Amino acid dipepetide frequency for Paenibacillus larvae subsp. larvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.724AlaAla: 6.724 ± 0.092	0.736AlaCys: 0.736 ± 0.024	3.723AlaAsp: 3.723 ± 0.06	5.22AlaGlu: 5.22 ± 0.075	3.073AlaPhe: 3.073 ± 0.056	5.919AlaGly: 5.919 ± 0.079	1.298AlaHis: 1.298 ± 0.034	5.155AlaIle: 5.155 ± 0.081	4.597AlaLys: 4.597 ± 0.064	7.278AlaLeu: 7.278 ± 0.092	2.024AlaMet: 2.024 ± 0.04	2.53AlaAsn: 2.53 ± 0.05	2.149AlaPro: 2.149 ± 0.051	2.255AlaGln: 2.255 ± 0.041	3.235AlaArg: 3.235 ± 0.047	4.339AlaSer: 4.339 ± 0.067	3.027AlaThr: 3.027 ± 0.054	5.745AlaVal: 5.745 ± 0.086	0.804AlaTrp: 0.804 ± 0.027	2.5AlaTyr: 2.5 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.477CysAla: 0.477 ± 0.021	0.133CysCys: 0.133 ± 0.01	0.42CysAsp: 0.42 ± 0.021	0.521CysGlu: 0.521 ± 0.019	0.422CysPhe: 0.422 ± 0.02	0.793CysGly: 0.793 ± 0.028	0.197CysHis: 0.197 ± 0.012	0.659CysIle: 0.659 ± 0.022	0.519CysLys: 0.519 ± 0.02	0.926CysLeu: 0.926 ± 0.033	0.25CysMet: 0.25 ± 0.015	0.303CysAsn: 0.303 ± 0.018	0.486CysPro: 0.486 ± 0.022	0.285CysGln: 0.285 ± 0.015	0.514CysArg: 0.514 ± 0.019	0.628CysSer: 0.628 ± 0.021	0.537CysThr: 0.537 ± 0.022	0.484CysVal: 0.484 ± 0.019	0.093CysTrp: 0.093 ± 0.008	0.345CysTyr: 0.345 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.328AspAla: 3.328 ± 0.058	0.405AspCys: 0.405 ± 0.017	2.223AspAsp: 2.223 ± 0.052	3.776AspGlu: 3.776 ± 0.061	2.263AspPhe: 2.263 ± 0.044	3.405AspGly: 3.405 ± 0.068	1.208AspHis: 1.208 ± 0.031	3.842AspIle: 3.842 ± 0.064	3.317AspLys: 3.317 ± 0.061	4.991AspLeu: 4.991 ± 0.071	1.43AspMet: 1.43 ± 0.034	1.764AspAsn: 1.764 ± 0.039	2.313AspPro: 2.313 ± 0.042	2.127AspGln: 2.127 ± 0.089	2.665AspArg: 2.665 ± 0.042	2.727AspSer: 2.727 ± 0.051	2.387AspThr: 2.387 ± 0.045	3.461AspVal: 3.461 ± 0.059	0.751AspTrp: 0.751 ± 0.025	1.977AspTyr: 1.977 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.544GluAla: 5.544 ± 0.073	0.499GluCys: 0.499 ± 0.022	3.557GluAsp: 3.557 ± 0.067	6.33GluGlu: 6.33 ± 0.106	2.246GluPhe: 2.246 ± 0.046	4.365GluGly: 4.365 ± 0.078	1.691GluHis: 1.691 ± 0.068	4.913GluIle: 4.913 ± 0.08	5.46GluLys: 5.46 ± 0.08	7.062GluLeu: 7.062 ± 0.092	2.219GluMet: 2.219 ± 0.042	2.877GluAsn: 2.877 ± 0.054	2.168GluPro: 2.168 ± 0.047	3.849GluGln: 3.849 ± 0.07	3.957GluArg: 3.957 ± 0.066	3.491GluSer: 3.491 ± 0.049	3.648GluThr: 3.648 ± 0.05	4.857GluVal: 4.857 ± 0.079	0.912GluTrp: 0.912 ± 0.032	2.267GluTyr: 2.267 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.983PheAla: 2.983 ± 0.055	0.423PheCys: 0.423 ± 0.019	2.129PheAsp: 2.129 ± 0.05	2.458PheGlu: 2.458 ± 0.05	2.067PhePhe: 2.067 ± 0.045	3.044PheGly: 3.044 ± 0.057	1.103PheHis: 1.103 ± 0.032	3.336PheIle: 3.336 ± 0.067	2.221PheLys: 2.221 ± 0.047	4.226PheLeu: 4.226 ± 0.074	1.126PheMet: 1.126 ± 0.032	1.64PheAsn: 1.64 ± 0.034	1.574PhePro: 1.574 ± 0.034	1.435PheGln: 1.435 ± 0.03	1.893PheArg: 1.893 ± 0.034	2.84PheSer: 2.84 ± 0.049	2.462PheThr: 2.462 ± 0.049	2.932PheVal: 2.932 ± 0.053	0.456PheTrp: 0.456 ± 0.019	1.493PheTyr: 1.493 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.673GlyAla: 4.673 ± 0.079	0.794GlyCys: 0.794 ± 0.028	3.271GlyAsp: 3.271 ± 0.09	4.533GlyGlu: 4.533 ± 0.073	3.264GlyPhe: 3.264 ± 0.062	5.03GlyGly: 5.03 ± 0.084	1.532GlyHis: 1.532 ± 0.041	5.989GlyIle: 5.989 ± 0.078	5.284GlyLys: 5.284 ± 0.073	6.795GlyLeu: 6.795 ± 0.087	2.256GlyMet: 2.256 ± 0.048	2.846GlyAsn: 2.846 ± 0.06	1.935GlyPro: 1.935 ± 0.135	2.51GlyGln: 2.51 ± 0.051	3.353GlyArg: 3.353 ± 0.061	4.154GlySer: 4.154 ± 0.064	4.191GlyThr: 4.191 ± 0.057	4.925GlyVal: 4.925 ± 0.063	0.915GlyTrp: 0.915 ± 0.028	2.78GlyTyr: 2.78 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.531HisAla: 1.531 ± 0.039	0.231HisCys: 0.231 ± 0.012	1.077HisAsp: 1.077 ± 0.031	1.421HisGlu: 1.421 ± 0.033	1.019HisPhe: 1.019 ± 0.026	1.415HisGly: 1.415 ± 0.034	0.657HisHis: 0.657 ± 0.027	1.572HisIle: 1.572 ± 0.043	1.141HisLys: 1.141 ± 0.03	2.415HisLeu: 2.415 ± 0.116	0.588HisMet: 0.588 ± 0.021	0.775HisAsn: 0.775 ± 0.028	1.216HisPro: 1.216 ± 0.036	0.855HisGln: 0.855 ± 0.028	1.046HisArg: 1.046 ± 0.03	1.329HisSer: 1.329 ± 0.038	1.161HisThr: 1.161 ± 0.029	1.536HisVal: 1.536 ± 0.035	0.235HisTrp: 0.235 ± 0.013	0.857HisTyr: 0.857 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.353IleAla: 5.353 ± 0.082	0.811IleCys: 0.811 ± 0.026	3.605IleAsp: 3.605 ± 0.063	4.847IleGlu: 4.847 ± 0.066	2.692IlePhe: 2.692 ± 0.048	5.653IleGly: 5.653 ± 0.077	1.716IleHis: 1.716 ± 0.044	4.773IleIle: 4.773 ± 0.072	4.017IleLys: 4.017 ± 0.068	6.671IleLeu: 6.671 ± 0.09	1.775IleMet: 1.775 ± 0.04	2.552IleAsn: 2.552 ± 0.052	3.417IlePro: 3.417 ± 0.049	3.067IleGln: 3.067 ± 0.065	4.214IleArg: 4.214 ± 0.054	4.714IleSer: 4.714 ± 0.063	3.873IleThr: 3.873 ± 0.06	4.933IleVal: 4.933 ± 0.059	0.709IleTrp: 0.709 ± 0.022	2.386IleTyr: 2.386 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.86LysAla: 4.86 ± 0.074	0.353LysCys: 0.353 ± 0.018	3.549LysAsp: 3.549 ± 0.061	6.092LysGlu: 6.092 ± 0.08	1.856LysPhe: 1.856 ± 0.042	4.332LysGly: 4.332 ± 0.067	1.35LysHis: 1.35 ± 0.031	4.132LysIle: 4.132 ± 0.062	5.143LysLys: 5.143 ± 0.093	6.046LysLeu: 6.046 ± 0.081	1.95LysMet: 1.95 ± 0.044	2.8LysAsn: 2.8 ± 0.05	2.564LysPro: 2.564 ± 0.049	3.382LysGln: 3.382 ± 0.057	3.543LysArg: 3.543 ± 0.067	3.419LysSer: 3.419 ± 0.059	3.605LysThr: 3.605 ± 0.05	4.225LysVal: 4.225 ± 0.068	0.843LysTrp: 0.843 ± 0.024	2.179LysTyr: 2.179 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.571LeuAla: 7.571 ± 0.115	0.897LeuCys: 0.897 ± 0.029	5.175LeuAsp: 5.175 ± 0.065	6.758LeuGlu: 6.758 ± 0.087	4.687LeuPhe: 4.687 ± 0.072	6.613LeuGly: 6.613 ± 0.091	2.204LeuHis: 2.204 ± 0.041	6.812LeuIle: 6.812 ± 0.091	6.22LeuLys: 6.22 ± 0.082	10.206LeuLeu: 10.206 ± 0.152	2.537LeuMet: 2.537 ± 0.043	3.999LeuAsn: 3.999 ± 0.057	4.144LeuPro: 4.144 ± 0.066	3.782LeuGln: 3.782 ± 0.06	4.492LeuArg: 4.492 ± 0.068	6.686LeuSer: 6.686 ± 0.076	5.455LeuThr: 5.455 ± 0.074	6.398LeuVal: 6.398 ± 0.081	0.909LeuTrp: 0.909 ± 0.028	3.231LeuTyr: 3.231 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.098MetAla: 2.098 ± 0.038	0.181MetCys: 0.181 ± 0.012	1.499MetAsp: 1.499 ± 0.034	2.138MetGlu: 2.138 ± 0.042	1.072MetPhe: 1.072 ± 0.027	1.82MetGly: 1.82 ± 0.038	0.468MetHis: 0.468 ± 0.02	2.082MetIle: 2.082 ± 0.044	2.453MetLys: 2.453 ± 0.044	2.681MetLeu: 2.681 ± 0.049	0.858MetMet: 0.858 ± 0.029	1.644MetAsn: 1.644 ± 0.034	1.069MetPro: 1.069 ± 0.03	0.971MetGln: 0.971 ± 0.027	1.249MetArg: 1.249 ± 0.033	1.665MetSer: 1.665 ± 0.039	1.587MetThr: 1.587 ± 0.037	1.719MetVal: 1.719 ± 0.045	0.197MetTrp: 0.197 ± 0.013	0.794MetTyr: 0.794 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.488AsnAla: 2.488 ± 0.048	0.341AsnCys: 0.341 ± 0.015	1.704AsnAsp: 1.704 ± 0.043	2.822AsnGlu: 2.822 ± 0.051	1.325AsnPhe: 1.325 ± 0.034	3.06AsnGly: 3.06 ± 0.063	0.912AsnHis: 0.912 ± 0.03	2.688AsnIle: 2.688 ± 0.043	2.855AsnLys: 2.855 ± 0.05	3.637AsnLeu: 3.637 ± 0.058	1.161AsnMet: 1.161 ± 0.032	1.638AsnAsn: 1.638 ± 0.04	2.174AsnPro: 2.174 ± 0.049	1.817AsnGln: 1.817 ± 0.045	2.399AsnArg: 2.399 ± 0.044	2.162AsnSer: 2.162 ± 0.05	1.989AsnThr: 1.989 ± 0.046	2.544AsnVal: 2.544 ± 0.046	0.552AsnTrp: 0.552 ± 0.021	1.318AsnTyr: 1.318 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.805ProAla: 2.805 ± 0.053	0.275ProCys: 0.275 ± 0.018	2.681ProAsp: 2.681 ± 0.048	3.348ProGlu: 3.348 ± 0.063	1.912ProPhe: 1.912 ± 0.041	2.792ProGly: 2.792 ± 0.05	0.862ProHis: 0.862 ± 0.029	2.399ProIle: 2.399 ± 0.05	2.29ProLys: 2.29 ± 0.045	3.616ProLeu: 3.616 ± 0.058	0.88ProMet: 0.88 ± 0.027	1.585ProAsn: 1.585 ± 0.039	1.141ProPro: 1.141 ± 0.033	1.318ProGln: 1.318 ± 0.12	1.373ProArg: 1.373 ± 0.034	2.517ProSer: 2.517 ± 0.053	1.912ProThr: 1.912 ± 0.043	3.305ProVal: 3.305 ± 0.058	0.41ProTrp: 0.41 ± 0.021	1.537ProTyr: 1.537 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.193GlnAla: 3.193 ± 0.048	0.267GlnCys: 0.267 ± 0.016	1.915GlnAsp: 1.915 ± 0.04	2.947GlnGlu: 2.947 ± 0.063	1.517GlnPhe: 1.517 ± 0.031	2.693GlnGly: 2.693 ± 0.226	0.852GlnHis: 0.852 ± 0.031	2.832GlnIle: 2.832 ± 0.046	2.674GlnLys: 2.674 ± 0.046	4.064GlnLeu: 4.064 ± 0.071	1.22GlnMet: 1.22 ± 0.031	1.555GlnAsn: 1.555 ± 0.04	1.37GlnPro: 1.37 ± 0.031	1.774GlnGln: 1.774 ± 0.048	1.762GlnArg: 1.762 ± 0.04	2.231GlnSer: 2.231 ± 0.091	2.188GlnThr: 2.188 ± 0.044	2.681GlnVal: 2.681 ± 0.039	0.403GlnTrp: 0.403 ± 0.019	1.333GlnTyr: 1.333 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.765ArgAla: 2.765 ± 0.053	0.415ArgCys: 0.415 ± 0.019	2.325ArgAsp: 2.325 ± 0.041	3.862ArgGlu: 3.862 ± 0.067	2.113ArgPhe: 2.113 ± 0.043	2.911ArgGly: 2.911 ± 0.05	1.116ArgHis: 1.116 ± 0.034	3.894ArgIle: 3.894 ± 0.06	3.851ArgLys: 3.851 ± 0.063	4.926ArgLeu: 4.926 ± 0.073	1.61ArgMet: 1.61 ± 0.034	2.195ArgAsn: 2.195 ± 0.04	1.639ArgPro: 1.639 ± 0.036	2.078ArgGln: 2.078 ± 0.04	2.657ArgArg: 2.657 ± 0.061	2.757ArgSer: 2.757 ± 0.046	2.548ArgThr: 2.548 ± 0.045	3.121ArgVal: 3.121 ± 0.055	0.637ArgTrp: 0.637 ± 0.022	1.852ArgTyr: 1.852 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.083SerAla: 4.083 ± 0.064	0.57SerCys: 0.57 ± 0.024	2.811SerAsp: 2.811 ± 0.056	3.663SerGlu: 3.663 ± 0.055	3.012SerPhe: 3.012 ± 0.048	4.898SerGly: 4.898 ± 0.058	1.339SerHis: 1.339 ± 0.034	4.533SerIle: 4.533 ± 0.075	3.726SerLys: 3.726 ± 0.052	6.239SerLeu: 6.239 ± 0.084	1.774SerMet: 1.774 ± 0.037	2.188SerAsn: 2.188 ± 0.046	2.387SerPro: 2.387 ± 0.049	1.99SerGln: 1.99 ± 0.042	2.969SerArg: 2.969 ± 0.052	4.169SerSer: 4.169 ± 0.07	2.945SerThr: 2.945 ± 0.051	4.285SerVal: 4.285 ± 0.089	0.74SerTrp: 0.74 ± 0.024	2.251SerTyr: 2.251 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.123ThrAla: 4.123 ± 0.055	0.455ThrCys: 0.455 ± 0.02	2.7ThrAsp: 2.7 ± 0.049	3.435ThrGlu: 3.435 ± 0.053	2.3ThrPhe: 2.3 ± 0.04	4.607ThrGly: 4.607 ± 0.062	1.06ThrHis: 1.06 ± 0.025	3.815ThrIle: 3.815 ± 0.066	3.076ThrLys: 3.076 ± 0.069	5.016ThrLeu: 5.016 ± 0.065	1.286ThrMet: 1.286 ± 0.036	2.004ThrAsn: 2.004 ± 0.049	2.394ThrPro: 2.394 ± 0.045	1.531ThrGln: 1.531 ± 0.038	2.242ThrArg: 2.242 ± 0.045	3.299ThrSer: 3.299 ± 0.052	2.617ThrThr: 2.617 ± 0.05	4.179ThrVal: 4.179 ± 0.056	0.616ThrTrp: 0.616 ± 0.024	2.021ThrTyr: 2.021 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.699ValAla: 4.699 ± 0.068	0.706ValCys: 0.706 ± 0.023	3.445ValAsp: 3.445 ± 0.059	4.5ValGlu: 4.5 ± 0.072	2.9ValPhe: 2.9 ± 0.051	4.429ValGly: 4.429 ± 0.068	1.521ValHis: 1.521 ± 0.039	5.132ValIle: 5.132 ± 0.07	4.5ValLys: 4.5 ± 0.068	7.18ValLeu: 7.18 ± 0.084	1.915ValMet: 1.915 ± 0.037	2.765ValAsn: 2.765 ± 0.053	2.961ValPro: 2.961 ± 0.05	2.646ValGln: 2.646 ± 0.066	3.274ValArg: 3.274 ± 0.056	4.666ValSer: 4.666 ± 0.07	4.101ValThr: 4.101 ± 0.056	4.619ValVal: 4.619 ± 0.076	0.752ValTrp: 0.752 ± 0.027	2.357ValTyr: 2.357 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.693TrpAla: 0.693 ± 0.023	0.103TrpCys: 0.103 ± 0.01	0.614TrpAsp: 0.614 ± 0.022	0.783TrpGlu: 0.783 ± 0.03	0.535TrpPhe: 0.535 ± 0.02	0.706TrpGly: 0.706 ± 0.023	0.232TrpHis: 0.232 ± 0.015	0.909TrpIle: 0.909 ± 0.028	0.865TrpLys: 0.865 ± 0.03	1.317TrpLeu: 1.317 ± 0.032	0.43TrpMet: 0.43 ± 0.022	0.584TrpAsn: 0.584 ± 0.024	0.271TrpPro: 0.271 ± 0.016	0.402TrpGln: 0.402 ± 0.021	0.506TrpArg: 0.506 ± 0.02	0.67TrpSer: 0.67 ± 0.023	0.617TrpThr: 0.617 ± 0.025	0.779TrpVal: 0.779 ± 0.022	0.175TrpTrp: 0.175 ± 0.013	0.343TrpTyr: 0.343 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.341TyrAla: 2.341 ± 0.046	0.398TyrCys: 0.398 ± 0.017	1.937TyrAsp: 1.937 ± 0.047	2.456TyrGlu: 2.456 ± 0.044	1.567TyrPhe: 1.567 ± 0.037	2.546TyrGly: 2.546 ± 0.05	0.759TyrHis: 0.759 ± 0.024	2.312TyrIle: 2.312 ± 0.045	2.015TyrLys: 2.015 ± 0.041	3.48TyrLeu: 3.48 ± 0.054	0.954TyrMet: 0.954 ± 0.03	1.341TyrAsn: 1.341 ± 0.033	1.588TyrPro: 1.588 ± 0.043	1.396TyrGln: 1.396 ± 0.039	1.93TyrArg: 1.93 ± 0.046	2.106TyrSer: 2.106 ± 0.036	1.928TyrThr: 1.928 ± 0.045	2.34TyrVal: 2.34 ± 0.045	0.428TyrTrp: 0.428 ± 0.02	1.374TyrTyr: 1.374 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4640 proteins (1256144 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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