Amino acid dipepetide frequency for Fonticella tunisiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.693AlaAla: 5.693 ± 0.107	0.684AlaCys: 0.684 ± 0.031	2.965AlaAsp: 2.965 ± 0.064	4.218AlaGlu: 4.218 ± 0.081	2.813AlaPhe: 2.813 ± 0.059	4.816AlaGly: 4.816 ± 0.091	0.957AlaHis: 0.957 ± 0.031	5.825AlaIle: 5.825 ± 0.088	4.512AlaLys: 4.512 ± 0.079	6.641AlaLeu: 6.641 ± 0.104	1.897AlaMet: 1.897 ± 0.047	2.479AlaAsn: 2.479 ± 0.054	1.728AlaPro: 1.728 ± 0.052	1.726AlaGln: 1.726 ± 0.048	2.907AlaArg: 2.907 ± 0.06	3.74AlaSer: 3.74 ± 0.07	2.45AlaThr: 2.45 ± 0.059	5.452AlaVal: 5.452 ± 0.092	0.401AlaTrp: 0.401 ± 0.02	2.303AlaTyr: 2.303 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.602CysAla: 0.602 ± 0.026	0.167CysCys: 0.167 ± 0.014	0.568CysAsp: 0.568 ± 0.029	0.646CysGlu: 0.646 ± 0.023	0.414CysPhe: 0.414 ± 0.022	1.021CysGly: 1.021 ± 0.043	0.221CysHis: 0.221 ± 0.016	0.988CysIle: 0.988 ± 0.033	0.681CysLys: 0.681 ± 0.029	0.772CysLeu: 0.772 ± 0.03	0.236CysMet: 0.236 ± 0.018	0.422CysAsn: 0.422 ± 0.024	0.502CysPro: 0.502 ± 0.027	0.215CysGln: 0.215 ± 0.014	0.539CysArg: 0.539 ± 0.024	0.758CysSer: 0.758 ± 0.031	0.464CysThr: 0.464 ± 0.024	0.56CysVal: 0.56 ± 0.025	0.062CysTrp: 0.062 ± 0.009	0.371CysTyr: 0.371 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.122AspAla: 3.122 ± 0.066	0.508AspCys: 0.508 ± 0.027	2.806AspAsp: 2.806 ± 0.069	4.919AspGlu: 4.919 ± 0.088	2.707AspPhe: 2.707 ± 0.065	3.814AspGly: 3.814 ± 0.074	0.621AspHis: 0.621 ± 0.03	6.223AspIle: 6.223 ± 0.093	4.663AspLys: 4.663 ± 0.085	4.316AspLeu: 4.316 ± 0.077	1.655AspMet: 1.655 ± 0.044	2.55AspAsn: 2.55 ± 0.056	1.641AspPro: 1.641 ± 0.056	0.763AspGln: 0.763 ± 0.029	2.767AspArg: 2.767 ± 0.067	2.724AspSer: 2.724 ± 0.055	2.258AspThr: 2.258 ± 0.048	4.057AspVal: 4.057 ± 0.067	0.379AspTrp: 0.379 ± 0.023	2.478AspTyr: 2.478 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	4.745GluAla: 4.745 ± 0.077	0.589GluCys: 0.589 ± 0.029	4.086GluAsp: 4.086 ± 0.078	6.463GluGlu: 6.463 ± 0.118	2.843GluPhe: 2.843 ± 0.063	4.924GluGly: 4.924 ± 0.079	1.06GluHis: 1.06 ± 0.034	7.252GluIle: 7.252 ± 0.099	6.967GluLys: 6.967 ± 0.096	6.574GluLeu: 6.574 ± 0.105	2.139GluMet: 2.139 ± 0.051	4.291GluAsn: 4.291 ± 0.071	1.641GluPro: 1.641 ± 0.044	1.63GluGln: 1.63 ± 0.045	3.975GluArg: 3.975 ± 0.077	3.347GluSer: 3.347 ± 0.058	2.896GluThr: 2.896 ± 0.057	5.182GluVal: 5.182 ± 0.081	0.494GluTrp: 0.494 ± 0.026	3.102GluTyr: 3.102 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.539PheAla: 2.539 ± 0.056	0.431PheCys: 0.431 ± 0.024	2.596PheAsp: 2.596 ± 0.056	2.978PheGlu: 2.978 ± 0.067	1.807PhePhe: 1.807 ± 0.054	3.107PheGly: 3.107 ± 0.064	0.568PheHis: 0.568 ± 0.026	4.306PheIle: 4.306 ± 0.082	3.552PheLys: 3.552 ± 0.062	3.809PheLeu: 3.809 ± 0.074	1.163PheMet: 1.163 ± 0.037	2.487PheAsn: 2.487 ± 0.052	1.272PhePro: 1.272 ± 0.039	0.9PheGln: 0.9 ± 0.031	1.485PheArg: 1.485 ± 0.043	2.72PheSer: 2.72 ± 0.064	2.239PheThr: 2.239 ± 0.058	2.729PheVal: 2.729 ± 0.061	0.279PheTrp: 0.279 ± 0.02	1.696PheTyr: 1.696 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.601GlyAla: 4.601 ± 0.09	0.931GlyCys: 0.931 ± 0.037	3.549GlyAsp: 3.549 ± 0.077	4.693GlyGlu: 4.693 ± 0.08	3.284GlyPhe: 3.284 ± 0.064	5.022GlyGly: 5.022 ± 0.112	1.124GlyHis: 1.124 ± 0.043	7.513GlyIle: 7.513 ± 0.117	5.717GlyLys: 5.717 ± 0.102	6.173GlyLeu: 6.173 ± 0.081	2.027GlyMet: 2.027 ± 0.049	3.102GlyAsn: 3.102 ± 0.063	1.612GlyPro: 1.612 ± 0.05	1.63GlyGln: 1.63 ± 0.04	3.327GlyArg: 3.327 ± 0.063	3.865GlySer: 3.865 ± 0.07	3.691GlyThr: 3.691 ± 0.073	5.146GlyVal: 5.146 ± 0.08	0.584GlyTrp: 0.584 ± 0.03	3.288GlyTyr: 3.288 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	0.86HisAla: 0.86 ± 0.034	0.185HisCys: 0.185 ± 0.015	0.743HisAsp: 0.743 ± 0.032	0.926HisGlu: 0.926 ± 0.031	0.629HisPhe: 0.629 ± 0.027	1.228HisGly: 1.228 ± 0.04	0.365HisHis: 0.365 ± 0.029	1.464HisIle: 1.464 ± 0.039	0.896HisLys: 0.896 ± 0.03	1.245HisLeu: 1.245 ± 0.043	0.385HisMet: 0.385 ± 0.022	0.763HisAsn: 0.763 ± 0.029	0.782HisPro: 0.782 ± 0.031	0.369HisGln: 0.369 ± 0.021	0.816HisArg: 0.816 ± 0.033	0.85HisSer: 0.85 ± 0.033	0.721HisThr: 0.721 ± 0.027	0.928HisVal: 0.928 ± 0.035	0.106HisTrp: 0.106 ± 0.011	0.576HisTyr: 0.576 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.354IleAla: 6.354 ± 0.099	1.041IleCys: 1.041 ± 0.043	5.783IleAsp: 5.783 ± 0.083	7.042IleGlu: 7.042 ± 0.109	3.776IlePhe: 3.776 ± 0.079	6.224IleGly: 6.224 ± 0.104	1.253IleHis: 1.253 ± 0.045	8.72IleIle: 8.72 ± 0.146	8.335IleLys: 8.335 ± 0.118	8.601IleLeu: 8.601 ± 0.113	2.333IleMet: 2.333 ± 0.057	5.196IleAsn: 5.196 ± 0.083	3.824IlePro: 3.824 ± 0.064	2.092IleGln: 2.092 ± 0.049	3.884IleArg: 3.884 ± 0.074	6.447IleSer: 6.447 ± 0.096	4.848IleThr: 4.848 ± 0.082	6.119IleVal: 6.119 ± 0.087	0.515IleTrp: 0.515 ± 0.024	3.43IleTyr: 3.43 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	5.116LysAla: 5.116 ± 0.094	0.683LysCys: 0.683 ± 0.03	4.956LysAsp: 4.956 ± 0.085	7.114LysGlu: 7.114 ± 0.09	2.736LysPhe: 2.736 ± 0.061	5.174LysGly: 5.174 ± 0.082	1.22LysHis: 1.22 ± 0.04	7.157LysIle: 7.157 ± 0.114	6.891LysLys: 6.891 ± 0.097	6.825LysLeu: 6.825 ± 0.095	2.348LysMet: 2.348 ± 0.046	5.147LysAsn: 5.147 ± 0.075	2.326LysPro: 2.326 ± 0.055	1.881LysGln: 1.881 ± 0.055	3.812LysArg: 3.812 ± 0.071	4.448LysSer: 4.448 ± 0.071	3.668LysThr: 3.668 ± 0.061	5.378LysVal: 5.378 ± 0.081	0.604LysTrp: 0.604 ± 0.026	3.736LysTyr: 3.736 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	5.536LeuAla: 5.536 ± 0.1	0.938LeuCys: 0.938 ± 0.032	4.684LeuAsp: 4.684 ± 0.076	6.098LeuGlu: 6.098 ± 0.091	3.717LeuPhe: 3.717 ± 0.077	6.324LeuGly: 6.324 ± 0.079	1.23LeuHis: 1.23 ± 0.038	8.078LeuIle: 8.078 ± 0.12	8.415LeuLys: 8.415 ± 0.109	7.813LeuLeu: 7.813 ± 0.125	2.478LeuMet: 2.478 ± 0.052	5.051LeuAsn: 5.051 ± 0.088	3.101LeuPro: 3.101 ± 0.061	2.114LeuGln: 2.114 ± 0.049	3.882LeuArg: 3.882 ± 0.081	6.286LeuSer: 6.286 ± 0.095	4.4LeuThr: 4.4 ± 0.066	5.293LeuVal: 5.293 ± 0.089	0.63LeuTrp: 0.63 ± 0.029	3.208LeuTyr: 3.208 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.073MetAla: 2.073 ± 0.054	0.217MetCys: 0.217 ± 0.016	1.756MetAsp: 1.756 ± 0.05	2.19MetGlu: 2.19 ± 0.056	1.014MetPhe: 1.014 ± 0.033	1.955MetGly: 1.955 ± 0.047	0.381MetHis: 0.381 ± 0.023	2.246MetIle: 2.246 ± 0.062	2.394MetLys: 2.394 ± 0.05	2.417MetLeu: 2.417 ± 0.052	0.803MetMet: 0.803 ± 0.037	1.417MetAsn: 1.417 ± 0.038	1.003MetPro: 1.003 ± 0.041	0.702MetGln: 0.702 ± 0.029	1.087MetArg: 1.087 ± 0.032	1.595MetSer: 1.595 ± 0.043	1.241MetThr: 1.241 ± 0.043	1.921MetVal: 1.921 ± 0.055	0.151MetTrp: 0.151 ± 0.012	0.857MetTyr: 0.857 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.979AsnAla: 2.979 ± 0.062	0.579AsnCys: 0.579 ± 0.027	2.418AsnAsp: 2.418 ± 0.056	3.418AsnGlu: 3.418 ± 0.061	2.12AsnPhe: 2.12 ± 0.053	3.359AsnGly: 3.359 ± 0.063	0.741AsnHis: 0.741 ± 0.036	5.735AsnIle: 5.735 ± 0.092	4.161AsnLys: 4.161 ± 0.078	4.67AsnLeu: 4.67 ± 0.074	1.503AsnMet: 1.503 ± 0.047	2.82AsnAsn: 2.82 ± 0.067	2.363AsnPro: 2.363 ± 0.06	1.138AsnGln: 1.138 ± 0.036	2.495AsnArg: 2.495 ± 0.054	3.046AsnSer: 3.046 ± 0.068	2.397AsnThr: 2.397 ± 0.054	3.172AsnVal: 3.172 ± 0.061	0.399AsnTrp: 0.399 ± 0.021	2.068AsnTyr: 2.068 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.978ProAla: 1.978 ± 0.048	0.288ProCys: 0.288 ± 0.018	1.98ProAsp: 1.98 ± 0.056	2.936ProGlu: 2.936 ± 0.059	1.585ProPhe: 1.585 ± 0.043	2.487ProGly: 2.487 ± 0.062	0.6ProHis: 0.6 ± 0.026	2.551ProIle: 2.551 ± 0.052	1.971ProLys: 1.971 ± 0.045	2.826ProLeu: 2.826 ± 0.056	0.782ProMet: 0.782 ± 0.034	1.344ProAsn: 1.344 ± 0.045	0.934ProPro: 0.934 ± 0.036	0.945ProGln: 0.945 ± 0.032	1.158ProArg: 1.158 ± 0.04	1.929ProSer: 1.929 ± 0.052	1.546ProThr: 1.546 ± 0.042	2.883ProVal: 2.883 ± 0.052	0.318ProTrp: 0.318 ± 0.022	1.411ProTyr: 1.411 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.539GlnAla: 1.539 ± 0.043	0.202GlnCys: 0.202 ± 0.019	1.184GlnAsp: 1.184 ± 0.035	1.651GlnGlu: 1.651 ± 0.044	0.931GlnPhe: 0.931 ± 0.035	1.569GlnGly: 1.569 ± 0.05	0.334GlnHis: 0.334 ± 0.02	2.205GlnIle: 2.205 ± 0.049	1.898GlnLys: 1.898 ± 0.049	1.977GlnLeu: 1.977 ± 0.047	0.716GlnMet: 0.716 ± 0.031	1.39GlnAsn: 1.39 ± 0.049	0.715GlnPro: 0.715 ± 0.028	0.716GlnGln: 0.716 ± 0.039	1.385GlnArg: 1.385 ± 0.041	1.29GlnSer: 1.29 ± 0.043	1.007GlnThr: 1.007 ± 0.034	1.351GlnVal: 1.351 ± 0.042	0.181GlnTrp: 0.181 ± 0.013	0.98GlnTyr: 0.98 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.843ArgAla: 2.843 ± 0.06	0.488ArgCys: 0.488 ± 0.025	2.806ArgAsp: 2.806 ± 0.063	4.175ArgGlu: 4.175 ± 0.078	1.939ArgPhe: 1.939 ± 0.051	2.933ArgGly: 2.933 ± 0.054	0.688ArgHis: 0.688 ± 0.028	4.347ArgIle: 4.347 ± 0.067	3.59ArgLys: 3.59 ± 0.064	4.1ArgLeu: 4.1 ± 0.078	1.29ArgMet: 1.29 ± 0.041	2.283ArgAsn: 2.283 ± 0.05	1.309ArgPro: 1.309 ± 0.039	1.206ArgGln: 1.206 ± 0.039	2.448ArgArg: 2.448 ± 0.059	2.011ArgSer: 2.011 ± 0.049	1.861ArgThr: 1.861 ± 0.044	3.263ArgVal: 3.263 ± 0.065	0.348ArgTrp: 0.348 ± 0.018	1.88ArgTyr: 1.88 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.434SerAla: 3.434 ± 0.064	0.596SerCys: 0.596 ± 0.025	2.904SerAsp: 2.904 ± 0.063	3.726SerGlu: 3.726 ± 0.06	2.891SerPhe: 2.891 ± 0.067	4.73SerGly: 4.73 ± 0.076	0.949SerHis: 0.949 ± 0.04	6.035SerIle: 6.035 ± 0.099	4.526SerLys: 4.526 ± 0.076	5.565SerLeu: 5.565 ± 0.091	1.599SerMet: 1.599 ± 0.042	2.736SerAsn: 2.736 ± 0.063	1.832SerPro: 1.832 ± 0.048	1.519SerGln: 1.519 ± 0.044	2.889SerArg: 2.889 ± 0.067	3.945SerSer: 3.945 ± 0.084	2.993SerThr: 2.993 ± 0.063	3.42SerVal: 3.42 ± 0.061	0.414SerTrp: 0.414 ± 0.021	2.341SerTyr: 2.341 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.392ThrAla: 3.392 ± 0.068	0.429ThrCys: 0.429 ± 0.024	2.35ThrAsp: 2.35 ± 0.053	2.685ThrGlu: 2.685 ± 0.061	2.078ThrPhe: 2.078 ± 0.05	4.253ThrGly: 4.253 ± 0.079	0.769ThrHis: 0.769 ± 0.032	4.295ThrIle: 4.295 ± 0.073	2.936ThrLys: 2.936 ± 0.06	4.435ThrLeu: 4.435 ± 0.071	1.15ThrMet: 1.15 ± 0.036	2.033ThrAsn: 2.033 ± 0.046	1.927ThrPro: 1.927 ± 0.051	1.054ThrGln: 1.054 ± 0.037	1.955ThrArg: 1.955 ± 0.05	2.922ThrSer: 2.922 ± 0.055	2.397ThrThr: 2.397 ± 0.06	3.372ThrVal: 3.372 ± 0.071	0.344ThrTrp: 0.344 ± 0.02	1.774ThrTyr: 1.774 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.217ValAla: 4.217 ± 0.081	0.704ValCys: 0.704 ± 0.029	4.157ValAsp: 4.157 ± 0.072	5.141ValGlu: 5.141 ± 0.091	3.025ValPhe: 3.025 ± 0.064	4.381ValGly: 4.381 ± 0.083	1.004ValHis: 1.004 ± 0.031	6.378ValIle: 6.378 ± 0.102	5.665ValLys: 5.665 ± 0.08	6.332ValLeu: 6.332 ± 0.087	1.749ValMet: 1.749 ± 0.047	3.376ValAsn: 3.376 ± 0.067	2.359ValPro: 2.359 ± 0.057	1.531ValGln: 1.531 ± 0.042	2.641ValArg: 2.641 ± 0.06	4.221ValSer: 4.221 ± 0.067	3.253ValThr: 3.253 ± 0.077	5.212ValVal: 5.212 ± 0.104	0.418ValTrp: 0.418 ± 0.021	2.634ValTyr: 2.634 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.42TrpAla: 0.42 ± 0.025	0.09TrpCys: 0.09 ± 0.011	0.399TrpAsp: 0.399 ± 0.022	0.441TrpGlu: 0.441 ± 0.021	0.331TrpPhe: 0.331 ± 0.019	0.578TrpGly: 0.578 ± 0.027	0.129TrpHis: 0.129 ± 0.011	0.616TrpIle: 0.616 ± 0.027	0.508TrpLys: 0.508 ± 0.026	0.606TrpLeu: 0.606 ± 0.029	0.199TrpMet: 0.199 ± 0.018	0.399TrpAsn: 0.399 ± 0.022	0.195TrpPro: 0.195 ± 0.015	0.21TrpGln: 0.21 ± 0.017	0.299TrpArg: 0.299 ± 0.02	0.405TrpSer: 0.405 ± 0.022	0.319TrpThr: 0.319 ± 0.019	0.467TrpVal: 0.467 ± 0.024	0.085TrpTrp: 0.085 ± 0.009	0.312TrpTyr: 0.312 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.164TyrAla: 2.164 ± 0.053	0.461TyrCys: 0.461 ± 0.023	2.282TyrAsp: 2.282 ± 0.062	2.742TyrGlu: 2.742 ± 0.057	2.024TyrPhe: 2.024 ± 0.047	2.979TyrGly: 2.979 ± 0.065	0.622TyrHis: 0.622 ± 0.031	3.882TyrIle: 3.882 ± 0.068	2.939TyrLys: 2.939 ± 0.055	3.58TyrLeu: 3.58 ± 0.074	0.965TyrMet: 0.965 ± 0.032	2.293TyrAsn: 2.293 ± 0.059	1.387TyrPro: 1.387 ± 0.044	0.884TyrGln: 0.884 ± 0.029	2.057TyrArg: 2.057 ± 0.052	2.492TyrSer: 2.492 ± 0.051	1.902TyrThr: 1.902 ± 0.046	2.493TyrVal: 2.493 ± 0.054	0.297TyrTrp: 0.297 ± 0.019	1.8TyrTyr: 1.8 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2943 proteins (868126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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