Amino acid dipepetide frequency for Lactobacillus buchneri subsp. silagei CD034

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.866AlaAla: 6.866 ± 0.124
0.384AlaCys: 0.384 ± 0.024
5.231AlaAsp: 5.231 ± 0.092
3.972AlaGlu: 3.972 ± 0.074
3.307AlaPhe: 3.307 ± 0.074
5.722AlaGly: 5.722 ± 0.097
1.392AlaHis: 1.392 ± 0.038
5.758AlaIle: 5.758 ± 0.091
5.954AlaLys: 5.954 ± 0.112
6.753AlaLeu: 6.753 ± 0.104
2.076AlaMet: 2.076 ± 0.055
3.973AlaAsn: 3.973 ± 0.069
2.229AlaPro: 2.229 ± 0.055
3.075AlaGln: 3.075 ± 0.062
2.636AlaArg: 2.636 ± 0.063
4.513AlaSer: 4.513 ± 0.083
4.81AlaThr: 4.81 ± 0.084
5.762AlaVal: 5.762 ± 0.102
0.639AlaTrp: 0.639 ± 0.028
2.517AlaTyr: 2.517 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.276CysAla: 0.276 ± 0.019
0.044CysCys: 0.044 ± 0.007
0.249CysAsp: 0.249 ± 0.018
0.213CysGlu: 0.213 ± 0.017
0.197CysPhe: 0.197 ± 0.017
0.462CysGly: 0.462 ± 0.026
0.139CysHis: 0.139 ± 0.013
0.249CysIle: 0.249 ± 0.015
0.137CysLys: 0.137 ± 0.012
0.474CysLeu: 0.474 ± 0.026
0.083CysMet: 0.083 ± 0.01
0.165CysAsn: 0.165 ± 0.015
0.194CysPro: 0.194 ± 0.024
0.148CysGln: 0.148 ± 0.015
0.197CysArg: 0.197 ± 0.018
0.306CysSer: 0.306 ± 0.019
0.221CysThr: 0.221 ± 0.02
0.314CysVal: 0.314 ± 0.021
0.064CysTrp: 0.064 ± 0.009
0.163CysTyr: 0.163 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.405AspAla: 4.405 ± 0.091
0.239AspCys: 0.239 ± 0.018
4.316AspAsp: 4.316 ± 0.107
3.93AspGlu: 3.93 ± 0.095
2.922AspPhe: 2.922 ± 0.07
3.947AspGly: 3.947 ± 0.094
1.586AspHis: 1.586 ± 0.046
3.867AspIle: 3.867 ± 0.08
4.053AspLys: 4.053 ± 0.079
5.578AspLeu: 5.578 ± 0.093
1.494AspMet: 1.494 ± 0.047
2.911AspAsn: 2.911 ± 0.06
2.7AspPro: 2.7 ± 0.071
3.515AspGln: 3.515 ± 0.074
2.498AspArg: 2.498 ± 0.061
3.482AspSer: 3.482 ± 0.075
3.182AspThr: 3.182 ± 0.071
4.221AspVal: 4.221 ± 0.083
0.774AspTrp: 0.774 ± 0.034
2.591AspTyr: 2.591 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
3.731GluAla: 3.731 ± 0.078
0.142GluCys: 0.142 ± 0.015
2.978GluAsp: 2.978 ± 0.068
2.632GluGlu: 2.632 ± 0.077
1.999GluPhe: 1.999 ± 0.054
2.594GluGly: 2.594 ± 0.072
1.118GluHis: 1.118 ± 0.034
3.761GluIle: 3.761 ± 0.077
3.85GluLys: 3.85 ± 0.081
4.956GluLeu: 4.956 ± 0.095
1.709GluMet: 1.709 ± 0.046
2.661GluAsn: 2.661 ± 0.071
1.739GluPro: 1.739 ± 0.053
2.319GluGln: 2.319 ± 0.06
2.021GluArg: 2.021 ± 0.065
2.717GluSer: 2.717 ± 0.076
2.874GluThr: 2.874 ± 0.062
3.344GluVal: 3.344 ± 0.078
0.468GluTrp: 0.468 ± 0.023
1.724GluTyr: 1.724 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.306PheAla: 3.306 ± 0.077
0.258PheCys: 0.258 ± 0.021
3.109PheAsp: 3.109 ± 0.076
2.127PheGlu: 2.127 ± 0.059
1.985PhePhe: 1.985 ± 0.054
3.517PheGly: 3.517 ± 0.065
0.893PheHis: 0.893 ± 0.035
2.941PheIle: 2.941 ± 0.077
2.718PheLys: 2.718 ± 0.064
3.707PheLeu: 3.707 ± 0.089
1.082PheMet: 1.082 ± 0.042
2.379PheAsn: 2.379 ± 0.053
1.574PhePro: 1.574 ± 0.05
1.523PheGln: 1.523 ± 0.046
1.314PheArg: 1.314 ± 0.044
2.961PheSer: 2.961 ± 0.064
2.562PheThr: 2.562 ± 0.055
3.339PheVal: 3.339 ± 0.076
0.585PheTrp: 0.585 ± 0.03
1.612PheTyr: 1.612 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.757GlyAla: 4.757 ± 0.091
0.327GlyCys: 0.327 ± 0.019
3.739GlyAsp: 3.739 ± 0.084
3.137GlyGlu: 3.137 ± 0.064
3.238GlyPhe: 3.238 ± 0.071
4.532GlyGly: 4.532 ± 0.109
1.619GlyHis: 1.619 ± 0.055
5.827GlyIle: 5.827 ± 0.103
4.878GlyLys: 4.878 ± 0.11
6.555GlyLeu: 6.555 ± 0.102
2.058GlyMet: 2.058 ± 0.05
3.108GlyAsn: 3.108 ± 0.065
1.62GlyPro: 1.62 ± 0.057
2.903GlyGln: 2.903 ± 0.068
2.564GlyArg: 2.564 ± 0.067
4.323GlySer: 4.323 ± 0.086
4.34GlyThr: 4.34 ± 0.096
5.131GlyVal: 5.131 ± 0.098
0.823GlyTrp: 0.823 ± 0.033
2.964GlyTyr: 2.964 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.421HisAla: 1.421 ± 0.046
0.129HisCys: 0.129 ± 0.015
1.358HisAsp: 1.358 ± 0.043
1.217HisGlu: 1.217 ± 0.046
1.177HisPhe: 1.177 ± 0.042
1.631HisGly: 1.631 ± 0.054
0.701HisHis: 0.701 ± 0.039
1.302HisIle: 1.302 ± 0.043
1.151HisLys: 1.151 ± 0.04
2.178HisLeu: 2.178 ± 0.055
0.552HisMet: 0.552 ± 0.029
1.035HisAsn: 1.035 ± 0.04
1.098HisPro: 1.098 ± 0.039
1.273HisGln: 1.273 ± 0.045
0.957HisArg: 0.957 ± 0.036
1.278HisSer: 1.278 ± 0.046
1.065HisThr: 1.065 ± 0.041
1.462HisVal: 1.462 ± 0.039
0.275HisTrp: 0.275 ± 0.022
1.009HisTyr: 1.009 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.972IleAla: 5.972 ± 0.117
0.435IleCys: 0.435 ± 0.025
4.738IleAsp: 4.738 ± 0.08
3.348IleGlu: 3.348 ± 0.077
3.0IlePhe: 3.0 ± 0.073
5.38IleGly: 5.38 ± 0.114
1.507IleHis: 1.507 ± 0.051
5.04IleIle: 5.04 ± 0.123
4.367IleLys: 4.367 ± 0.084
6.255IleLeu: 6.255 ± 0.12
1.712IleMet: 1.712 ± 0.058
3.804IleAsn: 3.804 ± 0.064
2.972IlePro: 2.972 ± 0.07
2.765IleGln: 2.765 ± 0.065
2.613IleArg: 2.613 ± 0.056
5.071IleSer: 5.071 ± 0.106
4.453IleThr: 4.453 ± 0.081
5.213IleVal: 5.213 ± 0.099
0.643IleTrp: 0.643 ± 0.029
2.182IleTyr: 2.182 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.079LysAla: 5.079 ± 0.092
0.137LysCys: 0.137 ± 0.013
3.905LysAsp: 3.905 ± 0.089
3.339LysGlu: 3.339 ± 0.084
2.446LysPhe: 2.446 ± 0.061
3.656LysGly: 3.656 ± 0.088
1.501LysHis: 1.501 ± 0.049
4.39LysIle: 4.39 ± 0.077
4.902LysLys: 4.902 ± 0.102
6.054LysLeu: 6.054 ± 0.095
2.227LysMet: 2.227 ± 0.053
3.533LysAsn: 3.533 ± 0.067
2.518LysPro: 2.518 ± 0.061
3.786LysGln: 3.786 ± 0.074
3.083LysArg: 3.083 ± 0.064
3.997LysSer: 3.997 ± 0.078
4.089LysThr: 4.089 ± 0.079
4.688LysVal: 4.688 ± 0.089
0.659LysTrp: 0.659 ± 0.032
2.691LysTyr: 2.691 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
7.899LeuAla: 7.899 ± 0.11
0.459LeuCys: 0.459 ± 0.027
5.384LeuAsp: 5.384 ± 0.094
3.946LeuGlu: 3.946 ± 0.094
4.013LeuPhe: 4.013 ± 0.099
6.354LeuGly: 6.354 ± 0.09
1.764LeuHis: 1.764 ± 0.048
6.984LeuIle: 6.984 ± 0.142
6.369LeuLys: 6.369 ± 0.102
8.23LeuLeu: 8.23 ± 0.163
2.534LeuMet: 2.534 ± 0.058
4.776LeuAsn: 4.776 ± 0.08
3.965LeuPro: 3.965 ± 0.068
3.369LeuGln: 3.369 ± 0.061
3.394LeuArg: 3.394 ± 0.069
6.538LeuSer: 6.538 ± 0.099
6.378LeuThr: 6.378 ± 0.095
6.406LeuVal: 6.406 ± 0.121
0.804LeuTrp: 0.804 ± 0.034
2.736LeuTyr: 2.736 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.419MetAla: 2.419 ± 0.063
0.119MetCys: 0.119 ± 0.015
1.579MetAsp: 1.579 ± 0.045
0.995MetGlu: 0.995 ± 0.04
1.123MetPhe: 1.123 ± 0.046
1.876MetGly: 1.876 ± 0.055
0.5MetHis: 0.5 ± 0.029
2.04MetIle: 2.04 ± 0.065
2.002MetLys: 2.002 ± 0.052
2.309MetLeu: 2.309 ± 0.058
0.85MetMet: 0.85 ± 0.033
1.52MetAsn: 1.52 ± 0.039
1.169MetPro: 1.169 ± 0.041
1.017MetGln: 1.017 ± 0.036
1.05MetArg: 1.05 ± 0.039
1.771MetSer: 1.771 ± 0.049
1.914MetThr: 1.914 ± 0.05
1.859MetVal: 1.859 ± 0.053
0.205MetTrp: 0.205 ± 0.018
0.771MetTyr: 0.771 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.655AsnAla: 3.655 ± 0.071
0.212AsnCys: 0.212 ± 0.02
3.116AsnAsp: 3.116 ± 0.067
2.566AsnGlu: 2.566 ± 0.074
2.059AsnPhe: 2.059 ± 0.05
3.897AsnGly: 3.897 ± 0.084
1.474AsnHis: 1.474 ± 0.044
3.015AsnIle: 3.015 ± 0.058
2.855AsnLys: 2.855 ± 0.066
4.49AsnLeu: 4.49 ± 0.085
1.289AsnMet: 1.289 ± 0.042
2.509AsnAsn: 2.509 ± 0.065
2.431AsnPro: 2.431 ± 0.07
2.971AsnGln: 2.971 ± 0.069
2.178AsnArg: 2.178 ± 0.058
3.007AsnSer: 3.007 ± 0.071
2.704AsnThr: 2.704 ± 0.066
3.481AsnVal: 3.481 ± 0.076
0.662AsnTrp: 0.662 ± 0.031
1.947AsnTyr: 1.947 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.96ProAla: 2.96 ± 0.066
0.104ProCys: 0.104 ± 0.011
2.747ProAsp: 2.747 ± 0.064
2.67ProGlu: 2.67 ± 0.062
1.762ProPhe: 1.762 ± 0.053
2.349ProGly: 2.349 ± 0.057
0.737ProHis: 0.737 ± 0.034
2.788ProIle: 2.788 ± 0.065
2.636ProLys: 2.636 ± 0.064
3.214ProLeu: 3.214 ± 0.07
0.935ProMet: 0.935 ± 0.033
2.062ProAsn: 2.062 ± 0.071
0.578ProPro: 0.578 ± 0.03
1.641ProGln: 1.641 ± 0.052
1.188ProArg: 1.188 ± 0.043
2.188ProSer: 2.188 ± 0.053
2.859ProThr: 2.859 ± 0.074
2.911ProVal: 2.911 ± 0.066
0.394ProTrp: 0.394 ± 0.025
1.395ProTyr: 1.395 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.755GlnAla: 3.755 ± 0.077
0.103GlnCys: 0.103 ± 0.012
2.117GlnAsp: 2.117 ± 0.058
1.929GlnGlu: 1.929 ± 0.06
1.89GlnPhe: 1.89 ± 0.051
2.212GlnGly: 2.212 ± 0.058
0.989GlnHis: 0.989 ± 0.039
3.404GlnIle: 3.404 ± 0.079
2.992GlnLys: 2.992 ± 0.065
4.904GlnLeu: 4.904 ± 0.091
1.282GlnMet: 1.282 ± 0.046
2.174GlnAsn: 2.174 ± 0.054
1.933GlnPro: 1.933 ± 0.067
2.457GlnGln: 2.457 ± 0.065
1.937GlnArg: 1.937 ± 0.056
2.721GlnSer: 2.721 ± 0.065
2.937GlnThr: 2.937 ± 0.073
3.117GlnVal: 3.117 ± 0.065
0.381GlnTrp: 0.381 ± 0.025
1.637GlnTyr: 1.637 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.477ArgAla: 2.477 ± 0.062
0.137ArgCys: 0.137 ± 0.014
2.281ArgAsp: 2.281 ± 0.055
2.1ArgGlu: 2.1 ± 0.061
1.771ArgPhe: 1.771 ± 0.053
2.307ArgGly: 2.307 ± 0.059
1.028ArgHis: 1.028 ± 0.039
2.933ArgIle: 2.933 ± 0.06
2.654ArgLys: 2.654 ± 0.069
3.82ArgLeu: 3.82 ± 0.081
1.073ArgMet: 1.073 ± 0.038
1.842ArgAsn: 1.842 ± 0.051
1.492ArgPro: 1.492 ± 0.045
1.961ArgGln: 1.961 ± 0.057
1.947ArgArg: 1.947 ± 0.054
2.119ArgSer: 2.119 ± 0.053
2.151ArgThr: 2.151 ± 0.057
2.673ArgVal: 2.673 ± 0.066
0.351ArgTrp: 0.351 ± 0.023
1.66ArgTyr: 1.66 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.892SerAla: 4.892 ± 0.081
0.223SerCys: 0.223 ± 0.018
4.009SerAsp: 4.009 ± 0.073
2.966SerGlu: 2.966 ± 0.064
2.918SerPhe: 2.918 ± 0.073
4.919SerGly: 4.919 ± 0.086
1.377SerHis: 1.377 ± 0.039
4.21SerIle: 4.21 ± 0.075
4.012SerLys: 4.012 ± 0.089
5.982SerLeu: 5.982 ± 0.108
1.672SerMet: 1.672 ± 0.048
2.952SerAsn: 2.952 ± 0.076
2.225SerPro: 2.225 ± 0.052
2.732SerGln: 2.732 ± 0.066
2.468SerArg: 2.468 ± 0.054
4.088SerSer: 4.088 ± 0.111
3.798SerThr: 3.798 ± 0.081
4.296SerVal: 4.296 ± 0.077
0.699SerTrp: 0.699 ± 0.031
2.156SerTyr: 2.156 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.821ThrAla: 4.821 ± 0.087
0.226ThrCys: 0.226 ± 0.019
3.843ThrAsp: 3.843 ± 0.087
2.803ThrGlu: 2.803 ± 0.063
2.54ThrPhe: 2.54 ± 0.059
4.694ThrGly: 4.694 ± 0.091
1.293ThrHis: 1.293 ± 0.043
4.723ThrIle: 4.723 ± 0.093
4.08ThrLys: 4.08 ± 0.083
5.479ThrLeu: 5.479 ± 0.094
1.477ThrMet: 1.477 ± 0.046
3.221ThrAsn: 3.221 ± 0.074
3.011ThrPro: 3.011 ± 0.078
2.261ThrGln: 2.261 ± 0.06
2.019ThrArg: 2.019 ± 0.051
3.72ThrSer: 3.72 ± 0.077
4.243ThrThr: 4.243 ± 0.11
4.625ThrVal: 4.625 ± 0.083
0.639ThrTrp: 0.639 ± 0.031
2.252ThrTyr: 2.252 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
5.846ValAla: 5.846 ± 0.091
0.371ValCys: 0.371 ± 0.025
4.657ValAsp: 4.657 ± 0.083
3.433ValGlu: 3.433 ± 0.071
2.863ValPhe: 2.863 ± 0.071
5.172ValGly: 5.172 ± 0.096
1.371ValHis: 1.371 ± 0.041
5.357ValIle: 5.357 ± 0.103
4.718ValLys: 4.718 ± 0.096
6.16ValLeu: 6.16 ± 0.124
1.836ValMet: 1.836 ± 0.051
3.681ValAsn: 3.681 ± 0.077
2.94ValPro: 2.94 ± 0.064
2.419ValGln: 2.419 ± 0.067
2.464ValArg: 2.464 ± 0.058
4.852ValSer: 4.852 ± 0.099
4.774ValThr: 4.774 ± 0.089
5.495ValVal: 5.495 ± 0.106
0.664ValTrp: 0.664 ± 0.028
2.33ValTyr: 2.33 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.597TrpAla: 0.597 ± 0.03
0.049TrpCys: 0.049 ± 0.009
0.567TrpAsp: 0.567 ± 0.028
0.387TrpGlu: 0.387 ± 0.022
0.502TrpPhe: 0.502 ± 0.028
0.689TrpGly: 0.689 ± 0.032
0.279TrpHis: 0.279 ± 0.018
0.807TrpIle: 0.807 ± 0.038
0.544TrpLys: 0.544 ± 0.029
1.287TrpLeu: 1.287 ± 0.048
0.313TrpMet: 0.313 ± 0.021
0.582TrpAsn: 0.582 ± 0.031
0.288TrpPro: 0.288 ± 0.019
0.561TrpGln: 0.561 ± 0.029
0.491TrpArg: 0.491 ± 0.027
0.606TrpSer: 0.606 ± 0.029
0.576TrpThr: 0.576 ± 0.027
0.673TrpVal: 0.673 ± 0.03
0.15TrpTrp: 0.15 ± 0.014
0.414TrpTyr: 0.414 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.434TyrAla: 2.434 ± 0.063
0.201TyrCys: 0.201 ± 0.016
2.289TyrAsp: 2.289 ± 0.061
1.627TyrGlu: 1.627 ± 0.053
1.783TyrPhe: 1.783 ± 0.051
2.532TyrGly: 2.532 ± 0.06
0.999TyrHis: 0.999 ± 0.038
2.076TyrIle: 2.076 ± 0.054
1.81TyrLys: 1.81 ± 0.052
3.914TyrLeu: 3.914 ± 0.078
0.833TyrMet: 0.833 ± 0.035
1.63TyrAsn: 1.63 ± 0.049
1.441TyrPro: 1.441 ± 0.038
2.177TyrGln: 2.177 ± 0.058
1.757TyrArg: 1.757 ± 0.05
2.333TyrSer: 2.333 ± 0.062
2.039TyrThr: 2.039 ± 0.061
2.393TyrVal: 2.393 ± 0.056
0.484TyrTrp: 0.484 ± 0.029
1.479TyrTyr: 1.479 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2369 proteins (731389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski