Amino acid dipepetide frequency for Citrus leaf rugose virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.714AlaAla: 6.714 ± 1.774
0.42AlaCys: 0.42 ± 0.534
6.714AlaAsp: 6.714 ± 1.312
2.098AlaGlu: 2.098 ± 0.64
1.259AlaPhe: 1.259 ± 0.419
2.937AlaGly: 2.937 ± 1.141
1.679AlaHis: 1.679 ± 0.386
5.455AlaIle: 5.455 ± 1.995
4.196AlaLys: 4.196 ± 0.983
4.196AlaLeu: 4.196 ± 1.091
1.679AlaMet: 1.679 ± 0.509
4.196AlaAsn: 4.196 ± 2.741
2.937AlaPro: 2.937 ± 1.936
1.679AlaGln: 1.679 ± 0.83
4.616AlaArg: 4.616 ± 0.996
6.295AlaSer: 6.295 ± 1.759
5.875AlaThr: 5.875 ± 0.516
4.616AlaVal: 4.616 ± 1.731
1.679AlaTrp: 1.679 ± 0.83
3.777AlaTyr: 3.777 ± 1.434
0.0AlaXaa: 0.0 ± 0.0
Cys
2.098CysAla: 2.098 ± 0.465
0.42CysCys: 0.42 ± 0.267
1.679CysAsp: 1.679 ± 0.509
1.259CysGlu: 1.259 ± 0.537
1.679CysPhe: 1.679 ± 0.509
2.098CysGly: 2.098 ± 0.711
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.839CysLys: 0.839 ± 0.635
1.259CysLeu: 1.259 ± 0.502
0.42CysMet: 0.42 ± 0.534
0.42CysAsn: 0.42 ± 0.267
1.679CysPro: 1.679 ± 1.069
0.42CysGln: 0.42 ± 0.311
0.42CysArg: 0.42 ± 0.311
1.259CysSer: 1.259 ± 0.378
0.839CysThr: 0.839 ± 0.529
1.259CysVal: 1.259 ± 0.802
1.259CysTrp: 1.259 ± 0.502
0.42CysTyr: 0.42 ± 0.311
0.0CysXaa: 0.0 ± 0.0
Asp
8.812AspAla: 8.812 ± 0.391
2.098AspCys: 2.098 ± 0.545
4.616AspAsp: 4.616 ± 0.864
4.196AspGlu: 4.196 ± 1.273
4.616AspPhe: 4.616 ± 1.617
3.357AspGly: 3.357 ± 0.877
0.839AspHis: 0.839 ± 0.534
3.357AspIle: 3.357 ± 0.576
2.937AspLys: 2.937 ± 0.865
5.875AspLeu: 5.875 ± 1.026
1.679AspMet: 1.679 ± 0.386
2.937AspAsn: 2.937 ± 1.936
2.098AspPro: 2.098 ± 0.733
0.42AspGln: 0.42 ± 0.267
2.937AspArg: 2.937 ± 0.715
4.616AspSer: 4.616 ± 0.197
4.616AspThr: 4.616 ± 0.548
7.134AspVal: 7.134 ± 1.323
0.0AspTrp: 0.0 ± 0.0
2.937AspTyr: 2.937 ± 0.879
0.0AspXaa: 0.0 ± 0.0
Glu
2.937GluAla: 2.937 ± 0.603
0.839GluCys: 0.839 ± 0.255
2.937GluAsp: 2.937 ± 0.96
4.616GluGlu: 4.616 ± 2.048
1.679GluPhe: 1.679 ± 1.383
0.839GluGly: 0.839 ± 0.255
1.679GluHis: 1.679 ± 1.057
4.616GluIle: 4.616 ± 0.941
3.357GluLys: 3.357 ± 0.576
4.616GluLeu: 4.616 ± 0.566
2.518GluMet: 2.518 ± 1.052
1.259GluAsn: 1.259 ± 0.802
2.098GluPro: 2.098 ± 0.733
2.098GluGln: 2.098 ± 0.705
3.777GluArg: 3.777 ± 0.703
2.937GluSer: 2.937 ± 0.603
2.937GluThr: 2.937 ± 0.879
5.455GluVal: 5.455 ± 0.722
0.0GluTrp: 0.0 ± 0.0
0.839GluTyr: 0.839 ± 0.255
0.0GluXaa: 0.0 ± 0.0
Phe
1.679PheAla: 1.679 ± 0.509
0.839PheCys: 0.839 ± 0.255
3.357PheAsp: 3.357 ± 1.212
2.518PheGlu: 2.518 ± 1.004
0.42PhePhe: 0.42 ± 0.311
1.679PheGly: 1.679 ± 0.889
0.839PheHis: 0.839 ± 0.255
2.937PheIle: 2.937 ± 0.802
2.518PheLys: 2.518 ± 1.482
3.357PheLeu: 3.357 ± 1.236
0.839PheMet: 0.839 ± 0.635
2.098PheAsn: 2.098 ± 0.909
2.518PhePro: 2.518 ± 1.074
1.679PheGln: 1.679 ± 0.796
2.098PheArg: 2.098 ± 0.64
4.616PheSer: 4.616 ± 1.527
2.937PheThr: 2.937 ± 1.016
4.616PheVal: 4.616 ± 1.121
0.839PheTrp: 0.839 ± 0.502
1.679PheTyr: 1.679 ± 0.491
0.0PheXaa: 0.0 ± 0.0
Gly
2.518GlyAla: 2.518 ± 0.764
1.259GlyCys: 1.259 ± 0.502
2.937GlyAsp: 2.937 ± 0.603
2.518GlyGlu: 2.518 ± 0.492
2.937GlyPhe: 2.937 ± 1.895
0.839GlyGly: 0.839 ± 0.255
0.42GlyHis: 0.42 ± 0.311
2.518GlyIle: 2.518 ± 0.456
4.196GlyLys: 4.196 ± 0.297
5.036GlyLeu: 5.036 ± 2.349
0.839GlyMet: 0.839 ± 0.534
0.839GlyAsn: 0.839 ± 0.255
1.259GlyPro: 1.259 ± 0.537
1.679GlyGln: 1.679 ± 0.722
4.196GlyArg: 4.196 ± 1.199
3.777GlySer: 3.777 ± 1.78
0.839GlyThr: 0.839 ± 0.692
4.616GlyVal: 4.616 ± 0.548
0.839GlyTrp: 0.839 ± 0.502
0.839GlyTyr: 0.839 ± 0.692
0.0GlyXaa: 0.0 ± 0.0
His
1.259HisAla: 1.259 ± 0.802
0.839HisCys: 0.839 ± 0.534
0.839HisAsp: 0.839 ± 0.255
2.518HisGlu: 2.518 ± 1.052
1.259HisPhe: 1.259 ± 0.419
0.0HisGly: 0.0 ± 0.0
1.259HisHis: 1.259 ± 0.813
0.839HisIle: 0.839 ± 0.255
2.937HisLys: 2.937 ± 0.715
0.839HisLeu: 0.839 ± 0.623
0.42HisMet: 0.42 ± 0.311
1.259HisAsn: 1.259 ± 0.419
0.839HisPro: 0.839 ± 0.534
0.839HisGln: 0.839 ± 0.623
2.098HisArg: 2.098 ± 0.545
1.679HisSer: 1.679 ± 0.783
1.259HisThr: 1.259 ± 0.677
2.518HisVal: 2.518 ± 0.553
0.42HisTrp: 0.42 ± 0.311
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.196IleAla: 4.196 ± 0.805
1.259IleCys: 1.259 ± 0.934
3.357IleAsp: 3.357 ± 0.99
2.098IleGlu: 2.098 ± 0.58
0.839IlePhe: 0.839 ± 0.623
1.259IleGly: 1.259 ± 0.502
1.259IleHis: 1.259 ± 0.502
3.357IleIle: 3.357 ± 0.788
3.357IleLys: 3.357 ± 1.173
4.616IleLeu: 4.616 ± 1.056
1.679IleMet: 1.679 ± 0.655
2.518IleAsn: 2.518 ± 0.858
7.134IlePro: 7.134 ± 1.247
2.518IleGln: 2.518 ± 1.406
3.357IleArg: 3.357 ± 0.399
5.036IleSer: 5.036 ± 1.633
3.777IleThr: 3.777 ± 0.68
2.937IleVal: 2.937 ± 0.603
0.0IleTrp: 0.0 ± 0.0
2.518IleTyr: 2.518 ± 0.755
0.0IleXaa: 0.0 ± 0.0
Lys
3.777LysAla: 3.777 ± 1.421
0.839LysCys: 0.839 ± 0.255
4.196LysAsp: 4.196 ± 2.253
2.518LysGlu: 2.518 ± 0.419
4.616LysPhe: 4.616 ± 2.035
2.518LysGly: 2.518 ± 0.974
1.259LysHis: 1.259 ± 0.802
4.616LysIle: 4.616 ± 1.052
3.777LysLys: 3.777 ± 0.802
2.937LysLeu: 2.937 ± 0.976
3.357LysMet: 3.357 ± 1.337
1.679LysAsn: 1.679 ± 0.796
5.455LysPro: 5.455 ± 0.632
1.259LysGln: 1.259 ± 0.802
1.679LysArg: 1.679 ± 1.245
3.777LysSer: 3.777 ± 1.047
5.036LysThr: 5.036 ± 2.31
3.357LysVal: 3.357 ± 0.895
1.679LysTrp: 1.679 ± 0.477
2.098LysTyr: 2.098 ± 0.465
0.0LysXaa: 0.0 ± 0.0
Leu
4.616LeuAla: 4.616 ± 0.735
1.679LeuCys: 1.679 ± 1.245
5.875LeuAsp: 5.875 ± 2.232
5.455LeuGlu: 5.455 ± 1.359
3.777LeuPhe: 3.777 ± 0.986
2.518LeuGly: 2.518 ± 0.621
1.259LeuHis: 1.259 ± 0.813
4.616LeuIle: 4.616 ± 1.085
5.036LeuLys: 5.036 ± 1.449
8.393LeuLeu: 8.393 ± 1.572
2.098LeuMet: 2.098 ± 0.832
3.357LeuAsn: 3.357 ± 1.694
5.455LeuPro: 5.455 ± 1.567
1.679LeuGln: 1.679 ± 0.796
4.616LeuArg: 4.616 ± 1.051
10.071LeuSer: 10.071 ± 1.896
2.098LeuThr: 2.098 ± 0.361
7.134LeuVal: 7.134 ± 0.954
0.42LeuTrp: 0.42 ± 0.311
2.518LeuTyr: 2.518 ± 0.838
0.0LeuXaa: 0.0 ± 0.0
Met
2.098MetAla: 2.098 ± 1.15
0.0MetCys: 0.0 ± 0.0
3.357MetAsp: 3.357 ± 0.981
2.098MetGlu: 2.098 ± 0.545
0.42MetPhe: 0.42 ± 0.534
0.839MetGly: 0.839 ± 0.255
1.259MetHis: 1.259 ± 0.502
2.518MetIle: 2.518 ± 0.767
0.42MetLys: 0.42 ± 0.311
2.937MetLeu: 2.937 ± 0.497
0.42MetMet: 0.42 ± 0.534
2.098MetAsn: 2.098 ± 2.061
1.679MetPro: 1.679 ± 0.722
1.259MetGln: 1.259 ± 0.419
1.259MetArg: 1.259 ± 0.859
1.259MetSer: 1.259 ± 0.419
0.839MetThr: 0.839 ± 0.534
2.518MetVal: 2.518 ± 1.033
0.839MetTrp: 0.839 ± 0.623
0.839MetTyr: 0.839 ± 0.692
0.0MetXaa: 0.0 ± 0.0
Asn
4.616AsnAla: 4.616 ± 2.652
0.0AsnCys: 0.0 ± 0.0
2.518AsnAsp: 2.518 ± 0.553
1.259AsnGlu: 1.259 ± 1.001
2.937AsnPhe: 2.937 ± 1.752
1.679AsnGly: 1.679 ± 0.606
1.259AsnHis: 1.259 ± 0.419
1.259AsnIle: 1.259 ± 0.903
1.679AsnLys: 1.679 ± 0.889
2.098AsnLeu: 2.098 ± 1.336
0.42AsnMet: 0.42 ± 0.311
0.0AsnAsn: 0.0 ± 0.0
2.098AsnPro: 2.098 ± 0.64
0.839AsnGln: 0.839 ± 0.255
3.777AsnArg: 3.777 ± 2.387
3.357AsnSer: 3.357 ± 0.771
3.777AsnThr: 3.777 ± 1.31
5.036AsnVal: 5.036 ± 2.788
0.42AsnTrp: 0.42 ± 0.7
1.259AsnTyr: 1.259 ± 0.677
0.0AsnXaa: 0.0 ± 0.0
Pro
3.777ProAla: 3.777 ± 1.434
0.0ProCys: 0.0 ± 0.0
5.455ProAsp: 5.455 ± 0.79
2.518ProGlu: 2.518 ± 1.406
1.679ProPhe: 1.679 ± 0.477
3.357ProGly: 3.357 ± 1.954
1.259ProHis: 1.259 ± 0.419
2.098ProIle: 2.098 ± 0.58
2.518ProLys: 2.518 ± 1.406
5.036ProLeu: 5.036 ± 0.943
1.679ProMet: 1.679 ± 1.458
1.679ProAsn: 1.679 ± 1.221
3.357ProPro: 3.357 ± 2.236
2.098ProGln: 2.098 ± 0.465
3.777ProArg: 3.777 ± 1.171
4.196ProSer: 4.196 ± 1.273
3.357ProThr: 3.357 ± 0.99
2.518ProVal: 2.518 ± 1.322
0.42ProTrp: 0.42 ± 0.267
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.357GlnAla: 3.357 ± 1.019
0.42GlnCys: 0.42 ± 0.267
1.259GlnAsp: 1.259 ± 0.934
0.42GlnGlu: 0.42 ± 0.267
0.839GlnPhe: 0.839 ± 0.255
1.679GlnGly: 1.679 ± 0.606
0.0GlnHis: 0.0 ± 0.0
1.259GlnIle: 1.259 ± 0.502
1.679GlnLys: 1.679 ± 0.477
2.098GlnLeu: 2.098 ± 0.8
0.839GlnMet: 0.839 ± 0.529
1.679GlnAsn: 1.679 ± 0.386
1.259GlnPro: 1.259 ± 0.537
0.839GlnGln: 0.839 ± 0.623
2.937GlnArg: 2.937 ± 1.345
2.937GlnSer: 2.937 ± 1.294
2.518GlnThr: 2.518 ± 1.004
1.259GlnVal: 1.259 ± 0.802
0.42GlnTrp: 0.42 ± 0.7
1.259GlnTyr: 1.259 ± 0.419
0.0GlnXaa: 0.0 ± 0.0
Arg
1.679ArgAla: 1.679 ± 0.722
1.259ArgCys: 1.259 ± 0.601
4.616ArgAsp: 4.616 ± 0.566
3.357ArgGlu: 3.357 ± 0.576
1.679ArgPhe: 1.679 ± 0.509
4.616ArgGly: 4.616 ± 0.548
1.679ArgHis: 1.679 ± 0.655
3.777ArgIle: 3.777 ± 1.408
2.518ArgLys: 2.518 ± 0.764
4.616ArgLeu: 4.616 ± 2.076
1.259ArgMet: 1.259 ± 0.537
2.937ArgAsn: 2.937 ± 0.976
1.679ArgPro: 1.679 ± 1.018
3.357ArgGln: 3.357 ± 1.216
6.714ArgArg: 6.714 ± 0.579
5.455ArgSer: 5.455 ± 1.483
2.937ArgThr: 2.937 ± 0.359
5.455ArgVal: 5.455 ± 0.434
1.679ArgTrp: 1.679 ± 0.783
2.098ArgTyr: 2.098 ± 1.004
0.0ArgXaa: 0.0 ± 0.0
Ser
4.196SerAla: 4.196 ± 1.208
1.679SerCys: 1.679 ± 0.509
3.777SerAsp: 3.777 ± 1.081
1.679SerGlu: 1.679 ± 0.796
5.875SerPhe: 5.875 ± 0.718
6.295SerGly: 6.295 ± 0.913
2.518SerHis: 2.518 ± 0.767
3.777SerIle: 3.777 ± 1.561
5.875SerLys: 5.875 ± 1.642
8.812SerLeu: 8.812 ± 0.929
2.518SerMet: 2.518 ± 1.059
3.357SerAsn: 3.357 ± 0.877
2.937SerPro: 2.937 ± 0.976
1.259SerGln: 1.259 ± 0.813
5.875SerArg: 5.875 ± 1.173
9.652SerSer: 9.652 ± 1.904
4.196SerThr: 4.196 ± 1.426
5.455SerVal: 5.455 ± 1.991
1.259SerTrp: 1.259 ± 0.502
2.098SerTyr: 2.098 ± 0.909
0.0SerXaa: 0.0 ± 0.0
Thr
3.777ThrAla: 3.777 ± 1.715
2.518ThrCys: 2.518 ± 0.758
4.616ThrAsp: 4.616 ± 0.921
2.518ThrGlu: 2.518 ± 0.492
3.777ThrPhe: 3.777 ± 0.703
2.937ThrGly: 2.937 ± 0.359
2.098ThrHis: 2.098 ± 0.545
2.518ThrIle: 2.518 ± 0.456
4.196ThrLys: 4.196 ± 1.426
6.295ThrLeu: 6.295 ± 1.388
1.679ThrMet: 1.679 ± 1.003
2.098ThrAsn: 2.098 ± 0.58
2.098ThrPro: 2.098 ± 1.074
1.259ThrGln: 1.259 ± 0.502
2.098ThrArg: 2.098 ± 0.733
3.777ThrSer: 3.777 ± 0.986
2.937ThrThr: 2.937 ± 0.702
2.098ThrVal: 2.098 ± 1.134
1.259ThrTrp: 1.259 ± 0.537
2.098ThrTyr: 2.098 ± 1.099
0.0ThrXaa: 0.0 ± 0.0
Val
6.295ValAla: 6.295 ± 1.802
2.098ValCys: 2.098 ± 0.705
5.875ValAsp: 5.875 ± 1.884
5.036ValGlu: 5.036 ± 1.464
1.259ValPhe: 1.259 ± 0.802
3.777ValGly: 3.777 ± 1.296
1.679ValHis: 1.679 ± 0.655
5.036ValIle: 5.036 ± 1.017
6.714ValLys: 6.714 ± 0.66
5.036ValLeu: 5.036 ± 1.306
2.518ValMet: 2.518 ± 0.599
2.937ValAsn: 2.937 ± 0.524
2.937ValPro: 2.937 ± 1.329
1.259ValGln: 1.259 ± 0.502
4.196ValArg: 4.196 ± 2.264
5.875ValSer: 5.875 ± 1.079
4.196ValThr: 4.196 ± 0.55
3.357ValVal: 3.357 ± 0.553
1.679ValTrp: 1.679 ± 1.221
1.679ValTyr: 1.679 ± 0.722
0.0ValXaa: 0.0 ± 0.0
Trp
1.679TrpAla: 1.679 ± 0.811
0.42TrpCys: 0.42 ± 0.311
0.42TrpAsp: 0.42 ± 0.267
2.098TrpGlu: 2.098 ± 1.22
1.679TrpPhe: 1.679 ± 0.509
1.259TrpGly: 1.259 ± 0.537
0.839TrpHis: 0.839 ± 0.692
0.42TrpIle: 0.42 ± 0.534
0.839TrpLys: 0.839 ± 0.635
1.679TrpLeu: 1.679 ± 0.509
0.839TrpMet: 0.839 ± 0.623
0.839TrpAsn: 0.839 ± 0.529
0.42TrpPro: 0.42 ± 0.534
0.0TrpGln: 0.0 ± 0.0
0.42TrpArg: 0.42 ± 0.267
0.839TrpSer: 0.839 ± 0.255
0.0TrpThr: 0.0 ± 0.0
0.42TrpVal: 0.42 ± 0.311
0.0TrpTrp: 0.0 ± 0.0
0.42TrpTyr: 0.42 ± 0.7
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.937TyrAla: 2.937 ± 1.141
0.839TyrCys: 0.839 ± 0.635
1.679TyrAsp: 1.679 ± 0.509
1.259TyrGlu: 1.259 ± 0.601
0.839TyrPhe: 0.839 ± 0.623
0.42TyrGly: 0.42 ± 0.7
0.839TyrHis: 0.839 ± 0.623
2.098TyrIle: 2.098 ± 0.361
0.839TyrLys: 0.839 ± 0.534
2.937TyrLeu: 2.937 ± 0.821
0.839TyrMet: 0.839 ± 0.255
2.098TyrAsn: 2.098 ± 1.134
0.839TyrPro: 0.839 ± 0.623
2.518TyrGln: 2.518 ± 1.482
2.518TyrArg: 2.518 ± 1.168
2.098TyrSer: 2.098 ± 0.58
1.679TyrThr: 1.679 ± 0.655
1.679TyrVal: 1.679 ± 0.606
0.42TyrTrp: 0.42 ± 0.267
1.679TyrTyr: 1.679 ± 0.655
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski