Amino acid dipepetide frequency for Streptococcus ictaluri 707-05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.477AlaAla: 5.477 ± 0.14	0.512AlaCys: 0.512 ± 0.029	4.01AlaAsp: 4.01 ± 0.087	4.425AlaGlu: 4.425 ± 0.119	3.807AlaPhe: 3.807 ± 0.079	4.774AlaGly: 4.774 ± 0.111	1.25AlaHis: 1.25 ± 0.049	6.696AlaIle: 6.696 ± 0.112	5.985AlaLys: 5.985 ± 0.106	8.058AlaLeu: 8.058 ± 0.124	2.098AlaMet: 2.098 ± 0.057	3.349AlaAsn: 3.349 ± 0.068	2.019AlaPro: 2.019 ± 0.054	3.133AlaGln: 3.133 ± 0.085	2.845AlaArg: 2.845 ± 0.077	4.962AlaSer: 4.962 ± 0.1	3.888AlaThr: 3.888 ± 0.077	4.916AlaVal: 4.916 ± 0.103	0.602AlaTrp: 0.602 ± 0.034	3.001AlaTyr: 3.001 ± 0.072	0.0AlaXaa: 0.0 ± 0.0
Cys	0.327CysAla: 0.327 ± 0.028	0.059CysCys: 0.059 ± 0.01	0.322CysAsp: 0.322 ± 0.025	0.263CysGlu: 0.263 ± 0.02	0.327CysPhe: 0.327 ± 0.022	0.49CysGly: 0.49 ± 0.026	0.214CysHis: 0.214 ± 0.019	0.325CysIle: 0.325 ± 0.023	0.2CysLys: 0.2 ± 0.018	0.832CysLeu: 0.832 ± 0.041	0.138CysMet: 0.138 ± 0.016	0.191CysAsn: 0.191 ± 0.017	0.322CysPro: 0.322 ± 0.022	0.485CysGln: 0.485 ± 0.027	0.3CysArg: 0.3 ± 0.023	0.437CysSer: 0.437 ± 0.028	0.21CysThr: 0.21 ± 0.017	0.28CysVal: 0.28 ± 0.021	0.033CysTrp: 0.033 ± 0.007	0.244CysTyr: 0.244 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.591AspAla: 3.591 ± 0.086	0.402AspCys: 0.402 ± 0.024	3.036AspAsp: 3.036 ± 0.074	3.339AspGlu: 3.339 ± 0.076	3.25AspPhe: 3.25 ± 0.082	3.539AspGly: 3.539 ± 0.08	1.189AspHis: 1.189 ± 0.046	4.447AspIle: 4.447 ± 0.088	4.516AspLys: 4.516 ± 0.095	6.256AspLeu: 6.256 ± 0.118	1.634AspMet: 1.634 ± 0.049	2.529AspAsn: 2.529 ± 0.074	1.707AspPro: 1.707 ± 0.055	2.516AspGln: 2.516 ± 0.057	2.145AspArg: 2.145 ± 0.056	3.355AspSer: 3.355 ± 0.074	2.549AspThr: 2.549 ± 0.062	3.214AspVal: 3.214 ± 0.085	0.651AspTrp: 0.651 ± 0.04	3.062AspTyr: 3.062 ± 0.077	0.0AspXaa: 0.0 ± 0.0
Glu	5.974GluAla: 5.974 ± 0.115	0.221GluCys: 0.221 ± 0.02	3.723GluAsp: 3.723 ± 0.091	5.539GluGlu: 5.539 ± 0.117	2.274GluPhe: 2.274 ± 0.066	3.643GluGly: 3.643 ± 0.093	1.225GluHis: 1.225 ± 0.052	4.68GluIle: 4.68 ± 0.098	5.533GluLys: 5.533 ± 0.107	6.691GluLeu: 6.691 ± 0.108	1.848GluMet: 1.848 ± 0.057	3.233GluAsn: 3.233 ± 0.068	1.518GluPro: 1.518 ± 0.056	2.543GluGln: 2.543 ± 0.063	3.256GluArg: 3.256 ± 0.084	3.331GluSer: 3.331 ± 0.076	3.76GluThr: 3.76 ± 0.078	4.571GluVal: 4.571 ± 0.089	0.599GluTrp: 0.599 ± 0.033	1.751GluTyr: 1.751 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.236PheAla: 3.236 ± 0.067	0.285PheCys: 0.285 ± 0.021	3.05PheAsp: 3.05 ± 0.065	2.923PheGlu: 2.923 ± 0.082	2.083PhePhe: 2.083 ± 0.071	3.275PheGly: 3.275 ± 0.081	0.811PheHis: 0.811 ± 0.04	3.186PheIle: 3.186 ± 0.088	2.81PheLys: 2.81 ± 0.067	4.647PheLeu: 4.647 ± 0.087	1.1PheMet: 1.1 ± 0.046	2.036PheAsn: 2.036 ± 0.052	1.61PhePro: 1.61 ± 0.056	1.676PheGln: 1.676 ± 0.049	1.515PheArg: 1.515 ± 0.049	3.278PheSer: 3.278 ± 0.074	2.333PheThr: 2.333 ± 0.062	2.887PheVal: 2.887 ± 0.065	0.452PheTrp: 0.452 ± 0.026	1.812PheTyr: 1.812 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.367GlyAla: 4.367 ± 0.11	0.355GlyCys: 0.355 ± 0.021	3.397GlyAsp: 3.397 ± 0.079	3.289GlyGlu: 3.289 ± 0.073	3.201GlyPhe: 3.201 ± 0.083	3.846GlyGly: 3.846 ± 0.097	1.427GlyHis: 1.427 ± 0.045	5.276GlyIle: 5.276 ± 0.116	4.959GlyLys: 4.959 ± 0.107	6.758GlyLeu: 6.758 ± 0.107	1.774GlyMet: 1.774 ± 0.059	2.558GlyAsn: 2.558 ± 0.063	1.393GlyPro: 1.393 ± 0.052	3.197GlyGln: 3.197 ± 0.08	2.496GlyArg: 2.496 ± 0.063	3.715GlySer: 3.715 ± 0.071	3.397GlyThr: 3.397 ± 0.077	4.289GlyVal: 4.289 ± 0.081	0.615GlyTrp: 0.615 ± 0.037	2.601GlyTyr: 2.601 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.113HisAla: 1.113 ± 0.04	0.15HisCys: 0.15 ± 0.017	1.077HisAsp: 1.077 ± 0.044	1.056HisGlu: 1.056 ± 0.04	1.282HisPhe: 1.282 ± 0.05	1.15HisGly: 1.15 ± 0.043	0.657HisHis: 0.657 ± 0.037	1.432HisIle: 1.432 ± 0.054	1.095HisLys: 1.095 ± 0.041	2.546HisLeu: 2.546 ± 0.076	0.555HisMet: 0.555 ± 0.026	0.74HisAsn: 0.74 ± 0.032	0.976HisPro: 0.976 ± 0.039	1.114HisGln: 1.114 ± 0.044	0.917HisArg: 0.917 ± 0.042	1.228HisSer: 1.228 ± 0.048	0.864HisThr: 0.864 ± 0.043	1.052HisVal: 1.052 ± 0.041	0.258HisTrp: 0.258 ± 0.02	1.078HisTyr: 1.078 ± 0.045	0.0HisXaa: 0.0 ± 0.0
Ile	6.077IleAla: 6.077 ± 0.103	0.637IleCys: 0.637 ± 0.031	4.638IleAsp: 4.638 ± 0.085	4.719IleGlu: 4.719 ± 0.097	3.103IlePhe: 3.103 ± 0.076	4.802IleGly: 4.802 ± 0.102	1.208IleHis: 1.208 ± 0.048	5.112IleIle: 5.112 ± 0.104	5.076IleLys: 5.076 ± 0.092	7.051IleLeu: 7.051 ± 0.12	1.778IleMet: 1.778 ± 0.055	3.469IleAsn: 3.469 ± 0.078	2.799IlePro: 2.799 ± 0.077	2.585IleGln: 2.585 ± 0.064	2.751IleArg: 2.751 ± 0.068	5.215IleSer: 5.215 ± 0.101	4.103IleThr: 4.103 ± 0.068	4.524IleVal: 4.524 ± 0.09	0.674IleTrp: 0.674 ± 0.039	2.421IleTyr: 2.421 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	6.264LysAla: 6.264 ± 0.121	0.253LysCys: 0.253 ± 0.02	4.434LysAsp: 4.434 ± 0.087	6.586LysGlu: 6.586 ± 0.116	1.707LysPhe: 1.707 ± 0.047	4.505LysGly: 4.505 ± 0.089	1.399LysHis: 1.399 ± 0.046	4.334LysIle: 4.334 ± 0.098	5.608LysLys: 5.608 ± 0.119	5.927LysLeu: 5.927 ± 0.102	2.142LysMet: 2.142 ± 0.055	3.22LysAsn: 3.22 ± 0.077	2.31LysPro: 2.31 ± 0.066	3.156LysGln: 3.156 ± 0.075	3.15LysArg: 3.15 ± 0.089	4.452LysSer: 4.452 ± 0.078	4.514LysThr: 4.514 ± 0.076	4.909LysVal: 4.909 ± 0.097	0.657LysTrp: 0.657 ± 0.028	2.047LysTyr: 2.047 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	9.083LeuAla: 9.083 ± 0.138	0.674LeuCys: 0.674 ± 0.038	5.934LeuAsp: 5.934 ± 0.12	6.913LeuGlu: 6.913 ± 0.143	4.591LeuPhe: 4.591 ± 0.098	6.5LeuGly: 6.5 ± 0.112	1.61LeuHis: 1.61 ± 0.05	7.401LeuIle: 7.401 ± 0.128	7.293LeuLys: 7.293 ± 0.116	11.177LeuLeu: 11.177 ± 0.187	2.709LeuMet: 2.709 ± 0.064	4.303LeuAsn: 4.303 ± 0.084	4.045LeuPro: 4.045 ± 0.094	3.586LeuGln: 3.586 ± 0.078	3.676LeuArg: 3.676 ± 0.087	8.099LeuSer: 8.099 ± 0.142	6.339LeuThr: 6.339 ± 0.113	6.98LeuVal: 6.98 ± 0.117	0.807LeuTrp: 0.807 ± 0.035	3.017LeuTyr: 3.017 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	2.374MetAla: 2.374 ± 0.065	0.117MetCys: 0.117 ± 0.015	1.307MetAsp: 1.307 ± 0.047	1.422MetGlu: 1.422 ± 0.047	0.817MetPhe: 0.817 ± 0.038	1.754MetGly: 1.754 ± 0.059	0.363MetHis: 0.363 ± 0.024	2.05MetIle: 2.05 ± 0.061	1.854MetLys: 1.854 ± 0.046	2.375MetLeu: 2.375 ± 0.056	0.74MetMet: 0.74 ± 0.036	1.13MetAsn: 1.13 ± 0.046	0.987MetPro: 0.987 ± 0.039	0.906MetGln: 0.906 ± 0.033	1.083MetArg: 1.083 ± 0.04	1.948MetSer: 1.948 ± 0.064	2.4MetThr: 2.4 ± 0.058	1.845MetVal: 1.845 ± 0.053	0.208MetTrp: 0.208 ± 0.017	0.523MetTyr: 0.523 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.029AsnAla: 3.029 ± 0.074	0.271AsnCys: 0.271 ± 0.021	2.414AsnAsp: 2.414 ± 0.061	2.335AsnGlu: 2.335 ± 0.068	1.74AsnPhe: 1.74 ± 0.053	3.175AsnGly: 3.175 ± 0.072	1.343AsnHis: 1.343 ± 0.045	2.94AsnIle: 2.94 ± 0.07	2.832AsnLys: 2.832 ± 0.079	4.239AsnLeu: 4.239 ± 0.086	1.261AsnMet: 1.261 ± 0.048	1.795AsnAsn: 1.795 ± 0.054	2.253AsnPro: 2.253 ± 0.058	2.45AsnGln: 2.45 ± 0.063	2.087AsnArg: 2.087 ± 0.064	2.353AsnSer: 2.353 ± 0.067	2.059AsnThr: 2.059 ± 0.068	2.425AsnVal: 2.425 ± 0.056	0.51AsnTrp: 0.51 ± 0.029	1.793AsnTyr: 1.793 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.117ProAla: 2.117 ± 0.065	0.18ProCys: 0.18 ± 0.016	1.909ProAsp: 1.909 ± 0.057	2.863ProGlu: 2.863 ± 0.072	1.727ProPhe: 1.727 ± 0.05	1.665ProGly: 1.665 ± 0.06	0.72ProHis: 0.72 ± 0.034	2.54ProIle: 2.54 ± 0.068	2.608ProLys: 2.608 ± 0.076	3.353ProLeu: 3.353 ± 0.086	0.79ProMet: 0.79 ± 0.036	1.655ProAsn: 1.655 ± 0.051	0.54ProPro: 0.54 ± 0.031	1.35ProGln: 1.35 ± 0.048	1.025ProArg: 1.025 ± 0.042	2.335ProSer: 2.335 ± 0.063	1.717ProThr: 1.717 ± 0.045	2.407ProVal: 2.407 ± 0.069	0.258ProTrp: 0.258 ± 0.019	1.435ProTyr: 1.435 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	4.028GlnAla: 4.028 ± 0.094	0.178GlnCys: 0.178 ± 0.017	2.178GlnAsp: 2.178 ± 0.061	3.802GlnGlu: 3.802 ± 0.083	1.789GlnPhe: 1.789 ± 0.052	2.327GlnGly: 2.327 ± 0.064	0.726GlnHis: 0.726 ± 0.035	2.687GlnIle: 2.687 ± 0.063	3.516GlnLys: 3.516 ± 0.078	5.001GlnLeu: 5.001 ± 0.103	1.21GlnMet: 1.21 ± 0.045	1.765GlnAsn: 1.765 ± 0.055	1.1GlnPro: 1.1 ± 0.045	1.472GlnGln: 1.472 ± 0.051	1.512GlnArg: 1.512 ± 0.049	2.835GlnSer: 2.835 ± 0.074	2.483GlnThr: 2.483 ± 0.072	3.292GlnVal: 3.292 ± 0.072	0.369GlnTrp: 0.369 ± 0.028	1.343GlnTyr: 1.343 ± 0.05	0.0GlnXaa: 0.0 ± 0.0
Arg	2.33ArgAla: 2.33 ± 0.066	0.23ArgCys: 0.23 ± 0.02	2.166ArgAsp: 2.166 ± 0.06	2.652ArgGlu: 2.652 ± 0.07	2.012ArgPhe: 2.012 ± 0.054	2.331ArgGly: 2.331 ± 0.063	0.981ArgHis: 0.981 ± 0.037	2.762ArgIle: 2.762 ± 0.07	2.633ArgLys: 2.633 ± 0.077	4.5ArgLeu: 4.5 ± 0.098	1.001ArgMet: 1.001 ± 0.042	1.588ArgAsn: 1.588 ± 0.05	1.352ArgPro: 1.352 ± 0.049	2.536ArgGln: 2.536 ± 0.068	2.011ArgArg: 2.011 ± 0.067	2.194ArgSer: 2.194 ± 0.059	1.837ArgThr: 1.837 ± 0.062	2.641ArgVal: 2.641 ± 0.065	0.275ArgTrp: 0.275 ± 0.018	1.646ArgTyr: 1.646 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.054SerAla: 4.054 ± 0.092	0.343SerCys: 0.343 ± 0.025	3.746SerAsp: 3.746 ± 0.073	3.893SerGlu: 3.893 ± 0.08	3.388SerPhe: 3.388 ± 0.076	4.503SerGly: 4.503 ± 0.092	1.77SerHis: 1.77 ± 0.052	4.478SerIle: 4.478 ± 0.093	4.373SerLys: 4.373 ± 0.081	7.484SerLeu: 7.484 ± 0.126	1.505SerMet: 1.505 ± 0.05	2.572SerAsn: 2.572 ± 0.062	2.15SerPro: 2.15 ± 0.06	3.751SerGln: 3.751 ± 0.079	2.563SerArg: 2.563 ± 0.058	4.481SerSer: 4.481 ± 0.102	3.144SerThr: 3.144 ± 0.07	4.039SerVal: 4.039 ± 0.084	0.593SerTrp: 0.593 ± 0.033	2.696SerTyr: 2.696 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	4.057ThrAla: 4.057 ± 0.08	0.308ThrCys: 0.308 ± 0.023	3.064ThrAsp: 3.064 ± 0.076	3.155ThrGlu: 3.155 ± 0.073	2.644ThrPhe: 2.644 ± 0.067	3.752ThrGly: 3.752 ± 0.093	1.123ThrHis: 1.123 ± 0.041	4.621ThrIle: 4.621 ± 0.085	3.776ThrLys: 3.776 ± 0.08	5.791ThrLeu: 5.791 ± 0.1	1.139ThrMet: 1.139 ± 0.041	2.41ThrAsn: 2.41 ± 0.071	2.184ThrPro: 2.184 ± 0.07	1.997ThrGln: 1.997 ± 0.057	1.912ThrArg: 1.912 ± 0.055	3.665ThrSer: 3.665 ± 0.078	2.96ThrThr: 2.96 ± 0.086	3.863ThrVal: 3.863 ± 0.093	0.505ThrTrp: 0.505 ± 0.029	2.432ThrTyr: 2.432 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.33ValAla: 5.33 ± 0.109	0.494ValCys: 0.494 ± 0.032	3.771ValAsp: 3.771 ± 0.075	4.131ValGlu: 4.131 ± 0.087	2.771ValPhe: 2.771 ± 0.074	3.99ValGly: 3.99 ± 0.085	1.067ValHis: 1.067 ± 0.042	4.888ValIle: 4.888 ± 0.099	4.295ValLys: 4.295 ± 0.091	6.467ValLeu: 6.467 ± 0.114	1.745ValMet: 1.745 ± 0.051	2.848ValAsn: 2.848 ± 0.072	2.363ValPro: 2.363 ± 0.064	2.009ValGln: 2.009 ± 0.053	2.377ValArg: 2.377 ± 0.07	4.876ValSer: 4.876 ± 0.091	4.555ValThr: 4.555 ± 0.098	4.209ValVal: 4.209 ± 0.104	0.493ValTrp: 0.493 ± 0.032	2.294ValTyr: 2.294 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.515TrpAla: 0.515 ± 0.03	0.053TrpCys: 0.053 ± 0.009	0.462TrpAsp: 0.462 ± 0.028	0.599TrpGlu: 0.599 ± 0.035	0.479TrpPhe: 0.479 ± 0.032	0.582TrpGly: 0.582 ± 0.032	0.227TrpHis: 0.227 ± 0.019	0.584TrpIle: 0.584 ± 0.036	0.598TrpLys: 0.598 ± 0.031	1.066TrpLeu: 1.066 ± 0.042	0.257TrpMet: 0.257 ± 0.02	0.457TrpAsn: 0.457 ± 0.031	0.178TrpPro: 0.178 ± 0.018	0.502TrpGln: 0.502 ± 0.028	0.413TrpArg: 0.413 ± 0.024	0.576TrpSer: 0.576 ± 0.029	0.485TrpThr: 0.485 ± 0.029	0.504TrpVal: 0.504 ± 0.027	0.128TrpTrp: 0.128 ± 0.013	0.349TrpTyr: 0.349 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.464TyrAla: 2.464 ± 0.072	0.277TyrCys: 0.277 ± 0.021	2.291TyrAsp: 2.291 ± 0.063	2.006TyrGlu: 2.006 ± 0.058	2.012TyrPhe: 2.012 ± 0.061	2.306TyrGly: 2.306 ± 0.071	1.03TyrHis: 1.03 ± 0.038	2.303TyrIle: 2.303 ± 0.057	2.014TyrLys: 2.014 ± 0.061	4.517TyrLeu: 4.517 ± 0.103	0.778TyrMet: 0.778 ± 0.035	1.458TyrAsn: 1.458 ± 0.052	1.388TyrPro: 1.388 ± 0.043	2.648TyrGln: 2.648 ± 0.065	1.648TyrArg: 1.648 ± 0.051	2.192TyrSer: 2.192 ± 0.053	1.762TyrThr: 1.762 ± 0.058	2.126TyrVal: 2.126 ± 0.062	0.322TyrTrp: 0.322 ± 0.02	1.634TyrTyr: 1.634 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2397 proteins (639083 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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