Amino acid dipepetide frequency for Chitinophagaceae bacterium IBVUCB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.235AlaAla: 7.235 ± 0.125	0.831AlaCys: 0.831 ± 0.031	4.734AlaAsp: 4.734 ± 0.08	4.196AlaGlu: 4.196 ± 0.08	3.315AlaPhe: 3.315 ± 0.057	6.259AlaGly: 6.259 ± 0.118	1.478AlaHis: 1.478 ± 0.041	5.949AlaIle: 5.949 ± 0.09	4.859AlaLys: 4.859 ± 0.085	6.988AlaLeu: 6.988 ± 0.104	2.24AlaMet: 2.24 ± 0.055	4.26AlaAsn: 4.26 ± 0.078	2.56AlaPro: 2.56 ± 0.055	3.282AlaGln: 3.282 ± 0.06	2.696AlaArg: 2.696 ± 0.053	4.518AlaSer: 4.518 ± 0.098	5.238AlaThr: 5.238 ± 0.128	4.904AlaVal: 4.904 ± 0.082	0.84AlaTrp: 0.84 ± 0.032	3.284AlaTyr: 3.284 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.76CysAla: 0.76 ± 0.032	0.168CysCys: 0.168 ± 0.013	0.533CysAsp: 0.533 ± 0.023	0.505CysGlu: 0.505 ± 0.024	0.472CysPhe: 0.472 ± 0.024	0.868CysGly: 0.868 ± 0.033	0.26CysHis: 0.26 ± 0.018	0.845CysIle: 0.845 ± 0.03	0.646CysLys: 0.646 ± 0.026	0.819CysLeu: 0.819 ± 0.025	0.313CysMet: 0.313 ± 0.017	0.609CysAsn: 0.609 ± 0.029	0.442CysPro: 0.442 ± 0.027	0.279CysGln: 0.279 ± 0.021	0.391CysArg: 0.391 ± 0.018	0.637CysSer: 0.637 ± 0.031	0.7CysThr: 0.7 ± 0.042	0.65CysVal: 0.65 ± 0.029	0.101CysTrp: 0.101 ± 0.01	0.446CysTyr: 0.446 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.719AspAla: 4.719 ± 0.071	0.512AspCys: 0.512 ± 0.026	2.623AspAsp: 2.623 ± 0.052	3.292AspGlu: 3.292 ± 0.054	2.506AspPhe: 2.506 ± 0.058	3.929AspGly: 3.929 ± 0.067	0.665AspHis: 0.665 ± 0.024	4.001AspIle: 4.001 ± 0.073	4.325AspLys: 4.325 ± 0.076	3.596AspLeu: 3.596 ± 0.066	1.561AspMet: 1.561 ± 0.042	3.049AspAsn: 3.049 ± 0.058	1.419AspPro: 1.419 ± 0.035	0.868AspGln: 0.868 ± 0.032	1.854AspArg: 1.854 ± 0.049	3.235AspSer: 3.235 ± 0.07	3.499AspThr: 3.499 ± 0.068	3.975AspVal: 3.975 ± 0.065	0.721AspTrp: 0.721 ± 0.028	2.548AspTyr: 2.548 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.428GluAla: 4.428 ± 0.08	0.396GluCys: 0.396 ± 0.02	2.665GluAsp: 2.665 ± 0.059	3.498GluGlu: 3.498 ± 0.072	1.888GluPhe: 1.888 ± 0.048	3.081GluGly: 3.081 ± 0.067	1.186GluHis: 1.186 ± 0.036	3.485GluIle: 3.485 ± 0.072	4.33GluLys: 4.33 ± 0.087	5.152GluLeu: 5.152 ± 0.093	1.679GluMet: 1.679 ± 0.043	2.702GluAsn: 2.702 ± 0.055	1.603GluPro: 1.603 ± 0.043	2.572GluGln: 2.572 ± 0.059	2.574GluArg: 2.574 ± 0.06	2.188GluSer: 2.188 ± 0.041	2.761GluThr: 2.761 ± 0.062	3.589GluVal: 3.589 ± 0.064	0.712GluTrp: 0.712 ± 0.026	2.26GluTyr: 2.26 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.36PheAla: 3.36 ± 0.067	0.488PheCys: 0.488 ± 0.019	2.557PheAsp: 2.557 ± 0.052	2.307PheGlu: 2.307 ± 0.058	2.145PhePhe: 2.145 ± 0.055	3.056PheGly: 3.056 ± 0.059	0.744PheHis: 0.744 ± 0.025	3.261PheIle: 3.261 ± 0.07	2.547PheLys: 2.547 ± 0.056	3.485PheLeu: 3.485 ± 0.072	1.106PheMet: 1.106 ± 0.034	2.549PheAsn: 2.549 ± 0.065	1.555PhePro: 1.555 ± 0.04	1.17PheGln: 1.17 ± 0.032	1.782PheArg: 1.782 ± 0.046	3.196PheSer: 3.196 ± 0.065	3.14PheThr: 3.14 ± 0.067	2.859PheVal: 2.859 ± 0.053	0.491PheTrp: 0.491 ± 0.026	1.925PheTyr: 1.925 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.745GlyAla: 4.745 ± 0.106	0.853GlyCys: 0.853 ± 0.048	3.366GlyAsp: 3.366 ± 0.071	3.138GlyGlu: 3.138 ± 0.058	3.326GlyPhe: 3.326 ± 0.062	5.111GlyGly: 5.111 ± 0.123	1.201GlyHis: 1.201 ± 0.038	5.597GlyIle: 5.597 ± 0.074	5.149GlyLys: 5.149 ± 0.08	5.462GlyLeu: 5.462 ± 0.084	2.148GlyMet: 2.148 ± 0.05	3.995GlyAsn: 3.995 ± 0.086	1.395GlyPro: 1.395 ± 0.043	2.076GlyGln: 2.076 ± 0.044	2.584GlyArg: 2.584 ± 0.058	4.371GlySer: 4.371 ± 0.095	4.767GlyThr: 4.767 ± 0.149	4.411GlyVal: 4.411 ± 0.072	0.906GlyTrp: 0.906 ± 0.035	3.385GlyTyr: 3.385 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.361HisAla: 1.361 ± 0.041	0.246HisCys: 0.246 ± 0.015	0.918HisAsp: 0.918 ± 0.029	0.934HisGlu: 0.934 ± 0.031	1.031HisPhe: 1.031 ± 0.034	1.204HisGly: 1.204 ± 0.041	0.563HisHis: 0.563 ± 0.025	1.749HisIle: 1.749 ± 0.038	1.232HisLys: 1.232 ± 0.034	1.822HisLeu: 1.822 ± 0.045	0.427HisMet: 0.427 ± 0.019	1.138HisAsn: 1.138 ± 0.035	1.027HisPro: 1.027 ± 0.035	0.681HisGln: 0.681 ± 0.026	0.793HisArg: 0.793 ± 0.028	1.117HisSer: 1.117 ± 0.035	1.366HisThr: 1.366 ± 0.039	0.969HisVal: 0.969 ± 0.031	0.236HisTrp: 0.236 ± 0.017	1.008HisTyr: 1.008 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.485IleAla: 6.485 ± 0.119	0.845IleCys: 0.845 ± 0.031	4.313IleAsp: 4.313 ± 0.072	4.026IleGlu: 4.026 ± 0.074	2.671IlePhe: 2.671 ± 0.064	4.825IleGly: 4.825 ± 0.08	1.388IleHis: 1.388 ± 0.039	5.058IleIle: 5.058 ± 0.099	4.603IleLys: 4.603 ± 0.08	5.921IleLeu: 5.921 ± 0.089	1.451IleMet: 1.451 ± 0.042	4.174IleAsn: 4.174 ± 0.067	3.071IlePro: 3.071 ± 0.059	2.375IleGln: 2.375 ± 0.051	3.02IleArg: 3.02 ± 0.053	4.75IleSer: 4.75 ± 0.077	4.943IleThr: 4.943 ± 0.088	4.657IleVal: 4.657 ± 0.08	0.697IleTrp: 0.697 ± 0.027	2.711IleTyr: 2.711 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.288LysAla: 5.288 ± 0.087	0.448LysCys: 0.448 ± 0.02	3.996LysAsp: 3.996 ± 0.079	4.78LysGlu: 4.78 ± 0.081	2.067LysPhe: 2.067 ± 0.053	4.123LysGly: 4.123 ± 0.077	1.502LysHis: 1.502 ± 0.034	4.453LysIle: 4.453 ± 0.071	5.33LysLys: 5.33 ± 0.098	6.026LysLeu: 6.026 ± 0.085	2.129LysMet: 2.129 ± 0.054	3.577LysAsn: 3.577 ± 0.067	2.708LysPro: 2.708 ± 0.057	3.34LysGln: 3.34 ± 0.064	2.917LysArg: 2.917 ± 0.058	3.208LysSer: 3.208 ± 0.062	3.752LysThr: 3.752 ± 0.063	3.939LysVal: 3.939 ± 0.069	0.881LysTrp: 0.881 ± 0.03	2.932LysTyr: 2.932 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	6.53LeuAla: 6.53 ± 0.092	1.064LeuCys: 1.064 ± 0.034	4.246LeuAsp: 4.246 ± 0.071	4.108LeuGlu: 4.108 ± 0.079	4.316LeuPhe: 4.316 ± 0.084	5.284LeuGly: 5.284 ± 0.085	2.088LeuHis: 2.088 ± 0.052	5.714LeuIle: 5.714 ± 0.107	5.899LeuLys: 5.899 ± 0.089	9.338LeuLeu: 9.338 ± 0.155	2.407LeuMet: 2.407 ± 0.05	4.678LeuAsn: 4.678 ± 0.085	4.089LeuPro: 4.089 ± 0.061	4.471LeuGln: 4.471 ± 0.082	3.848LeuArg: 3.848 ± 0.071	5.995LeuSer: 5.995 ± 0.077	5.001LeuThr: 5.001 ± 0.089	5.057LeuVal: 5.057 ± 0.079	1.01LeuTrp: 1.01 ± 0.04	3.748LeuTyr: 3.748 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.262MetAla: 2.262 ± 0.048	0.214MetCys: 0.214 ± 0.014	1.33MetAsp: 1.33 ± 0.033	1.406MetGlu: 1.406 ± 0.037	0.977MetPhe: 0.977 ± 0.037	1.799MetGly: 1.799 ± 0.047	0.61MetHis: 0.61 ± 0.024	1.597MetIle: 1.597 ± 0.048	2.018MetLys: 2.018 ± 0.044	2.782MetLeu: 2.782 ± 0.061	0.847MetMet: 0.847 ± 0.033	1.393MetAsn: 1.393 ± 0.039	1.378MetPro: 1.378 ± 0.042	1.568MetGln: 1.568 ± 0.039	1.374MetArg: 1.374 ± 0.04	1.54MetSer: 1.54 ± 0.038	1.276MetThr: 1.276 ± 0.034	1.685MetVal: 1.685 ± 0.039	0.265MetTrp: 0.265 ± 0.018	1.007MetTyr: 1.007 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	4.328AsnAla: 4.328 ± 0.068	0.588AsnCys: 0.588 ± 0.033	2.958AsnAsp: 2.958 ± 0.055	2.861AsnGlu: 2.861 ± 0.057	2.025AsnPhe: 2.025 ± 0.05	4.56AsnGly: 4.56 ± 0.098	0.939AsnHis: 0.939 ± 0.034	4.331AsnIle: 4.331 ± 0.066	3.846AsnLys: 3.846 ± 0.074	4.216AsnLeu: 4.216 ± 0.069	1.456AsnMet: 1.456 ± 0.035	3.907AsnAsn: 3.907 ± 0.1	2.847AsnPro: 2.847 ± 0.066	1.596AsnGln: 1.596 ± 0.048	2.241AsnArg: 2.241 ± 0.054	3.068AsnSer: 3.068 ± 0.075	4.127AsnThr: 4.127 ± 0.103	3.35AsnVal: 3.35 ± 0.069	0.689AsnTrp: 0.689 ± 0.028	2.496AsnTyr: 2.496 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	3.669ProAla: 3.669 ± 0.072	0.317ProCys: 0.317 ± 0.018	2.499ProAsp: 2.499 ± 0.054	2.235ProGlu: 2.235 ± 0.048	1.832ProPhe: 1.832 ± 0.045	2.212ProGly: 2.212 ± 0.059	0.752ProHis: 0.752 ± 0.029	2.505ProIle: 2.505 ± 0.05	2.057ProLys: 2.057 ± 0.047	3.162ProLeu: 3.162 ± 0.058	0.9ProMet: 0.9 ± 0.032	2.165ProAsn: 2.165 ± 0.056	1.184ProPro: 1.184 ± 0.04	1.462ProGln: 1.462 ± 0.046	1.091ProArg: 1.091 ± 0.032	2.155ProSer: 2.155 ± 0.059	2.325ProThr: 2.325 ± 0.07	3.232ProVal: 3.232 ± 0.066	0.361ProTrp: 0.361 ± 0.021	1.715ProTyr: 1.715 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.898GlnAla: 2.898 ± 0.06	0.297GlnCys: 0.297 ± 0.017	1.673GlnAsp: 1.673 ± 0.036	1.903GlnGlu: 1.903 ± 0.046	1.521GlnPhe: 1.521 ± 0.042	2.124GlnGly: 2.124 ± 0.044	0.971GlnHis: 0.971 ± 0.036	2.244GlnIle: 2.244 ± 0.045	2.473GlnLys: 2.473 ± 0.055	3.883GlnLeu: 3.883 ± 0.063	1.118GlnMet: 1.118 ± 0.035	1.87GlnAsn: 1.87 ± 0.044	1.684GlnPro: 1.684 ± 0.039	2.452GlnGln: 2.452 ± 0.065	1.758GlnArg: 1.758 ± 0.043	2.177GlnSer: 2.177 ± 0.044	2.244GlnThr: 2.244 ± 0.061	2.444GlnVal: 2.444 ± 0.05	0.59GlnTrp: 0.59 ± 0.032	1.972GlnTyr: 1.972 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	2.549ArgAla: 2.549 ± 0.057	0.351ArgCys: 0.351 ± 0.026	1.963ArgAsp: 1.963 ± 0.052	2.143ArgGlu: 2.143 ± 0.051	2.073ArgPhe: 2.073 ± 0.049	2.242ArgGly: 2.242 ± 0.054	0.851ArgHis: 0.851 ± 0.033	3.338ArgIle: 3.338 ± 0.066	2.984ArgLys: 2.984 ± 0.069	3.74ArgLeu: 3.74 ± 0.056	1.416ArgMet: 1.416 ± 0.039	2.278ArgAsn: 2.278 ± 0.045	1.25ArgPro: 1.25 ± 0.037	1.59ArgGln: 1.59 ± 0.046	1.809ArgArg: 1.809 ± 0.05	2.087ArgSer: 2.087 ± 0.054	2.226ArgThr: 2.226 ± 0.051	2.601ArgVal: 2.601 ± 0.055	0.528ArgTrp: 0.528 ± 0.025	2.113ArgTyr: 2.113 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.518SerAla: 4.518 ± 0.076	0.73SerCys: 0.73 ± 0.037	2.558SerAsp: 2.558 ± 0.055	2.517SerGlu: 2.517 ± 0.048	3.342SerPhe: 3.342 ± 0.058	4.63SerGly: 4.63 ± 0.105	1.018SerHis: 1.018 ± 0.031	4.785SerIle: 4.785 ± 0.07	3.592SerLys: 3.592 ± 0.065	5.568SerLeu: 5.568 ± 0.085	1.515SerMet: 1.515 ± 0.043	3.42SerAsn: 3.42 ± 0.104	2.233SerPro: 2.233 ± 0.055	1.78SerGln: 1.78 ± 0.041	2.129SerArg: 2.129 ± 0.042	3.758SerSer: 3.758 ± 0.091	3.668SerThr: 3.668 ± 0.096	4.068SerVal: 4.068 ± 0.079	0.652SerTrp: 0.652 ± 0.026	2.721SerTyr: 2.721 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.288ThrAla: 5.288 ± 0.131	0.619ThrCys: 0.619 ± 0.032	3.726ThrAsp: 3.726 ± 0.064	2.989ThrGlu: 2.989 ± 0.053	2.479ThrPhe: 2.479 ± 0.061	5.386ThrGly: 5.386 ± 0.128	1.136ThrHis: 1.136 ± 0.033	4.851ThrIle: 4.851 ± 0.09	3.297ThrLys: 3.297 ± 0.055	5.51ThrLeu: 5.51 ± 0.082	1.366ThrMet: 1.366 ± 0.042	3.484ThrAsn: 3.484 ± 0.082	2.882ThrPro: 2.882 ± 0.068	2.135ThrGln: 2.135 ± 0.049	1.979ThrArg: 1.979 ± 0.045	3.612ThrSer: 3.612 ± 0.111	4.505ThrThr: 4.505 ± 0.14	4.501ThrVal: 4.501 ± 0.117	0.707ThrTrp: 0.707 ± 0.032	2.783ThrTyr: 2.783 ± 0.081	0.0ThrXaa: 0.0 ± 0.0
Val	5.203ValAla: 5.203 ± 0.077	0.85ValCys: 0.85 ± 0.031	3.064ValAsp: 3.064 ± 0.063	3.033ValGlu: 3.033 ± 0.059	3.116ValPhe: 3.116 ± 0.062	3.683ValGly: 3.683 ± 0.072	1.208ValHis: 1.208 ± 0.038	4.329ValIle: 4.329 ± 0.067	4.315ValLys: 4.315 ± 0.081	6.338ValLeu: 6.338 ± 0.085	1.735ValMet: 1.735 ± 0.045	3.634ValAsn: 3.634 ± 0.071	2.494ValPro: 2.494 ± 0.055	2.332ValGln: 2.332 ± 0.048	2.732ValArg: 2.732 ± 0.051	4.311ValSer: 4.311 ± 0.074	3.897ValThr: 3.897 ± 0.113	4.731ValVal: 4.731 ± 0.084	0.839ValTrp: 0.839 ± 0.028	3.05ValTyr: 3.05 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.834TrpAla: 0.834 ± 0.03	0.137TrpCys: 0.137 ± 0.012	0.665TrpAsp: 0.665 ± 0.028	0.589TrpGlu: 0.589 ± 0.025	0.516TrpPhe: 0.516 ± 0.026	0.819TrpGly: 0.819 ± 0.04	0.3TrpHis: 0.3 ± 0.016	0.734TrpIle: 0.734 ± 0.029	0.78TrpLys: 0.78 ± 0.033	1.273TrpLeu: 1.273 ± 0.042	0.43TrpMet: 0.43 ± 0.019	0.649TrpAsn: 0.649 ± 0.029	0.294TrpPro: 0.294 ± 0.018	0.671TrpGln: 0.671 ± 0.03	0.531TrpArg: 0.531 ± 0.023	0.607TrpSer: 0.607 ± 0.028	0.605TrpThr: 0.605 ± 0.03	0.838TrpVal: 0.838 ± 0.031	0.218TrpTrp: 0.218 ± 0.013	0.535TrpTyr: 0.535 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.205TyrAla: 3.205 ± 0.066	0.488TyrCys: 0.488 ± 0.024	2.511TyrAsp: 2.511 ± 0.061	2.29TyrGlu: 2.29 ± 0.052	2.104TyrPhe: 2.104 ± 0.051	2.789TyrGly: 2.789 ± 0.055	0.964TyrHis: 0.964 ± 0.03	3.159TyrIle: 3.159 ± 0.06	3.118TyrLys: 3.118 ± 0.066	3.808TyrLeu: 3.808 ± 0.067	1.085TyrMet: 1.085 ± 0.036	2.902TyrAsn: 2.902 ± 0.064	1.714TyrPro: 1.714 ± 0.039	1.598TyrGln: 1.598 ± 0.043	2.03TyrArg: 2.03 ± 0.054	2.669TyrSer: 2.669 ± 0.053	3.196TyrThr: 3.196 ± 0.071	2.432TyrVal: 2.432 ± 0.049	0.579TyrTrp: 0.579 ± 0.026	2.421TyrTyr: 2.421 ± 0.067	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3055 proteins (1028320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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