Amino acid dipepetide frequency for Sunshine Coast virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.27AlaAla: 2.27 ± 1.672
0.413AlaCys: 0.413 ± 0.267
1.444AlaAsp: 1.444 ± 0.732
2.064AlaGlu: 2.064 ± 0.547
1.444AlaPhe: 1.444 ± 0.445
1.857AlaGly: 1.857 ± 0.886
0.619AlaHis: 0.619 ± 0.268
4.333AlaIle: 4.333 ± 0.787
3.921AlaLys: 3.921 ± 0.739
5.365AlaLeu: 5.365 ± 1.723
0.619AlaMet: 0.619 ± 0.268
1.032AlaAsn: 1.032 ± 0.652
2.27AlaPro: 2.27 ± 0.865
0.413AlaGln: 0.413 ± 0.359
1.651AlaArg: 1.651 ± 0.943
3.508AlaSer: 3.508 ± 0.72
1.444AlaThr: 1.444 ± 0.589
1.444AlaVal: 1.444 ± 0.669
0.413AlaTrp: 0.413 ± 0.313
0.825AlaTyr: 0.825 ± 0.223
0.0AlaXaa: 0.0 ± 0.0
Cys
0.619CysAla: 0.619 ± 0.299
0.825CysCys: 0.825 ± 0.534
1.238CysAsp: 1.238 ± 0.423
1.238CysGlu: 1.238 ± 0.412
1.444CysPhe: 1.444 ± 0.538
1.032CysGly: 1.032 ± 0.288
0.206CysHis: 0.206 ± 0.207
1.651CysIle: 1.651 ± 0.314
0.619CysLys: 0.619 ± 0.256
2.064CysLeu: 2.064 ± 0.63
0.0CysMet: 0.0 ± 0.0
0.413CysAsn: 0.413 ± 0.267
0.413CysPro: 0.413 ± 0.175
0.619CysGln: 0.619 ± 0.217
0.825CysArg: 0.825 ± 0.243
1.857CysSer: 1.857 ± 0.832
1.444CysThr: 1.444 ± 0.756
0.825CysVal: 0.825 ± 0.251
0.206CysTrp: 0.206 ± 0.134
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.651AspAla: 1.651 ± 0.701
1.032AspCys: 1.032 ± 0.854
3.095AspAsp: 3.095 ± 0.885
3.921AspGlu: 3.921 ± 0.654
1.238AspPhe: 1.238 ± 0.218
1.651AspGly: 1.651 ± 0.668
1.238AspHis: 1.238 ± 0.419
5.365AspIle: 5.365 ± 0.793
3.508AspLys: 3.508 ± 0.966
6.603AspLeu: 6.603 ± 0.644
1.444AspMet: 1.444 ± 0.856
3.302AspAsn: 3.302 ± 0.702
2.889AspPro: 2.889 ± 0.706
1.857AspGln: 1.857 ± 0.712
1.238AspArg: 1.238 ± 0.514
4.127AspSer: 4.127 ± 1.047
3.095AspThr: 3.095 ± 1.144
2.683AspVal: 2.683 ± 0.543
0.619AspTrp: 0.619 ± 0.256
1.238AspTyr: 1.238 ± 0.434
0.0AspXaa: 0.0 ± 0.0
Glu
2.27GluAla: 2.27 ± 0.837
0.825GluCys: 0.825 ± 0.251
4.333GluAsp: 4.333 ± 1.357
5.984GluGlu: 5.984 ± 1.011
1.238GluPhe: 1.238 ± 0.419
2.889GluGly: 2.889 ± 0.806
1.444GluHis: 1.444 ± 0.503
6.81GluIle: 6.81 ± 0.721
5.365GluLys: 5.365 ± 1.285
5.778GluLeu: 5.778 ± 0.793
1.651GluMet: 1.651 ± 0.443
5.159GluAsn: 5.159 ± 0.688
2.27GluPro: 2.27 ± 0.623
1.444GluGln: 1.444 ± 0.455
3.921GluArg: 3.921 ± 0.936
4.746GluSer: 4.746 ± 0.598
5.365GluThr: 5.365 ± 0.794
4.54GluVal: 4.54 ± 0.837
0.619GluTrp: 0.619 ± 0.401
2.476GluTyr: 2.476 ± 0.49
0.0GluXaa: 0.0 ± 0.0
Phe
2.27PheAla: 2.27 ± 0.915
0.825PheCys: 0.825 ± 0.281
2.476PheAsp: 2.476 ± 1.183
2.064PheGlu: 2.064 ± 0.389
2.476PhePhe: 2.476 ± 0.551
2.064PheGly: 2.064 ± 0.661
0.619PheHis: 0.619 ± 0.401
3.921PheIle: 3.921 ± 0.724
2.683PheLys: 2.683 ± 0.306
4.127PheLeu: 4.127 ± 0.907
0.825PheMet: 0.825 ± 0.381
2.27PheAsn: 2.27 ± 0.536
1.444PhePro: 1.444 ± 0.366
1.651PheGln: 1.651 ± 0.314
1.444PheArg: 1.444 ± 0.526
3.921PheSer: 3.921 ± 0.745
1.238PheThr: 1.238 ± 0.589
2.064PheVal: 2.064 ± 0.62
0.206PheTrp: 0.206 ± 0.224
0.413PheTyr: 0.413 ± 0.448
0.0PheXaa: 0.0 ± 0.0
Gly
1.651GlyAla: 1.651 ± 1.201
0.619GlyCys: 0.619 ± 0.572
3.714GlyAsp: 3.714 ± 0.393
4.127GlyGlu: 4.127 ± 1.118
3.095GlyPhe: 3.095 ± 0.767
1.651GlyGly: 1.651 ± 0.718
1.238GlyHis: 1.238 ± 0.377
3.921GlyIle: 3.921 ± 1.041
4.746GlyLys: 4.746 ± 1.316
6.191GlyLeu: 6.191 ± 1.583
0.825GlyMet: 0.825 ± 0.572
2.27GlyAsn: 2.27 ± 0.589
1.651GlyPro: 1.651 ± 0.81
1.032GlyGln: 1.032 ± 0.406
3.095GlyArg: 3.095 ± 0.375
5.365GlySer: 5.365 ± 0.827
0.825GlyThr: 0.825 ± 0.301
2.683GlyVal: 2.683 ± 0.593
0.619GlyTrp: 0.619 ± 0.315
2.476GlyTyr: 2.476 ± 1.217
0.0GlyXaa: 0.0 ± 0.0
His
0.825HisAla: 0.825 ± 0.486
0.413HisCys: 0.413 ± 0.175
0.413HisAsp: 0.413 ± 0.19
1.651HisGlu: 1.651 ± 0.489
1.032HisPhe: 1.032 ± 0.288
1.651HisGly: 1.651 ± 0.789
0.206HisHis: 0.206 ± 0.207
1.651HisIle: 1.651 ± 0.508
0.619HisLys: 0.619 ± 0.401
2.683HisLeu: 2.683 ± 0.823
0.206HisMet: 0.206 ± 0.254
0.619HisAsn: 0.619 ± 0.217
1.444HisPro: 1.444 ± 0.514
0.825HisGln: 0.825 ± 0.47
0.619HisArg: 0.619 ± 0.217
0.825HisSer: 0.825 ± 0.534
0.413HisThr: 0.413 ± 0.267
1.444HisVal: 1.444 ± 0.275
0.0HisTrp: 0.0 ± 0.0
0.413HisTyr: 0.413 ± 0.256
0.0HisXaa: 0.0 ± 0.0
Ile
3.302IleAla: 3.302 ± 0.932
1.032IleCys: 1.032 ± 0.371
4.127IleAsp: 4.127 ± 0.701
5.159IleGlu: 5.159 ± 0.913
3.095IlePhe: 3.095 ± 0.375
4.54IleGly: 4.54 ± 1.111
1.857IleHis: 1.857 ± 0.479
8.667IleIle: 8.667 ± 0.979
7.429IleLys: 7.429 ± 1.717
10.111IleLeu: 10.111 ± 0.995
2.476IleMet: 2.476 ± 1.177
4.54IleAsn: 4.54 ± 0.677
5.984IlePro: 5.984 ± 0.892
2.889IleGln: 2.889 ± 0.773
5.159IleArg: 5.159 ± 0.641
8.667IleSer: 8.667 ± 1.673
5.159IleThr: 5.159 ± 0.667
4.746IleVal: 4.746 ± 0.854
0.825IleTrp: 0.825 ± 0.381
2.889IleTyr: 2.889 ± 0.621
0.0IleXaa: 0.0 ± 0.0
Lys
1.444LysAla: 1.444 ± 0.397
0.825LysCys: 0.825 ± 0.361
2.889LysAsp: 2.889 ± 0.856
8.048LysGlu: 8.048 ± 0.455
1.032LysPhe: 1.032 ± 0.255
4.54LysGly: 4.54 ± 0.937
0.825LysHis: 0.825 ± 0.251
8.667LysIle: 8.667 ± 0.822
6.603LysLys: 6.603 ± 2.454
4.953LysLeu: 4.953 ± 1.446
3.302LysMet: 3.302 ± 0.882
4.54LysAsn: 4.54 ± 1.32
1.444LysPro: 1.444 ± 0.414
1.857LysGln: 1.857 ± 0.683
5.778LysArg: 5.778 ± 1.064
3.508LysSer: 3.508 ± 0.388
5.365LysThr: 5.365 ± 0.69
3.302LysVal: 3.302 ± 0.711
0.413LysTrp: 0.413 ± 0.19
2.476LysTyr: 2.476 ± 0.986
0.0LysXaa: 0.0 ± 0.0
Leu
4.746LeuAla: 4.746 ± 1.581
2.683LeuCys: 2.683 ± 0.673
6.81LeuAsp: 6.81 ± 2.02
7.842LeuGlu: 7.842 ± 1.785
4.746LeuPhe: 4.746 ± 0.845
6.397LeuGly: 6.397 ± 1.096
2.064LeuHis: 2.064 ± 0.679
8.873LeuIle: 8.873 ± 1.177
7.429LeuLys: 7.429 ± 0.937
8.048LeuLeu: 8.048 ± 1.19
2.889LeuMet: 2.889 ± 0.907
3.921LeuAsn: 3.921 ± 1.163
2.889LeuPro: 2.889 ± 0.592
4.54LeuGln: 4.54 ± 0.633
7.016LeuArg: 7.016 ± 0.598
11.35LeuSer: 11.35 ± 1.552
6.191LeuThr: 6.191 ± 2.244
4.127LeuVal: 4.127 ± 1.457
0.413LeuTrp: 0.413 ± 0.175
2.476LeuTyr: 2.476 ± 0.949
0.0LeuXaa: 0.0 ± 0.0
Met
1.032MetAla: 1.032 ± 0.735
0.206MetCys: 0.206 ± 0.134
1.444MetAsp: 1.444 ± 0.377
1.444MetGlu: 1.444 ± 0.51
0.206MetPhe: 0.206 ± 0.134
1.651MetGly: 1.651 ± 0.643
1.032MetHis: 1.032 ± 0.301
1.857MetIle: 1.857 ± 0.656
2.889MetLys: 2.889 ± 0.436
2.889MetLeu: 2.889 ± 1.463
0.825MetMet: 0.825 ± 0.381
1.032MetAsn: 1.032 ± 0.668
0.619MetPro: 0.619 ± 0.267
0.619MetGln: 0.619 ± 0.374
1.032MetArg: 1.032 ± 0.528
1.857MetSer: 1.857 ± 0.305
1.857MetThr: 1.857 ± 0.115
1.857MetVal: 1.857 ± 0.453
0.0MetTrp: 0.0 ± 0.0
0.619MetTyr: 0.619 ± 0.315
0.0MetXaa: 0.0 ± 0.0
Asn
1.857AsnAla: 1.857 ± 0.316
1.032AsnCys: 1.032 ± 0.255
1.651AsnAsp: 1.651 ± 0.643
2.27AsnGlu: 2.27 ± 0.534
2.476AsnPhe: 2.476 ± 0.663
2.27AsnGly: 2.27 ± 0.508
1.444AsnHis: 1.444 ± 0.727
4.127AsnIle: 4.127 ± 1.278
2.889AsnLys: 2.889 ± 1.033
5.778AsnLeu: 5.778 ± 0.821
0.206AsnMet: 0.206 ± 0.134
1.857AsnAsn: 1.857 ± 0.491
4.54AsnPro: 4.54 ± 0.823
3.508AsnGln: 3.508 ± 0.688
3.302AsnArg: 3.302 ± 0.365
5.778AsnSer: 5.778 ± 0.63
2.064AsnThr: 2.064 ± 0.994
1.651AsnVal: 1.651 ± 0.569
0.619AsnTrp: 0.619 ± 0.315
2.476AsnTyr: 2.476 ± 0.287
0.0AsnXaa: 0.0 ± 0.0
Pro
0.825ProAla: 0.825 ± 0.301
0.825ProCys: 0.825 ± 0.351
2.683ProAsp: 2.683 ± 0.665
3.921ProGlu: 3.921 ± 0.652
1.238ProPhe: 1.238 ± 0.644
1.444ProGly: 1.444 ± 0.72
1.238ProHis: 1.238 ± 0.301
4.54ProIle: 4.54 ± 1.268
3.508ProLys: 3.508 ± 0.835
5.365ProLeu: 5.365 ± 1.034
0.825ProMet: 0.825 ± 0.317
0.825ProAsn: 0.825 ± 0.487
1.857ProPro: 1.857 ± 0.532
1.651ProGln: 1.651 ± 0.613
1.444ProArg: 1.444 ± 0.4
3.302ProSer: 3.302 ± 0.532
3.095ProThr: 3.095 ± 0.863
2.064ProVal: 2.064 ± 0.551
0.206ProTrp: 0.206 ± 0.254
2.27ProTyr: 2.27 ± 0.58
0.0ProXaa: 0.0 ± 0.0
Gln
1.238GlnAla: 1.238 ± 0.88
0.825GlnCys: 0.825 ± 0.361
2.27GlnAsp: 2.27 ± 0.462
2.889GlnGlu: 2.889 ± 1.106
1.444GlnPhe: 1.444 ± 0.549
2.27GlnGly: 2.27 ± 0.58
0.413GlnHis: 0.413 ± 0.229
2.476GlnIle: 2.476 ± 0.707
2.683GlnLys: 2.683 ± 0.739
2.683GlnLeu: 2.683 ± 0.995
1.032GlnMet: 1.032 ± 0.255
2.889GlnAsn: 2.889 ± 0.561
0.825GlnPro: 0.825 ± 0.394
1.238GlnGln: 1.238 ± 0.275
1.032GlnArg: 1.032 ± 0.301
3.095GlnSer: 3.095 ± 0.63
3.508GlnThr: 3.508 ± 0.707
2.683GlnVal: 2.683 ± 1.054
0.206GlnTrp: 0.206 ± 0.266
0.206GlnTyr: 0.206 ± 0.134
0.0GlnXaa: 0.0 ± 0.0
Arg
2.889ArgAla: 2.889 ± 1.088
1.032ArgCys: 1.032 ± 0.462
1.651ArgAsp: 1.651 ± 0.402
4.746ArgGlu: 4.746 ± 1.175
2.683ArgPhe: 2.683 ± 1.417
2.476ArgGly: 2.476 ± 0.265
0.619ArgHis: 0.619 ± 0.267
5.572ArgIle: 5.572 ± 1.268
3.714ArgLys: 3.714 ± 0.991
5.572ArgLeu: 5.572 ± 1.01
1.857ArgMet: 1.857 ± 0.465
2.683ArgAsn: 2.683 ± 0.694
1.857ArgPro: 1.857 ± 1.2
1.032ArgGln: 1.032 ± 0.287
4.127ArgArg: 4.127 ± 0.681
4.127ArgSer: 4.127 ± 1.048
2.889ArgThr: 2.889 ± 0.736
2.476ArgVal: 2.476 ± 0.778
0.825ArgTrp: 0.825 ± 0.486
1.444ArgTyr: 1.444 ± 0.414
0.0ArgXaa: 0.0 ± 0.0
Ser
3.095SerAla: 3.095 ± 0.632
1.444SerCys: 1.444 ± 0.532
5.984SerAsp: 5.984 ± 1.241
3.921SerGlu: 3.921 ± 0.692
4.333SerPhe: 4.333 ± 0.505
5.778SerGly: 5.778 ± 0.785
0.619SerHis: 0.619 ± 0.549
8.461SerIle: 8.461 ± 0.992
4.54SerLys: 4.54 ± 0.975
7.635SerLeu: 7.635 ± 1.205
2.27SerMet: 2.27 ± 0.621
4.953SerAsn: 4.953 ± 0.611
3.508SerPro: 3.508 ± 0.436
3.921SerGln: 3.921 ± 0.458
3.921SerArg: 3.921 ± 1.085
7.016SerSer: 7.016 ± 0.802
5.778SerThr: 5.778 ± 1.017
5.778SerVal: 5.778 ± 1.255
1.238SerTrp: 1.238 ± 0.395
2.683SerTyr: 2.683 ± 0.345
0.0SerXaa: 0.0 ± 0.0
Thr
2.889ThrAla: 2.889 ± 1.487
1.857ThrCys: 1.857 ± 0.491
1.238ThrAsp: 1.238 ± 0.348
2.476ThrGlu: 2.476 ± 0.379
2.27ThrPhe: 2.27 ± 0.561
3.921ThrGly: 3.921 ± 0.585
1.444ThrHis: 1.444 ± 0.503
4.127ThrIle: 4.127 ± 0.773
2.889ThrLys: 2.889 ± 0.745
7.222ThrLeu: 7.222 ± 0.54
0.825ThrMet: 0.825 ± 0.315
4.54ThrAsn: 4.54 ± 0.816
2.476ThrPro: 2.476 ± 0.367
2.889ThrGln: 2.889 ± 1.1
4.333ThrArg: 4.333 ± 0.654
5.365ThrSer: 5.365 ± 1.216
2.27ThrThr: 2.27 ± 0.36
1.444ThrVal: 1.444 ± 0.436
0.413ThrTrp: 0.413 ± 0.376
2.683ThrTyr: 2.683 ± 0.3
0.0ThrXaa: 0.0 ± 0.0
Val
2.064ValAla: 2.064 ± 0.735
0.413ValCys: 0.413 ± 0.355
2.683ValAsp: 2.683 ± 1.026
3.302ValGlu: 3.302 ± 0.833
1.651ValPhe: 1.651 ± 0.582
1.857ValGly: 1.857 ± 0.565
0.619ValHis: 0.619 ± 0.401
4.953ValIle: 4.953 ± 0.665
3.921ValLys: 3.921 ± 0.42
5.984ValLeu: 5.984 ± 1.336
1.238ValMet: 1.238 ± 0.526
2.27ValAsn: 2.27 ± 0.782
2.889ValPro: 2.889 ± 0.483
1.444ValGln: 1.444 ± 0.338
3.095ValArg: 3.095 ± 0.765
4.953ValSer: 4.953 ± 1.567
3.302ValThr: 3.302 ± 0.568
2.889ValVal: 2.889 ± 0.651
0.206ValTrp: 0.206 ± 0.134
1.651ValTyr: 1.651 ± 0.608
0.0ValXaa: 0.0 ± 0.0
Trp
0.206TrpAla: 0.206 ± 0.207
0.0TrpCys: 0.0 ± 0.0
0.825TrpAsp: 0.825 ± 0.394
0.206TrpGlu: 0.206 ± 0.224
0.619TrpPhe: 0.619 ± 0.24
0.619TrpGly: 0.619 ± 0.268
0.0TrpHis: 0.0 ± 0.0
0.619TrpIle: 0.619 ± 0.315
0.413TrpLys: 0.413 ± 0.229
0.825TrpLeu: 0.825 ± 0.336
0.413TrpMet: 0.413 ± 0.175
0.413TrpAsn: 0.413 ± 0.338
0.206TrpPro: 0.206 ± 0.134
0.0TrpGln: 0.0 ± 0.0
0.206TrpArg: 0.206 ± 0.134
1.651TrpSer: 1.651 ± 0.233
0.206TrpThr: 0.206 ± 0.134
0.619TrpVal: 0.619 ± 0.257
0.0TrpTrp: 0.0 ± 0.0
0.206TrpTyr: 0.206 ± 0.134
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.206TyrAla: 0.206 ± 0.207
0.413TyrCys: 0.413 ± 0.267
0.825TyrAsp: 0.825 ± 0.349
2.064TyrGlu: 2.064 ± 0.689
1.238TyrPhe: 1.238 ± 0.416
1.238TyrGly: 1.238 ± 0.508
0.206TyrHis: 0.206 ± 0.207
2.064TyrIle: 2.064 ± 0.6
1.444TyrLys: 1.444 ± 0.377
5.572TyrLeu: 5.572 ± 1.137
1.032TyrMet: 1.032 ± 0.36
2.27TyrAsn: 2.27 ± 0.7
1.651TyrPro: 1.651 ± 0.893
2.476TyrGln: 2.476 ± 0.627
1.032TyrArg: 1.032 ± 0.459
1.857TyrSer: 1.857 ± 0.532
2.064TyrThr: 2.064 ± 0.792
2.064TyrVal: 2.064 ± 0.402
0.206TyrTrp: 0.206 ± 0.134
1.444TyrTyr: 1.444 ± 0.35
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (4847 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski