Amino acid dipepetide frequency for Jannaschia sp. (strain CCS1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.394AlaAla: 16.394 ± 0.183	1.184AlaCys: 1.184 ± 0.035	7.797AlaAsp: 7.797 ± 0.098	7.985AlaGlu: 7.985 ± 0.096	4.499AlaPhe: 4.499 ± 0.064	10.239AlaGly: 10.239 ± 0.109	2.539AlaHis: 2.539 ± 0.045	6.058AlaIle: 6.058 ± 0.077	3.359AlaLys: 3.359 ± 0.062	13.839AlaLeu: 13.839 ± 0.125	4.151AlaMet: 4.151 ± 0.066	2.798AlaAsn: 2.798 ± 0.048	6.293AlaPro: 6.293 ± 0.095	4.59AlaGln: 4.59 ± 0.064	8.798AlaArg: 8.798 ± 0.092	5.885AlaSer: 5.885 ± 0.067	6.693AlaThr: 6.693 ± 0.075	8.46AlaVal: 8.46 ± 0.091	1.566AlaTrp: 1.566 ± 0.035	2.616AlaTyr: 2.616 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.156CysAla: 1.156 ± 0.034	0.118CysCys: 0.118 ± 0.009	0.621CysAsp: 0.621 ± 0.023	0.436CysGlu: 0.436 ± 0.02	0.362CysPhe: 0.362 ± 0.017	0.98CysGly: 0.98 ± 0.031	0.254CysHis: 0.254 ± 0.013	0.426CysIle: 0.426 ± 0.019	0.199CysLys: 0.199 ± 0.012	0.893CysLeu: 0.893 ± 0.027	0.188CysMet: 0.188 ± 0.01	0.232CysAsn: 0.232 ± 0.014	0.513CysPro: 0.513 ± 0.021	0.249CysGln: 0.249 ± 0.014	0.502CysArg: 0.502 ± 0.02	0.423CysSer: 0.423 ± 0.019	0.502CysThr: 0.502 ± 0.024	0.73CysVal: 0.73 ± 0.022	0.122CysTrp: 0.122 ± 0.011	0.219CysTyr: 0.219 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.511AspAla: 8.511 ± 0.102	0.505AspCys: 0.505 ± 0.021	3.853AspAsp: 3.853 ± 0.064	3.323AspGlu: 3.323 ± 0.056	2.323AspPhe: 2.323 ± 0.045	6.392AspGly: 6.392 ± 0.082	1.488AspHis: 1.488 ± 0.035	3.384AspIle: 3.384 ± 0.05	1.352AspLys: 1.352 ± 0.039	6.725AspLeu: 6.725 ± 0.085	1.825AspMet: 1.825 ± 0.04	1.326AspAsn: 1.326 ± 0.032	3.881AspPro: 3.881 ± 0.066	1.93AspGln: 1.93 ± 0.041	4.398AspArg: 4.398 ± 0.065	2.006AspSer: 2.006 ± 0.046	3.529AspThr: 3.529 ± 0.065	4.965AspVal: 4.965 ± 0.072	1.245AspTrp: 1.245 ± 0.033	1.528AspTyr: 1.528 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.17GluAla: 8.17 ± 0.1	0.349GluCys: 0.349 ± 0.017	3.606GluAsp: 3.606 ± 0.061	3.282GluGlu: 3.282 ± 0.06	1.792GluPhe: 1.792 ± 0.038	4.784GluGly: 4.784 ± 0.069	1.068GluHis: 1.068 ± 0.03	3.345GluIle: 3.345 ± 0.055	1.503GluLys: 1.503 ± 0.04	4.59GluLeu: 4.59 ± 0.068	1.833GluMet: 1.833 ± 0.038	1.507GluAsn: 1.507 ± 0.031	2.435GluPro: 2.435 ± 0.05	1.782GluGln: 1.782 ± 0.042	3.884GluArg: 3.884 ± 0.063	1.739GluSer: 1.739 ± 0.034	3.724GluThr: 3.724 ± 0.057	4.444GluVal: 4.444 ± 0.057	0.652GluTrp: 0.652 ± 0.025	0.973GluTyr: 0.973 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.64PheAla: 4.64 ± 0.063	0.423PheCys: 0.423 ± 0.016	2.862PheAsp: 2.862 ± 0.046	2.197PheGlu: 2.197 ± 0.041	1.409PhePhe: 1.409 ± 0.033	3.794PheGly: 3.794 ± 0.054	0.767PheHis: 0.767 ± 0.028	1.732PheIle: 1.732 ± 0.043	0.816PheLys: 0.816 ± 0.028	3.429PheLeu: 3.429 ± 0.06	0.862PheMet: 0.862 ± 0.028	1.125PheAsn: 1.125 ± 0.028	1.643PhePro: 1.643 ± 0.034	1.121PheGln: 1.121 ± 0.03	2.141PheArg: 2.141 ± 0.042	2.114PheSer: 2.114 ± 0.04	2.258PheThr: 2.258 ± 0.042	2.703PheVal: 2.703 ± 0.052	0.587PheTrp: 0.587 ± 0.022	0.911PheTyr: 0.911 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.189GlyAla: 10.189 ± 0.111	0.901GlyCys: 0.901 ± 0.025	5.173GlyAsp: 5.173 ± 0.081	4.531GlyGlu: 4.531 ± 0.065	3.756GlyPhe: 3.756 ± 0.061	7.754GlyGly: 7.754 ± 0.111	2.019GlyHis: 2.019 ± 0.044	4.487GlyIle: 4.487 ± 0.067	2.475GlyLys: 2.475 ± 0.055	9.362GlyLeu: 9.362 ± 0.095	2.54GlyMet: 2.54 ± 0.047	2.112GlyAsn: 2.112 ± 0.05	4.087GlyPro: 4.087 ± 0.062	3.264GlyGln: 3.264 ± 0.055	5.549GlyArg: 5.549 ± 0.067	4.258GlySer: 4.258 ± 0.07	5.135GlyThr: 5.135 ± 0.071	6.642GlyVal: 6.642 ± 0.076	1.458GlyTrp: 1.458 ± 0.036	2.287GlyTyr: 2.287 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.485HisAla: 2.485 ± 0.053	0.253HisCys: 0.253 ± 0.014	1.344HisAsp: 1.344 ± 0.032	0.946HisGlu: 0.946 ± 0.026	0.78HisPhe: 0.78 ± 0.026	2.062HisGly: 2.062 ± 0.041	0.593HisHis: 0.593 ± 0.021	1.038HisIle: 1.038 ± 0.026	0.48HisLys: 0.48 ± 0.021	2.261HisLeu: 2.261 ± 0.044	0.601HisMet: 0.601 ± 0.022	0.455HisAsn: 0.455 ± 0.02	1.392HisPro: 1.392 ± 0.033	0.608HisGln: 0.608 ± 0.023	1.412HisArg: 1.412 ± 0.031	0.947HisSer: 0.947 ± 0.028	0.961HisThr: 0.961 ± 0.029	1.61HisVal: 1.61 ± 0.038	0.38HisTrp: 0.38 ± 0.018	0.527HisTyr: 0.527 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.326IleAla: 7.326 ± 0.078	0.64IleCys: 0.64 ± 0.023	3.515IleAsp: 3.515 ± 0.054	3.32IleGlu: 3.32 ± 0.056	1.915IlePhe: 1.915 ± 0.041	4.918IleGly: 4.918 ± 0.071	0.97IleHis: 0.97 ± 0.027	2.348IleIle: 2.348 ± 0.051	1.156IleLys: 1.156 ± 0.032	5.007IleLeu: 5.007 ± 0.068	1.109IleMet: 1.109 ± 0.031	1.367IleAsn: 1.367 ± 0.034	2.419IlePro: 2.419 ± 0.046	1.195IleGln: 1.195 ± 0.031	3.113IleArg: 3.113 ± 0.047	2.937IleSer: 2.937 ± 0.05	3.23IleThr: 3.23 ± 0.053	3.922IleVal: 3.922 ± 0.062	0.796IleTrp: 0.796 ± 0.027	1.2IleTyr: 1.2 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.217LysAla: 