Amino acid dipepetide frequency for Drancourtella sp. An177

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.845AlaAla: 6.845 ± 0.122
1.122AlaCys: 1.122 ± 0.04
4.164AlaAsp: 4.164 ± 0.071
5.439AlaGlu: 5.439 ± 0.093
3.055AlaPhe: 3.055 ± 0.069
5.913AlaGly: 5.913 ± 0.103
1.158AlaHis: 1.158 ± 0.04
4.65AlaIle: 4.65 ± 0.08
5.163AlaLys: 5.163 ± 0.09
6.43AlaLeu: 6.43 ± 0.095
2.369AlaMet: 2.369 ± 0.05
2.364AlaAsn: 2.364 ± 0.052
1.884AlaPro: 1.884 ± 0.051
2.187AlaGln: 2.187 ± 0.048
3.042AlaArg: 3.042 ± 0.064
3.872AlaSer: 3.872 ± 0.08
2.665AlaThr: 2.665 ± 0.062
6.328AlaVal: 6.328 ± 0.091
0.623AlaTrp: 0.623 ± 0.029
2.724AlaTyr: 2.724 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.989CysAla: 0.989 ± 0.034
0.285CysCys: 0.285 ± 0.016
0.825CysAsp: 0.825 ± 0.034
0.924CysGlu: 0.924 ± 0.036
0.659CysPhe: 0.659 ± 0.029
1.552CysGly: 1.552 ± 0.048
0.346CysHis: 0.346 ± 0.02
1.123CysIle: 1.123 ± 0.039
0.804CysLys: 0.804 ± 0.031
1.23CysLeu: 1.23 ± 0.04
0.474CysMet: 0.474 ± 0.023
0.483CysAsn: 0.483 ± 0.026
0.717CysPro: 0.717 ± 0.028
0.414CysGln: 0.414 ± 0.021
0.876CysArg: 0.876 ± 0.034
0.895CysSer: 0.895 ± 0.031
0.758CysThr: 0.758 ± 0.029
1.018CysVal: 1.018 ± 0.03
0.119CysTrp: 0.119 ± 0.011
0.551CysTyr: 0.551 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.865AspAla: 3.865 ± 0.073
0.832AspCys: 0.832 ± 0.029
2.699AspAsp: 2.699 ± 0.069
4.642AspGlu: 4.642 ± 0.079
2.651AspPhe: 2.651 ± 0.051
4.4AspGly: 4.4 ± 0.076
0.904AspHis: 0.904 ± 0.029
4.552AspIle: 4.552 ± 0.076
3.406AspLys: 3.406 ± 0.07
4.631AspLeu: 4.631 ± 0.08
1.87AspMet: 1.87 ± 0.05
1.869AspAsn: 1.869 ± 0.048
1.895AspPro: 1.895 ± 0.046
1.454AspGln: 1.454 ± 0.039
2.76AspArg: 2.76 ± 0.068
2.714AspSer: 2.714 ± 0.064
3.106AspThr: 3.106 ± 0.067
3.778AspVal: 3.778 ± 0.077
0.569AspTrp: 0.569 ± 0.028
2.592AspTyr: 2.592 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.889GluAla: 5.889 ± 0.091
0.915GluCys: 0.915 ± 0.036
4.397GluAsp: 4.397 ± 0.073
9.024GluGlu: 9.024 ± 0.143
2.761GluPhe: 2.761 ± 0.06
4.869GluGly: 4.869 ± 0.081
1.421GluHis: 1.421 ± 0.045
6.281GluIle: 6.281 ± 0.086
8.089GluLys: 8.089 ± 0.104
6.704GluLeu: 6.704 ± 0.106
2.717GluMet: 2.717 ± 0.057
4.006GluAsn: 4.006 ± 0.065
1.932GluPro: 1.932 ± 0.047
2.998GluGln: 2.998 ± 0.069
3.86GluArg: 3.86 ± 0.08
3.326GluSer: 3.326 ± 0.064
4.242GluThr: 4.242 ± 0.072
4.6GluVal: 4.6 ± 0.084
0.766GluTrp: 0.766 ± 0.03
3.228GluTyr: 3.228 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
2.982PheAla: 2.982 ± 0.064
0.824PheCys: 0.824 ± 0.033
2.551PheAsp: 2.551 ± 0.052
2.777PheGlu: 2.777 ± 0.054
1.948PhePhe: 1.948 ± 0.056
3.141PheGly: 3.141 ± 0.06
0.918PheHis: 0.918 ± 0.034
2.703PheIle: 2.703 ± 0.059
1.775PheLys: 1.775 ± 0.049
4.363PheLeu: 4.363 ± 0.09
1.114PheMet: 1.114 ± 0.036
1.252PheAsn: 1.252 ± 0.047
1.476PhePro: 1.476 ± 0.043
1.504PheGln: 1.504 ± 0.04
2.158PheArg: 2.158 ± 0.047
2.927PheSer: 2.927 ± 0.058
2.187PheThr: 2.187 ± 0.052
2.929PheVal: 2.929 ± 0.067
0.424PheTrp: 0.424 ± 0.024
1.789PheTyr: 1.789 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.809GlyAla: 4.809 ± 0.083
1.279GlyCys: 1.279 ± 0.042
3.273GlyAsp: 3.273 ± 0.063
5.111GlyGlu: 5.111 ± 0.083
3.184GlyPhe: 3.184 ± 0.065
4.75GlyGly: 4.75 ± 0.087
1.28GlyHis: 1.28 ± 0.042
6.415GlyIle: 6.415 ± 0.1
6.211GlyLys: 6.211 ± 0.088
5.634GlyLeu: 5.634 ± 0.088
2.579GlyMet: 2.579 ± 0.055
3.016GlyAsn: 3.016 ± 0.063
1.265GlyPro: 1.265 ± 0.039
2.195GlyGln: 2.195 ± 0.048
3.227GlyArg: 3.227 ± 0.068
3.857GlySer: 3.857 ± 0.078
4.335GlyThr: 4.335 ± 0.072
4.817GlyVal: 4.817 ± 0.079
0.756GlyTrp: 0.756 ± 0.037
3.228GlyTyr: 3.228 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.183HisAla: 1.183 ± 0.035
0.333HisCys: 0.333 ± 0.018
0.934HisAsp: 0.934 ± 0.034
1.135HisGlu: 1.135 ± 0.039
0.867HisPhe: 0.867 ± 0.035
1.268HisGly: 1.268 ± 0.038
0.47HisHis: 0.47 ± 0.027
1.494HisIle: 1.494 ± 0.042
0.915HisLys: 0.915 ± 0.035
1.579HisLeu: 1.579 ± 0.045
0.601HisMet: 0.601 ± 0.026
0.648HisAsn: 0.648 ± 0.03
0.925HisPro: 0.925 ± 0.034
0.53HisGln: 0.53 ± 0.026
0.828HisArg: 0.828 ± 0.034
0.992HisSer: 0.992 ± 0.035
1.034HisThr: 1.034 ± 0.034
1.252HisVal: 1.252 ± 0.043
0.155HisTrp: 0.155 ± 0.013
0.766HisTyr: 0.766 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.483IleAla: 5.483 ± 0.08
1.349IleCys: 1.349 ± 0.046
4.01IleAsp: 4.01 ± 0.08
4.805IleGlu: 4.805 ± 0.092
3.109IlePhe: 3.109 ± 0.072
5.237IleGly: 5.237 ± 0.079
1.464IleHis: 1.464 ± 0.043
4.83IleIle: 4.83 ± 0.093
3.967IleLys: 3.967 ± 0.07
7.53IleLeu: 7.53 ± 0.106
1.993IleMet: 1.993 ± 0.054
2.47IleAsn: 2.47 ± 0.057
3.43IlePro: 3.43 ± 0.066
2.601IleGln: 2.601 ± 0.065
4.549IleArg: 4.549 ± 0.072
4.649IleSer: 4.649 ± 0.07
3.882IleThr: 3.882 ± 0.071
5.114IleVal: 5.114 ± 0.081
0.679IleTrp: 0.679 ± 0.03
2.812IleTyr: 2.812 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.273LysAla: 5.273 ± 0.093
0.72LysCys: 0.72 ± 0.032
4.088LysAsp: 4.088 ± 0.069
8.39LysGlu: 8.39 ± 0.126
1.9LysPhe: 1.9 ± 0.043
4.704LysGly: 4.704 ± 0.075
1.011LysHis: 1.011 ± 0.033
5.151LysIle: 5.151 ± 0.08
6.936LysLys: 6.936 ± 0.113
5.163LysLeu: 5.163 ± 0.077
2.454LysMet: 2.454 ± 0.055
3.329LysAsn: 3.329 ± 0.065
2.019LysPro: 2.019 ± 0.054
2.438LysGln: 2.438 ± 0.062
3.661LysArg: 3.661 ± 0.067
3.303LysSer: 3.303 ± 0.058
3.951LysThr: 3.951 ± 0.076
4.234LysVal: 4.234 ± 0.079
0.684LysTrp: 0.684 ± 0.029
3.065LysTyr: 3.065 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
6.597LeuAla: 6.597 ± 0.095
1.426LeuCys: 1.426 ± 0.042
4.969LeuAsp: 4.969 ± 0.081
6.45LeuGlu: 6.45 ± 0.09
4.034LeuPhe: 4.034 ± 0.082
5.82LeuGly: 5.82 ± 0.094
1.564LeuHis: 1.564 ± 0.044
6.032LeuIle: 6.032 ± 0.094
6.179LeuLys: 6.179 ± 0.098
8.543LeuLeu: 8.543 ± 0.134
2.503LeuMet: 2.503 ± 0.051
3.474LeuAsn: 3.474 ± 0.059
3.609LeuPro: 3.609 ± 0.07
2.584LeuGln: 2.584 ± 0.054
4.027LeuArg: 4.027 ± 0.08
6.284LeuSer: 6.284 ± 0.094
4.669LeuThr: 4.669 ± 0.075
5.214LeuVal: 5.214 ± 0.089
0.711LeuTrp: 0.711 ± 0.031
3.375LeuTyr: 3.375 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.363MetAla: 2.363 ± 0.051
0.376MetCys: 0.376 ± 0.022
1.95MetAsp: 1.95 ± 0.048
3.057MetGlu: 3.057 ± 0.055
1.068MetPhe: 1.068 ± 0.036
2.027MetGly: 2.027 ± 0.052
0.458MetHis: 0.458 ± 0.022
2.319MetIle: 2.319 ± 0.054
2.808MetLys: 2.808 ± 0.051
2.674MetLeu: 2.674 ± 0.062
1.045MetMet: 1.045 ± 0.034
1.418MetAsn: 1.418 ± 0.041
1.133MetPro: 1.133 ± 0.039
1.115MetGln: 1.115 ± 0.032
1.496MetArg: 1.496 ± 0.045
1.68MetSer: 1.68 ± 0.048
1.856MetThr: 1.856 ± 0.048
1.782MetVal: 1.782 ± 0.05
0.233MetTrp: 0.233 ± 0.014
0.965MetTyr: 0.965 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.797AsnAla: 2.797 ± 0.057
0.533AsnCys: 0.533 ± 0.023
1.917AsnAsp: 1.917 ± 0.053
2.679AsnGlu: 2.679 ± 0.053
1.437AsnPhe: 1.437 ± 0.036
3.174AsnGly: 3.174 ± 0.075
0.774AsnHis: 0.774 ± 0.029
2.967AsnIle: 2.967 ± 0.061
2.222AsnLys: 2.222 ± 0.053
3.568AsnLeu: 3.568 ± 0.062
1.3AsnMet: 1.3 ± 0.044
1.518AsnAsn: 1.518 ± 0.045
1.945AsnPro: 1.945 ± 0.045
1.371AsnGln: 1.371 ± 0.044
2.132AsnArg: 2.132 ± 0.048
2.016AsnSer: 2.016 ± 0.053
2.08AsnThr: 2.08 ± 0.051
2.698AsnVal: 2.698 ± 0.057
0.397AsnTrp: 0.397 ± 0.021
1.655AsnTyr: 1.655 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.262ProAla: 2.262 ± 0.05
0.478ProCys: 0.478 ± 0.023
2.524ProAsp: 2.524 ± 0.06
3.413ProGlu: 3.413 ± 0.064
1.613ProPhe: 1.613 ± 0.046
2.343ProGly: 2.343 ± 0.051
0.605ProHis: 0.605 ± 0.028
2.087ProIle: 2.087 ± 0.051
2.129ProLys: 2.129 ± 0.055
2.695ProLeu: 2.695 ± 0.066
0.888ProMet: 0.888 ± 0.032
1.252ProAsn: 1.252 ± 0.041
0.836ProPro: 0.836 ± 0.034
1.039ProGln: 1.039 ± 0.036
1.057ProArg: 1.057 ± 0.038
1.863ProSer: 1.863 ± 0.047
1.51ProThr: 1.51 ± 0.042
2.87ProVal: 2.87 ± 0.059
0.305ProTrp: 0.305 ± 0.021
1.529ProTyr: 1.529 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.371GlnAla: 2.371 ± 0.061
0.321GlnCys: 0.321 ± 0.017
1.691GlnAsp: 1.691 ± 0.043
3.013GlnGlu: 3.013 ± 0.062
1.207GlnPhe: 1.207 ± 0.037
2.015GlnGly: 2.015 ± 0.05
0.472GlnHis: 0.472 ± 0.025
2.89GlnIle: 2.89 ± 0.057
2.959GlnLys: 2.959 ± 0.064
2.411GlnLeu: 2.411 ± 0.059
1.254GlnMet: 1.254 ± 0.038
1.571GlnAsn: 1.571 ± 0.05
0.811GlnPro: 0.811 ± 0.03
1.081GlnGln: 1.081 ± 0.046
1.467GlnArg: 1.467 ± 0.042
1.639GlnSer: 1.639 ± 0.045
1.798GlnThr: 1.798 ± 0.045
1.893GlnVal: 1.893 ± 0.04
0.286GlnTrp: 0.286 ± 0.021
1.362GlnTyr: 1.362 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.791ArgAla: 2.791 ± 0.057
0.613ArgCys: 0.613 ± 0.026
2.282ArgAsp: 2.282 ± 0.058
4.418ArgGlu: 4.418 ± 0.087
2.082ArgPhe: 2.082 ± 0.055
2.722ArgGly: 2.722 ± 0.064
0.867ArgHis: 0.867 ± 0.036
4.021ArgIle: 4.021 ± 0.065
4.517ArgLys: 4.517 ± 0.074
4.184ArgLeu: 4.184 ± 0.067
1.84ArgMet: 1.84 ± 0.047
2.173ArgAsn: 2.173 ± 0.053
1.446ArgPro: 1.446 ± 0.036
1.976ArgGln: 1.976 ± 0.053
2.718ArgArg: 2.718 ± 0.063
2.211ArgSer: 2.211 ± 0.052
2.564ArgThr: 2.564 ± 0.052
2.59ArgVal: 2.59 ± 0.052
0.402ArgTrp: 0.402 ± 0.022
2.093ArgTyr: 2.093 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
3.77SerAla: 3.77 ± 0.067
0.842SerCys: 0.842 ± 0.032
3.188SerAsp: 3.188 ± 0.07
3.925SerGlu: 3.925 ± 0.067
2.709SerPhe: 2.709 ± 0.06
4.852SerGly: 4.852 ± 0.081
1.041SerHis: 1.041 ± 0.036
3.873SerIle: 3.873 ± 0.07
3.186SerLys: 3.186 ± 0.065
4.81SerLeu: 4.81 ± 0.08
1.853SerMet: 1.853 ± 0.043
1.854SerAsn: 1.854 ± 0.05
1.731SerPro: 1.731 ± 0.045
1.756SerGln: 1.756 ± 0.049
2.844SerArg: 2.844 ± 0.058
3.252SerSer: 3.252 ± 0.067
2.45SerThr: 2.45 ± 0.057
4.209SerVal: 4.209 ± 0.077
0.523SerTrp: 0.523 ± 0.028
2.397SerTyr: 2.397 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.171ThrAla: 4.171 ± 0.092
0.695ThrCys: 0.695 ± 0.029
3.157ThrAsp: 3.157 ± 0.073
4.127ThrGlu: 4.127 ± 0.076
2.156ThrPhe: 2.156 ± 0.053
4.498ThrGly: 4.498 ± 0.075
0.914ThrHis: 0.914 ± 0.038
3.733ThrIle: 3.733 ± 0.066
3.337ThrLys: 3.337 ± 0.064
4.481ThrLeu: 4.481 ± 0.071
1.431ThrMet: 1.431 ± 0.039
1.862ThrAsn: 1.862 ± 0.047
2.008ThrPro: 2.008 ± 0.047
1.413ThrGln: 1.413 ± 0.043
2.019ThrArg: 2.019 ± 0.052
2.682ThrSer: 2.682 ± 0.061
2.598ThrThr: 2.598 ± 0.065
4.333ThrVal: 4.333 ± 0.076
0.45ThrTrp: 0.45 ± 0.023
2.126ThrTyr: 2.126 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
4.277ValAla: 4.277 ± 0.08
1.299ValCys: 1.299 ± 0.039
3.523ValAsp: 3.523 ± 0.07
4.649ValGlu: 4.649 ± 0.079
3.114ValPhe: 3.114 ± 0.065
4.129ValGly: 4.129 ± 0.073
1.155ValHis: 1.155 ± 0.041
5.228ValIle: 5.228 ± 0.093
4.767ValLys: 4.767 ± 0.085
6.737ValLeu: 6.737 ± 0.098
2.047ValMet: 2.047 ± 0.052
2.519ValAsn: 2.519 ± 0.055
2.5ValPro: 2.5 ± 0.054
2.012ValGln: 2.012 ± 0.058
3.131ValArg: 3.131 ± 0.064
4.295ValSer: 4.295 ± 0.077
3.918ValThr: 3.918 ± 0.079
4.529ValVal: 4.529 ± 0.083
0.664ValTrp: 0.664 ± 0.027
2.815ValTyr: 2.815 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.537TrpAla: 0.537 ± 0.026
0.146TrpCys: 0.146 ± 0.013
0.544TrpAsp: 0.544 ± 0.025
0.743TrpGlu: 0.743 ± 0.031
0.39TrpPhe: 0.39 ± 0.022
0.645TrpGly: 0.645 ± 0.032
0.162TrpHis: 0.162 ± 0.014
0.789TrpIle: 0.789 ± 0.033
0.852TrpLys: 0.852 ± 0.035
0.813TrpLeu: 0.813 ± 0.03
0.36TrpMet: 0.36 ± 0.021
0.537TrpAsn: 0.537 ± 0.027
0.186TrpPro: 0.186 ± 0.017
0.335TrpGln: 0.335 ± 0.021
0.359TrpArg: 0.359 ± 0.023
0.433TrpSer: 0.433 ± 0.024
0.385TrpThr: 0.385 ± 0.019
0.494TrpVal: 0.494 ± 0.023
0.099TrpTrp: 0.099 ± 0.011
0.38TrpTyr: 0.38 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.743TyrAla: 2.743 ± 0.055
0.653TyrCys: 0.653 ± 0.027
2.502TyrAsp: 2.502 ± 0.057
3.31TyrGlu: 3.31 ± 0.073
1.798TyrPhe: 1.798 ± 0.049
3.166TyrGly: 3.166 ± 0.066
0.925TyrHis: 0.925 ± 0.031
2.824TyrIle: 2.824 ± 0.053
2.25TyrLys: 2.25 ± 0.055
3.882TyrLeu: 3.882 ± 0.069
1.133TyrMet: 1.133 ± 0.034
1.566TyrAsn: 1.566 ± 0.042
1.55TyrPro: 1.55 ± 0.039
1.509TyrGln: 1.509 ± 0.042
2.296TyrArg: 2.296 ± 0.059
2.175TyrSer: 2.175 ± 0.049
2.203TyrThr: 2.203 ± 0.049
2.623TyrVal: 2.623 ± 0.056
0.344TyrTrp: 0.344 ± 0.018
1.855TyrTyr: 1.855 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2789 proteins (871670 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski