Amino acid dipepetide frequency for Dentipellis fragilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.046AlaAla: 10.046 ± 0.063	1.337AlaCys: 1.337 ± 0.018	4.678AlaAsp: 4.678 ± 0.031	5.07AlaGlu: 5.07 ± 0.042	3.34AlaPhe: 3.34 ± 0.029	6.015AlaGly: 6.015 ± 0.04	2.543AlaHis: 2.543 ± 0.021	4.027AlaIle: 4.027 ± 0.028	3.788AlaLys: 3.788 ± 0.033	9.047AlaLeu: 9.047 ± 0.041	1.966AlaMet: 1.966 ± 0.017	2.712AlaAsn: 2.712 ± 0.022	6.457AlaPro: 6.457 ± 0.048	3.515AlaGln: 3.515 ± 0.027	6.399AlaArg: 6.399 ± 0.043	8.553AlaSer: 8.553 ± 0.043	5.225AlaThr: 5.225 ± 0.033	5.755AlaVal: 5.755 ± 0.036	1.222AlaTrp: 1.222 ± 0.016	2.216AlaTyr: 2.216 ± 0.02	0.075AlaXaa: 0.075 ± 0.005
Cys	1.241CysAla: 1.241 ± 0.018	0.29CysCys: 0.29 ± 0.008	0.693CysAsp: 0.693 ± 0.012	0.576CysGlu: 0.576 ± 0.01	0.518CysPhe: 0.518 ± 0.01	0.922CysGly: 0.922 ± 0.013	0.415CysHis: 0.415 ± 0.009	0.723CysIle: 0.723 ± 0.013	0.482CysLys: 0.482 ± 0.011	1.361CysLeu: 1.361 ± 0.019	0.31CysMet: 0.31 ± 0.008	0.413CysAsn: 0.413 ± 0.009	0.903CysPro: 0.903 ± 0.016	0.446CysGln: 0.446 ± 0.009	0.974CysArg: 0.974 ± 0.013	1.105CysSer: 1.105 ± 0.014	0.867CysThr: 0.867 ± 0.014	0.872CysVal: 0.872 ± 0.013	0.199CysTrp: 0.199 ± 0.006	0.33CysTyr: 0.33 ± 0.008	0.016CysXaa: 0.016 ± 0.002
Asp	5.535AspAla: 5.535 ± 0.035	0.64AspCys: 0.64 ± 0.012	4.066AspAsp: 4.066 ± 0.035	4.202AspGlu: 4.202 ± 0.041	2.003AspPhe: 2.003 ± 0.018	3.925AspGly: 3.925 ± 0.026	1.229AspHis: 1.229 ± 0.017	2.964AspIle: 2.964 ± 0.028	2.003AspLys: 2.003 ± 0.02	4.892AspLeu: 4.892 ± 0.038	1.263AspMet: 1.263 ± 0.015	1.577AspAsn: 1.577 ± 0.018	3.43AspPro: 3.43 ± 0.029	1.471AspGln: 1.471 ± 0.016	2.967AspArg: 2.967 ± 0.025	3.975AspSer: 3.975 ± 0.029	3.034AspThr: 3.034 ± 0.023	4.097AspVal: 4.097 ± 0.027	0.863AspTrp: 0.863 ± 0.013	1.339AspTyr: 1.339 ± 0.018	0.047AspXaa: 0.047 ± 0.004
Glu	5.018GluAla: 5.018 ± 0.035	0.639GluCys: 0.639 ± 0.012	4.088GluAsp: 4.088 ± 0.034	4.924GluGlu: 4.924 ± 0.058	1.727GluPhe: 1.727 ± 0.021	3.648GluGly: 3.648 ± 0.028	1.535GluHis: 1.535 ± 0.015	2.519GluIle: 2.519 ± 0.022	2.866GluLys: 2.866 ± 0.027	5.022GluLeu: 5.022 ± 0.039	1.279GluMet: 1.279 ± 0.016	1.692GluAsn: 1.692 ± 0.019	2.817GluPro: 2.817 ± 0.028	2.164GluGln: 2.164 ± 0.023	4.047GluArg: 4.047 ± 0.034	3.702GluSer: 3.702 ± 0.028	2.906GluThr: 2.906 ± 0.023	3.432GluVal: 3.432 ± 0.027	0.83GluTrp: 0.83 ± 0.012	1.445GluTyr: 1.445 ± 0.016	0.046GluXaa: 0.046 ± 0.004
Phe	3.21PheAla: 3.21 ± 0.026	0.568PheCys: 0.568 ± 0.01	2.162PheAsp: 2.162 ± 0.019	1.878PheGlu: 1.878 ± 0.02	1.482PhePhe: 1.482 ± 0.016	2.53PheGly: 2.53 ± 0.024	0.919PheHis: 0.919 ± 0.012	1.67PheIle: 1.67 ± 0.017	1.361PheLys: 1.361 ± 0.014	3.444PheLeu: 3.444 ± 0.027	0.724PheMet: 0.724 ± 0.012	1.201PheAsn: 1.201 ± 0.016	2.143PhePro: 2.143 ± 0.021	1.163PheGln: 1.163 ± 0.016	2.007PheArg: 2.007 ± 0.019	3.032PheSer: 3.032 ± 0.023	2.059PheThr: 2.059 ± 0.021	2.445PheVal: 2.445 ± 0.022	0.54PheTrp: 0.54 ± 0.01	0.953PheTyr: 0.953 ± 0.014	0.026PheXaa: 0.026 ± 0.003
Gly	5.609GlyAla: 5.609 ± 0.036	0.851GlyCys: 0.851 ± 0.012	3.387GlyAsp: 3.387 ± 0.028	3.374GlyGlu: 3.374 ± 0.027	2.387GlyPhe: 2.387 ± 0.022	5.147GlyGly: 5.147 ± 0.049	1.749GlyHis: 1.749 ± 0.02	3.012GlyIle: 3.012 ± 0.025	3.133GlyLys: 3.133 ± 0.028	5.526GlyLeu: 5.526 ± 0.038	1.431GlyMet: 1.431 ± 0.018	2.054GlyAsn: 2.054 ± 0.024	3.539GlyPro: 3.539 ± 0.025	2.221GlyGln: 2.221 ± 0.022	4.401GlyArg: 4.401 ± 0.031	5.441GlySer: 5.441 ± 0.039	3.848GlyThr: 3.848 ± 0.028	4.118GlyVal: 4.118 ± 0.031	1.075GlyTrp: 1.075 ± 0.013	1.719GlyTyr: 1.719 ± 0.019	0.056GlyXaa: 0.056 ± 0.004
His	2.666HisAla: 2.666 ± 0.025	0.408HisCys: 0.408 ± 0.01	1.418HisAsp: 1.418 ± 0.018	1.353HisGlu: 1.353 ± 0.018	0.995HisPhe: 0.995 ± 0.014	1.818HisGly: 1.818 ± 0.02	0.972HisHis: 0.972 ± 0.016	1.408HisIle: 1.408 ± 0.014	0.872HisLys: 0.872 ± 0.013	2.749HisLeu: 2.749 ± 0.022	0.526HisMet: 0.526 ± 0.008	0.787HisAsn: 0.787 ± 0.011	2.215HisPro: 2.215 ± 0.021	0.899HisGln: 0.899 ± 0.011	1.945HisArg: 1.945 ± 0.017	2.16HisSer: 2.16 ± 0.017	1.603HisThr: 1.603 ± 0.017	1.845HisVal: 1.845 ± 0.019	0.374HisTrp: 0.374 ± 0.008	0.691HisTyr: 0.691 ± 0.011	0.025HisXaa: 0.025 ± 0.002
Ile	4.134IleAla: 4.134 ± 0.032	0.746IleCys: 0.746 ± 0.011	2.61IleAsp: 2.61 ± 0.019	2.369IleGlu: 2.369 ± 0.023	1.824IlePhe: 1.824 ± 0.019	2.671IleGly: 2.671 ± 0.023	1.242IleHis: 1.242 ± 0.015	2.157IleIle: 2.157 ± 0.021	1.677IleLys: 1.677 ± 0.02	4.381IleLeu: 4.381 ± 0.035	0.897IleMet: 0.897 ± 0.014	1.384IleAsn: 1.384 ± 0.017	3.241IlePro: 3.241 ± 0.027	1.586IleGln: 1.586 ± 0.017	2.797IleArg: 2.797 ± 0.022	3.684IleSer: 3.684 ± 0.028	2.566IleThr: 2.566 ± 0.022	3.117IleVal: 3.117 ± 0.028	0.683IleTrp: 0.683 ± 0.011	1.27IleTyr: 1.27 ± 0.015	0.032IleXaa: 0.032 ± 0.003
Lys	4.099LysAla: 4.099 ± 0.039	0.445LysCys: 0.445 ± 0.011	2.324LysAsp: 2.324 ± 0.026	2.799LysGlu: 2.799 ± 0.03	1.223LysPhe: 1.223 ± 0.015	2.635LysGly: 2.635 ± 0.025	1.064LysHis: 1.064 ± 0.015	1.732LysIle: 1.732 ± 0.019	2.627LysLys: 2.627 ± 0.03	3.522LysLeu: 3.522 ± 0.029	0.841LysMet: 0.841 ± 0.011	1.279LysAsn: 1.279 ± 0.015	2.444LysPro: 2.444 ± 0.023	1.461LysGln: 1.461 ± 0.019	3.118LysArg: 3.118 ± 0.026	2.878LysSer: 2.878 ± 0.025	2.376LysThr: 2.376 ± 0.021	2.411LysVal: 2.411 ± 0.022	0.579LysTrp: 0.579 ± 0.009	1.108LysTyr: 1.108 ± 0.016	0.029LysXaa: 0.029 ± 0.002
Leu	8.552LeuAla: 8.552 ± 0.042	1.366LeuCys: 1.366 ± 0.015	5.143LeuAsp: 5.143 ± 0.036	5.203LeuGlu: 5.203 ± 0.039	3.313LeuPhe: 3.313 ± 0.025	5.472LeuGly: 5.472 ± 0.035	2.731LeuHis: 2.731 ± 0.024	3.66LeuIle: 3.66 ± 0.027	3.693LeuLys: 3.693 ± 0.029	8.759LeuLeu: 8.759 ± 0.057	1.612LeuMet: 1.612 ± 0.016	2.778LeuAsn: 2.778 ± 0.026	6.747LeuPro: 6.747 ± 0.044	3.815LeuGln: 3.815 ± 0.031	6.595LeuArg: 6.595 ± 0.039	8.04LeuSer: 8.04 ± 0.041	5.219LeuThr: 5.219 ± 0.034	5.717LeuVal: 5.717 ± 0.04	1.258LeuTrp: 1.258 ± 0.018	2.325LeuTyr: 2.325 ± 0.021	0.074LeuXaa: 0.074 ± 0.005
Met	1.891MetAla: 1.891 ± 0.018	0.259MetCys: 0.259 ± 0.007	1.213MetAsp: 1.213 ± 0.014	1.105MetGlu: 1.105 ± 0.015	0.687MetPhe: 0.687 ± 0.011	1.215MetGly: 1.215 ± 0.014	0.627MetHis: 0.627 ± 0.01	0.813MetIle: 0.813 ± 0.012	0.839MetLys: 0.839 ± 0.014	1.9MetLeu: 1.9 ± 0.018	0.475MetMet: 0.475 ± 0.01	0.671MetAsn: 0.671 ± 0.01	1.506MetPro: 1.506 ± 0.016	0.875MetGln: 0.875 ± 0.012	1.398MetArg: 1.398 ± 0.016	1.915MetSer: 1.915 ± 0.018	1.159MetThr: 1.159 ± 0.015	1.111MetVal: 1.111 ± 0.016	0.257MetTrp: 0.257 ± 0.007	0.491MetTyr: 0.491 ± 0.009	0.016MetXaa: 0.016 ± 0.002
Asn	3.097AsnAla: 3.097 ± 0.023	0.372AsnCys: 0.372 ± 0.008	1.601AsnAsp: 1.601 ± 0.015	1.563AsnGlu: 1.563 ± 0.017	1.121AsnPhe: 1.121 ± 0.014	2.371AsnGly: 2.371 ± 0.022	0.751AsnHis: 0.751 ± 0.012	1.672AsnIle: 1.672 ± 0.019	1.133AsnLys: 1.133 ± 0.014	2.808AsnLeu: 2.808 ± 0.026	0.708AsnMet: 0.708 ± 0.013	1.075AsnAsn: 1.075 ± 0.016	2.125AsnPro: 2.125 ± 0.019	0.969AsnGln: 0.969 ± 0.015	1.618AsnArg: 1.618 ± 0.019	2.256AsnSer: 2.256 ± 0.021	1.904AsnThr: 1.904 ± 0.019	2.212AsnVal: 2.212 ± 0.021	0.439AsnTrp: 0.439 ± 0.01	0.815AsnTyr: 0.815 ± 0.013	0.02AsnXaa: 0.02 ± 0.002
Pro	6.852ProAla: 6.852 ± 0.056	0.771ProCys: 0.771 ± 0.011	3.433ProAsp: 3.433 ± 0.028	3.656ProGlu: 3.656 ± 0.03	2.302ProPhe: 2.302 ± 0.019	3.998ProGly: 3.998 ± 0.036	1.935ProHis: 1.935 ± 0.022	2.694ProIle: 2.694 ± 0.02	2.322ProLys: 2.322 ± 0.024	5.721ProLeu: 5.721 ± 0.04	1.169ProMet: 1.169 ± 0.016	2.043ProAsn: 2.043 ± 0.019	7.162ProPro: 7.162 ± 0.072	2.473ProGln: 2.473 ± 0.025	4.461ProArg: 4.461 ± 0.036	7.927ProSer: 7.927 ± 0.056	4.594ProThr: 4.594 ± 0.037	4.13ProVal: 4.13 ± 0.028	0.781ProTrp: 0.781 ± 0.012	1.605ProTyr: 1.605 ± 0.015	0.071ProXaa: 0.071 ± 0.005
Gln	3.397GlnAla: 3.397 ± 0.028	0.464GlnCys: 0.464 ± 0.009	1.899GlnAsp: 1.899 ± 0.018	2.017GlnGlu: 2.017 ± 0.02	1.185GlnPhe: 1.185 ± 0.014	2.105GlnGly: 2.105 ± 0.018	1.16GlnHis: 1.16 ± 0.015	1.615GlnIle: 1.615 ± 0.019	1.499GlnLys: 1.499 ± 0.02	3.304GlnLeu: 3.304 ± 0.025	0.777GlnMet: 0.777 ± 0.014	1.218GlnAsn: 1.218 ± 0.017	2.486GlnPro: 2.486 ± 0.027	1.858GlnGln: 1.858 ± 0.035	2.583GlnArg: 2.583 ± 0.023	2.905GlnSer: 2.905 ± 0.023	2.148GlnThr: 2.148 ± 0.019	2.081GlnVal: 2.081 ± 0.02	0.524GlnTrp: 0.524 ± 0.009	1.023GlnTyr: 1.023 ± 0.014	0.029GlnXaa: 0.029 ± 0.003
Arg	6.343ArgAla: 6.343 ± 0.045	1.004ArgCys: 1.004 ± 0.015	3.499ArgAsp: 3.499 ± 0.027	3.726ArgGlu: 3.726 ± 0.032	2.13ArgPhe: 2.13 ± 0.02	3.972ArgGly: 3.972 ± 0.032	1.942ArgHis: 1.942 ± 0.018	3.078ArgIle: 3.078 ± 0.024	3.096ArgLys: 3.096 ± 0.025	6.122ArgLeu: 6.122 ± 0.039	1.426ArgMet: 1.426 ± 0.016	1.965ArgAsn: 1.965 ± 0.018	4.435ArgPro: 4.435 ± 0.036	2.416ArgGln: 2.416 ± 0.022	6.212ArgArg: 6.212 ± 0.05	5.515ArgSer: 5.515 ± 0.038	4.1ArgThr: 4.1 ± 0.028	4.003ArgVal: 4.003 ± 0.031	0.995ArgTrp: 0.995 ± 0.015	1.66ArgTyr: 1.66 ± 0.018	0.065ArgXaa: 0.065 ± 0.005
Ser	7.917SerAla: 7.917 ± 0.042	1.078SerCys: 1.078 ± 0.015	4.318SerAsp: 4.318 ± 0.032	3.975SerGlu: 3.975 ± 0.029	3.043SerPhe: 3.043 ± 0.025	5.446SerGly: 5.446 ± 0.041	2.294SerHis: 2.294 ± 0.022	3.771SerIle: 3.771 ± 0.024	3.135SerLys: 3.135 ± 0.024	7.808SerLeu: 7.808 ± 0.042	1.717SerMet: 1.717 ± 0.017	2.543SerAsn: 2.543 ± 0.023	6.757SerPro: 6.757 ± 0.057	3.151SerGln: 3.151 ± 0.027	5.714SerArg: 5.714 ± 0.039	9.955SerSer: 9.955 ± 0.076	5.999SerThr: 5.999 ± 0.038	5.058SerVal: 5.058 ± 0.031	1.045SerTrp: 1.045 ± 0.015	1.942SerTyr: 1.942 ± 0.017	0.074SerXaa: 0.074 ± 0.005
Thr	5.41ThrAla: 5.41 ± 0.036	0.834ThrCys: 0.834 ± 0.014	2.774ThrAsp: 2.774 ± 0.022	2.678ThrGlu: 2.678 ± 0.024	2.272ThrPhe: 2.272 ± 0.023	3.762ThrGly: 3.762 ± 0.028	1.684ThrHis: 1.684 ± 0.016	2.822ThrIle: 2.822 ± 0.023	2.163ThrLys: 2.163 ± 0.021	5.712ThrLeu: 5.712 ± 0.033	1.201ThrMet: 1.201 ± 0.015	1.819ThrAsn: 1.819 ± 0.019	4.965ThrPro: 4.965 ± 0.041	1.97ThrGln: 1.97 ± 0.015	3.702ThrArg: 3.702 ± 0.026	5.744ThrSer: 5.744 ± 0.036	4.026ThrThr: 4.026 ± 0.033	3.746ThrVal: 3.746 ± 0.026	0.776ThrTrp: 0.776 ± 0.011	1.535ThrTyr: 1.535 ± 0.017	0.054ThrXaa: 0.054 ± 0.004
Val	5.544ValAla: 5.544 ± 0.03	0.962ValCys: 0.962 ± 0.014	3.765ValAsp: 3.765 ± 0.026	3.727ValGlu: 3.727 ± 0.025	2.427ValPhe: 2.427 ± 0.023	3.765ValGly: 3.765 ± 0.029	1.784ValHis: 1.784 ± 0.017	2.733ValIle: 2.733 ± 0.024	2.638ValLys: 2.638 ± 0.021	6.225ValLeu: 6.225 ± 0.041	1.214ValMet: 1.214 ± 0.015	1.974ValAsn: 1.974 ± 0.021	4.362ValPro: 4.362 ± 0.033	2.407ValGln: 2.407 ± 0.022	4.034ValArg: 4.034 ± 0.031	4.968ValSer: 4.968 ± 0.03	3.493ValThr: 3.493 ± 0.027	4.463ValVal: 4.463 ± 0.034	0.901ValTrp: 0.901 ± 0.013	1.687ValTyr: 1.687 ± 0.016	0.048ValXaa: 0.048 ± 0.004
Trp	1.105TrpAla: 1.105 ± 0.015	0.213TrpCys: 0.213 ± 0.006	0.897TrpAsp: 0.897 ± 0.013	0.775TrpGlu: 0.775 ± 0.011	0.502TrpPhe: 0.502 ± 0.009	0.815TrpGly: 0.815 ± 0.013	0.384TrpHis: 0.384 ± 0.008	0.686TrpIle: 0.686 ± 0.011	0.72TrpLys: 0.72 ± 0.012	1.253TrpLeu: 1.253 ± 0.015	0.336TrpMet: 0.336 ± 0.008	0.526TrpAsn: 0.526 ± 0.01	0.706TrpPro: 0.706 ± 0.012	0.511TrpGln: 0.511 ± 0.009	1.08TrpArg: 1.08 ± 0.014	1.051TrpSer: 1.051 ± 0.013	0.929TrpThr: 0.929 ± 0.015	0.826TrpVal: 0.826 ± 0.014	0.25TrpTrp: 0.25 ± 0.006	0.391TrpTyr: 0.391 ± 0.009	0.01TrpXaa: 0.01 ± 0.001
Tyr	2.234TyrAla: 2.234 ± 0.021	0.392TyrCys: 0.392 ± 0.009	1.508TyrAsp: 1.508 ± 0.016	1.335TyrGlu: 1.335 ± 0.016	1.008TyrPhe: 1.008 ± 0.015	1.79TyrGly: 1.79 ± 0.019	0.743TyrHis: 0.743 ± 0.01	1.277TyrIle: 1.277 ± 0.015	0.921TyrLys: 0.921 ± 0.012	2.441TyrLeu: 2.441 ± 0.021	0.535TyrMet: 0.535 ± 0.01	0.895TyrAsn: 0.895 ± 0.012	1.589TyrPro: 1.589 ± 0.018	0.875TyrGln: 0.875 ± 0.014	1.597TyrArg: 1.597 ± 0.016	1.861TyrSer: 1.861 ± 0.019	1.548TyrThr: 1.548 ± 0.018	1.624TyrVal: 1.624 ± 0.016	0.365TyrTrp: 0.365 ± 0.008	0.767TyrTyr: 0.767 ± 0.012	0.021TyrXaa: 0.021 ± 0.002
Xaa	0.087XaaAla: 0.087 ± 0.006	0.015XaaCys: 0.015 ± 0.002	0.044XaaAsp: 0.044 ± 0.003	0.04XaaGlu: 0.04 ± 0.003	0.03XaaPhe: 0.03 ± 0.003	0.055XaaGly: 0.055 ± 0.004	0.025XaaHis: 0.025 ± 0.002	0.034XaaIle: 0.034 ± 0.003	0.026XaaLys: 0.026 ± 0.003	0.078XaaLeu: 0.078 ± 0.006	0.014XaaMet: 0.014 ± 0.002	0.019XaaAsn: 0.019 ± 0.002	0.073XaaPro: 0.073 ± 0.005	0.034XaaGln: 0.034 ± 0.003	0.059XaaArg: 0.059 ± 0.004	0.072XaaSer: 0.072 ± 0.004	0.046XaaThr: 0.046 ± 0.004	0.057XaaVal: 0.057 ± 0.004	0.01XaaTrp: 0.01 ± 0.001	0.016XaaTyr: 0.016 ± 0.002	0.267XaaXaa: 0.267 ± 0.034

Statistics based on 11715 proteins (5974488 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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