3.217 ± 0.067	0.148LysCys: 0.148 ± 0.011	1.531LysAsp: 1.531 ± 0.036	1.123LysGlu: 1.123 ± 0.035	0.702LysPhe: 0.702 ± 0.028	2.221LysGly: 2.221 ± 0.054	0.541LysHis: 0.541 ± 0.021	1.432LysIle: 1.432 ± 0.037	0.891LysLys: 0.891 ± 0.033	2.409LysLeu: 2.409 ± 0.051	0.759LysMet: 0.759 ± 0.024	0.611LysAsn: 0.611 ± 0.023	1.489LysPro: 1.489 ± 0.041	0.724LysGln: 0.724 ± 0.023	1.961LysArg: 1.961 ± 0.042	1.432LysSer: 1.432 ± 0.041	1.708LysThr: 1.708 ± 0.033	1.78LysVal: 1.78 ± 0.038	0.322LysTrp: 0.322 ± 0.016	0.507LysTyr: 0.507 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	12.548LeuAla: 12.548 ± 0.115	0.977LeuCys: 0.977 ± 0.03	6.24LeuAsp: 6.24 ± 0.076	5.169LeuGlu: 5.169 ± 0.07	3.457LeuPhe: 3.457 ± 0.062	8.393LeuGly: 8.393 ± 0.09	1.994LeuHis: 1.994 ± 0.042	5.475LeuIle: 5.475 ± 0.076	2.62LeuLys: 2.62 ± 0.05	8.462LeuLeu: 8.462 ± 0.117	2.699LeuMet: 2.699 ± 0.047	2.604LeuAsn: 2.604 ± 0.049	5.687LeuPro: 5.687 ± 0.075	2.795LeuGln: 2.795 ± 0.055	6.77LeuArg: 6.77 ± 0.073	6.733LeuSer: 6.733 ± 0.092	6.401LeuThr: 6.401 ± 0.08	6.542LeuVal: 6.542 ± 0.077	1.269LeuTrp: 1.269 ± 0.035	1.894LeuTyr: 1.894 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.797MetAla: 3.797 ± 0.063	0.212MetCys: 0.212 ± 0.013	1.566MetAsp: 1.566 ± 0.037	1.502MetGlu: 1.502 ± 0.038	0.792MetPhe: 0.792 ± 0.028	2.437MetGly: 2.437 ± 0.042	0.502MetHis: 0.502 ± 0.017	1.605MetIle: 1.605 ± 0.037	0.899MetLys: 0.899 ± 0.027	2.518MetLeu: 2.518 ± 0.044	0.788MetMet: 0.788 ± 0.025	0.839MetAsn: 0.839 ± 0.026	1.55MetPro: 1.55 ± 0.035	0.947MetGln: 0.947 ± 0.025	2.015MetArg: 2.015 ± 0.038	1.827MetSer: 1.827 ± 0.039	2.203MetThr: 2.203 ± 0.038	1.944MetVal: 1.944 ± 0.037	0.277MetTrp: 0.277 ± 0.015	0.368MetTyr: 0.368 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.262AsnAla: 3.262 ± 0.05	0.256AsnCys: 0.256 ± 0.014	1.461AsnAsp: 1.461 ± 0.04	1.066AsnGlu: 1.066 ± 0.031	0.977AsnPhe: 0.977 ± 0.031	2.45AsnGly: 2.45 ± 0.045	0.497AsnHis: 0.497 ± 0.021	1.375AsnIle: 1.375 ± 0.031	0.523AsnLys: 0.523 ± 0.023	2.404AsnLeu: 2.404 ± 0.046	0.692AsnMet: 0.692 ± 0.022	0.641AsnAsn: 0.641 ± 0.025	1.831AsnPro: 1.831 ± 0.042	0.71AsnGln: 0.71 ± 0.026	1.669AsnArg: 1.669 ± 0.037	1.114AsnSer: 1.114 ± 0.034	1.445AsnThr: 1.445 ± 0.042	1.923AsnVal: 1.923 ± 0.043	0.403AsnTrp: 0.403 ± 0.02	0.647AsnTyr: 0.647 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.802ProAla: 5.802 ± 0.082	0.375ProCys: 0.375 ± 0.018	4.461ProAsp: 4.461 ± 0.065	3.816ProGlu: 3.816 ± 0.057	2.073ProPhe: 2.073 ± 0.045	4.6ProGly: 4.6 ± 0.062	1.146ProHis: 1.146 ± 0.029	2.471ProIle: 2.471 ± 0.048	1.442ProLys: 1.442 ± 0.037	4.713ProLeu: 4.713 ± 0.063	1.535ProMet: 1.535 ± 0.035	1.458ProAsn: 1.458 ± 0.036	2.499ProPro: 2.499 ± 0.056	1.731ProGln: 1.731 ± 0.035	2.925ProArg: 2.925 ± 0.055	2.752ProSer: 2.752 ± 0.044	2.783ProThr: 2.783 ± 0.051	4.138ProVal: 4.138 ± 0.057	0.726ProTrp: 0.726 ± 0.025	1.127ProTyr: 1.127 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.06GlnAla: 4.06 ± 0.056	0.225GlnCys: 0.225 ± 0.014	1.883GlnAsp: 1.883 ± 0.041	1.463GlnGlu: 1.463 ± 0.039	1.118GlnPhe: 1.118 ± 0.032	2.621GlnGly: 2.621 ± 0.046	0.6GlnHis: 0.6 ± 0.022	2.187GlnIle: 2.187 ± 0.044	0.811GlnLys: 0.811 ± 0.025	2.712GlnLeu: 2.712 ± 0.048	1.16GlnMet: 1.16 ± 0.028	0.869GlnAsn: 0.869 ± 0.025	1.648GlnPro: 1.648 ± 0.041	1.01GlnGln: 1.01 ± 0.03	2.072GlnArg: 2.072 ± 0.045	1.831GlnSer: 1.831 ± 0.039	2.074GlnThr: 2.074 ± 0.04	2.336GlnVal: 2.336 ± 0.044	0.433GlnTrp: 0.433 ± 0.018	0.575GlnTyr: 0.575 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.408ArgAla: 8.408 ± 0.089	0.497ArgCys: 0.497 ± 0.022	4.587ArgAsp: 4.587 ± 0.07	3.347ArgGlu: 3.347 ± 0.064	2.641ArgPhe: 2.641 ± 0.05	4.597ArgGly: 4.597 ± 0.063	1.535ArgHis: 1.535 ± 0.037	3.615ArgIle: 3.615 ± 0.053	1.838ArgLys: 1.838 ± 0.047	6.959ArgLeu: 6.959 ± 0.087	2.016ArgMet: 2.016 ± 0.042	1.704ArgAsn: 1.704 ± 0.039	3.205ArgPro: 3.205 ± 0.06	2.16ArgGln: 2.16 ± 0.05	4.56ArgArg: 4.56 ± 0.073	3.045ArgSer: 3.045 ± 0.047	3.246ArgThr: 3.246 ± 0.049	4.889ArgVal: 4.889 ± 0.063	0.914ArgTrp: 0.914 ± 0.027	1.469ArgTyr: 1.469 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.035SerAla: 6.035 ± 0.072	0.448SerCys: 0.448 ± 0.02	3.53SerAsp: 3.53 ± 0.05	2.74SerGlu: 2.74 ± 0.04	2.183SerPhe: 2.183 ± 0.041	5.205SerGly: 5.205 ± 0.071	1.078SerHis: 1.078 ± 0.034	2.52SerIle: 2.52 ± 0.047	1.254SerLys: 1.254 ± 0.033	4.942SerLeu: 4.942 ± 0.064	1.337SerMet: 1.337 ± 0.033	1.333SerAsn: 1.333 ± 0.033	2.525SerPro: 2.525 ± 0.048	1.554SerGln: 1.554 ± 0.031	2.962SerArg: 2.962 ± 0.057	2.514SerSer: 2.514 ± 0.049	2.616SerThr: 2.616 ± 0.045	3.933SerVal: 3.933 ± 0.052	0.641SerTrp: 0.641 ± 0.023	1.25SerTyr: 1.25 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.693ThrAla: 6.693 ± 0.09	0.56ThrCys: 0.56 ± 0.025	3.631ThrAsp: 3.631 ± 0.055	2.936ThrGlu: 2.936 ± 0.056	2.311ThrPhe: 2.311 ± 0.041	5.668ThrGly: 5.668 ± 0.087	1.311ThrHis: 1.311 ± 0.033	2.974ThrIle: 2.974 ± 0.05	1.268ThrLys: 1.268 ± 0.034	6.51ThrLeu: 6.51 ± 0.074	1.424ThrMet: 1.424 ± 0.032	1.417ThrAsn: 1.417 ± 0.033	3.878ThrPro: 3.878 ± 0.058	1.888ThrGln: 1.888 ± 0.043	3.77ThrArg: 3.77 ± 0.053	3.033ThrSer: 3.033 ± 0.05	3.135ThrThr: 3.135 ± 0.058	4.162ThrVal: 4.162 ± 0.064	0.777ThrTrp: 0.777 ± 0.022	1.422ThrTyr: 1.422 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.145ValAla: 9.145 ± 0.091	0.661ValCys: 0.661 ± 0.025	4.361ValAsp: 4.361 ± 0.059	4.494ValGlu: 4.494 ± 0.063	2.953ValPhe: 2.953 ± 0.057	5.706ValGly: 5.706 ± 0.066	1.38ValHis: 1.38 ± 0.032	4.178ValIle: 4.178 ± 0.055	1.824ValLys: 1.824 ± 0.046	7.288ValLeu: 7.288 ± 0.081	2.129ValMet: 2.129 ± 0.046	1.956ValAsn: 1.956 ± 0.043	3.819ValPro: 3.819 ± 0.053	2.173ValGln: 2.173 ± 0.042	4.109ValArg: 4.109 ± 0.063	4.13ValSer: 4.13 ± 0.056	4.968ValThr: 4.968 ± 0.078	5.557ValVal: 5.557 ± 0.075	0.998ValTrp: 0.998 ± 0.027	1.368ValTyr: 1.368 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.406TrpAla: 1.406 ± 0.035	0.143TrpCys: 0.143 ± 0.01	0.85TrpAsp: 0.85 ± 0.027	0.658TrpGlu: 0.658 ± 0.023	0.58TrpPhe: 0.58 ± 0.022	1.037TrpGly: 1.037 ± 0.028	0.346TrpHis: 0.346 ± 0.016	0.791TrpIle: 0.791 ± 0.027	0.325TrpLys: 0.325 ± 0.017	1.548TrpLeu: 1.548 ± 0.033	0.452TrpMet: 0.452 ± 0.02	0.436TrpAsn: 0.436 ± 0.016	0.708TrpPro: 0.708 ± 0.02	0.593TrpGln: 0.593 ± 0.02	1.115TrpArg: 1.115 ± 0.031	0.813TrpSer: 0.813 ± 0.022	0.906TrpThr: 0.906 ± 0.027	0.961TrpVal: 0.961 ± 0.027	0.251TrpTrp: 0.251 ± 0.015	0.276TrpTyr: 0.276 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.502TyrAla: 2.502 ± 0.043	0.253TyrCys: 0.253 ± 0.014	1.617TyrAsp: 1.617 ± 0.037	1.129TyrGlu: 1.129 ± 0.036	0.912TyrPhe: 0.912 ± 0.031	2.121TyrGly: 2.121 ± 0.042	0.507TyrHis: 0.507 ± 0.02	0.961TyrIle: 0.961 ± 0.03	0.47TyrLys: 0.47 ± 0.019	2.159TyrLeu: 2.159 ± 0.041	0.483TyrMet: 0.483 ± 0.016	0.557TyrAsn: 0.557 ± 0.022	1.071TyrPro: 1.071 ± 0.028	0.661TyrGln: 0.661 ± 0.022	1.508TyrArg: 1.508 ± 0.034	1.068TyrSer: 1.068 ± 0.03	1.251TyrThr: 1.251 ± 0.036	1.556TyrVal: 1.556 ± 0.029	0.375TyrTrp: 0.375 ± 0.019	0.543TyrTyr: 0.543 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4271 proteins (1324290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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