Amino acid dipepetide frequency for Marinomonas piezotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.017AlaAla: 8.017 ± 0.1	0.942AlaCys: 0.942 ± 0.03	4.667AlaAsp: 4.667 ± 0.067	5.449AlaGlu: 5.449 ± 0.085	3.521AlaPhe: 3.521 ± 0.052	6.153AlaGly: 6.153 ± 0.09	1.838AlaHis: 1.838 ± 0.041	5.824AlaIle: 5.824 ± 0.075	4.649AlaLys: 4.649 ± 0.067	10.354AlaLeu: 10.354 ± 0.112	2.719AlaMet: 2.719 ± 0.05	3.479AlaAsn: 3.479 ± 0.06	3.246AlaPro: 3.246 ± 0.06	3.92AlaGln: 3.92 ± 0.073	4.008AlaArg: 4.008 ± 0.059	5.644AlaSer: 5.644 ± 0.067	4.666AlaThr: 4.666 ± 0.074	6.042AlaVal: 6.042 ± 0.074	1.041AlaTrp: 1.041 ± 0.032	2.425AlaTyr: 2.425 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.793CysAla: 0.793 ± 0.027	0.157CysCys: 0.157 ± 0.011	0.661CysAsp: 0.661 ± 0.024	0.6CysGlu: 0.6 ± 0.024	0.462CysPhe: 0.462 ± 0.022	0.837CysGly: 0.837 ± 0.022	0.322CysHis: 0.322 ± 0.016	0.597CysIle: 0.597 ± 0.024	0.357CysLys: 0.357 ± 0.017	1.069CysLeu: 1.069 ± 0.031	0.214CysMet: 0.214 ± 0.013	0.345CysAsn: 0.345 ± 0.018	0.431CysPro: 0.431 ± 0.02	0.433CysGln: 0.433 ± 0.023	0.531CysArg: 0.531 ± 0.02	0.703CysSer: 0.703 ± 0.024	0.43CysThr: 0.43 ± 0.019	0.72CysVal: 0.72 ± 0.023	0.155CysTrp: 0.155 ± 0.01	0.361CysTyr: 0.361 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.892AspAla: 4.892 ± 0.075	0.532AspCys: 0.532 ± 0.02	3.188AspAsp: 3.188 ± 0.046	3.976AspGlu: 3.976 ± 0.057	2.338AspPhe: 2.338 ± 0.042	3.831AspGly: 3.831 ± 0.065	1.332AspHis: 1.332 ± 0.038	4.02AspIle: 4.02 ± 0.063	2.684AspLys: 2.684 ± 0.049	5.652AspLeu: 5.652 ± 0.066	1.476AspMet: 1.476 ± 0.035	2.078AspAsn: 2.078 ± 0.042	2.212AspPro: 2.212 ± 0.049	2.573AspGln: 2.573 ± 0.054	2.717AspArg: 2.717 ± 0.05	3.426AspSer: 3.426 ± 0.057	2.988AspThr: 2.988 ± 0.061	4.302AspVal: 4.302 ± 0.07	0.918AspTrp: 0.918 ± 0.027	1.961AspTyr: 1.961 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.858GluAla: 5.858 ± 0.078	0.562GluCys: 0.562 ± 0.025	3.165GluAsp: 3.165 ± 0.052	4.161GluGlu: 4.161 ± 0.075	2.471GluPhe: 2.471 ± 0.047	3.828GluGly: 3.828 ± 0.058	1.739GluHis: 1.739 ± 0.043	3.693GluIle: 3.693 ± 0.061	3.357GluLys: 3.357 ± 0.058	6.933GluLeu: 6.933 ± 0.081	1.593GluMet: 1.593 ± 0.038	2.367GluAsn: 2.367 ± 0.042	2.129GluPro: 2.129 ± 0.058	3.746GluGln: 3.746 ± 0.063	3.838GluArg: 3.838 ± 0.067	3.958GluSer: 3.958 ± 0.067	3.18GluThr: 3.18 ± 0.052	4.307GluVal: 4.307 ± 0.061	0.839GluTrp: 0.839 ± 0.027	1.788GluTyr: 1.788 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.491PheAla: 3.491 ± 0.06	0.51PheCys: 0.51 ± 0.022	2.855PheAsp: 2.855 ± 0.057	2.57PheGlu: 2.57 ± 0.042	1.711PhePhe: 1.711 ± 0.043	3.231PheGly: 3.231 ± 0.06	0.836PheHis: 0.836 ± 0.024	2.635PheIle: 2.635 ± 0.052	1.832PheLys: 1.832 ± 0.036	3.486PheLeu: 3.486 ± 0.06	0.997PheMet: 0.997 ± 0.027	1.782PheAsn: 1.782 ± 0.04	1.481PhePro: 1.481 ± 0.037	1.341PheGln: 1.341 ± 0.034	1.645PheArg: 1.645 ± 0.041	3.246PheSer: 3.246 ± 0.059	2.167PheThr: 2.167 ± 0.036	2.84PheVal: 2.84 ± 0.054	0.526PheTrp: 0.526 ± 0.022	1.318PheTyr: 1.318 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.743GlyAla: 5.743 ± 0.076	0.839GlyCys: 0.839 ± 0.026	3.703GlyAsp: 3.703 ± 0.06	4.152GlyGlu: 4.152 ± 0.065	3.205GlyPhe: 3.205 ± 0.055	4.885GlyGly: 4.885 ± 0.084	1.628GlyHis: 1.628 ± 0.037	4.613GlyIle: 4.613 ± 0.069	3.558GlyLys: 3.558 ± 0.065	7.125GlyLeu: 7.125 ± 0.089	2.092GlyMet: 2.092 ± 0.045	2.385GlyAsn: 2.385 ± 0.046	1.859GlyPro: 1.859 ± 0.052	2.887GlyGln: 2.887 ± 0.052	3.413GlyArg: 3.413 ± 0.052	4.212GlySer: 4.212 ± 0.062	3.388GlyThr: 3.388 ± 0.058	5.582GlyVal: 5.582 ± 0.078	1.003GlyTrp: 1.003 ± 0.03	2.448GlyTyr: 2.448 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.761HisAla: 1.761 ± 0.035	0.303HisCys: 0.303 ± 0.016	1.262HisAsp: 1.262 ± 0.041	1.226HisGlu: 1.226 ± 0.036	1.169HisPhe: 1.169 ± 0.031	1.559HisGly: 1.559 ± 0.037	0.714HisHis: 0.714 ± 0.029	1.462HisIle: 1.462 ± 0.031	1.034HisLys: 1.034 ± 0.032	2.333HisLeu: 2.333 ± 0.05	0.549HisMet: 0.549 ± 0.02	0.869HisAsn: 0.869 ± 0.029	1.244HisPro: 1.244 ± 0.035	1.088HisGln: 1.088 ± 0.031	1.173HisArg: 1.173 ± 0.034	1.472HisSer: 1.472 ± 0.037	1.141HisThr: 1.141 ± 0.031	1.364HisVal: 1.364 ± 0.028	0.34HisTrp: 0.34 ± 0.018	0.876HisTyr: 0.876 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.22IleAla: 6.22 ± 0.087	0.661IleCys: 0.661 ± 0.025	4.16IleAsp: 4.16 ± 0.065	4.535IleGlu: 4.535 ± 0.057	2.142IlePhe: 2.142 ± 0.048	4.637IleGly: 4.637 ± 0.066	1.283IleHis: 1.283 ± 0.035	3.378IleIle: 3.378 ± 0.053	3.021IleLys: 3.021 ± 0.052	5.32IleLeu: 5.32 ± 0.076	1.39IleMet: 1.39 ± 0.038	2.64IleAsn: 2.64 ± 0.049	2.671IlePro: 2.671 ± 0.047	2.312IleGln: 2.312 ± 0.042	3.15IleArg: 3.15 ± 0.056	4.399IleSer: 4.399 ± 0.064	3.46IleThr: 3.46 ± 0.059	4.245IleVal: 4.245 ± 0.058	0.698IleTrp: 0.698 ± 0.024	1.558IleTyr: 1.558 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.657LysAla: 4.657 ± 0.078	0.326LysCys: 0.326 ± 0.015	2.71LysAsp: 2.71 ± 0.045	3.413LysGlu: 3.413 ± 0.051	1.357LysPhe: 1.357 ± 0.035	3.231LysGly: 3.231 ± 0.053	1.269LysHis: 1.269 ± 0.031	2.585LysIle: 2.585 ± 0.047	2.596LysLys: 2.596 ± 0.064	4.608LysLeu: 4.608 ± 0.067	1.275LysMet: 1.275 ± 0.035	1.796LysAsn: 1.796 ± 0.037	2.161LysPro: 2.161 ± 0.045	2.618LysGln: 2.618 ± 0.05	2.93LysArg: 2.93 ± 0.052	3.025LysSer: 3.025 ± 0.055	2.648LysThr: 2.648 ± 0.048	3.634LysVal: 3.634 ± 0.057	0.59LysTrp: 0.59 ± 0.025	1.217LysTyr: 1.217 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.855LeuAla: 9.855 ± 0.102	1.073LeuCys: 1.073 ± 0.027	6.174LeuAsp: 6.174 ± 0.065	6.501LeuGlu: 6.501 ± 0.085	4.05LeuPhe: 4.05 ± 0.062	7.148LeuGly: 7.148 ± 0.088	2.033LeuHis: 2.033 ± 0.04	6.238LeuIle: 6.238 ± 0.091	5.289LeuLys: 5.289 ± 0.074	10.295LeuLeu: 10.295 ± 0.126	2.728LeuMet: 2.728 ± 0.052	4.365LeuAsn: 4.365 ± 0.072	4.766LeuPro: 4.766 ± 0.062	3.761LeuGln: 3.761 ± 0.063	4.728LeuArg: 4.728 ± 0.069	8.148LeuSer: 8.148 ± 0.097	5.891LeuThr: 5.891 ± 0.083	7.188LeuVal: 7.188 ± 0.095	1.112LeuTrp: 1.112 ± 0.035	2.67LeuTyr: 2.67 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.584MetAla: 2.584 ± 0.047	0.209MetCys: 0.209 ± 0.013	1.324MetAsp: 1.324 ± 0.033	1.283MetGlu: 1.283 ± 0.032	0.878MetPhe: 0.878 ± 0.029	1.852MetGly: 1.852 ± 0.044	0.525MetHis: 0.525 ± 0.023	1.589MetIle: 1.589 ± 0.036	1.354MetLys: 1.354 ± 0.037	2.718MetLeu: 2.718 ± 0.052	0.739MetMet: 0.739 ± 0.03	1.062MetAsn: 1.062 ± 0.03	1.261MetPro: 1.261 ± 0.032	1.038MetGln: 1.038 ± 0.032	1.308MetArg: 1.308 ± 0.033	2.236MetSer: 2.236 ± 0.039	1.7MetThr: 1.7 ± 0.043	1.727MetVal: 1.727 ± 0.039	0.229MetTrp: 0.229 ± 0.015	0.561MetTyr: 0.561 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.506AsnAla: 3.506 ± 0.05	0.349AsnCys: 0.349 ± 0.018	2.374AsnAsp: 2.374 ± 0.05	2.45AsnGlu: 2.45 ± 0.05	1.386AsnPhe: 1.386 ± 0.032	2.783AsnGly: 2.783 ± 0.05	0.899AsnHis: 0.899 ± 0.026	2.472AsnIle: 2.472 ± 0.041	1.807AsnLys: 1.807 ± 0.045	3.748AsnLeu: 3.748 ± 0.056	0.976AsnMet: 0.976 ± 0.028	1.562AsnAsn: 1.562 ± 0.039	1.873AsnPro: 1.873 ± 0.037	1.85AsnGln: 1.85 ± 0.039	2.009AsnArg: 2.009 ± 0.049	2.359AsnSer: 2.359 ± 0.054	2.302AsnThr: 2.302 ± 0.047	2.655AsnVal: 2.655 ± 0.046	0.544AsnTrp: 0.544 ± 0.019	1.148AsnTyr: 1.148 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.137ProAla: 3.137 ± 0.059	0.32ProCys: 0.32 ± 0.016	2.539ProAsp: 2.539 ± 0.046	3.251ProGlu: 3.251 ± 0.057	1.82ProPhe: 1.82 ± 0.038	2.248ProGly: 2.248 ± 0.045	0.891ProHis: 0.891 ± 0.03	2.665ProIle: 2.665 ± 0.046	2.146ProLys: 2.146 ± 0.044	4.055ProLeu: 4.055 ± 0.065	1.073ProMet: 1.073 ± 0.032	1.93ProAsn: 1.93 ± 0.045	1.274ProPro: 1.274 ± 0.031	1.398ProGln: 1.398 ± 0.035	1.464ProArg: 1.464 ± 0.034	2.826ProSer: 2.826 ± 0.052	2.349ProThr: 2.349 ± 0.047	2.943ProVal: 2.943 ± 0.057	0.54ProTrp: 0.54 ± 0.023	1.358ProTyr: 1.358 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.333GlnAla: 4.333 ± 0.068	0.4GlnCys: 0.4 ± 0.02	2.09GlnAsp: 2.09 ± 0.044	2.48GlnGlu: 2.48 ± 0.047	1.63GlnPhe: 1.63 ± 0.036	2.865GlnGly: 2.865 ± 0.05	1.136GlnHis: 1.136 ± 0.037	2.399GlnIle: 2.399 ± 0.051	2.054GlnLys: 2.054 ± 0.045	4.822GlnLeu: 4.822 ± 0.079	1.039GlnMet: 1.039 ± 0.032	1.571GlnAsn: 1.571 ± 0.038	1.664GlnPro: 1.664 ± 0.039	2.599GlnGln: 2.599 ± 0.06	2.517GlnArg: 2.517 ± 0.055	2.945GlnSer: 2.945 ± 0.054	2.408GlnThr: 2.408 ± 0.054	3.007GlnVal: 3.007 ± 0.059	0.61GlnTrp: 0.61 ± 0.022	1.347GlnTyr: 1.347 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.9ArgAla: 3.9 ± 0.065	0.505ArgCys: 0.505 ± 0.018	2.634ArgAsp: 2.634 ± 0.052	3.142ArgGlu: 3.142 ± 0.059	2.397ArgPhe: 2.397 ± 0.045	2.785ArgGly: 2.785 ± 0.05	1.267ArgHis: 1.267 ± 0.029	3.294ArgIle: 3.294 ± 0.052	2.405ArgLys: 2.405 ± 0.042	5.516ArgLeu: 5.516 ± 0.073	1.396ArgMet: 1.396 ± 0.035	1.923ArgAsn: 1.923 ± 0.041	1.873ArgPro: 1.873 ± 0.041	2.319ArgGln: 2.319 ± 0.048	2.695ArgArg: 2.695 ± 0.065	3.068ArgSer: 3.068 ± 0.053	2.293ArgThr: 2.293 ± 0.047	3.43ArgVal: 3.43 ± 0.054	0.712ArgTrp: 0.712 ± 0.027	1.905ArgTyr: 1.905 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.724SerAla: 5.724 ± 0.071	0.599SerCys: 0.599 ± 0.024	4.159SerAsp: 4.159 ± 0.066	4.304SerGlu: 4.304 ± 0.063	2.83SerPhe: 2.83 ± 0.055	4.971SerGly: 4.971 ± 0.064	1.571SerHis: 1.571 ± 0.035	4.322SerIle: 4.322 ± 0.064	3.21SerLys: 3.21 ± 0.055	7.267SerLeu: 7.267 ± 0.075	1.803SerMet: 1.803 ± 0.038	2.779SerAsn: 2.779 ± 0.055	2.563SerPro: 2.563 ± 0.044	2.846SerGln: 2.846 ± 0.052	3.097SerArg: 3.097 ± 0.059	4.809SerSer: 4.809 ± 0.087	3.414SerThr: 3.414 ± 0.065	4.934SerVal: 4.934 ± 0.065	0.813SerTrp: 0.813 ± 0.026	1.979SerTyr: 1.979 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.317ThrAla: 4.317 ± 0.063	0.501ThrCys: 0.501 ± 0.02	2.932ThrAsp: 2.932 ± 0.063	3.024ThrGlu: 3.024 ± 0.048	2.192ThrPhe: 2.192 ± 0.045	4.013ThrGly: 4.013 ± 0.063	1.252ThrHis: 1.252 ± 0.034	3.231ThrIle: 3.231 ± 0.05	2.27ThrLys: 2.27 ± 0.044	6.454ThrLeu: 6.454 ± 0.081	1.185ThrMet: 1.185 ± 0.031	1.961ThrAsn: 1.961 ± 0.05	2.932ThrPro: 2.932 ± 0.056	2.377ThrGln: 2.377 ± 0.046	2.311ThrArg: 2.311 ± 0.045	3.454ThrSer: 3.454 ± 0.059	3.044ThrThr: 3.044 ± 0.065	3.853ThrVal: 3.853 ± 0.079	0.631ThrTrp: 0.631 ± 0.027	1.535ThrTyr: 1.535 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	6.617ValAla: 6.617 ± 0.085	0.859ValCys: 0.859 ± 0.029	4.169ValAsp: 4.169 ± 0.075	4.654ValGlu: 4.654 ± 0.068	2.953ValPhe: 2.953 ± 0.054	4.913ValGly: 4.913 ± 0.077	1.273ValHis: 1.273 ± 0.034	4.565ValIle: 4.565 ± 0.064	3.319ValLys: 3.319 ± 0.056	7.164ValLeu: 7.164 ± 0.084	1.979ValMet: 1.979 ± 0.042	2.736ValAsn: 2.736 ± 0.053	2.751ValPro: 2.751 ± 0.045	2.287ValGln: 2.287 ± 0.045	3.34ValArg: 3.34 ± 0.052	5.287ValSer: 5.287 ± 0.077	4.05ValThr: 4.05 ± 0.068	5.548ValVal: 5.548 ± 0.066	0.812ValTrp: 0.812 ± 0.03	1.9ValTyr: 1.9 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.869TrpAla: 0.869 ± 0.028	0.166TrpCys: 0.166 ± 0.011	0.606TrpAsp: 0.606 ± 0.024	0.592TrpGlu: 0.592 ± 0.022	0.594TrpPhe: 0.594 ± 0.024	0.83TrpGly: 0.83 ± 0.027	0.386TrpHis: 0.386 ± 0.02	0.707TrpIle: 0.707 ± 0.022	0.499TrpLys: 0.499 ± 0.02	1.831TrpLeu: 1.831 ± 0.043	0.342TrpMet: 0.342 ± 0.019	0.431TrpAsn: 0.431 ± 0.02	0.508TrpPro: 0.508 ± 0.022	0.831TrpGln: 0.831 ± 0.03	0.789TrpArg: 0.789 ± 0.027	0.818TrpSer: 0.818 ± 0.027	0.513TrpThr: 0.513 ± 0.022	0.933TrpVal: 0.933 ± 0.025	0.196TrpTrp: 0.196 ± 0.012	0.349TrpTyr: 0.349 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.332TyrAla: 2.332 ± 0.043	0.367TyrCys: 0.367 ± 0.018	1.724TyrAsp: 1.724 ± 0.038	1.748TyrGlu: 1.748 ± 0.042	1.392TyrPhe: 1.392 ± 0.033	2.12TyrGly: 2.12 ± 0.045	0.746TyrHis: 0.746 ± 0.025	1.594TyrIle: 1.594 ± 0.039	1.206TyrLys: 1.206 ± 0.036	3.262TyrLeu: 3.262 ± 0.062	0.613TyrMet: 0.613 ± 0.025	0.989TyrAsn: 0.989 ± 0.029	1.329TyrPro: 1.329 ± 0.041	1.691TyrGln: 1.691 ± 0.041	1.796TyrArg: 1.796 ± 0.041	1.956TyrSer: 1.956 ± 0.047	1.436TyrThr: 1.436 ± 0.035	1.922TyrVal: 1.922 ± 0.038	0.482TyrTrp: 0.482 ± 0.02	0.941TyrTyr: 0.941 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3665 proteins (1196071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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