Amino acid dipepetide frequency for Apple green crinkle associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.003AlaAla: 5.003 ± 2.132
1.334AlaCys: 1.334 ± 0.761
2.001AlaAsp: 2.001 ± 0.743
3.669AlaGlu: 3.669 ± 1.293
3.002AlaPhe: 3.002 ± 0.817
2.001AlaGly: 2.001 ± 0.556
2.001AlaHis: 2.001 ± 0.489
6.004AlaIle: 6.004 ± 1.085
4.67AlaLys: 4.67 ± 1.772
6.338AlaLeu: 6.338 ± 1.586
0.667AlaMet: 0.667 ± 0.329
2.001AlaAsn: 2.001 ± 0.489
2.668AlaPro: 2.668 ± 2.371
1.668AlaGln: 1.668 ± 0.711
2.335AlaArg: 2.335 ± 0.821
6.004AlaSer: 6.004 ± 3.016
2.335AlaThr: 2.335 ± 0.861
5.67AlaVal: 5.67 ± 2.285
0.334AlaTrp: 0.334 ± 0.164
2.001AlaTyr: 2.001 ± 1.092
0.0AlaXaa: 0.0 ± 0.0
Cys
1.334CysAla: 1.334 ± 0.87
0.334CysCys: 0.334 ± 0.887
0.667CysAsp: 0.667 ± 0.329
1.334CysGlu: 1.334 ± 0.657
1.668CysPhe: 1.668 ± 0.821
1.668CysGly: 1.668 ± 0.786
0.0CysHis: 0.0 ± 0.0
1.668CysIle: 1.668 ± 1.578
1.668CysLys: 1.668 ± 0.821
2.335CysLeu: 2.335 ± 1.988
0.667CysMet: 0.667 ± 0.329
1.668CysAsn: 1.668 ± 0.821
0.667CysPro: 0.667 ± 0.329
1.668CysGln: 1.668 ± 0.627
1.334CysArg: 1.334 ± 0.657
1.668CysSer: 1.668 ± 0.627
2.001CysThr: 2.001 ± 1.254
1.334CysVal: 1.334 ± 0.637
0.0CysTrp: 0.0 ± 0.0
0.334CysTyr: 0.334 ± 0.164
0.0CysXaa: 0.0 ± 0.0
Asp
1.668AspAla: 1.668 ± 0.664
0.667AspCys: 0.667 ± 0.687
3.336AspAsp: 3.336 ± 1.643
3.002AspGlu: 3.002 ± 0.5
1.334AspPhe: 1.334 ± 0.605
3.002AspGly: 3.002 ± 0.88
1.668AspHis: 1.668 ± 0.821
3.336AspIle: 3.336 ± 1.254
2.335AspLys: 2.335 ± 0.688
9.34AspLeu: 9.34 ± 3.991
1.334AspMet: 1.334 ± 0.657
2.668AspAsn: 2.668 ± 1.029
3.002AspPro: 3.002 ± 1.894
1.334AspGln: 1.334 ± 0.87
2.668AspArg: 2.668 ± 1.314
3.336AspSer: 3.336 ± 0.844
0.667AspThr: 0.667 ± 0.329
2.668AspVal: 2.668 ± 0.832
0.667AspTrp: 0.667 ± 0.329
1.668AspTyr: 1.668 ± 0.786
0.0AspXaa: 0.0 ± 0.0
Glu
6.671GluAla: 6.671 ± 1.585
1.668GluCys: 1.668 ± 0.821
2.668GluAsp: 2.668 ± 0.895
6.004GluGlu: 6.004 ± 1.0
3.669GluPhe: 3.669 ± 0.518
4.003GluGly: 4.003 ± 0.549
1.668GluHis: 1.668 ± 0.445
2.668GluIle: 2.668 ± 0.832
3.669GluLys: 3.669 ± 1.211
5.67GluLeu: 5.67 ± 1.739
0.334GluMet: 0.334 ± 0.705
2.668GluAsn: 2.668 ± 0.832
2.335GluPro: 2.335 ± 1.437
2.001GluGln: 2.001 ± 0.556
2.001GluArg: 2.001 ± 1.326
5.003GluSer: 5.003 ± 0.558
2.335GluThr: 2.335 ± 0.821
6.671GluVal: 6.671 ± 1.78
0.334GluTrp: 0.334 ± 0.164
2.335GluTyr: 2.335 ± 1.988
0.0GluXaa: 0.0 ± 0.0
Phe
3.002PheAla: 3.002 ± 1.146
1.001PheCys: 1.001 ± 0.493
2.668PheAsp: 2.668 ± 0.832
6.338PheGlu: 6.338 ± 1.098
3.669PhePhe: 3.669 ± 0.993
3.002PheGly: 3.002 ± 2.134
1.668PheHis: 1.668 ± 0.821
4.67PheIle: 4.67 ± 1.404
3.669PheLys: 3.669 ± 1.293
6.338PheLeu: 6.338 ± 1.629
1.001PheMet: 1.001 ± 0.372
3.669PheAsn: 3.669 ± 1.301
3.336PhePro: 3.336 ± 1.989
2.335PheGln: 2.335 ± 0.434
2.001PheArg: 2.001 ± 0.986
6.004PheSer: 6.004 ± 1.583
2.668PheThr: 2.668 ± 0.722
1.334PheVal: 1.334 ± 0.605
0.334PheTrp: 0.334 ± 0.164
2.001PheTyr: 2.001 ± 0.556
0.0PheXaa: 0.0 ± 0.0
Gly
4.003GlyAla: 4.003 ± 0.864
2.668GlyCys: 2.668 ± 0.613
4.003GlyAsp: 4.003 ± 1.064
4.67GlyGlu: 4.67 ± 0.569
5.337GlyPhe: 5.337 ± 0.877
3.002GlyGly: 3.002 ± 0.88
0.667GlyHis: 0.667 ± 0.329
4.003GlyIle: 4.003 ± 0.864
5.337GlyLys: 5.337 ± 0.987
6.004GlyLeu: 6.004 ± 1.832
1.668GlyMet: 1.668 ± 1.683
3.669GlyAsn: 3.669 ± 2.576
1.668GlyPro: 1.668 ± 1.252
2.001GlyGln: 2.001 ± 0.489
4.336GlyArg: 4.336 ± 1.016
3.336GlySer: 3.336 ± 0.549
3.669GlyThr: 3.669 ± 2.075
5.003GlyVal: 5.003 ± 2.424
0.667GlyTrp: 0.667 ± 0.329
1.334GlyTyr: 1.334 ± 0.605
0.0GlyXaa: 0.0 ± 0.0
His
0.667HisAla: 0.667 ± 0.687
0.334HisCys: 0.334 ± 0.543
2.335HisAsp: 2.335 ± 0.688
1.668HisGlu: 1.668 ± 0.925
1.668HisPhe: 1.668 ± 0.627
3.336HisGly: 3.336 ± 1.216
0.667HisHis: 0.667 ± 0.329
1.334HisIle: 1.334 ± 0.657
1.668HisLys: 1.668 ± 0.627
2.668HisLeu: 2.668 ± 1.314
0.334HisMet: 0.334 ± 0.164
2.001HisAsn: 2.001 ± 0.856
1.001HisPro: 1.001 ± 0.652
1.334HisGln: 1.334 ± 0.376
1.001HisArg: 1.001 ± 0.845
3.336HisSer: 3.336 ± 1.158
0.334HisThr: 0.334 ± 0.164
1.668HisVal: 1.668 ± 0.445
0.0HisTrp: 0.0 ± 0.0
1.001HisTyr: 1.001 ± 0.493
0.0HisXaa: 0.0 ± 0.0
Ile
3.002IleAla: 3.002 ± 0.892
1.668IleCys: 1.668 ± 0.925
3.669IleAsp: 3.669 ± 1.293
4.003IleGlu: 4.003 ± 1.107
4.67IlePhe: 4.67 ± 1.234
3.002IleGly: 3.002 ± 1.819
1.668IleHis: 1.668 ± 1.637
3.336IleIle: 3.336 ± 1.472
4.336IleLys: 4.336 ± 1.016
5.67IleLeu: 5.67 ± 2.222
1.668IleMet: 1.668 ± 0.821
2.668IleAsn: 2.668 ± 1.314
2.668IlePro: 2.668 ± 1.029
3.002IleGln: 3.002 ± 1.115
3.002IleArg: 3.002 ± 1.656
4.336IleSer: 4.336 ± 1.709
4.67IleThr: 4.67 ± 1.037
4.336IleVal: 4.336 ± 2.785
0.0IleTrp: 0.0 ± 0.0
2.001IleTyr: 2.001 ± 0.739
0.0IleXaa: 0.0 ± 0.0
Lys
2.668LysAla: 2.668 ± 1.209
2.001LysCys: 2.001 ± 0.986
3.669LysAsp: 3.669 ± 1.409
3.669LysGlu: 3.669 ± 0.993
6.004LysPhe: 6.004 ± 2.418
4.003LysGly: 4.003 ± 1.482
0.667LysHis: 0.667 ± 0.435
4.67LysIle: 4.67 ± 1.248
4.336LysLys: 4.336 ± 1.599
5.003LysLeu: 5.003 ± 1.672
2.668LysMet: 2.668 ± 0.827
2.335LysAsn: 2.335 ± 0.781
4.003LysPro: 4.003 ± 0.644
2.001LysGln: 2.001 ± 1.868
2.668LysArg: 2.668 ± 1.029
4.67LysSer: 4.67 ± 0.949
3.669LysThr: 3.669 ± 1.307
3.002LysVal: 3.002 ± 1.478
0.667LysTrp: 0.667 ± 1.243
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
6.671LeuAla: 6.671 ± 1.875
2.001LeuCys: 2.001 ± 0.986
5.337LeuAsp: 5.337 ± 1.471
4.67LeuGlu: 4.67 ± 0.869
6.004LeuPhe: 6.004 ± 1.583
7.005LeuGly: 7.005 ± 1.09
2.668LeuHis: 2.668 ± 0.832
6.671LeuIle: 6.671 ± 1.867
9.34LeuLys: 9.34 ± 2.428
5.67LeuLeu: 5.67 ± 2.858
0.667LeuMet: 0.667 ± 0.706
4.67LeuAsn: 4.67 ± 1.753
5.003LeuPro: 5.003 ± 1.22
2.335LeuGln: 2.335 ± 0.821
4.336LeuArg: 4.336 ± 0.91
10.007LeuSer: 10.007 ± 2.868
5.003LeuThr: 5.003 ± 0.379
6.338LeuVal: 6.338 ± 2.768
0.667LeuTrp: 0.667 ± 0.329
1.334LeuTyr: 1.334 ± 0.657
0.0LeuXaa: 0.0 ± 0.0
Met
2.335MetAla: 2.335 ± 0.729
0.667MetCys: 0.667 ± 0.329
0.0MetAsp: 0.0 ± 0.0
1.668MetGlu: 1.668 ± 0.586
0.334MetPhe: 0.334 ± 0.791
2.001MetGly: 2.001 ± 0.743
0.667MetHis: 0.667 ± 0.329
0.667MetIle: 0.667 ± 0.329
2.001MetLys: 2.001 ± 0.986
1.668MetLeu: 1.668 ± 0.445
0.667MetMet: 0.667 ± 0.329
1.001MetAsn: 1.001 ± 0.928
1.668MetPro: 1.668 ± 1.252
0.0MetGln: 0.0 ± 0.0
2.335MetArg: 2.335 ± 0.688
0.334MetSer: 0.334 ± 0.164
0.334MetThr: 0.334 ± 0.164
1.668MetVal: 1.668 ± 0.792
0.0MetTrp: 0.0 ± 0.0
0.334MetTyr: 0.334 ± 0.543
0.0MetXaa: 0.0 ± 0.0
Asn
2.001AsnAla: 2.001 ± 0.743
2.335AsnCys: 2.335 ± 0.781
0.667AsnAsp: 0.667 ± 0.329
2.001AsnGlu: 2.001 ± 0.489
2.668AsnPhe: 2.668 ± 0.701
3.336AsnGly: 3.336 ± 0.89
2.335AsnHis: 2.335 ± 1.22
3.669AsnIle: 3.669 ± 2.813
1.001AsnLys: 1.001 ± 0.493
4.67AsnLeu: 4.67 ± 1.321
1.334AsnMet: 1.334 ± 0.611
0.334AsnAsn: 0.334 ± 0.164
2.668AsnPro: 2.668 ± 1.159
1.001AsnGln: 1.001 ± 0.626
2.335AsnArg: 2.335 ± 0.712
3.336AsnSer: 3.336 ± 0.748
1.334AsnThr: 1.334 ± 0.657
2.668AsnVal: 2.668 ± 1.314
0.667AsnTrp: 0.667 ± 0.435
1.334AsnTyr: 1.334 ± 0.761
0.0AsnXaa: 0.0 ± 0.0
Pro
2.001ProAla: 2.001 ± 1.135
2.668ProCys: 2.668 ± 0.895
3.002ProAsp: 3.002 ± 0.831
3.336ProGlu: 3.336 ± 1.01
1.668ProPhe: 1.668 ± 1.252
2.335ProGly: 2.335 ± 0.861
1.001ProHis: 1.001 ± 0.771
3.002ProIle: 3.002 ± 0.5
1.334ProLys: 1.334 ± 0.887
4.336ProLeu: 4.336 ± 1.708
0.667ProMet: 0.667 ± 1.085
1.668ProAsn: 1.668 ± 1.402
2.668ProPro: 2.668 ± 0.944
2.335ProGln: 2.335 ± 1.589
1.668ProArg: 1.668 ± 0.445
3.336ProSer: 3.336 ± 1.271
3.002ProThr: 3.002 ± 0.807
3.669ProVal: 3.669 ± 1.745
1.001ProTrp: 1.001 ± 0.493
1.668ProTyr: 1.668 ± 1.211
0.0ProXaa: 0.0 ± 0.0
Gln
2.668GlnAla: 2.668 ± 1.303
0.667GlnCys: 0.667 ± 0.706
1.668GlnAsp: 1.668 ± 1.142
2.335GlnGlu: 2.335 ± 0.688
1.334GlnPhe: 1.334 ± 0.657
2.335GlnGly: 2.335 ± 1.551
1.334GlnHis: 1.334 ± 0.376
0.667GlnIle: 0.667 ± 0.329
2.001GlnLys: 2.001 ± 0.639
3.002GlnLeu: 3.002 ± 1.494
2.001GlnMet: 2.001 ± 1.305
0.667GlnAsn: 0.667 ± 0.687
0.667GlnPro: 0.667 ± 0.815
1.668GlnGln: 1.668 ± 1.215
2.001GlnArg: 2.001 ± 0.954
3.336GlnSer: 3.336 ± 2.175
2.335GlnThr: 2.335 ± 2.089
2.668GlnVal: 2.668 ± 0.735
0.667GlnTrp: 0.667 ± 0.329
0.334GlnTyr: 0.334 ± 0.543
0.0GlnXaa: 0.0 ± 0.0
Arg
3.669ArgAla: 3.669 ± 0.957
0.667ArgCys: 0.667 ± 1.243
1.001ArgAsp: 1.001 ± 0.493
3.002ArgGlu: 3.002 ± 1.478
4.003ArgPhe: 4.003 ± 1.449
3.669ArgGly: 3.669 ± 1.821
2.668ArgHis: 2.668 ± 0.439
3.669ArgIle: 3.669 ± 0.837
3.336ArgLys: 3.336 ± 0.601
4.336ArgLeu: 4.336 ± 1.463
0.334ArgMet: 0.334 ± 0.164
1.668ArgAsn: 1.668 ± 0.627
1.668ArgPro: 1.668 ± 0.445
1.334ArgGln: 1.334 ± 1.243
4.336ArgArg: 4.336 ± 1.091
3.336ArgSer: 3.336 ± 1.436
2.335ArgThr: 2.335 ± 0.434
1.334ArgVal: 1.334 ± 0.376
1.001ArgTrp: 1.001 ± 0.493
2.335ArgTyr: 2.335 ± 0.688
0.0ArgXaa: 0.0 ± 0.0
Ser
4.003SerAla: 4.003 ± 1.097
1.334SerCys: 1.334 ± 0.657
4.336SerAsp: 4.336 ± 1.283
4.003SerGlu: 4.003 ± 0.864
4.003SerPhe: 4.003 ± 1.55
7.338SerGly: 7.338 ± 1.361
2.668SerHis: 2.668 ± 0.807
7.005SerIle: 7.005 ± 1.44
4.67SerLys: 4.67 ± 0.687
5.003SerLeu: 5.003 ± 0.379
2.335SerMet: 2.335 ± 0.729
2.335SerAsn: 2.335 ± 1.223
5.003SerPro: 5.003 ± 0.738
3.669SerGln: 3.669 ± 2.157
4.336SerArg: 4.336 ± 1.695
6.004SerSer: 6.004 ± 3.011
5.003SerThr: 5.003 ± 1.361
5.003SerVal: 5.003 ± 2.376
0.0SerTrp: 0.0 ± 0.0
2.335SerTyr: 2.335 ± 0.926
0.0SerXaa: 0.0 ± 0.0
Thr
3.002ThrAla: 3.002 ± 1.365
0.0ThrCys: 0.0 ± 0.0
1.668ThrAsp: 1.668 ± 0.821
2.668ThrGlu: 2.668 ± 1.159
6.004ThrPhe: 6.004 ± 1.0
4.67ThrGly: 4.67 ± 0.569
1.334ThrHis: 1.334 ± 0.657
1.334ThrIle: 1.334 ± 0.637
3.002ThrLys: 3.002 ± 0.628
6.671ThrLeu: 6.671 ± 1.965
0.667ThrMet: 0.667 ± 0.329
2.335ThrAsn: 2.335 ± 0.434
1.668ThrPro: 1.668 ± 1.252
1.334ThrGln: 1.334 ± 1.51
3.336ThrArg: 3.336 ± 0.549
3.002ThrSer: 3.002 ± 2.601
2.001ThrThr: 2.001 ± 0.689
3.336ThrVal: 3.336 ± 1.842
1.001ThrTrp: 1.001 ± 0.493
1.334ThrTyr: 1.334 ± 1.374
0.0ThrXaa: 0.0 ± 0.0
Val
5.003ValAla: 5.003 ± 3.973
1.001ValCys: 1.001 ± 0.493
4.336ValAsp: 4.336 ± 1.599
4.67ValGlu: 4.67 ± 2.347
2.335ValPhe: 2.335 ± 0.926
5.67ValGly: 5.67 ± 3.436
2.001ValHis: 2.001 ± 0.689
2.668ValIle: 2.668 ± 0.832
2.001ValLys: 2.001 ± 0.728
7.005ValLeu: 7.005 ± 1.095
0.667ValMet: 0.667 ± 0.329
2.335ValAsn: 2.335 ± 0.729
2.668ValPro: 2.668 ± 1.209
2.668ValGln: 2.668 ± 0.439
2.335ValArg: 2.335 ± 0.781
7.005ValSer: 7.005 ± 1.024
4.336ValThr: 4.336 ± 2.454
5.003ValVal: 5.003 ± 0.738
0.334ValTrp: 0.334 ± 0.543
0.667ValTyr: 0.667 ± 1.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.334TrpAla: 0.334 ± 0.164
0.334TrpCys: 0.334 ± 0.164
0.667TrpAsp: 0.667 ± 0.329
0.0TrpGlu: 0.0 ± 0.0
0.667TrpPhe: 0.667 ± 0.329
0.667TrpGly: 0.667 ± 0.329
0.667TrpHis: 0.667 ± 0.687
0.334TrpIle: 0.334 ± 0.164
1.001TrpLys: 1.001 ± 0.493
0.667TrpLeu: 0.667 ± 0.329
0.0TrpMet: 0.0 ± 0.0
0.334TrpAsn: 0.334 ± 0.543
0.667TrpPro: 0.667 ± 0.329
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.334TrpSer: 0.334 ± 0.887
0.667TrpThr: 0.667 ± 0.329
1.001TrpVal: 1.001 ± 0.372
0.334TrpTrp: 0.334 ± 0.164
0.334TrpTyr: 0.334 ± 0.164
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.001TyrAla: 2.001 ± 1.305
0.667TyrCys: 0.667 ± 1.115
2.001TyrAsp: 2.001 ± 0.689
1.668TyrGlu: 1.668 ± 0.445
0.667TyrPhe: 0.667 ± 0.329
1.334TyrGly: 1.334 ± 0.657
0.334TyrHis: 0.334 ± 0.791
2.001TyrIle: 2.001 ± 0.689
1.001TyrLys: 1.001 ± 0.626
4.003TyrLeu: 4.003 ± 0.644
0.334TyrMet: 0.334 ± 0.164
1.001TyrAsn: 1.001 ± 0.626
0.667TyrPro: 0.667 ± 0.435
0.667TyrGln: 0.667 ± 1.243
1.334TyrArg: 1.334 ± 0.376
2.668TyrSer: 2.668 ± 1.402
1.668TyrThr: 1.668 ± 0.821
0.334TyrVal: 0.334 ± 0.887
0.334TyrTrp: 0.334 ± 0.164
0.334TyrTyr: 0.334 ± 0.791
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2999 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski