0.062	3.597ThrVal: 3.597 ± 0.052	0.582ThrTrp: 0.582 ± 0.021	1.707ThrTyr: 1.707 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	5.623ValAla: 5.623 ± 0.065	0.656ValCys: 0.656 ± 0.023	4.25ValAsp: 4.25 ± 0.05	4.627ValGlu: 4.627 ± 0.056	3.05ValPhe: 3.05 ± 0.049	4.511ValGly: 4.511 ± 0.057	1.189ValHis: 1.189 ± 0.026	4.673ValIle: 4.673 ± 0.059	3.527ValLys: 3.527 ± 0.05	6.507ValLeu: 6.507 ± 0.072	1.598ValMet: 1.598 ± 0.034	3.325ValAsn: 3.325 ± 0.044	2.53ValPro: 2.53 ± 0.038	2.175ValGln: 2.175 ± 0.038	2.891ValArg: 2.891 ± 0.041	5.286ValSer: 5.286 ± 0.063	4.012ValThr: 4.012 ± 0.057	4.996ValVal: 4.996 ± 0.061	0.733ValTrp: 0.733 ± 0.024	1.793ValTyr: 1.793 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.788TrpAla: 0.788 ± 0.023	0.131TrpCys: 0.131 ± 0.009	0.646TrpAsp: 0.646 ± 0.02	0.614TrpGlu: 0.614 ± 0.02	0.614TrpPhe: 0.614 ± 0.021	0.74TrpGly: 0.74 ± 0.022	0.354TrpHis: 0.354 ± 0.016	0.716TrpIle: 0.716 ± 0.022	0.59TrpLys: 0.59 ± 0.022	1.617TrpLeu: 1.617 ± 0.036	0.308TrpMet: 0.308 ± 0.016	0.467TrpAsn: 0.467 ± 0.017	0.493TrpPro: 0.493 ± 0.017	0.907TrpGln: 0.907 ± 0.024	0.685TrpArg: 0.685 ± 0.024	0.837TrpSer: 0.837 ± 0.022	0.552TrpThr: 0.552 ± 0.02	0.81TrpVal: 0.81 ± 0.023	0.189TrpTrp: 0.189 ± 0.011	0.366TrpTyr: 0.366 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.391TyrAla: 2.391 ± 0.04	0.361TyrCys: 0.361 ± 0.014	1.794TyrAsp: 1.794 ± 0.037	1.844TyrGlu: 1.844 ± 0.036	1.58TyrPhe: 1.58 ± 0.039	1.979TyrGly: 1.979 ± 0.037	0.686TyrHis: 0.686 ± 0.019	1.694TyrIle: 1.694 ± 0.031	1.514TyrLys: 1.514 ± 0.04	3.328TyrLeu: 3.328 ± 0.044	0.627TyrMet: 0.627 ± 0.02	1.199TyrAsn: 1.199 ± 0.031	1.298TyrPro: 1.298 ± 0.026	1.803TyrGln: 1.803 ± 0.036	1.76TyrArg: 1.76 ± 0.037	2.161TyrSer: 2.161 ± 0.038	1.553TyrThr: 1.553 ± 0.032	1.879TyrVal: 1.879 ± 0.029	0.507TyrTrp: 0.507 ± 0.017	1.081TyrTyr: 1.081 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4871 proteins (1643643 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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