Amino acid dipepetide frequency for Pseudodesulfovibrio cashew

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.302AlaAla: 10.302 ± 0.151	1.413AlaCys: 1.413 ± 0.036	5.435AlaAsp: 5.435 ± 0.078	6.759AlaGlu: 6.759 ± 0.088	3.74AlaPhe: 3.74 ± 0.061	8.204AlaGly: 8.204 ± 0.113	1.806AlaHis: 1.806 ± 0.038	4.93AlaIle: 4.93 ± 0.072	4.552AlaLys: 4.552 ± 0.07	10.438AlaLeu: 10.438 ± 0.099	3.422AlaMet: 3.422 ± 0.058	2.63AlaAsn: 2.63 ± 0.064	3.636AlaPro: 3.636 ± 0.067	2.716AlaGln: 2.716 ± 0.055	5.756AlaArg: 5.756 ± 0.094	5.027AlaSer: 5.027 ± 0.069	4.37AlaThr: 4.37 ± 0.077	7.544AlaVal: 7.544 ± 0.098	1.183AlaTrp: 1.183 ± 0.038	2.547AlaTyr: 2.547 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.159CysAla: 1.159 ± 0.034	0.24CysCys: 0.24 ± 0.015	0.656CysAsp: 0.656 ± 0.023	0.729CysGlu: 0.729 ± 0.026	0.479CysPhe: 0.479 ± 0.019	1.364CysGly: 1.364 ± 0.043	0.404CysHis: 0.404 ± 0.025	0.618CysIle: 0.618 ± 0.025	0.469CysLys: 0.469 ± 0.023	1.341CysLeu: 1.341 ± 0.034	0.336CysMet: 0.336 ± 0.017	0.395CysAsn: 0.395 ± 0.019	0.882CysPro: 0.882 ± 0.025	0.316CysGln: 0.316 ± 0.019	0.852CysArg: 0.852 ± 0.026	0.795CysSer: 0.795 ± 0.026	0.576CysThr: 0.576 ± 0.023	0.949CysVal: 0.949 ± 0.028	0.15CysTrp: 0.15 ± 0.012	0.345CysTyr: 0.345 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.094AspAla: 5.094 ± 0.078	0.696AspCys: 0.696 ± 0.027	3.126AspAsp: 3.126 ± 0.077	4.28AspGlu: 4.28 ± 0.07	2.694AspPhe: 2.694 ± 0.043	4.731AspGly: 4.731 ± 0.142	1.118AspHis: 1.118 ± 0.031	3.588AspIle: 3.588 ± 0.081	2.892AspLys: 2.892 ± 0.055	5.725AspLeu: 5.725 ± 0.073	1.831AspMet: 1.831 ± 0.043	1.763AspAsn: 1.763 ± 0.051	3.056AspPro: 3.056 ± 0.058	1.56AspGln: 1.56 ± 0.039	3.496AspArg: 3.496 ± 0.062	2.758AspSer: 2.758 ± 0.052	2.773AspThr: 2.773 ± 0.079	4.209AspVal: 4.209 ± 0.068	0.752AspTrp: 0.752 ± 0.027	1.868AspTyr: 1.868 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	7.309GluAla: 7.309 ± 0.1	0.709GluCys: 0.709 ± 0.023	3.72GluAsp: 3.72 ± 0.068	5.075GluGlu: 5.075 ± 0.091	2.491GluPhe: 2.491 ± 0.047	4.857GluGly: 4.857 ± 0.063	1.339GluHis: 1.339 ± 0.033	3.962GluIle: 3.962 ± 0.062	3.778GluLys: 3.778 ± 0.064	6.812GluLeu: 6.812 ± 0.08	2.073GluMet: 2.073 ± 0.044	2.355GluAsn: 2.355 ± 0.045	2.667GluPro: 2.667 ± 0.056	2.327GluGln: 2.327 ± 0.048	4.499GluArg: 4.499 ± 0.08	3.264GluSer: 3.264 ± 0.056	3.652GluThr: 3.652 ± 0.065	4.707GluVal: 4.707 ± 0.071	0.639GluTrp: 0.639 ± 0.029	1.846GluTyr: 1.846 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.55PheAla: 3.55 ± 0.058	0.597PheCys: 0.597 ± 0.024	2.591PheAsp: 2.591 ± 0.046	2.435PheGlu: 2.435 ± 0.043	1.871PhePhe: 1.871 ± 0.049	3.391PheGly: 3.391 ± 0.075	0.841PheHis: 0.841 ± 0.026	2.128PheIle: 2.128 ± 0.05	1.812PheLys: 1.812 ± 0.04	4.387PheLeu: 4.387 ± 0.068	1.145PheMet: 1.145 ± 0.036	1.373PheAsn: 1.373 ± 0.038	1.813PhePro: 1.813 ± 0.042	1.148PheGln: 1.148 ± 0.03	2.228PheArg: 2.228 ± 0.047	2.684PheSer: 2.684 ± 0.049	2.385PheThr: 2.385 ± 0.066	2.821PheVal: 2.821 ± 0.059	0.519PheTrp: 0.519 ± 0.024	1.24PheTyr: 1.24 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.816GlyAla: 6.816 ± 0.09	1.297GlyCys: 1.297 ± 0.034	4.493GlyAsp: 4.493 ± 0.1	5.507GlyGlu: 5.507 ± 0.072	3.534GlyPhe: 3.534 ± 0.063	6.659GlyGly: 6.659 ± 0.115	1.765GlyHis: 1.765 ± 0.042	4.694GlyIle: 4.694 ± 0.066	4.611GlyLys: 4.611 ± 0.076	8.765GlyLeu: 8.765 ± 0.113	2.87GlyMet: 2.87 ± 0.057	2.418GlyAsn: 2.418 ± 0.043	2.797GlyPro: 2.797 ± 0.054	2.54GlyGln: 2.54 ± 0.049	4.838GlyArg: 4.838 ± 0.066	4.357GlySer: 4.357 ± 0.104	4.258GlyThr: 4.258 ± 0.104	6.342GlyVal: 6.342 ± 0.079	1.059GlyTrp: 1.059 ± 0.033	2.621GlyTyr: 2.621 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.752HisAla: 1.752 ± 0.044	0.35HisCys: 0.35 ± 0.018	1.193HisAsp: 1.193 ± 0.03	1.156HisGlu: 1.156 ± 0.032	0.961HisPhe: 0.961 ± 0.03	1.768HisGly: 1.768 ± 0.036	0.512HisHis: 0.512 ± 0.025	1.036HisIle: 1.036 ± 0.028	0.79HisLys: 0.79 ± 0.028	2.006HisLeu: 2.006 ± 0.047	0.526HisMet: 0.526 ± 0.021	0.639HisAsn: 0.639 ± 0.025	1.263HisPro: 1.263 ± 0.036	0.592HisGln: 0.592 ± 0.022	1.163HisArg: 1.163 ± 0.034	1.085HisSer: 1.085 ± 0.031	0.978HisThr: 0.978 ± 0.033	1.354HisVal: 1.354 ± 0.037	0.251HisTrp: 0.251 ± 0.013	0.629HisTyr: 0.629 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.836IleAla: 4.836 ± 0.073	0.718IleCys: 0.718 ± 0.029	2.992IleAsp: 2.992 ± 0.061	3.39IleGlu: 3.39 ± 0.061	2.117IlePhe: 2.117 ± 0.048	4.318IleGly: 4.318 ± 0.064	1.056IleHis: 1.056 ± 0.031	2.954IleIle: 2.954 ± 0.062	2.542IleLys: 2.542 ± 0.047	5.604IleLeu: 5.604 ± 0.086	1.517IleMet: 1.517 ± 0.045	1.86IleAsn: 1.86 ± 0.045	2.855IlePro: 2.855 ± 0.051	1.486IleGln: 1.486 ± 0.043	3.515IleArg: 3.515 ± 0.054	3.331IleSer: 3.331 ± 0.06	2.9IleThr: 2.9 ± 0.061	3.801IleVal: 3.801 ± 0.055	0.553IleTrp: 0.553 ± 0.024	1.417IleTyr: 1.417 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.992LysAla: 4.992 ± 0.08	0.466LysCys: 0.466 ± 0.021	2.85LysAsp: 2.85 ± 0.059	3.394LysGlu: 3.394 ± 0.066	1.428LysPhe: 1.428 ± 0.038	3.85LysGly: 3.85 ± 0.066	0.872LysHis: 0.872 ± 0.026	2.541LysIle: 2.541 ± 0.051	2.9LysLys: 2.9 ± 0.078	4.54LysLeu: 4.54 ± 0.069	1.323LysMet: 1.323 ± 0.041	1.566LysAsn: 1.566 ± 0.036	2.332LysPro: 2.332 ± 0.052	1.611LysGln: 1.611 ± 0.042	3.08LysArg: 3.08 ± 0.051	2.48LysSer: 2.48 ± 0.055	2.618LysThr: 2.618 ± 0.046	3.523LysVal: 3.523 ± 0.056	0.472LysTrp: 0.472 ± 0.02	1.31LysTyr: 1.31 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.444LeuAla: 11.444 ± 0.128	1.325LeuCys: 1.325 ± 0.034	6.421LeuAsp: 6.421 ± 0.082	6.815LeuGlu: 6.815 ± 0.097	4.386LeuPhe: 4.386 ± 0.071	8.516LeuGly: 8.516 ± 0.098	1.901LeuHis: 1.901 ± 0.045	4.971LeuIle: 4.971 ± 0.087	5.063LeuLys: 5.063 ± 0.069	10.412LeuLeu: 10.412 ± 0.142	2.584LeuMet: 2.584 ± 0.048	3.139LeuAsn: 3.139 ± 0.054	5.117LeuPro: 5.117 ± 0.074	2.575LeuGln: 2.575 ± 0.052	5.832LeuArg: 5.832 ± 0.084	6.538LeuSer: 6.538 ± 0.096	5.741LeuThr: 5.741 ± 0.083	7.124LeuVal: 7.124 ± 0.08	1.031LeuTrp: 1.031 ± 0.038	2.499LeuTyr: 2.499 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	3.368MetAla: 3.368 ± 0.052	0.263MetCys: 0.263 ± 0.016	1.958MetAsp: 1.958 ± 0.048	1.997MetGlu: 1.997 ± 0.041	0.928MetPhe: 0.928 ± 0.034	2.443MetGly: 2.443 ± 0.052	0.563MetHis: 0.563 ± 0.023	1.41MetIle: 1.41 ± 0.036	1.421MetLys: 1.421 ± 0.041	2.726MetLeu: 2.726 ± 0.058	0.619MetMet: 0.619 ± 0.03	0.94MetAsn: 0.94 ± 0.03	1.476MetPro: 1.476 ± 0.039	0.944MetGln: 0.944 ± 0.031	1.738MetArg: 1.738 ± 0.041	1.836MetSer: 1.836 ± 0.044	1.802MetThr: 1.802 ± 0.042	2.133MetVal: 2.133 ± 0.043	0.216MetTrp: 0.216 ± 0.015	0.556MetTyr: 0.556 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.755AsnAla: 2.755 ± 0.056	0.456AsnCys: 0.456 ± 0.02	1.62AsnAsp: 1.62 ± 0.044	1.793AsnGlu: 1.793 ± 0.04	1.247AsnPhe: 1.247 ± 0.037	2.525AsnGly: 2.525 ± 0.076	0.591AsnHis: 0.591 ± 0.021	1.897AsnIle: 1.897 ± 0.039	1.335AsnLys: 1.335 ± 0.034	3.24AsnLeu: 3.24 ± 0.05	0.921AsnMet: 0.921 ± 0.028	1.0AsnAsn: 1.0 ± 0.035	1.939AsnPro: 1.939 ± 0.043	0.887AsnGln: 0.887 ± 0.029	2.018AsnArg: 2.018 ± 0.042	1.529AsnSer: 1.529 ± 0.035	1.494AsnThr: 1.494 ± 0.035	2.25AsnVal: 2.25 ± 0.046	0.436AsnTrp: 0.436 ± 0.02	0.874AsnTyr: 0.874 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.397ProAla: 4.397 ± 0.076	0.548ProCys: 0.548 ± 0.022	3.386ProAsp: 3.386 ± 0.052	4.438ProGlu: 4.438 ± 0.066	1.914ProPhe: 1.914 ± 0.041	4.357ProGly: 4.357 ± 0.072	0.955ProHis: 0.955 ± 0.03	1.975ProIle: 1.975 ± 0.046	2.031ProLys: 2.031 ± 0.051	4.5ProLeu: 4.5 ± 0.066	1.245ProMet: 1.245 ± 0.034	1.198ProAsn: 1.198 ± 0.029	1.888ProPro: 1.888 ± 0.051	1.221ProGln: 1.221 ± 0.034	2.108ProArg: 2.108 ± 0.044	2.378ProSer: 2.378 ± 0.046	1.967ProThr: 1.967 ± 0.045	3.934ProVal: 3.934 ± 0.068	0.604ProTrp: 0.604 ± 0.026	1.331ProTyr: 1.331 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.409GlnAla: 3.409 ± 0.067	0.394GlnCys: 0.394 ± 0.023	1.516GlnAsp: 1.516 ± 0.037	1.915GlnGlu: 1.915 ± 0.044	1.06GlnPhe: 1.06 ± 0.031	2.5GlnGly: 2.5 ± 0.047	0.535GlnHis: 0.535 ± 0.019	1.504GlnIle: 1.504 ± 0.04	1.35GlnLys: 1.35 ± 0.038	2.747GlnLeu: 2.747 ± 0.048	0.842GlnMet: 0.842 ± 0.029	0.884GlnAsn: 0.884 ± 0.028	1.238GlnPro: 1.238 ± 0.033	1.049GlnGln: 1.049 ± 0.036	1.779GlnArg: 1.779 ± 0.05	1.63GlnSer: 1.63 ± 0.038	1.448GlnThr: 1.448 ± 0.036	2.222GlnVal: 2.222 ± 0.044	0.401GlnTrp: 0.401 ± 0.02	0.843GlnTyr: 0.843 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	4.935ArgAla: 4.935 ± 0.079	0.698ArgCys: 0.698 ± 0.026	3.496ArgAsp: 3.496 ± 0.062	4.858ArgGlu: 4.858 ± 0.079	2.784ArgPhe: 2.784 ± 0.053	3.651ArgGly: 3.651 ± 0.058	1.37ArgHis: 1.37 ± 0.046	3.762ArgIle: 3.762 ± 0.062	3.339ArgLys: 3.339 ± 0.061	6.48ArgLeu: 6.48 ± 0.107	1.84ArgMet: 1.84 ± 0.041	2.003ArgAsn: 2.003 ± 0.047	2.472ArgPro: 2.472 ± 0.051	2.154ArgGln: 2.154 ± 0.05	3.932ArgArg: 3.932 ± 0.081	3.043ArgSer: 3.043 ± 0.055	2.993ArgThr: 2.993 ± 0.06	4.024ArgVal: 4.024 ± 0.069	0.636ArgTrp: 0.636 ± 0.023	1.826ArgTyr: 1.826 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.711SerAla: 4.711 ± 0.066	0.698SerCys: 0.698 ± 0.024	2.85SerAsp: 2.85 ± 0.055	3.289SerGlu: 3.289 ± 0.061	2.382SerPhe: 2.382 ± 0.058	5.496SerGly: 5.496 ± 0.084	1.12SerHis: 1.12 ± 0.03	2.981SerIle: 2.981 ± 0.062	2.33SerLys: 2.33 ± 0.047	6.15SerLeu: 6.15 ± 0.086	1.771SerMet: 1.771 ± 0.047	1.466SerAsn: 1.466 ± 0.037	2.661SerPro: 2.661 ± 0.055	1.649SerGln: 1.649 ± 0.039	3.441SerArg: 3.441 ± 0.067	3.103SerSer: 3.103 ± 0.065	2.696SerThr: 2.696 ± 0.053	4.154SerVal: 4.154 ± 0.084	0.681SerTrp: 0.681 ± 0.03	1.454SerTyr: 1.454 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.839ThrAla: 4.839 ± 0.063	0.597ThrCys: 0.597 ± 0.025	2.867ThrAsp: 2.867 ± 0.078	2.913ThrGlu: 2.913 ± 0.052	2.024ThrPhe: 2.024 ± 0.05	5.073ThrGly: 5.073 ± 0.071	1.024ThrHis: 1.024 ± 0.031	2.848ThrIle: 2.848 ± 0.072	1.89ThrLys: 1.89 ± 0.047	5.667ThrLeu: 5.667 ± 0.076	1.367ThrMet: 1.367 ± 0.035	1.441ThrAsn: 1.441 ± 0.041	3.054ThrPro: 3.054 ± 0.055	1.283ThrGln: 1.283 ± 0.034	2.907ThrArg: 2.907 ± 0.048	2.611ThrSer: 2.611 ± 0.054	2.61ThrThr: 2.61 ± 0.061	4.441ThrVal: 4.441 ± 0.113	0.632ThrTrp: 0.632 ± 0.037	1.337ThrTyr: 1.337 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.199ValAla: 7.199 ± 0.095	1.014ValCys: 1.014 ± 0.034	4.418ValAsp: 4.418 ± 0.063	4.945ValGlu: 4.945 ± 0.072	3.083ValPhe: 3.083 ± 0.052	5.353ValGly: 5.353 ± 0.067	1.402ValHis: 1.402 ± 0.037	4.193ValIle: 4.193 ± 0.065	3.285ValLys: 3.285 ± 0.058	7.722ValLeu: 7.722 ± 0.109	2.072ValMet: 2.072 ± 0.042	2.456ValAsn: 2.456 ± 0.053	3.333ValPro: 3.333 ± 0.055	1.968ValGln: 1.968 ± 0.042	4.583ValArg: 4.583 ± 0.076	4.497ValSer: 4.497 ± 0.075	4.118ValThr: 4.118 ± 0.051	5.861ValVal: 5.861 ± 0.09	0.748ValTrp: 0.748 ± 0.029	1.849ValTyr: 1.849 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.983TrpAla: 0.983 ± 0.03	0.143TrpCys: 0.143 ± 0.01	0.712TrpAsp: 0.712 ± 0.026	0.717TrpGlu: 0.717 ± 0.026	0.512TrpPhe: 0.512 ± 0.024	0.883TrpGly: 0.883 ± 0.031	0.251TrpHis: 0.251 ± 0.016	0.55TrpIle: 0.55 ± 0.025	0.605TrpLys: 0.605 ± 0.023	1.273TrpLeu: 1.273 ± 0.04	0.335TrpMet: 0.335 ± 0.017	0.413TrpAsn: 0.413 ± 0.016	0.547TrpPro: 0.547 ± 0.021	0.451TrpGln: 0.451 ± 0.019	0.736TrpArg: 0.736 ± 0.028	0.572TrpSer: 0.572 ± 0.023	0.657TrpThr: 0.657 ± 0.037	0.735TrpVal: 0.735 ± 0.028	0.195TrpTrp: 0.195 ± 0.013	0.291TrpTyr: 0.291 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.561TyrAla: 2.561 ± 0.051	0.432TyrCys: 0.432 ± 0.022	1.709TyrAsp: 1.709 ± 0.044	1.672TyrGlu: 1.672 ± 0.035	1.325TyrPhe: 1.325 ± 0.033	2.303TyrGly: 2.303 ± 0.044	0.581TyrHis: 0.581 ± 0.022	1.219TyrIle: 1.219 ± 0.036	1.15TyrLys: 1.15 ± 0.035	2.9TyrLeu: 2.9 ± 0.053	0.701TyrMet: 0.701 ± 0.028	0.869TyrAsn: 0.869 ± 0.031	1.347TyrPro: 1.347 ± 0.036	0.791TyrGln: 0.791 ± 0.03	1.795TyrArg: 1.795 ± 0.043	1.567TyrSer: 1.567 ± 0.046	1.39TyrThr: 1.39 ± 0.039	1.971TyrVal: 1.971 ± 0.044	0.399TyrTrp: 0.399 ± 0.018	0.952TyrTyr: 0.952 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3498 proteins (1141533 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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