Amino acid dipepetide frequency for Klebsiella phage ST15-VIM1phi2.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.566AlaAla: 12.566 ± 1.477
0.918AlaCys: 0.918 ± 0.296
6.212AlaAsp: 6.212 ± 0.96
7.413AlaGlu: 7.413 ± 1.001
3.671AlaPhe: 3.671 ± 0.432
7.695AlaGly: 7.695 ± 0.926
0.918AlaHis: 0.918 ± 0.277
6.212AlaIle: 6.212 ± 0.623
5.083AlaLys: 5.083 ± 0.542
9.46AlaLeu: 9.46 ± 0.754
3.953AlaMet: 3.953 ± 0.497
3.883AlaAsn: 3.883 ± 0.483
2.965AlaPro: 2.965 ± 0.483
4.306AlaGln: 4.306 ± 0.613
4.024AlaArg: 4.024 ± 0.579
6.918AlaSer: 6.918 ± 0.731
5.577AlaThr: 5.577 ± 0.646
6.001AlaVal: 6.001 ± 0.855
2.118AlaTrp: 2.118 ± 0.439
2.4AlaTyr: 2.4 ± 0.492
0.0AlaXaa: 0.0 ± 0.0
Cys
0.918CysAla: 0.918 ± 0.242
0.212CysCys: 0.212 ± 0.133
0.706CysAsp: 0.706 ± 0.212
0.353CysGlu: 0.353 ± 0.2
0.141CysPhe: 0.141 ± 0.099
0.635CysGly: 0.635 ± 0.193
0.282CysHis: 0.282 ± 0.141
0.565CysIle: 0.565 ± 0.204
0.494CysLys: 0.494 ± 0.184
1.13CysLeu: 1.13 ± 0.281
0.353CysMet: 0.353 ± 0.144
0.282CysAsn: 0.282 ± 0.154
0.777CysPro: 0.777 ± 0.25
0.494CysGln: 0.494 ± 0.225
1.059CysArg: 1.059 ± 0.244
0.988CysSer: 0.988 ± 0.291
0.494CysThr: 0.494 ± 0.168
0.212CysVal: 0.212 ± 0.136
0.212CysTrp: 0.212 ± 0.11
0.212CysTyr: 0.212 ± 0.117
0.0CysXaa: 0.0 ± 0.0
Asp
6.848AspAla: 6.848 ± 0.771
0.424AspCys: 0.424 ± 0.182
3.742AspAsp: 3.742 ± 0.751
3.953AspGlu: 3.953 ± 0.639
2.753AspPhe: 2.753 ± 0.4
5.648AspGly: 5.648 ± 0.572
0.635AspHis: 0.635 ± 0.207
2.824AspIle: 2.824 ± 0.397
3.318AspLys: 3.318 ± 0.511
4.095AspLeu: 4.095 ± 0.54
1.483AspMet: 1.483 ± 0.265
2.188AspAsn: 2.188 ± 0.423
2.541AspPro: 2.541 ± 0.37
1.906AspGln: 1.906 ± 0.367
2.259AspArg: 2.259 ± 0.392
3.177AspSer: 3.177 ± 0.527
2.965AspThr: 2.965 ± 0.527
4.095AspVal: 4.095 ± 0.561
0.918AspTrp: 0.918 ± 0.234
2.259AspTyr: 2.259 ± 0.28
0.0AspXaa: 0.0 ± 0.0
Glu
6.142GluAla: 6.142 ± 0.875
0.847GluCys: 0.847 ± 0.247
2.33GluAsp: 2.33 ± 0.561
3.671GluGlu: 3.671 ± 0.634
3.247GluPhe: 3.247 ± 0.43
3.53GluGly: 3.53 ± 0.467
0.847GluHis: 0.847 ± 0.273
3.6GluIle: 3.6 ± 0.569
4.448GluLys: 4.448 ± 0.779
5.507GluLeu: 5.507 ± 0.833
1.977GluMet: 1.977 ± 0.427
3.106GluAsn: 3.106 ± 0.585
2.541GluPro: 2.541 ± 0.554
2.683GluGln: 2.683 ± 0.594
4.165GluArg: 4.165 ± 0.676
3.389GluSer: 3.389 ± 0.426
3.036GluThr: 3.036 ± 0.389
3.106GluVal: 3.106 ± 0.499
1.2GluTrp: 1.2 ± 0.247
1.624GluTyr: 1.624 ± 0.287
0.0GluXaa: 0.0 ± 0.0
Phe
2.33PheAla: 2.33 ± 0.471
0.424PheCys: 0.424 ± 0.204
2.471PheAsp: 2.471 ± 0.577
1.906PheGlu: 1.906 ± 0.354
0.706PhePhe: 0.706 ± 0.198
2.541PheGly: 2.541 ± 0.391
0.847PheHis: 0.847 ± 0.222
1.341PheIle: 1.341 ± 0.298
1.483PheLys: 1.483 ± 0.343
2.612PheLeu: 2.612 ± 0.381
0.706PheMet: 0.706 ± 0.235
1.553PheAsn: 1.553 ± 0.264
1.483PhePro: 1.483 ± 0.293
1.341PheGln: 1.341 ± 0.287
2.471PheArg: 2.471 ± 0.404
2.894PheSer: 2.894 ± 0.499
3.036PheThr: 3.036 ± 0.416
1.765PheVal: 1.765 ± 0.402
0.494PheTrp: 0.494 ± 0.155
1.553PheTyr: 1.553 ± 0.26
0.0PheXaa: 0.0 ± 0.0
Gly
5.718GlyAla: 5.718 ± 0.808
0.847GlyCys: 0.847 ± 0.225
4.236GlyAsp: 4.236 ± 0.477
4.236GlyGlu: 4.236 ± 0.516
3.177GlyPhe: 3.177 ± 0.522
6.001GlyGly: 6.001 ± 1.123
0.706GlyHis: 0.706 ± 0.277
5.295GlyIle: 5.295 ± 0.59
5.295GlyLys: 5.295 ± 0.608
5.86GlyLeu: 5.86 ± 0.64
1.694GlyMet: 1.694 ± 0.38
3.389GlyAsn: 3.389 ± 0.673
2.047GlyPro: 2.047 ± 0.317
3.247GlyGln: 3.247 ± 0.585
4.448GlyArg: 4.448 ± 0.446
4.659GlySer: 4.659 ± 0.865
5.507GlyThr: 5.507 ± 0.866
5.365GlyVal: 5.365 ± 0.592
1.271GlyTrp: 1.271 ± 0.298
2.33GlyTyr: 2.33 ± 0.615
0.0GlyXaa: 0.0 ± 0.0
His
1.2HisAla: 1.2 ± 0.255
0.282HisCys: 0.282 ± 0.137
0.565HisAsp: 0.565 ± 0.224
0.918HisGlu: 0.918 ± 0.293
0.565HisPhe: 0.565 ± 0.183
0.635HisGly: 0.635 ± 0.201
0.282HisHis: 0.282 ± 0.159
0.777HisIle: 0.777 ± 0.247
0.635HisLys: 0.635 ± 0.198
1.13HisLeu: 1.13 ± 0.305
0.635HisMet: 0.635 ± 0.205
0.635HisAsn: 0.635 ± 0.18
0.988HisPro: 0.988 ± 0.344
0.424HisGln: 0.424 ± 0.2
1.341HisArg: 1.341 ± 0.302
1.13HisSer: 1.13 ± 0.288
0.777HisThr: 0.777 ± 0.215
0.565HisVal: 0.565 ± 0.181
0.353HisTrp: 0.353 ± 0.154
0.918HisTyr: 0.918 ± 0.297
0.0HisXaa: 0.0 ± 0.0
Ile
5.93IleAla: 5.93 ± 0.676
0.565IleCys: 0.565 ± 0.232
4.448IleAsp: 4.448 ± 0.657
4.73IleGlu: 4.73 ± 0.637
1.836IlePhe: 1.836 ± 0.356
4.024IleGly: 4.024 ± 0.611
0.565IleHis: 0.565 ± 0.212
3.106IleIle: 3.106 ± 0.56
2.894IleLys: 2.894 ± 0.447
2.612IleLeu: 2.612 ± 0.402
1.2IleMet: 1.2 ± 0.296
2.471IleAsn: 2.471 ± 0.405
2.824IlePro: 2.824 ± 0.432
1.906IleGln: 1.906 ± 0.367
3.318IleArg: 3.318 ± 0.489
4.518IleSer: 4.518 ± 0.559
3.883IleThr: 3.883 ± 0.457
2.683IleVal: 2.683 ± 0.426
0.847IleTrp: 0.847 ± 0.237
1.694IleTyr: 1.694 ± 0.358
0.0IleXaa: 0.0 ± 0.0
Lys
6.707LysAla: 6.707 ± 0.71
0.706LysCys: 0.706 ± 0.229
3.389LysAsp: 3.389 ± 0.459
2.824LysGlu: 2.824 ± 0.487
1.483LysPhe: 1.483 ± 0.307
3.883LysGly: 3.883 ± 0.56
1.13LysHis: 1.13 ± 0.278
2.894LysIle: 2.894 ± 0.501
4.024LysLys: 4.024 ± 0.609
3.742LysLeu: 3.742 ± 0.506
1.553LysMet: 1.553 ± 0.35
1.694LysAsn: 1.694 ± 0.358
2.683LysPro: 2.683 ± 0.346
2.894LysGln: 2.894 ± 0.401
3.671LysArg: 3.671 ± 0.628
2.824LysSer: 2.824 ± 0.537
3.53LysThr: 3.53 ± 0.564
3.106LysVal: 3.106 ± 0.426
0.706LysTrp: 0.706 ± 0.282
1.341LysTyr: 1.341 ± 0.296
0.0LysXaa: 0.0 ± 0.0
Leu
7.977LeuAla: 7.977 ± 0.718
1.059LeuCys: 1.059 ± 0.279
4.024LeuAsp: 4.024 ± 0.618
3.812LeuGlu: 3.812 ± 0.524
1.483LeuPhe: 1.483 ± 0.319
4.095LeuGly: 4.095 ± 0.652
1.2LeuHis: 1.2 ± 0.357
4.73LeuIle: 4.73 ± 0.518
4.306LeuLys: 4.306 ± 0.427
6.071LeuLeu: 6.071 ± 0.651
2.118LeuMet: 2.118 ± 0.413
4.448LeuAsn: 4.448 ± 0.498
3.036LeuPro: 3.036 ± 0.48
3.742LeuGln: 3.742 ± 0.566
4.871LeuArg: 4.871 ± 0.629
6.354LeuSer: 6.354 ± 0.601
5.718LeuThr: 5.718 ± 0.619
5.507LeuVal: 5.507 ± 0.761
1.13LeuTrp: 1.13 ± 0.266
1.483LeuTyr: 1.483 ± 0.31
0.0LeuXaa: 0.0 ± 0.0
Met
3.177MetAla: 3.177 ± 0.463
0.282MetCys: 0.282 ± 0.156
1.483MetAsp: 1.483 ± 0.312
0.918MetGlu: 0.918 ± 0.261
0.424MetPhe: 0.424 ± 0.25
1.2MetGly: 1.2 ± 0.257
0.424MetHis: 0.424 ± 0.192
0.918MetIle: 0.918 ± 0.263
1.412MetLys: 1.412 ± 0.376
1.906MetLeu: 1.906 ± 0.376
0.777MetMet: 0.777 ± 0.253
1.694MetAsn: 1.694 ± 0.353
2.188MetPro: 2.188 ± 0.361
0.847MetGln: 0.847 ± 0.266
1.483MetArg: 1.483 ± 0.331
2.824MetSer: 2.824 ± 0.434
2.4MetThr: 2.4 ± 0.359
2.047MetVal: 2.047 ± 0.325
0.282MetTrp: 0.282 ± 0.144
0.706MetTyr: 0.706 ± 0.236
0.0MetXaa: 0.0 ± 0.0
Asn
5.436AsnAla: 5.436 ± 0.561
0.282AsnCys: 0.282 ± 0.176
2.4AsnAsp: 2.4 ± 0.348
1.977AsnGlu: 1.977 ± 0.39
1.694AsnPhe: 1.694 ± 0.319
4.095AsnGly: 4.095 ± 0.532
1.059AsnHis: 1.059 ± 0.274
2.612AsnIle: 2.612 ± 0.44
1.483AsnLys: 1.483 ± 0.338
2.824AsnLeu: 2.824 ± 0.397
1.059AsnMet: 1.059 ± 0.29
2.259AsnAsn: 2.259 ± 0.455
1.977AsnPro: 1.977 ± 0.335
1.906AsnGln: 1.906 ± 0.374
1.836AsnArg: 1.836 ± 0.373
2.612AsnSer: 2.612 ± 0.385
2.118AsnThr: 2.118 ± 0.372
3.036AsnVal: 3.036 ± 0.468
0.635AsnTrp: 0.635 ± 0.181
1.694AsnTyr: 1.694 ± 0.373
0.0AsnXaa: 0.0 ± 0.0
Pro
4.095ProAla: 4.095 ± 0.618
0.424ProCys: 0.424 ± 0.16
2.894ProAsp: 2.894 ± 0.499
3.742ProGlu: 3.742 ± 0.577
1.271ProPhe: 1.271 ± 0.289
4.659ProGly: 4.659 ± 0.617
0.706ProHis: 0.706 ± 0.239
1.271ProIle: 1.271 ± 0.35
1.624ProLys: 1.624 ± 0.435
3.389ProLeu: 3.389 ± 0.496
0.847ProMet: 0.847 ± 0.274
1.694ProAsn: 1.694 ± 0.257
1.694ProPro: 1.694 ± 0.457
1.906ProGln: 1.906 ± 0.38
1.694ProArg: 1.694 ± 0.323
3.742ProSer: 3.742 ± 0.615
2.118ProThr: 2.118 ± 0.387
2.965ProVal: 2.965 ± 0.38
0.706ProTrp: 0.706 ± 0.206
2.188ProTyr: 2.188 ± 0.403
0.0ProXaa: 0.0 ± 0.0
Gln
4.942GlnAla: 4.942 ± 0.724
0.635GlnCys: 0.635 ± 0.193
1.836GlnAsp: 1.836 ± 0.37
1.765GlnGlu: 1.765 ± 0.313
1.483GlnPhe: 1.483 ± 0.324
3.247GlnGly: 3.247 ± 0.531
0.777GlnHis: 0.777 ± 0.258
2.4GlnIle: 2.4 ± 0.384
2.047GlnLys: 2.047 ± 0.364
3.177GlnLeu: 3.177 ± 0.422
1.059GlnMet: 1.059 ± 0.304
2.047GlnAsn: 2.047 ± 0.405
1.483GlnPro: 1.483 ± 0.363
2.259GlnGln: 2.259 ± 0.459
3.106GlnArg: 3.106 ± 0.571
2.4GlnSer: 2.4 ± 0.376
2.118GlnThr: 2.118 ± 0.403
1.906GlnVal: 1.906 ± 0.382
1.341GlnTrp: 1.341 ± 0.289
1.2GlnTyr: 1.2 ± 0.336
0.0GlnXaa: 0.0 ± 0.0
Arg
4.306ArgAla: 4.306 ± 0.495
0.706ArgCys: 0.706 ± 0.213
3.812ArgAsp: 3.812 ± 0.535
5.436ArgGlu: 5.436 ± 0.885
1.694ArgPhe: 1.694 ± 0.431
2.894ArgGly: 2.894 ± 0.47
1.13ArgHis: 1.13 ± 0.312
4.095ArgIle: 4.095 ± 0.558
4.306ArgLys: 4.306 ± 0.653
4.659ArgLeu: 4.659 ± 0.598
1.483ArgMet: 1.483 ± 0.271
1.836ArgAsn: 1.836 ± 0.336
2.118ArgPro: 2.118 ± 0.433
2.612ArgGln: 2.612 ± 0.43
5.93ArgArg: 5.93 ± 1.11
3.812ArgSer: 3.812 ± 0.544
2.894ArgThr: 2.894 ± 0.442
3.459ArgVal: 3.459 ± 0.525
1.2ArgTrp: 1.2 ± 0.25
1.694ArgTyr: 1.694 ± 0.342
0.0ArgXaa: 0.0 ± 0.0
Ser
7.413SerAla: 7.413 ± 0.812
0.424SerCys: 0.424 ± 0.165
3.389SerAsp: 3.389 ± 0.484
3.177SerGlu: 3.177 ± 0.476
2.612SerPhe: 2.612 ± 0.362
7.201SerGly: 7.201 ± 0.677
1.059SerHis: 1.059 ± 0.25
3.53SerIle: 3.53 ± 0.61
3.671SerLys: 3.671 ± 0.591
5.93SerLeu: 5.93 ± 0.567
1.624SerMet: 1.624 ± 0.302
1.906SerAsn: 1.906 ± 0.4
3.247SerPro: 3.247 ± 0.584
2.683SerGln: 2.683 ± 0.4
4.095SerArg: 4.095 ± 0.436
4.942SerSer: 4.942 ± 0.972
4.024SerThr: 4.024 ± 0.496
4.801SerVal: 4.801 ± 0.632
0.777SerTrp: 0.777 ± 0.204
2.259SerTyr: 2.259 ± 0.351
0.0SerXaa: 0.0 ± 0.0
Thr
6.424ThrAla: 6.424 ± 0.752
0.353ThrCys: 0.353 ± 0.147
3.53ThrAsp: 3.53 ± 0.432
3.742ThrGlu: 3.742 ± 0.423
2.047ThrPhe: 2.047 ± 0.314
5.648ThrGly: 5.648 ± 0.662
0.777ThrHis: 0.777 ± 0.205
3.177ThrIle: 3.177 ± 0.535
2.612ThrLys: 2.612 ± 0.439
4.801ThrLeu: 4.801 ± 0.638
0.918ThrMet: 0.918 ± 0.287
2.541ThrAsn: 2.541 ± 0.407
3.6ThrPro: 3.6 ± 0.458
1.694ThrGln: 1.694 ± 0.358
3.459ThrArg: 3.459 ± 0.466
4.024ThrSer: 4.024 ± 0.504
3.106ThrThr: 3.106 ± 0.426
5.295ThrVal: 5.295 ± 0.624
1.271ThrTrp: 1.271 ± 0.26
1.694ThrTyr: 1.694 ± 0.335
0.0ThrXaa: 0.0 ± 0.0
Val
5.648ValAla: 5.648 ± 0.652
0.635ValCys: 0.635 ± 0.228
3.812ValAsp: 3.812 ± 0.452
4.095ValGlu: 4.095 ± 0.535
2.118ValPhe: 2.118 ± 0.389
3.53ValGly: 3.53 ± 0.49
0.706ValHis: 0.706 ± 0.204
4.024ValIle: 4.024 ± 0.443
3.671ValLys: 3.671 ± 0.398
4.589ValLeu: 4.589 ± 0.54
2.683ValMet: 2.683 ± 0.345
3.6ValAsn: 3.6 ± 0.46
3.177ValPro: 3.177 ± 0.408
2.047ValGln: 2.047 ± 0.375
3.671ValArg: 3.671 ± 0.568
4.518ValSer: 4.518 ± 0.581
4.306ValThr: 4.306 ± 0.628
3.953ValVal: 3.953 ± 0.42
0.777ValTrp: 0.777 ± 0.21
1.836ValTyr: 1.836 ± 0.305
0.0ValXaa: 0.0 ± 0.0
Trp
1.271TrpAla: 1.271 ± 0.288
0.353TrpCys: 0.353 ± 0.143
1.13TrpAsp: 1.13 ± 0.275
1.271TrpGlu: 1.271 ± 0.322
0.565TrpPhe: 0.565 ± 0.205
1.271TrpGly: 1.271 ± 0.258
0.353TrpHis: 0.353 ± 0.14
0.988TrpIle: 0.988 ± 0.276
0.847TrpLys: 0.847 ± 0.226
1.694TrpLeu: 1.694 ± 0.417
0.494TrpMet: 0.494 ± 0.156
0.282TrpAsn: 0.282 ± 0.129
0.494TrpPro: 0.494 ± 0.169
0.777TrpGln: 0.777 ± 0.227
1.059TrpArg: 1.059 ± 0.285
1.341TrpSer: 1.341 ± 0.279
1.13TrpThr: 1.13 ± 0.283
1.2TrpVal: 1.2 ± 0.254
0.212TrpTrp: 0.212 ± 0.123
0.635TrpTyr: 0.635 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.247TyrAla: 3.247 ± 0.647
0.141TyrCys: 0.141 ± 0.094
1.624TyrAsp: 1.624 ± 0.318
1.059TyrGlu: 1.059 ± 0.284
1.059TyrPhe: 1.059 ± 0.386
2.894TyrGly: 2.894 ± 0.454
0.353TyrHis: 0.353 ± 0.137
1.694TyrIle: 1.694 ± 0.309
1.13TyrLys: 1.13 ± 0.267
1.977TyrLeu: 1.977 ± 0.448
0.706TyrMet: 0.706 ± 0.212
1.483TyrAsn: 1.483 ± 0.321
1.765TyrPro: 1.765 ± 0.317
1.553TyrGln: 1.553 ± 0.343
2.118TyrArg: 2.118 ± 0.375
1.694TyrSer: 1.694 ± 0.385
1.977TyrThr: 1.977 ± 0.357
2.33TyrVal: 2.33 ± 0.361
0.918TyrTrp: 0.918 ± 0.279
0.847TyrTyr: 0.847 ± 0.253
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (14166 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski