Amino acid dipepetide frequency for Halomonas sp. JB380

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.391AlaAla: 11.391 ± 0.13
1.148AlaCys: 1.148 ± 0.031
5.412AlaAsp: 5.412 ± 0.076
6.441AlaGlu: 6.441 ± 0.084
3.983AlaPhe: 3.983 ± 0.065
8.144AlaGly: 8.144 ± 0.099
2.4AlaHis: 2.4 ± 0.049
5.988AlaIle: 5.988 ± 0.08
3.316AlaLys: 3.316 ± 0.063
13.946AlaLeu: 13.946 ± 0.135
3.276AlaMet: 3.276 ± 0.053
3.302AlaAsn: 3.302 ± 0.054
4.499AlaPro: 4.499 ± 0.073
4.727AlaGln: 4.727 ± 0.066
6.287AlaArg: 6.287 ± 0.097
6.449AlaSer: 6.449 ± 0.083
5.453AlaThr: 5.453 ± 0.081
7.202AlaVal: 7.202 ± 0.08
1.633AlaTrp: 1.633 ± 0.044
2.546AlaTyr: 2.546 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.901CysAla: 0.901 ± 0.027
0.14CysCys: 0.14 ± 0.011
0.546CysAsp: 0.546 ± 0.019
0.548CysGlu: 0.548 ± 0.024
0.393CysPhe: 0.393 ± 0.021
0.839CysGly: 0.839 ± 0.028
0.295CysHis: 0.295 ± 0.016
0.435CysIle: 0.435 ± 0.019
0.259CysLys: 0.259 ± 0.013
1.008CysLeu: 1.008 ± 0.034
0.211CysMet: 0.211 ± 0.013
0.227CysAsn: 0.227 ± 0.013
0.464CysPro: 0.464 ± 0.025
0.44CysGln: 0.44 ± 0.022
0.563CysArg: 0.563 ± 0.022
0.497CysSer: 0.497 ± 0.023
0.415CysThr: 0.415 ± 0.018
0.639CysVal: 0.639 ± 0.024
0.116CysTrp: 0.116 ± 0.009
0.303CysTyr: 0.303 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.103AspAla: 6.103 ± 0.079
0.394AspCys: 0.394 ± 0.018
3.213AspAsp: 3.213 ± 0.06
3.774AspGlu: 3.774 ± 0.063
2.038AspPhe: 2.038 ± 0.044
3.89AspGly: 3.89 ± 0.065
1.291AspHis: 1.291 ± 0.032
3.369AspIle: 3.369 ± 0.064
1.757AspLys: 1.757 ± 0.041
4.785AspLeu: 4.785 ± 0.072
1.422AspMet: 1.422 ± 0.034
1.864AspAsn: 1.864 ± 0.041
2.545AspPro: 2.545 ± 0.04
2.21AspGln: 2.21 ± 0.043
2.827AspArg: 2.827 ± 0.054
2.795AspSer: 2.795 ± 0.055
2.883AspThr: 2.883 ± 0.049
4.19AspVal: 4.19 ± 0.069
0.814AspTrp: 0.814 ± 0.031
1.649AspTyr: 1.649 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.316GluAla: 7.316 ± 0.091
0.48GluCys: 0.48 ± 0.025
2.769GluAsp: 2.769 ± 0.054
3.927GluGlu: 3.927 ± 0.072
1.742GluPhe: 1.742 ± 0.039
4.389GluGly: 4.389 ± 0.074
1.78GluHis: 1.78 ± 0.04
2.969GluIle: 2.969 ± 0.055
2.22GluLys: 2.22 ± 0.054
6.58GluLeu: 6.58 ± 0.097
1.539GluMet: 1.539 ± 0.036
1.885GluAsn: 1.885 ± 0.042
2.48GluPro: 2.48 ± 0.056
3.757GluGln: 3.757 ± 0.072
5.181GluArg: 5.181 ± 0.073
3.261GluSer: 3.261 ± 0.052
3.123GluThr: 3.123 ± 0.053
4.117GluVal: 4.117 ± 0.059
0.936GluTrp: 0.936 ± 0.029
1.31GluTyr: 1.31 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.55PheAla: 3.55 ± 0.061
0.403PheCys: 0.403 ± 0.019
2.404PheAsp: 2.404 ± 0.051
2.191PheGlu: 2.191 ± 0.049
1.426PhePhe: 1.426 ± 0.042
3.121PheGly: 3.121 ± 0.059
0.796PheHis: 0.796 ± 0.025
2.146PheIle: 2.146 ± 0.045
1.21PheLys: 1.21 ± 0.036
3.274PheLeu: 3.274 ± 0.069
0.977PheMet: 0.977 ± 0.031
1.368PheAsn: 1.368 ± 0.035
1.404PhePro: 1.404 ± 0.033
1.263PheGln: 1.263 ± 0.033
1.72PheArg: 1.72 ± 0.034
2.698PheSer: 2.698 ± 0.048
2.116PheThr: 2.116 ± 0.046
2.423PheVal: 2.423 ± 0.05
0.526PheTrp: 0.526 ± 0.023
1.084PheTyr: 1.084 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.028GlyAla: 7.028 ± 0.104
0.833GlyCys: 0.833 ± 0.028
4.046GlyAsp: 4.046 ± 0.062
4.873GlyGlu: 4.873 ± 0.072
3.226GlyPhe: 3.226 ± 0.053
5.935GlyGly: 5.935 ± 0.099
1.829GlyHis: 1.829 ± 0.041
4.809GlyIle: 4.809 ± 0.069
2.96GlyLys: 2.96 ± 0.051
8.622GlyLeu: 8.622 ± 0.093
2.43GlyMet: 2.43 ± 0.049
2.377GlyAsn: 2.377 ± 0.053
2.445GlyPro: 2.445 ± 0.047
3.187GlyGln: 3.187 ± 0.056
4.442GlyArg: 4.442 ± 0.064
4.45GlySer: 4.45 ± 0.065
3.743GlyThr: 3.743 ± 0.053
6.135GlyVal: 6.135 ± 0.085
1.298GlyTrp: 1.298 ± 0.036
2.41GlyTyr: 2.41 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.419HisAla: 2.419 ± 0.046
0.27HisCys: 0.27 ± 0.016
1.351HisAsp: 1.351 ± 0.036
1.28HisGlu: 1.28 ± 0.035
1.051HisPhe: 1.051 ± 0.027
1.908HisGly: 1.908 ± 0.04
0.781HisHis: 0.781 ± 0.028
1.165HisIle: 1.165 ± 0.032
0.65HisLys: 0.65 ± 0.025
2.647HisLeu: 2.647 ± 0.053
0.522HisMet: 0.522 ± 0.022
0.734HisAsn: 0.734 ± 0.023
1.382HisPro: 1.382 ± 0.039
1.212HisGln: 1.212 ± 0.034
1.525HisArg: 1.525 ± 0.041
1.284HisSer: 1.284 ± 0.038
1.205HisThr: 1.205 ± 0.032
1.538HisVal: 1.538 ± 0.042
0.42HisTrp: 0.42 ± 0.016
0.872HisTyr: 0.872 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.423IleAla: 6.423 ± 0.076
0.496IleCys: 0.496 ± 0.023
3.517IleAsp: 3.517 ± 0.058
3.875IleGlu: 3.875 ± 0.063
1.753IlePhe: 1.753 ± 0.052
4.546IleGly: 4.546 ± 0.075
1.13IleHis: 1.13 ± 0.03
2.707IleIle: 2.707 ± 0.061
1.782IleLys: 1.782 ± 0.039
4.293IleLeu: 4.293 ± 0.064
1.182IleMet: 1.182 ± 0.036
2.086IleAsn: 2.086 ± 0.042
2.363IlePro: 2.363 ± 0.05
1.668IleGln: 1.668 ± 0.036
2.81IleArg: 2.81 ± 0.059
3.412IleSer: 3.412 ± 0.049
3.307IleThr: 3.307 ± 0.058
3.696IleVal: 3.696 ± 0.06
0.529IleTrp: 0.529 ± 0.021
1.265IleTyr: 1.265 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.76LysAla: 3.76 ± 0.067
0.185LysCys: 0.185 ± 0.012
1.495LysAsp: 1.495 ± 0.038
2.0LysGlu: 2.0 ± 0.043
0.691LysPhe: 0.691 ± 0.028
2.498LysGly: 2.498 ± 0.049
0.775LysHis: 0.775 ± 0.027
1.439LysIle: 1.439 ± 0.037
1.351LysLys: 1.351 ± 0.04
3.275LysLeu: 3.275 ± 0.063
0.783LysMet: 0.783 ± 0.029
0.922LysAsn: 0.922 ± 0.032
1.751LysPro: 1.751 ± 0.043
1.534LysGln: 1.534 ± 0.038
2.703LysArg: 2.703 ± 0.053
1.769LysSer: 1.769 ± 0.04
1.828LysThr: 1.828 ± 0.046
2.293LysVal: 2.293 ± 0.047
0.336LysTrp: 0.336 ± 0.017
0.591LysTyr: 0.591 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
13.303LeuAla: 13.303 ± 0.132
1.107LeuCys: 1.107 ± 0.028
6.126LeuAsp: 6.126 ± 0.086
6.857LeuGlu: 6.857 ± 0.098
4.0LeuPhe: 4.0 ± 0.068
8.673LeuGly: 8.673 ± 0.097
2.275LeuHis: 2.275 ± 0.047
5.857LeuIle: 5.857 ± 0.083
3.986LeuLys: 3.986 ± 0.064
12.323LeuLeu: 12.323 ± 0.159
2.975LeuMet: 2.975 ± 0.051
3.838LeuAsn: 3.838 ± 0.055
6.197LeuPro: 6.197 ± 0.087
3.391LeuGln: 3.391 ± 0.062
6.229LeuArg: 6.229 ± 0.09
7.499LeuSer: 7.499 ± 0.093
6.249LeuThr: 6.249 ± 0.077
7.741LeuVal: 7.741 ± 0.097
1.403LeuTrp: 1.403 ± 0.045
2.457LeuTyr: 2.457 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
3.213MetAla: 3.213 ± 0.059
0.194MetCys: 0.194 ± 0.013
1.188MetAsp: 1.188 ± 0.032
1.26MetGlu: 1.26 ± 0.032
0.743MetPhe: 0.743 ± 0.028
2.102MetGly: 2.102 ± 0.045
0.566MetHis: 0.566 ± 0.023
1.351MetIle: 1.351 ± 0.035
0.907MetLys: 0.907 ± 0.027
3.02MetLeu: 3.02 ± 0.057
0.718MetMet: 0.718 ± 0.027
0.89MetAsn: 0.89 ± 0.027
1.453MetPro: 1.453 ± 0.037
1.164MetGln: 1.164 ± 0.035
1.627MetArg: 1.627 ± 0.035
1.85MetSer: 1.85 ± 0.041
1.686MetThr: 1.686 ± 0.038
1.96MetVal: 1.96 ± 0.043
0.231MetTrp: 0.231 ± 0.014
0.391MetTyr: 0.391 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.74AsnAla: 3.74 ± 0.057
0.267AsnCys: 0.267 ± 0.015
1.865AsnAsp: 1.865 ± 0.042
1.841AsnGlu: 1.841 ± 0.035
0.982AsnPhe: 0.982 ± 0.031
2.454AsnGly: 2.454 ± 0.056
0.741AsnHis: 0.741 ± 0.025
1.71AsnIle: 1.71 ± 0.039
0.935AsnLys: 0.935 ± 0.028
2.978AsnLeu: 2.978 ± 0.048
0.752AsnMet: 0.752 ± 0.027
1.053AsnAsn: 1.053 ± 0.035
1.764AsnPro: 1.764 ± 0.04
1.38AsnGln: 1.38 ± 0.034
1.965AsnArg: 1.965 ± 0.041
1.685AsnSer: 1.685 ± 0.044
1.74AsnThr: 1.74 ± 0.041
2.431AsnVal: 2.431 ± 0.046
0.417AsnTrp: 0.417 ± 0.019
0.821AsnTyr: 0.821 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
4.646ProAla: 4.646 ± 0.078
0.329ProCys: 0.329 ± 0.015
2.913ProAsp: 2.913 ± 0.058
3.658ProGlu: 3.658 ± 0.052
1.822ProPhe: 1.822 ± 0.04
3.814ProGly: 3.814 ± 0.058
1.121ProHis: 1.121 ± 0.031
2.214ProIle: 2.214 ± 0.038
1.408ProLys: 1.408 ± 0.033
5.479ProLeu: 5.479 ± 0.083
1.269ProMet: 1.269 ± 0.032
1.486ProAsn: 1.486 ± 0.034
1.96ProPro: 1.96 ± 0.043
1.761ProGln: 1.761 ± 0.04
2.364ProArg: 2.364 ± 0.046
2.835ProSer: 2.835 ± 0.044
2.435ProThr: 2.435 ± 0.05
3.652ProVal: 3.652 ± 0.056
0.742ProTrp: 0.742 ± 0.026
1.158ProTyr: 1.158 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
5.599GlnAla: 5.599 ± 0.084
0.332GlnCys: 0.332 ± 0.016
1.773GlnAsp: 1.773 ± 0.044
2.384GlnGlu: 2.384 ± 0.049
1.217GlnPhe: 1.217 ± 0.032
3.311GlnGly: 3.311 ± 0.057
1.284GlnHis: 1.284 ± 0.038
1.816GlnIle: 1.816 ± 0.042
1.28GlnLys: 1.28 ± 0.037
5.047GlnLeu: 5.047 ± 0.082
1.05GlnMet: 1.05 ± 0.031
1.068GlnAsn: 1.068 ± 0.033
2.12GlnPro: 2.12 ± 0.043
2.834GlnGln: 2.834 ± 0.065
3.502GlnArg: 3.502 ± 0.064
2.218GlnSer: 2.218 ± 0.048
2.035GlnThr: 2.035 ± 0.042
2.976GlnVal: 2.976 ± 0.053
0.733GlnTrp: 0.733 ± 0.026
0.884GlnTyr: 0.884 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.325ArgAla: 5.325 ± 0.074
0.563ArgCys: 0.563 ± 0.022
3.469ArgAsp: 3.469 ± 0.063
4.342ArgGlu: 4.342 ± 0.068
2.73ArgPhe: 2.73 ± 0.048
3.793ArgGly: 3.793 ± 0.059
1.921ArgHis: 1.921 ± 0.049
3.246ArgIle: 3.246 ± 0.056
1.872ArgLys: 1.872 ± 0.049
7.963ArgLeu: 7.963 ± 0.101
1.604ArgMet: 1.604 ± 0.035
1.746ArgAsn: 1.746 ± 0.032
2.392ArgPro: 2.392 ± 0.05
3.227ArgGln: 3.227 ± 0.054
4.108ArgArg: 4.108 ± 0.076
3.081ArgSer: 3.081 ± 0.054
2.705ArgThr: 2.705 ± 0.047
4.135ArgVal: 4.135 ± 0.061
1.043ArgTrp: 1.043 ± 0.037
2.152ArgTyr: 2.152 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.129SerAla: 6.129 ± 0.075
0.474SerCys: 0.474 ± 0.021
3.312SerAsp: 3.312 ± 0.059
3.569SerGlu: 3.569 ± 0.063
2.169SerPhe: 2.169 ± 0.045
5.092SerGly: 5.092 ± 0.066
1.42SerHis: 1.42 ± 0.036
2.998SerIle: 2.998 ± 0.057
1.61SerLys: 1.61 ± 0.036
6.772SerLeu: 6.772 ± 0.092
1.568SerMet: 1.568 ± 0.038
1.776SerAsn: 1.776 ± 0.037
2.852SerPro: 2.852 ± 0.05
2.624SerGln: 2.624 ± 0.051
3.634SerArg: 3.634 ± 0.056
3.519SerSer: 3.519 ± 0.07
3.053SerThr: 3.053 ± 0.059
4.364SerVal: 4.364 ± 0.066
0.783SerTrp: 0.783 ± 0.026
1.391SerTyr: 1.391 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
5.284ThrAla: 5.284 ± 0.067
0.497ThrCys: 0.497 ± 0.023
2.515ThrAsp: 2.515 ± 0.05
2.522ThrGlu: 2.522 ± 0.055
2.034ThrPhe: 2.034 ± 0.045
4.186ThrGly: 4.186 ± 0.058
1.38ThrHis: 1.38 ± 0.035
2.509ThrIle: 2.509 ± 0.05
1.181ThrLys: 1.181 ± 0.034
7.608ThrLeu: 7.608 ± 0.075
1.119ThrMet: 1.119 ± 0.031
1.451ThrAsn: 1.451 ± 0.032
3.707ThrPro: 3.707 ± 0.06
2.41ThrGln: 2.41 ± 0.045
3.148ThrArg: 3.148 ± 0.052
3.044ThrSer: 3.044 ± 0.054
2.796ThrThr: 2.796 ± 0.062
3.517ThrVal: 3.517 ± 0.052
0.7ThrTrp: 0.7 ± 0.025
1.26ThrTyr: 1.26 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
7.743ValAla: 7.743 ± 0.101
0.669ValCys: 0.669 ± 0.026
4.053ValAsp: 4.053 ± 0.063
4.452ValGlu: 4.452 ± 0.067
2.563ValPhe: 2.563 ± 0.051
5.405ValGly: 5.405 ± 0.079
1.392ValHis: 1.392 ± 0.035
4.368ValIle: 4.368 ± 0.074
2.262ValLys: 2.262 ± 0.049
7.589ValLeu: 7.589 ± 0.095
2.162ValMet: 2.162 ± 0.045
2.35ValAsn: 2.35 ± 0.053
3.275ValPro: 3.275 ± 0.061
2.247ValGln: 2.247 ± 0.047
3.807ValArg: 3.807 ± 0.063
4.567ValSer: 4.567 ± 0.064
4.228ValThr: 4.228 ± 0.06
5.888ValVal: 5.888 ± 0.078
0.882ValTrp: 0.882 ± 0.028
1.603ValTyr: 1.603 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.116TrpAla: 1.116 ± 0.036
0.174TrpCys: 0.174 ± 0.012
0.552TrpAsp: 0.552 ± 0.02
0.716TrpGlu: 0.716 ± 0.024
0.509TrpPhe: 0.509 ± 0.02
0.926TrpGly: 0.926 ± 0.031
0.406TrpHis: 0.406 ± 0.02
0.627TrpIle: 0.627 ± 0.025
0.423TrpLys: 0.423 ± 0.019
2.351TrpLeu: 2.351 ± 0.054
0.405TrpMet: 0.405 ± 0.018
0.396TrpAsn: 0.396 ± 0.019
0.681TrpPro: 0.681 ± 0.026
1.035TrpGln: 1.035 ± 0.029
1.023TrpArg: 1.023 ± 0.025
0.735TrpSer: 0.735 ± 0.03
0.543TrpThr: 0.543 ± 0.02
1.009TrpVal: 1.009 ± 0.034
0.28TrpTrp: 0.28 ± 0.015
0.332TrpTyr: 0.332 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.555TyrAla: 2.555 ± 0.044
0.287TyrCys: 0.287 ± 0.015
1.292TyrAsp: 1.292 ± 0.036
1.255TyrGlu: 1.255 ± 0.037
1.024TyrPhe: 1.024 ± 0.029
2.051TyrGly: 2.051 ± 0.042
0.631TyrHis: 0.631 ± 0.022
1.119TyrIle: 1.119 ± 0.031
0.612TyrLys: 0.612 ± 0.021
2.926TyrLeu: 2.926 ± 0.053
0.547TyrMet: 0.547 ± 0.019
0.7TyrAsn: 0.7 ± 0.026
1.333TyrPro: 1.333 ± 0.035
1.392TyrGln: 1.392 ± 0.034
1.953TyrArg: 1.953 ± 0.041
1.459TyrSer: 1.459 ± 0.034
1.323TyrThr: 1.323 ± 0.035
1.6TyrVal: 1.6 ± 0.036
0.419TyrTrp: 0.419 ± 0.019
0.768TyrTyr: 0.768 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3787 proteins (1169929 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski