Amino acid dipepetide frequency for Opitutaceae bacterium TAV4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.272AlaAla: 15.272 ± 0.141
1.2AlaCys: 1.2 ± 0.033
5.995AlaAsp: 5.995 ± 0.068
5.412AlaGlu: 5.412 ± 0.08
3.912AlaPhe: 3.912 ± 0.052
9.389AlaGly: 9.389 ± 0.103
2.342AlaHis: 2.342 ± 0.047
5.53AlaIle: 5.53 ± 0.077
3.534AlaLys: 3.534 ± 0.066
11.33AlaLeu: 11.33 ± 0.111
2.077AlaMet: 2.077 ± 0.038
3.35AlaAsn: 3.35 ± 0.064
5.864AlaPro: 5.864 ± 0.082
3.664AlaGln: 3.664 ± 0.058
8.448AlaArg: 8.448 ± 0.092
6.91AlaSer: 6.91 ± 0.079
7.558AlaThr: 7.558 ± 0.11
6.651AlaVal: 6.651 ± 0.072
1.938AlaTrp: 1.938 ± 0.047
2.405AlaTyr: 2.405 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.096CysAla: 1.096 ± 0.034
0.137CysCys: 0.137 ± 0.01
0.569CysAsp: 0.569 ± 0.021
0.555CysGlu: 0.555 ± 0.02
0.409CysPhe: 0.409 ± 0.017
0.877CysGly: 0.877 ± 0.028
0.339CysHis: 0.339 ± 0.017
0.51CysIle: 0.51 ± 0.018
0.26CysLys: 0.26 ± 0.016
0.925CysLeu: 0.925 ± 0.027
0.174CysMet: 0.174 ± 0.01
0.269CysAsn: 0.269 ± 0.014
0.631CysPro: 0.631 ± 0.021
0.286CysGln: 0.286 ± 0.014
0.744CysArg: 0.744 ± 0.026
0.561CysSer: 0.561 ± 0.019
0.462CysThr: 0.462 ± 0.016
0.716CysVal: 0.716 ± 0.027
0.175CysTrp: 0.175 ± 0.01
0.236CysTyr: 0.236 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.322AspAla: 6.322 ± 0.068
0.483AspCys: 0.483 ± 0.02
2.794AspAsp: 2.794 ± 0.051
2.899AspGlu: 2.899 ± 0.05
2.21AspPhe: 2.21 ± 0.044
4.784AspGly: 4.784 ± 0.075
1.121AspHis: 1.121 ± 0.031
2.812AspIle: 2.812 ± 0.052
1.675AspLys: 1.675 ± 0.038
4.72AspLeu: 4.72 ± 0.062
0.813AspMet: 0.813 ± 0.021
1.749AspAsn: 1.749 ± 0.04
3.003AspPro: 3.003 ± 0.055
1.472AspGln: 1.472 ± 0.035
3.055AspArg: 3.055 ± 0.05
2.644AspSer: 2.644 ± 0.042
3.414AspThr: 3.414 ± 0.056
3.279AspVal: 3.279 ± 0.049
1.068AspTrp: 1.068 ± 0.03
1.837AspTyr: 1.837 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
5.371GluAla: 5.371 ± 0.075
0.471GluCys: 0.471 ± 0.018
2.074GluAsp: 2.074 ± 0.041
2.398GluGlu: 2.398 ± 0.056
1.996GluPhe: 1.996 ± 0.036
3.439GluGly: 3.439 ± 0.064
1.254GluHis: 1.254 ± 0.03
3.21GluIle: 3.21 ± 0.051
2.524GluLys: 2.524 ± 0.05
5.108GluLeu: 5.108 ± 0.079
1.081GluMet: 1.081 ± 0.03
1.979GluAsn: 1.979 ± 0.037
2.49GluPro: 2.49 ± 0.044
1.911GluGln: 1.911 ± 0.035
3.932GluArg: 3.932 ± 0.064
2.64GluSer: 2.64 ± 0.038
3.355GluThr: 3.355 ± 0.054
3.051GluVal: 3.051 ± 0.057
0.869GluTrp: 0.869 ± 0.026
1.088GluTyr: 1.088 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.203PheAla: 4.203 ± 0.057
0.471PheCys: 0.471 ± 0.017
2.439PheAsp: 2.439 ± 0.039
1.895PheGlu: 1.895 ± 0.035
1.681PhePhe: 1.681 ± 0.041
3.11PheGly: 3.11 ± 0.053
0.877PheHis: 0.877 ± 0.026
1.734PheIle: 1.734 ± 0.039
1.103PheLys: 1.103 ± 0.028
3.403PheLeu: 3.403 ± 0.049
0.657PheMet: 0.657 ± 0.02
1.323PheAsn: 1.323 ± 0.034
1.93PhePro: 1.93 ± 0.034
1.117PheGln: 1.117 ± 0.028
2.395PheArg: 2.395 ± 0.054
2.653PheSer: 2.653 ± 0.047
2.694PheThr: 2.694 ± 0.043
2.626PheVal: 2.626 ± 0.05
0.618PheTrp: 0.618 ± 0.021
1.131PheTyr: 1.131 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
7.674GlyAla: 7.674 ± 0.097
0.941GlyCys: 0.941 ± 0.025
4.079GlyAsp: 4.079 ± 0.068
3.977GlyGlu: 3.977 ± 0.058
3.249GlyPhe: 3.249 ± 0.053
7.819GlyGly: 7.819 ± 0.129
1.874GlyHis: 1.874 ± 0.036
4.498GlyIle: 4.498 ± 0.062
3.356GlyLys: 3.356 ± 0.059
7.456GlyLeu: 7.456 ± 0.089
1.688GlyMet: 1.688 ± 0.04
2.96GlyAsn: 2.96 ± 0.067
2.852GlyPro: 2.852 ± 0.053
2.495GlyGln: 2.495 ± 0.043
5.502GlyArg: 5.502 ± 0.078
4.675GlySer: 4.675 ± 0.083
5.21GlyThr: 5.21 ± 0.133
5.596GlyVal: 5.596 ± 0.079
1.488GlyTrp: 1.488 ± 0.036
2.552GlyTyr: 2.552 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.709HisAla: 2.709 ± 0.048
0.287HisCys: 0.287 ± 0.015
1.301HisAsp: 1.301 ± 0.029
1.145HisGlu: 1.145 ± 0.035
1.095HisPhe: 1.095 ± 0.031
1.943HisGly: 1.943 ± 0.037
0.792HisHis: 0.792 ± 0.026
1.08HisIle: 1.08 ± 0.025
0.589HisLys: 0.589 ± 0.021
2.52HisLeu: 2.52 ± 0.047
0.387HisMet: 0.387 ± 0.017
0.73HisAsn: 0.73 ± 0.025
1.856HisPro: 1.856 ± 0.042
0.681HisGln: 0.681 ± 0.023
1.789HisArg: 1.789 ± 0.035
1.236HisSer: 1.236 ± 0.029
1.365HisThr: 1.365 ± 0.036
1.475HisVal: 1.475 ± 0.03
0.454HisTrp: 0.454 ± 0.02
0.75HisTyr: 0.75 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.96IleAla: 5.96 ± 0.067
0.53IleCys: 0.53 ± 0.017
3.192IleAsp: 3.192 ± 0.049
3.172IleGlu: 3.172 ± 0.052
1.707IlePhe: 1.707 ± 0.031
4.281IleGly: 4.281 ± 0.064
1.25IleHis: 1.25 ± 0.03
2.66IleIle: 2.66 ± 0.046
1.844IleLys: 1.844 ± 0.038
4.542IleLeu: 4.542 ± 0.065
0.771IleMet: 0.771 ± 0.023
1.929IleAsn: 1.929 ± 0.051
2.996IlePro: 2.996 ± 0.051
1.452IleGln: 1.452 ± 0.03
3.469IleArg: 3.469 ± 0.045
3.048IleSer: 3.048 ± 0.053
3.709IleThr: 3.709 ± 0.06
3.505IleVal: 3.505 ± 0.057
0.63IleTrp: 0.63 ± 0.021
1.339IleTyr: 1.339 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.329LysAla: 3.329 ± 0.064
0.208LysCys: 0.208 ± 0.014
1.671LysAsp: 1.671 ± 0.041
1.577LysGlu: 1.577 ± 0.041
1.18LysPhe: 1.18 ± 0.031
2.279LysGly: 2.279 ± 0.045
0.841LysHis: 0.841 ± 0.022
2.195LysIle: 2.195 ± 0.045
1.944LysLys: 1.944 ± 0.049
3.376LysLeu: 3.376 ± 0.054
0.778LysMet: 0.778 ± 0.027
1.628LysAsn: 1.628 ± 0.036
2.338LysPro: 2.338 ± 0.052
1.248LysGln: 1.248 ± 0.032
2.292LysArg: 2.292 ± 0.04
1.945LysSer: 1.945 ± 0.04
2.941LysThr: 2.941 ± 0.054
2.009LysVal: 2.009 ± 0.042
0.488LysTrp: 0.488 ± 0.017
0.787LysTyr: 0.787 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
12.658LeuAla: 12.658 ± 0.106
1.073LeuCys: 1.073 ± 0.029
5.246LeuAsp: 5.246 ± 0.064
4.542LeuGlu: 4.542 ± 0.066
3.612LeuPhe: 3.612 ± 0.063
7.188LeuGly: 7.188 ± 0.097
2.464LeuHis: 2.464 ± 0.047
4.608LeuIle: 4.608 ± 0.057
3.282LeuLys: 3.282 ± 0.055
9.981LeuLeu: 9.981 ± 0.102
1.68LeuMet: 1.68 ± 0.04
3.008LeuAsn: 3.008 ± 0.053
6.322LeuPro: 6.322 ± 0.085
2.974LeuGln: 2.974 ± 0.053
7.846LeuArg: 7.846 ± 0.083
5.812LeuSer: 5.812 ± 0.069
6.641LeuThr: 6.641 ± 0.095
6.598LeuVal: 6.598 ± 0.074
1.368LeuTrp: 1.368 ± 0.036
2.131LeuTyr: 2.131 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
1.9MetAla: 1.9 ± 0.042
0.15MetCys: 0.15 ± 0.011
0.865MetAsp: 0.865 ± 0.026
0.93MetGlu: 0.93 ± 0.028
0.581MetPhe: 0.581 ± 0.021
1.18MetGly: 1.18 ± 0.03
0.432MetHis: 0.432 ± 0.016
0.955MetIle: 0.955 ± 0.024
1.088MetLys: 1.088 ± 0.028
1.8MetLeu: 1.8 ± 0.04
0.399MetMet: 0.399 ± 0.019
0.8MetAsn: 0.8 ± 0.022
1.289MetPro: 1.289 ± 0.032
0.655MetGln: 0.655 ± 0.023
1.347MetArg: 1.347 ± 0.033
1.354MetSer: 1.354 ± 0.03
1.305MetThr: 1.305 ± 0.026
1.007MetVal: 1.007 ± 0.031
0.211MetTrp: 0.211 ± 0.013
0.247MetTyr: 0.247 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.571AsnAla: 3.571 ± 0.066
0.248AsnCys: 0.248 ± 0.017
1.678AsnAsp: 1.678 ± 0.037
1.563AsnGlu: 1.563 ± 0.032
1.235AsnPhe: 1.235 ± 0.03
2.939AsnGly: 2.939 ± 0.067
0.847AsnHis: 0.847 ± 0.023
1.843AsnIle: 1.843 ± 0.045
1.078AsnLys: 1.078 ± 0.032
3.303AsnLeu: 3.303 ± 0.056
0.553AsnMet: 0.553 ± 0.02
1.37AsnAsn: 1.37 ± 0.049
2.437AsnPro: 2.437 ± 0.042
1.066AsnGln: 1.066 ± 0.027
2.122AsnArg: 2.122 ± 0.045
1.815AsnSer: 1.815 ± 0.046
2.365AsnThr: 2.365 ± 0.064
2.054AsnVal: 2.054 ± 0.044
0.66AsnTrp: 0.66 ± 0.023
1.127AsnTyr: 1.127 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
7.739ProAla: 7.739 ± 0.094
0.477ProCys: 0.477 ± 0.019
3.925ProAsp: 3.925 ± 0.063
3.453ProGlu: 3.453 ± 0.053
1.952ProPhe: 1.952 ± 0.038
4.82ProGly: 4.82 ± 0.067
1.429ProHis: 1.429 ± 0.035
2.142ProIle: 2.142 ± 0.04
1.737ProLys: 1.737 ± 0.038
5.258ProLeu: 5.258 ± 0.071
1.034ProMet: 1.034 ± 0.027
1.59ProAsn: 1.59 ± 0.033
5.573ProPro: 5.573 ± 0.133
1.646ProGln: 1.646 ± 0.034
3.481ProArg: 3.481 ± 0.063
3.568ProSer: 3.568 ± 0.065
3.136ProThr: 3.136 ± 0.061
4.291ProVal: 4.291 ± 0.051
0.97ProTrp: 0.97 ± 0.031
1.259ProTyr: 1.259 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.294GlnAla: 3.294 ± 0.051
0.277GlnCys: 0.277 ± 0.014
1.208GlnAsp: 1.208 ± 0.031
1.323GlnGlu: 1.323 ± 0.035
1.117GlnPhe: 1.117 ± 0.028
2.027GlnGly: 2.027 ± 0.038
0.81GlnHis: 0.81 ± 0.023
1.954GlnIle: 1.954 ± 0.038
1.427GlnLys: 1.427 ± 0.041
3.36GlnLeu: 3.36 ± 0.054
0.684GlnMet: 0.684 ± 0.023
1.212GlnAsn: 1.212 ± 0.032
2.011GlnPro: 2.011 ± 0.043
1.28GlnGln: 1.28 ± 0.04
2.563GlnArg: 2.563 ± 0.049
1.856GlnSer: 1.856 ± 0.039
2.281GlnThr: 2.281 ± 0.045
1.934GlnVal: 1.934 ± 0.039
0.535GlnTrp: 0.535 ± 0.019
0.657GlnTyr: 0.657 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.124ArgAla: 7.124 ± 0.092
0.708ArgCys: 0.708 ± 0.023
3.653ArgAsp: 3.653 ± 0.051
4.362ArgGlu: 4.362 ± 0.07
2.838ArgPhe: 2.838 ± 0.054
4.527ArgGly: 4.527 ± 0.069
2.183ArgHis: 2.183 ± 0.044
4.306ArgIle: 4.306 ± 0.055
2.443ArgLys: 2.443 ± 0.045
7.576ArgLeu: 7.576 ± 0.083
1.611ArgMet: 1.611 ± 0.032
2.207ArgAsn: 2.207 ± 0.039
3.652ArgPro: 3.652 ± 0.061
2.676ArgGln: 2.676 ± 0.054
5.893ArgArg: 5.893 ± 0.096
3.563ArgSer: 3.563 ± 0.049
3.84ArgThr: 3.84 ± 0.053
4.618ArgVal: 4.618 ± 0.063
1.341ArgTrp: 1.341 ± 0.037
1.868ArgTyr: 1.868 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.529SerAla: 6.529 ± 0.07
0.492SerCys: 0.492 ± 0.022
2.967SerAsp: 2.967 ± 0.05
2.622SerGlu: 2.622 ± 0.045
2.227SerPhe: 2.227 ± 0.046
5.725SerGly: 5.725 ± 0.086
1.291SerHis: 1.291 ± 0.03
2.959SerIle: 2.959 ± 0.052
1.711SerLys: 1.711 ± 0.038
5.91SerLeu: 5.91 ± 0.064
1.112SerMet: 1.112 ± 0.027
1.943SerAsn: 1.943 ± 0.047
3.912SerPro: 3.912 ± 0.07
1.741SerGln: 1.741 ± 0.041
3.741SerArg: 3.741 ± 0.057
3.873SerSer: 3.873 ± 0.072
3.834SerThr: 3.834 ± 0.065
3.932SerVal: 3.932 ± 0.06
0.905SerTrp: 0.905 ± 0.027
1.454SerTyr: 1.454 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
7.104ThrAla: 7.104 ± 0.093
0.562ThrCys: 0.562 ± 0.021
3.292ThrAsp: 3.292 ± 0.054
2.703ThrGlu: 2.703 ± 0.049
2.458ThrPhe: 2.458 ± 0.053
6.193ThrGly: 6.193 ± 0.113
1.562ThrHis: 1.562 ± 0.039
3.446ThrIle: 3.446 ± 0.064
1.858ThrLys: 1.858 ± 0.039
7.746ThrLeu: 7.746 ± 0.115
0.908ThrMet: 0.908 ± 0.025
2.063ThrAsn: 2.063 ± 0.063
4.731ThrPro: 4.731 ± 0.069
1.868ThrGln: 1.868 ± 0.037
4.118ThrArg: 4.118 ± 0.049
3.784ThrSer: 3.784 ± 0.061
4.786ThrThr: 4.786 ± 0.086
4.442ThrVal: 4.442 ± 0.08
1.116ThrTrp: 1.116 ± 0.032
1.633ThrTyr: 1.633 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
7.053ValAla: 7.053 ± 0.08
0.768ValCys: 0.768 ± 0.024
2.932ValAsp: 2.932 ± 0.047
3.579ValGlu: 3.579 ± 0.053
2.785ValPhe: 2.785 ± 0.051
4.436ValGly: 4.436 ± 0.063
1.33ValHis: 1.33 ± 0.029
3.626ValIle: 3.626 ± 0.05
2.163ValLys: 2.163 ± 0.052
6.167ValLeu: 6.167 ± 0.079
1.289ValMet: 1.289 ± 0.033
2.196ValAsn: 2.196 ± 0.043
3.507ValPro: 3.507 ± 0.052
1.897ValGln: 1.897 ± 0.037
4.784ValArg: 4.784 ± 0.069
4.452ValSer: 4.452 ± 0.063
4.754ValThr: 4.754 ± 0.078
4.622ValVal: 4.622 ± 0.068
1.043ValTrp: 1.043 ± 0.031
1.444ValTyr: 1.444 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.277TrpAla: 1.277 ± 0.031
0.187TrpCys: 0.187 ± 0.01
0.791TrpAsp: 0.791 ± 0.023
0.796TrpGlu: 0.796 ± 0.026
0.677TrpPhe: 0.677 ± 0.02
1.03TrpGly: 1.03 ± 0.029
0.5TrpHis: 0.5 ± 0.02
0.843TrpIle: 0.843 ± 0.026
0.657TrpLys: 0.657 ± 0.021
2.064TrpLeu: 2.064 ± 0.043
0.405TrpMet: 0.405 ± 0.017
0.679TrpAsn: 0.679 ± 0.022
0.757TrpPro: 0.757 ± 0.025
0.761TrpGln: 0.761 ± 0.025
1.509TrpArg: 1.509 ± 0.038
1.023TrpSer: 1.023 ± 0.031
1.108TrpThr: 1.108 ± 0.034
0.9TrpVal: 0.9 ± 0.028
0.332TrpTrp: 0.332 ± 0.015
0.369TrpTyr: 0.369 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.596TyrAla: 2.596 ± 0.045
0.263TyrCys: 0.263 ± 0.013
1.482TyrAsp: 1.482 ± 0.039
1.335TyrGlu: 1.335 ± 0.034
1.138TyrPhe: 1.138 ± 0.028
1.959TyrGly: 1.959 ± 0.036
0.646TyrHis: 0.646 ± 0.022
1.074TyrIle: 1.074 ± 0.025
0.782TyrLys: 0.782 ± 0.027
2.488TyrLeu: 2.488 ± 0.042
0.394TyrMet: 0.394 ± 0.016
0.891TyrAsn: 0.891 ± 0.028
1.328TyrPro: 1.328 ± 0.03
0.918TyrGln: 0.918 ± 0.027
1.961TyrArg: 1.961 ± 0.036
1.467TyrSer: 1.467 ± 0.037
1.616TyrThr: 1.616 ± 0.043
1.52TyrVal: 1.52 ± 0.032
0.457TyrTrp: 0.457 ± 0.018
0.928TyrTyr: 0.928 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4229 proteins (1440389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski