Amino acid dipepetide frequency for Roseovarius faecimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.804AlaAla: 15.804 ± 0.172
1.253AlaCys: 1.253 ± 0.035
6.74AlaAsp: 6.74 ± 0.08
8.539AlaGlu: 8.539 ± 0.122
4.228AlaPhe: 4.228 ± 0.064
10.205AlaGly: 10.205 ± 0.112
2.561AlaHis: 2.561 ± 0.055
5.533AlaIle: 5.533 ± 0.07
3.58AlaLys: 3.58 ± 0.066
13.829AlaLeu: 13.829 ± 0.15
3.865AlaMet: 3.865 ± 0.06
2.655AlaAsn: 2.655 ± 0.055
5.827AlaPro: 5.827 ± 0.089
4.535AlaGln: 4.535 ± 0.067
8.85AlaArg: 8.85 ± 0.115
5.409AlaSer: 5.409 ± 0.069
5.613AlaThr: 5.613 ± 0.076
7.892AlaVal: 7.892 ± 0.09
1.511AlaTrp: 1.511 ± 0.031
2.722AlaTyr: 2.722 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
1.138CysAla: 1.138 ± 0.032
0.141CysCys: 0.141 ± 0.013
0.652CysAsp: 0.652 ± 0.026
0.505CysGlu: 0.505 ± 0.021
0.375CysPhe: 0.375 ± 0.02
1.057CysGly: 1.057 ± 0.034
0.315CysHis: 0.315 ± 0.021
0.484CysIle: 0.484 ± 0.018
0.239CysLys: 0.239 ± 0.014
0.986CysLeu: 0.986 ± 0.027
0.192CysMet: 0.192 ± 0.013
0.262CysAsn: 0.262 ± 0.015
0.581CysPro: 0.581 ± 0.024
0.258CysGln: 0.258 ± 0.016
0.578CysArg: 0.578 ± 0.022
0.477CysSer: 0.477 ± 0.019
0.54CysThr: 0.54 ± 0.023
0.663CysVal: 0.663 ± 0.022
0.121CysTrp: 0.121 ± 0.009
0.266CysTyr: 0.266 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.185AspAla: 7.185 ± 0.083
0.561AspCys: 0.561 ± 0.023
3.424AspAsp: 3.424 ± 0.082
3.702AspGlu: 3.702 ± 0.064
2.143AspPhe: 2.143 ± 0.044
5.641AspGly: 5.641 ± 0.1
1.349AspHis: 1.349 ± 0.039
3.189AspIle: 3.189 ± 0.051
1.812AspLys: 1.812 ± 0.035
6.001AspLeu: 6.001 ± 0.091
1.894AspMet: 1.894 ± 0.042
1.304AspAsn: 1.304 ± 0.039
3.685AspPro: 3.685 ± 0.06
1.956AspGln: 1.956 ± 0.044
3.99AspArg: 3.99 ± 0.066
2.127AspSer: 2.127 ± 0.062
3.2AspThr: 3.2 ± 0.083
4.317AspVal: 4.317 ± 0.063
1.171AspTrp: 1.171 ± 0.034
1.638AspTyr: 1.638 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
8.827GluAla: 8.827 ± 0.115
0.414GluCys: 0.414 ± 0.021
3.526GluAsp: 3.526 ± 0.067
3.993GluGlu: 3.993 ± 0.075
1.945GluPhe: 1.945 ± 0.038
4.979GluGly: 4.979 ± 0.068
1.234GluHis: 1.234 ± 0.034
3.667GluIle: 3.667 ± 0.063
2.208GluLys: 2.208 ± 0.052
5.51GluLeu: 5.51 ± 0.066
2.019GluMet: 2.019 ± 0.042
1.774GluAsn: 1.774 ± 0.044
2.707GluPro: 2.707 ± 0.056
2.034GluGln: 2.034 ± 0.045
4.254GluArg: 4.254 ± 0.066
2.28GluSer: 2.28 ± 0.047
3.812GluThr: 3.812 ± 0.057
4.488GluVal: 4.488 ± 0.068
0.755GluTrp: 0.755 ± 0.03
1.142GluTyr: 1.142 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.339PheAla: 4.339 ± 0.064
0.452PheCys: 0.452 ± 0.022
2.886PheAsp: 2.886 ± 0.055
2.332PheGlu: 2.332 ± 0.044
1.497PhePhe: 1.497 ± 0.046
3.664PheGly: 3.664 ± 0.074
0.787PheHis: 0.787 ± 0.031
1.675PheIle: 1.675 ± 0.039
0.941PheLys: 0.941 ± 0.03
3.396PheLeu: 3.396 ± 0.063
0.89PheMet: 0.89 ± 0.031
1.079PheAsn: 1.079 ± 0.03
1.455PhePro: 1.455 ± 0.04
1.043PheGln: 1.043 ± 0.025
2.04PheArg: 2.04 ± 0.039
2.151PheSer: 2.151 ± 0.047
2.198PheThr: 2.198 ± 0.052
2.623PheVal: 2.623 ± 0.051
0.606PheTrp: 0.606 ± 0.025
0.976PheTyr: 0.976 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
9.894GlyAla: 9.894 ± 0.11
0.935GlyCys: 0.935 ± 0.032
4.725GlyAsp: 4.725 ± 0.104
4.973GlyGlu: 4.973 ± 0.071
3.714GlyPhe: 3.714 ± 0.059
7.522GlyGly: 7.522 ± 0.134
2.072GlyHis: 2.072 ± 0.043
4.338GlyIle: 4.338 ± 0.065
3.127GlyLys: 3.127 ± 0.065
9.23GlyLeu: 9.23 ± 0.095
2.801GlyMet: 2.801 ± 0.052
2.183GlyAsn: 2.183 ± 0.079
3.689GlyPro: 3.689 ± 0.055
3.336GlyGln: 3.336 ± 0.058
5.557GlyArg: 5.557 ± 0.081
4.109GlySer: 4.109 ± 0.074
4.692GlyThr: 4.692 ± 0.082
6.4GlyVal: 6.4 ± 0.074
1.488GlyTrp: 1.488 ± 0.041
2.453GlyTyr: 2.453 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.456HisAla: 2.456 ± 0.049
0.285HisCys: 0.285 ± 0.015
1.332HisAsp: 1.332 ± 0.035
1.191HisGlu: 1.191 ± 0.034
0.9HisPhe: 0.9 ± 0.027
1.97HisGly: 1.97 ± 0.038
0.597HisHis: 0.597 ± 0.025
1.076HisIle: 1.076 ± 0.029
0.579HisLys: 0.579 ± 0.023
2.193HisLeu: 2.193 ± 0.047
0.607HisMet: 0.607 ± 0.023
0.482HisAsn: 0.482 ± 0.02
1.459HisPro: 1.459 ± 0.036
0.646HisGln: 0.646 ± 0.022
1.399HisArg: 1.399 ± 0.034
0.993HisSer: 0.993 ± 0.031
0.926HisThr: 0.926 ± 0.028
1.609HisVal: 1.609 ± 0.036
0.37HisTrp: 0.37 ± 0.016
0.593HisTyr: 0.593 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.645IleAla: 6.645 ± 0.07
0.686IleCys: 0.686 ± 0.025
3.455IleAsp: 3.455 ± 0.061
3.541IleGlu: 3.541 ± 0.056
1.733IlePhe: 1.733 ± 0.04
4.813IleGly: 4.813 ± 0.066
0.88IleHis: 0.88 ± 0.031
2.254IleIle: 2.254 ± 0.053
1.504IleLys: 1.504 ± 0.038
4.82IleLeu: 4.82 ± 0.068
1.11IleMet: 1.11 ± 0.032
1.466IleAsn: 1.466 ± 0.04
2.427IlePro: 2.427 ± 0.046
1.202IleGln: 1.202 ± 0.03
3.185IleArg: 3.185 ± 0.047
3.033IleSer: 3.033 ± 0.051
3.144IleThr: 3.144 ± 0.055
3.585IleVal: 3.585 ± 0.061
0.751IleTrp: 0.751 ± 0.028
1.195IleTyr: 1.195 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.945LysAla: 3.945 ± 0.07
0.205LysCys: 0.205 ± 0.012
1.753LysAsp: 1.753 ± 0.042
1.583LysGlu: 1.583 ± 0.041
0.895LysPhe: 0.895 ± 0.028
2.714LysGly: 2.714 ± 0.051
0.698LysHis: 0.698 ± 0.022
1.642LysIle: 1.642 ± 0.038
1.235LysLys: 1.235 ± 0.042
3.115LysLeu: 3.115 ± 0.059
0.887LysMet: 0.887 ± 0.028
0.767LysAsn: 0.767 ± 0.028
1.843LysPro: 1.843 ± 0.044
0.915LysGln: 0.915 ± 0.03
2.241LysArg: 2.241 ± 0.049
1.842LysSer: 1.842 ± 0.045
1.929LysThr: 1.929 ± 0.043
2.251LysVal: 2.251 ± 0.049
0.403LysTrp: 0.403 ± 0.02
0.678LysTyr: 0.678 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
12.443LeuAla: 12.443 ± 0.129
1.034LeuCys: 1.034 ± 0.032
5.911LeuAsp: 5.911 ± 0.066
5.599LeuGlu: 5.599 ± 0.08
3.479LeuPhe: 3.479 ± 0.068
8.378LeuGly: 8.378 ± 0.092
2.028LeuHis: 2.028 ± 0.043
5.468LeuIle: 5.468 ± 0.072
3.334LeuLys: 3.334 ± 0.06
8.899LeuLeu: 8.899 ± 0.123
2.766LeuMet: 2.766 ± 0.053
2.728LeuAsn: 2.728 ± 0.046
5.654LeuPro: 5.654 ± 0.077
2.677LeuGln: 2.677 ± 0.051
6.924LeuArg: 6.924 ± 0.092
6.819LeuSer: 6.819 ± 0.088
6.139LeuThr: 6.139 ± 0.092
6.54LeuVal: 6.54 ± 0.094
1.385LeuTrp: 1.385 ± 0.043
2.161LeuTyr: 2.161 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.607MetAla: 3.607 ± 0.064
0.215MetCys: 0.215 ± 0.014
1.478MetAsp: 1.478 ± 0.038
1.401MetGlu: 1.401 ± 0.029
0.809MetPhe: 0.809 ± 0.028
2.336MetGly: 2.336 ± 0.045
0.517MetHis: 0.517 ± 0.022
1.603MetIle: 1.603 ± 0.038
1.086MetLys: 1.086 ± 0.031
2.724MetLeu: 2.724 ± 0.048
0.822MetMet: 0.822 ± 0.026
0.83MetAsn: 0.83 ± 0.03
1.627MetPro: 1.627 ± 0.041
1.139MetGln: 1.139 ± 0.03
2.07MetArg: 2.07 ± 0.038
1.953MetSer: 1.953 ± 0.04
2.047MetThr: 2.047 ± 0.039
1.942MetVal: 1.942 ± 0.045
0.256MetTrp: 0.256 ± 0.017
0.38MetTyr: 0.38 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.139AsnAla: 3.139 ± 0.057
0.267AsnCys: 0.267 ± 0.016
1.541AsnAsp: 1.541 ± 0.084
1.278AsnGlu: 1.278 ± 0.033
0.96AsnPhe: 0.96 ± 0.026
2.456AsnGly: 2.456 ± 0.06
0.511AsnHis: 0.511 ± 0.021
1.394AsnIle: 1.394 ± 0.035
0.664AsnLys: 0.664 ± 0.025
2.475AsnLeu: 2.475 ± 0.046
0.734AsnMet: 0.734 ± 0.024
0.727AsnAsn: 0.727 ± 0.026
1.812AsnPro: 1.812 ± 0.038
0.694AsnGln: 0.694 ± 0.023
1.666AsnArg: 1.666 ± 0.041
1.208AsnSer: 1.208 ± 0.035
1.403AsnThr: 1.403 ± 0.039
1.8AsnVal: 1.8 ± 0.045
0.496AsnTrp: 0.496 ± 0.02
0.632AsnTyr: 0.632 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
5.366ProAla: 5.366 ± 0.077
0.409ProCys: 0.409 ± 0.02
3.974ProAsp: 3.974 ± 0.061
4.48ProGlu: 4.48 ± 0.076
2.001ProPhe: 2.001 ± 0.042
4.861ProGly: 4.861 ± 0.066
1.159ProHis: 1.159 ± 0.034
2.185ProIle: 2.185 ± 0.047
1.653ProLys: 1.653 ± 0.043
4.715ProLeu: 4.715 ± 0.068
1.388ProMet: 1.388 ± 0.039
1.29ProAsn: 1.29 ± 0.036
2.304ProPro: 2.304 ± 0.062
1.655ProGln: 1.655 ± 0.047
2.778ProArg: 2.778 ± 0.05
2.434ProSer: 2.434 ± 0.05
2.274ProThr: 2.274 ± 0.05
4.286ProVal: 4.286 ± 0.061
0.678ProTrp: 0.678 ± 0.024
1.214ProTyr: 1.214 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.251GlnAla: 4.251 ± 0.064
0.239GlnCys: 0.239 ± 0.014
1.757GlnAsp: 1.757 ± 0.039
1.744GlnGlu: 1.744 ± 0.038
1.1GlnPhe: 1.1 ± 0.029
2.69GlnGly: 2.69 ± 0.052
0.643GlnHis: 0.643 ± 0.027
1.972GlnIle: 1.972 ± 0.041
1.073GlnLys: 1.073 ± 0.034
2.917GlnLeu: 2.917 ± 0.057
1.154GlnMet: 1.154 ± 0.03
0.998GlnAsn: 0.998 ± 0.039
1.586GlnPro: 1.586 ± 0.039
1.041GlnGln: 1.041 ± 0.033
2.009GlnArg: 2.009 ± 0.045
1.819GlnSer: 1.819 ± 0.043
1.796GlnThr: 1.796 ± 0.039
2.448GlnVal: 2.448 ± 0.048
0.402GlnTrp: 0.402 ± 0.019
0.582GlnTyr: 0.582 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
8.162ArgAla: 8.162 ± 0.105
0.53ArgCys: 0.53 ± 0.023
4.215ArgAsp: 4.215 ± 0.063
4.012ArgGlu: 4.012 ± 0.067
2.642ArgPhe: 2.642 ± 0.052
4.465ArgGly: 4.465 ± 0.067
1.583ArgHis: 1.583 ± 0.036
3.639ArgIle: 3.639 ± 0.052
2.243ArgLys: 2.243 ± 0.048
7.165ArgLeu: 7.165 ± 0.088
1.916ArgMet: 1.916 ± 0.038
1.699ArgAsn: 1.699 ± 0.044
3.192ArgPro: 3.192 ± 0.055
2.338ArgGln: 2.338 ± 0.045
4.806ArgArg: 4.806 ± 0.083
3.096ArgSer: 3.096 ± 0.053
2.778ArgThr: 2.778 ± 0.05
4.529ArgVal: 4.529 ± 0.071
0.96ArgTrp: 0.96 ± 0.03
1.649ArgTyr: 1.649 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
5.781SerAla: 5.781 ± 0.077
0.496SerCys: 0.496 ± 0.023
3.465SerAsp: 3.465 ± 0.063
2.955SerGlu: 2.955 ± 0.053
2.369SerPhe: 2.369 ± 0.049
5.417SerGly: 5.417 ± 0.086
1.113SerHis: 1.113 ± 0.03
2.402SerIle: 2.402 ± 0.054
1.503SerLys: 1.503 ± 0.038
4.904SerLeu: 4.904 ± 0.067
1.335SerMet: 1.335 ± 0.034
1.343SerAsn: 1.343 ± 0.034
2.558SerPro: 2.558 ± 0.05
1.594SerGln: 1.594 ± 0.034
2.982SerArg: 2.982 ± 0.049
2.574SerSer: 2.574 ± 0.058
2.582SerThr: 2.582 ± 0.045
3.637SerVal: 3.637 ± 0.055
0.708SerTrp: 0.708 ± 0.025
1.385SerTyr: 1.385 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
5.992ThrAla: 5.992 ± 0.067
0.568ThrCys: 0.568 ± 0.023
2.996ThrAsp: 2.996 ± 0.062
3.051ThrGlu: 3.051 ± 0.046
1.911ThrPhe: 1.911 ± 0.04
5.618ThrGly: 5.618 ± 0.093
1.208ThrHis: 1.208 ± 0.034
2.706ThrIle: 2.706 ± 0.06
1.471ThrLys: 1.471 ± 0.032
5.988ThrLeu: 5.988 ± 0.085
1.269ThrMet: 1.269 ± 0.032
1.305ThrAsn: 1.305 ± 0.032
3.455ThrPro: 3.455 ± 0.052
1.674ThrGln: 1.674 ± 0.048
3.645ThrArg: 3.645 ± 0.059
2.707ThrSer: 2.707 ± 0.047
2.8ThrThr: 2.8 ± 0.061
4.061ThrVal: 4.061 ± 0.078
0.69ThrTrp: 0.69 ± 0.027
1.38ThrTyr: 1.38 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
8.093ValAla: 8.093 ± 0.088
0.711ValCys: 0.711 ± 0.029
3.935ValAsp: 3.935 ± 0.065
4.518ValGlu: 4.518 ± 0.069
2.847ValPhe: 2.847 ± 0.055
5.223ValGly: 5.223 ± 0.076
1.412ValHis: 1.412 ± 0.037
4.422ValIle: 4.422 ± 0.063
2.219ValLys: 2.219 ± 0.052
7.365ValLeu: 7.365 ± 0.081
2.206ValMet: 2.206 ± 0.046
1.956ValAsn: 1.956 ± 0.055
3.414ValPro: 3.414 ± 0.053
2.125ValGln: 2.125 ± 0.045
4.009ValArg: 4.009 ± 0.06
4.136ValSer: 4.136 ± 0.061
4.581ValThr: 4.581 ± 0.06
5.206ValVal: 5.206 ± 0.074
0.912ValTrp: 0.912 ± 0.027
1.522ValTyr: 1.522 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.456TrpAla: 1.456 ± 0.039
0.149TrpCys: 0.149 ± 0.01
0.787TrpAsp: 0.787 ± 0.026
0.719TrpGlu: 0.719 ± 0.025
0.558TrpPhe: 0.558 ± 0.024
1.055TrpGly: 1.055 ± 0.031
0.374TrpHis: 0.374 ± 0.019
0.73TrpIle: 0.73 ± 0.03
0.447TrpLys: 0.447 ± 0.022
1.708TrpLeu: 1.708 ± 0.044
0.423TrpMet: 0.423 ± 0.018
0.433TrpAsn: 0.433 ± 0.023
0.728TrpPro: 0.728 ± 0.023
0.607TrpGln: 0.607 ± 0.022
1.023TrpArg: 1.023 ± 0.029
0.804TrpSer: 0.804 ± 0.028
0.797TrpThr: 0.797 ± 0.03
0.948TrpVal: 0.948 ± 0.028
0.246TrpTrp: 0.246 ± 0.014
0.324TrpTyr: 0.324 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.63TyrAla: 2.63 ± 0.054
0.279TyrCys: 0.279 ± 0.014
1.735TyrAsp: 1.735 ± 0.037
1.454TyrGlu: 1.454 ± 0.038
0.923TyrPhe: 0.923 ± 0.028
2.177TyrGly: 2.177 ± 0.05
0.622TyrHis: 0.622 ± 0.023
1.048TyrIle: 1.048 ± 0.03
0.619TyrLys: 0.619 ± 0.025
2.428TyrLeu: 2.428 ± 0.05
0.563TyrMet: 0.563 ± 0.024
0.574TyrAsn: 0.574 ± 0.028
1.1TyrPro: 1.1 ± 0.035
0.752TyrGln: 0.752 ± 0.024
1.613TyrArg: 1.613 ± 0.043
1.132TyrSer: 1.132 ± 0.03
1.247TyrThr: 1.247 ± 0.054
1.588TyrVal: 1.588 ± 0.037
0.405TyrTrp: 0.405 ± 0.019
0.642TyrTyr: 0.642 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3738 proteins (1185881 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski