Amino acid dipepetide frequency for Falsibacillus pallidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.889AlaAla: 6.889 ± 0.098	0.547AlaCys: 0.547 ± 0.026	3.58AlaAsp: 3.58 ± 0.064	4.948AlaGlu: 4.948 ± 0.072	3.401AlaPhe: 3.401 ± 0.059	5.647AlaGly: 5.647 ± 0.081	1.295AlaHis: 1.295 ± 0.034	5.508AlaIle: 5.508 ± 0.075	4.977AlaLys: 4.977 ± 0.083	6.934AlaLeu: 6.934 ± 0.081	2.128AlaMet: 2.128 ± 0.045	2.559AlaAsn: 2.559 ± 0.049	2.226AlaPro: 2.226 ± 0.059	2.072AlaGln: 2.072 ± 0.049	2.538AlaArg: 2.538 ± 0.053	4.344AlaSer: 4.344 ± 0.065	2.768AlaThr: 2.768 ± 0.053	5.609AlaVal: 5.609 ± 0.077	0.589AlaTrp: 0.589 ± 0.026	2.214AlaTyr: 2.214 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.466CysAla: 0.466 ± 0.024	0.107CysCys: 0.107 ± 0.01	0.382CysAsp: 0.382 ± 0.022	0.474CysGlu: 0.474 ± 0.019	0.328CysPhe: 0.328 ± 0.018	0.648CysGly: 0.648 ± 0.023	0.201CysHis: 0.201 ± 0.015	0.54CysIle: 0.54 ± 0.022	0.368CysLys: 0.368 ± 0.021	0.662CysLeu: 0.662 ± 0.026	0.186CysMet: 0.186 ± 0.014	0.236CysAsn: 0.236 ± 0.017	0.401CysPro: 0.401 ± 0.02	0.241CysGln: 0.241 ± 0.015	0.321CysArg: 0.321 ± 0.019	0.582CysSer: 0.582 ± 0.023	0.398CysThr: 0.398 ± 0.021	0.402CysVal: 0.402 ± 0.021	0.073CysTrp: 0.073 ± 0.008	0.234CysTyr: 0.234 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.618AspAla: 3.618 ± 0.063	0.41AspCys: 0.41 ± 0.02	2.405AspAsp: 2.405 ± 0.053	4.402AspGlu: 4.402 ± 0.077	2.543AspPhe: 2.543 ± 0.054	3.6AspGly: 3.6 ± 0.057	1.215AspHis: 1.215 ± 0.037	4.011AspIle: 4.011 ± 0.056	3.193AspLys: 3.193 ± 0.06	5.058AspLeu: 5.058 ± 0.065	1.412AspMet: 1.412 ± 0.041	1.716AspAsn: 1.716 ± 0.045	2.101AspPro: 2.101 ± 0.042	2.155AspGln: 2.155 ± 0.046	2.246AspArg: 2.246 ± 0.047	2.954AspSer: 2.954 ± 0.053	2.278AspThr: 2.278 ± 0.047	3.599AspVal: 3.599 ± 0.059	0.693AspTrp: 0.693 ± 0.029	2.113AspTyr: 2.113 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.411GluAla: 5.411 ± 0.073	0.433GluCys: 0.433 ± 0.022	3.911GluAsp: 3.911 ± 0.065	7.096GluGlu: 7.096 ± 0.115	2.837GluPhe: 2.837 ± 0.039	4.577GluGly: 4.577 ± 0.068	1.456GluHis: 1.456 ± 0.034	5.638GluIle: 5.638 ± 0.084	7.166GluLys: 7.166 ± 0.096	7.138GluLeu: 7.138 ± 0.101	2.545GluMet: 2.545 ± 0.046	3.722GluAsn: 3.722 ± 0.066	1.946GluPro: 1.946 ± 0.048	2.913GluGln: 2.913 ± 0.06	3.396GluArg: 3.396 ± 0.068	3.767GluSer: 3.767 ± 0.066	3.478GluThr: 3.478 ± 0.064	4.726GluVal: 4.726 ± 0.076	0.921GluTrp: 0.921 ± 0.029	2.227GluTyr: 2.227 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.104PheAla: 3.104 ± 0.057	0.372PheCys: 0.372 ± 0.019	2.389PheAsp: 2.389 ± 0.046	2.939PheGlu: 2.939 ± 0.05	2.48PhePhe: 2.48 ± 0.053	3.34PheGly: 3.34 ± 0.067	1.2PheHis: 1.2 ± 0.035	3.967PheIle: 3.967 ± 0.076	2.691PheLys: 2.691 ± 0.052	4.751PheLeu: 4.751 ± 0.074	1.307PheMet: 1.307 ± 0.04	1.95PheAsn: 1.95 ± 0.045	1.749PhePro: 1.749 ± 0.043	1.767PheGln: 1.767 ± 0.044	1.656PheArg: 1.656 ± 0.044	3.625PheSer: 3.625 ± 0.063	2.519PheThr: 2.519 ± 0.053	2.942PheVal: 2.942 ± 0.055	0.523PheTrp: 0.523 ± 0.023	1.75PheTyr: 1.75 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.906GlyAla: 4.906 ± 0.075	0.625GlyCys: 0.625 ± 0.025	3.358GlyAsp: 3.358 ± 0.059	4.65GlyGlu: 4.65 ± 0.072	3.537GlyPhe: 3.537 ± 0.069	4.859GlyGly: 4.859 ± 0.084	1.443GlyHis: 1.443 ± 0.039	6.141GlyIle: 6.141 ± 0.086	5.544GlyLys: 5.544 ± 0.069	6.639GlyLeu: 6.639 ± 0.09	2.302GlyMet: 2.302 ± 0.045	2.69GlyAsn: 2.69 ± 0.052	1.85GlyPro: 1.85 ± 0.061	2.199GlyGln: 2.199 ± 0.049	2.707GlyArg: 2.707 ± 0.055	4.32GlySer: 4.32 ± 0.078	4.039GlyThr: 4.039 ± 0.079	4.849GlyVal: 4.849 ± 0.073	0.859GlyTrp: 0.859 ± 0.032	2.77GlyTyr: 2.77 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.314HisAla: 1.314 ± 0.03	0.207HisCys: 0.207 ± 0.013	1.061HisAsp: 1.061 ± 0.029	1.433HisGlu: 1.433 ± 0.037	1.181HisPhe: 1.181 ± 0.031	1.439HisGly: 1.439 ± 0.04	0.721HisHis: 0.721 ± 0.029	1.458HisIle: 1.458 ± 0.041	1.114HisLys: 1.114 ± 0.028	2.156HisLeu: 2.156 ± 0.046	0.532HisMet: 0.532 ± 0.022	0.749HisAsn: 0.749 ± 0.029	1.206HisPro: 1.206 ± 0.04	0.869HisGln: 0.869 ± 0.027	0.874HisArg: 0.874 ± 0.03	1.354HisSer: 1.354 ± 0.038	1.04HisThr: 1.04 ± 0.03	1.335HisVal: 1.335 ± 0.038	0.262HisTrp: 0.262 ± 0.016	0.922HisTyr: 0.922 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.699IleAla: 5.699 ± 0.077	0.671IleCys: 0.671 ± 0.027	4.128IleAsp: 4.128 ± 0.066	5.627IleGlu: 5.627 ± 0.08	3.502IlePhe: 3.502 ± 0.06	6.052IleGly: 6.052 ± 0.096	1.87IleHis: 1.87 ± 0.044	5.941IleIle: 5.941 ± 0.093	4.816IleLys: 4.816 ± 0.066	7.54IleLeu: 7.54 ± 0.092	1.954IleMet: 1.954 ± 0.04	3.113IleAsn: 3.113 ± 0.062	3.377IlePro: 3.377 ± 0.051	2.922IleGln: 2.922 ± 0.062	3.068IleArg: 3.068 ± 0.053	5.272IleSer: 5.272 ± 0.082	3.95IleThr: 3.95 ± 0.067	5.08IleVal: 5.08 ± 0.068	0.681IleTrp: 0.681 ± 0.026	2.495IleTyr: 2.495 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.995LysAla: 4.995 ± 0.074	0.371LysCys: 0.371 ± 0.019	4.396LysAsp: 4.396 ± 0.063	7.317LysGlu: 7.317 ± 0.098	2.117LysPhe: 2.117 ± 0.049	5.01LysGly: 5.01 ± 0.066	1.307LysHis: 1.307 ± 0.034	4.882LysIle: 4.882 ± 0.068	6.614LysLys: 6.614 ± 0.093	5.984LysLeu: 5.984 ± 0.075	2.543LysMet: 2.543 ± 0.048	3.669LysAsn: 3.669 ± 0.067	2.413LysPro: 2.413 ± 0.044	2.743LysGln: 2.743 ± 0.057	3.309LysArg: 3.309 ± 0.048	3.928LysSer: 3.928 ± 0.063	3.737LysThr: 3.737 ± 0.056	4.737LysVal: 4.737 ± 0.064	0.978LysTrp: 0.978 ± 0.034	2.181LysTyr: 2.181 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	7.22LeuAla: 7.22 ± 0.091	0.658LeuCys: 0.658 ± 0.026	4.854LeuAsp: 4.854 ± 0.073	6.52LeuGlu: 6.52 ± 0.088	5.025LeuPhe: 5.025 ± 0.091	6.292LeuGly: 6.292 ± 0.087	1.971LeuHis: 1.971 ± 0.048	7.332LeuIle: 7.332 ± 0.097	7.374LeuLys: 7.374 ± 0.078	10.08LeuLeu: 10.08 ± 0.121	2.77LeuMet: 2.77 ± 0.06	4.369LeuAsn: 4.369 ± 0.065	3.912LeuPro: 3.912 ± 0.069	3.401LeuGln: 3.401 ± 0.055	3.435LeuArg: 3.435 ± 0.064	6.945LeuSer: 6.945 ± 0.091	5.263LeuThr: 5.263 ± 0.067	5.806LeuVal: 5.806 ± 0.075	0.852LeuTrp: 0.852 ± 0.029	3.138LeuTyr: 3.138 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.257MetAla: 2.257 ± 0.045	0.172MetCys: 0.172 ± 0.013	1.746MetAsp: 1.746 ± 0.039	2.381MetGlu: 2.381 ± 0.047	1.067MetPhe: 1.067 ± 0.035	2.005MetGly: 2.005 ± 0.047	0.481MetHis: 0.481 ± 0.021	2.323MetIle: 2.323 ± 0.046	2.871MetLys: 2.871 ± 0.051	2.621MetLeu: 2.621 ± 0.048	1.005MetMet: 1.005 ± 0.037	1.826MetAsn: 1.826 ± 0.039	1.088MetPro: 1.088 ± 0.03	0.884MetGln: 0.884 ± 0.03	1.079MetArg: 1.079 ± 0.034	1.69MetSer: 1.69 ± 0.04	1.677MetThr: 1.677 ± 0.038	1.755MetVal: 1.755 ± 0.038	0.197MetTrp: 0.197 ± 0.012	0.706MetTyr: 0.706 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.789AsnAla: 2.789 ± 0.047	0.303AsnCys: 0.303 ± 0.019	2.15AsnAsp: 2.15 ± 0.05	3.583AsnGlu: 3.583 ± 0.062	1.504AsnPhe: 1.504 ± 0.037	3.721AsnGly: 3.721 ± 0.076	1.07AsnHis: 1.07 ± 0.03	3.09AsnIle: 3.09 ± 0.056	2.794AsnLys: 2.794 ± 0.051	3.806AsnLeu: 3.806 ± 0.063	1.217AsnMet: 1.217 ± 0.035	1.672AsnAsn: 1.672 ± 0.045	2.175AsnPro: 2.175 ± 0.041	1.867AsnGln: 1.867 ± 0.043	1.942AsnArg: 1.942 ± 0.035	2.318AsnSer: 2.318 ± 0.05	1.957AsnThr: 1.957 ± 0.049	2.785AsnVal: 2.785 ± 0.054	0.491AsnTrp: 0.491 ± 0.02	1.379AsnTyr: 1.379 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.462ProAla: 2.462 ± 0.044	0.212ProCys: 0.212 ± 0.016	2.215ProAsp: 2.215 ± 0.047	3.043ProGlu: 3.043 ± 0.051	2.074ProPhe: 2.074 ± 0.044	2.472ProGly: 2.472 ± 0.059	0.816ProHis: 0.816 ± 0.024	2.851ProIle: 2.851 ± 0.054	2.3ProLys: 2.3 ± 0.047	3.537ProLeu: 3.537 ± 0.056	0.914ProMet: 0.914 ± 0.031	1.577ProAsn: 1.577 ± 0.038	1.075ProPro: 1.075 ± 0.033	1.157ProGln: 1.157 ± 0.036	1.101ProArg: 1.101 ± 0.033	2.547ProSer: 2.547 ± 0.048	1.661ProThr: 1.661 ± 0.038	2.949ProVal: 2.949 ± 0.141	0.392ProTrp: 0.392 ± 0.02	1.489ProTyr: 1.489 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.473GlnAla: 2.473 ± 0.041	0.195GlnCys: 0.195 ± 0.013	1.621GlnAsp: 1.621 ± 0.038	2.702GlnGlu: 2.702 ± 0.05	1.655GlnPhe: 1.655 ± 0.042	2.146GlnGly: 2.146 ± 0.046	0.706GlnHis: 0.706 ± 0.026	2.39GlnIle: 2.39 ± 0.056	2.979GlnLys: 2.979 ± 0.06	3.671GlnLeu: 3.671 ± 0.063	1.276GlnMet: 1.276 ± 0.034	1.644GlnAsn: 1.644 ± 0.036	1.17GlnPro: 1.17 ± 0.036	1.521GlnGln: 1.521 ± 0.045	1.416GlnArg: 1.416 ± 0.033	2.244GlnSer: 2.244 ± 0.049	1.889GlnThr: 1.889 ± 0.042	2.074GlnVal: 2.074 ± 0.046	0.419GlnTrp: 0.419 ± 0.018	1.35GlnTyr: 1.35 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.312ArgAla: 2.312 ± 0.052	0.264ArgCys: 0.264 ± 0.015	2.025ArgAsp: 2.025 ± 0.038	3.151ArgGlu: 3.151 ± 0.059	1.929ArgPhe: 1.929 ± 0.038	2.365ArgGly: 2.365 ± 0.05	0.776ArgHis: 0.776 ± 0.029	3.078ArgIle: 3.078 ± 0.051	3.329ArgLys: 3.329 ± 0.053	3.878ArgLeu: 3.878 ± 0.06	1.365ArgMet: 1.365 ± 0.036	1.832ArgAsn: 1.832 ± 0.039	1.283ArgPro: 1.283 ± 0.033	1.394ArgGln: 1.394 ± 0.038	1.797ArgArg: 1.797 ± 0.042	2.283ArgSer: 2.283 ± 0.046	1.984ArgThr: 1.984 ± 0.044	2.456ArgVal: 2.456 ± 0.05	0.399ArgTrp: 0.399 ± 0.02	1.505ArgTyr: 1.505 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.054SerAla: 4.054 ± 0.062	0.437SerCys: 0.437 ± 0.021	2.985SerAsp: 2.985 ± 0.057	4.0SerGlu: 4.0 ± 0.058	3.594SerPhe: 3.594 ± 0.06	4.749SerGly: 4.749 ± 0.079	1.321SerHis: 1.321 ± 0.036	5.531SerIle: 5.531 ± 0.077	4.109SerLys: 4.109 ± 0.064	6.406SerLeu: 6.406 ± 0.09	1.932SerMet: 1.932 ± 0.043	2.487SerAsn: 2.487 ± 0.056	2.36SerPro: 2.36 ± 0.045	2.015SerGln: 2.015 ± 0.041	2.425SerArg: 2.425 ± 0.049	4.387SerSer: 4.387 ± 0.075	3.106SerThr: 3.106 ± 0.054	4.144SerVal: 4.144 ± 0.063	0.68SerTrp: 0.68 ± 0.026	2.221SerTyr: 2.221 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	3.92ThrAla: 3.92 ± 0.07	0.315ThrCys: 0.315 ± 0.016	2.525ThrAsp: 2.525 ± 0.051	3.157ThrGlu: 3.157 ± 0.055	2.51ThrPhe: 2.51 ± 0.048	4.053ThrGly: 4.053 ± 0.071	0.987ThrHis: 0.987 ± 0.032	4.249ThrIle: 4.249 ± 0.071	3.132ThrLys: 3.132 ± 0.059	4.87ThrLeu: 4.87 ± 0.051	1.287ThrMet: 1.287 ± 0.032	2.02ThrAsn: 2.02 ± 0.045	2.195ThrPro: 2.195 ± 0.045	1.274ThrGln: 1.274 ± 0.04	1.707ThrArg: 1.707 ± 0.037	3.123ThrSer: 3.123 ± 0.048	2.399ThrThr: 2.399 ± 0.06	3.814ThrVal: 3.814 ± 0.064	0.465ThrTrp: 0.465 ± 0.021	1.676ThrTyr: 1.676 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	4.235ValAla: 4.235 ± 0.066	0.568ValCys: 0.568 ± 0.024	3.571ValAsp: 3.571 ± 0.058	4.73ValGlu: 4.73 ± 0.078	3.297ValPhe: 3.297 ± 0.063	4.197ValGly: 4.197 ± 0.072	1.351ValHis: 1.351 ± 0.037	5.424ValIle: 5.424 ± 0.065	4.914ValLys: 4.914 ± 0.068	6.745ValLeu: 6.745 ± 0.091	1.901ValMet: 1.901 ± 0.037	2.844ValAsn: 2.844 ± 0.058	2.622ValPro: 2.622 ± 0.053	2.372ValGln: 2.372 ± 0.047	2.445ValArg: 2.445 ± 0.046	4.392ValSer: 4.392 ± 0.073	3.273ValThr: 3.273 ± 0.05	4.644ValVal: 4.644 ± 0.074	0.611ValTrp: 0.611 ± 0.025	2.231ValTyr: 2.231 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.64TrpAla: 0.64 ± 0.024	0.077TrpCys: 0.077 ± 0.008	0.562TrpAsp: 0.562 ± 0.026	0.676TrpGlu: 0.676 ± 0.025	0.521TrpPhe: 0.521 ± 0.025	0.731TrpGly: 0.731 ± 0.03	0.21TrpHis: 0.21 ± 0.016	0.983TrpIle: 0.983 ± 0.033	0.845TrpLys: 0.845 ± 0.029	1.123TrpLeu: 1.123 ± 0.035	0.388TrpMet: 0.388 ± 0.022	0.576TrpAsn: 0.576 ± 0.026	0.273TrpPro: 0.273 ± 0.016	0.322TrpGln: 0.322 ± 0.017	0.398TrpArg: 0.398 ± 0.019	0.613TrpSer: 0.613 ± 0.025	0.561TrpThr: 0.561 ± 0.022	0.642TrpVal: 0.642 ± 0.028	0.153TrpTrp: 0.153 ± 0.013	0.337TrpTyr: 0.337 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.01TyrAla: 2.01 ± 0.048	0.308TyrCys: 0.308 ± 0.016	1.859TyrAsp: 1.859 ± 0.048	2.474TyrGlu: 2.474 ± 0.049	1.919TyrPhe: 1.919 ± 0.048	2.384TyrGly: 2.384 ± 0.054	0.829TyrHis: 0.829 ± 0.028	2.421TyrIle: 2.421 ± 0.048	2.101TyrLys: 2.101 ± 0.049	3.617TyrLeu: 3.617 ± 0.063	0.868TyrMet: 0.868 ± 0.028	1.36TyrAsn: 1.36 ± 0.032	1.421TyrPro: 1.421 ± 0.038	1.452TyrGln: 1.452 ± 0.034	1.549TyrArg: 1.549 ± 0.038	2.254TyrSer: 2.254 ± 0.042	1.7TyrThr: 1.7 ± 0.041	2.02TyrVal: 2.02 ± 0.049	0.394TyrTrp: 0.394 ± 0.02	1.429TyrTyr: 1.429 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3956 proteins (1115423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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