Amino acid dipepetide frequency for Streptococcus phage Javan565

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.895AlaAla: 3.895 ± 0.951
0.254AlaCys: 0.254 ± 0.171
4.826AlaAsp: 4.826 ± 0.625
5.927AlaGlu: 5.927 ± 0.925
2.202AlaPhe: 2.202 ± 0.435
3.641AlaGly: 3.641 ± 0.933
1.016AlaHis: 1.016 ± 0.328
5.08AlaIle: 5.08 ± 1.054
5.25AlaLys: 5.25 ± 0.622
5.504AlaLeu: 5.504 ± 0.93
2.032AlaMet: 2.032 ± 0.42
4.657AlaAsn: 4.657 ± 0.471
1.693AlaPro: 1.693 ± 0.56
2.202AlaGln: 2.202 ± 0.515
3.387AlaArg: 3.387 ± 0.573
7.621AlaSer: 7.621 ± 0.997
4.826AlaThr: 4.826 ± 0.64
4.149AlaVal: 4.149 ± 0.731
0.847AlaTrp: 0.847 ± 0.256
2.964AlaTyr: 2.964 ± 0.468
0.0AlaXaa: 0.0 ± 0.0
Cys
0.423CysAla: 0.423 ± 0.212
0.169CysCys: 0.169 ± 0.127
0.254CysAsp: 0.254 ± 0.146
0.931CysGlu: 0.931 ± 0.276
0.0CysPhe: 0.0 ± 0.0
0.593CysGly: 0.593 ± 0.196
0.254CysHis: 0.254 ± 0.138
0.762CysIle: 0.762 ± 0.249
0.254CysLys: 0.254 ± 0.116
0.254CysLeu: 0.254 ± 0.168
0.0CysMet: 0.0 ± 0.0
0.254CysAsn: 0.254 ± 0.141
0.169CysPro: 0.169 ± 0.127
0.254CysGln: 0.254 ± 0.168
0.169CysArg: 0.169 ± 0.103
0.677CysSer: 0.677 ± 0.223
0.169CysThr: 0.169 ± 0.118
0.423CysVal: 0.423 ± 0.205
0.0CysTrp: 0.0 ± 0.0
0.254CysTyr: 0.254 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
3.302AspAla: 3.302 ± 0.712
0.593AspCys: 0.593 ± 0.251
3.98AspAsp: 3.98 ± 0.743
5.758AspGlu: 5.758 ± 0.83
4.149AspPhe: 4.149 ± 0.522
4.064AspGly: 4.064 ± 0.741
0.847AspHis: 0.847 ± 0.238
4.403AspIle: 4.403 ± 0.555
5.588AspLys: 5.588 ± 0.509
4.826AspLeu: 4.826 ± 0.47
1.693AspMet: 1.693 ± 0.351
3.641AspAsn: 3.641 ± 0.65
1.185AspPro: 1.185 ± 0.4
1.609AspGln: 1.609 ± 0.33
2.202AspArg: 2.202 ± 0.436
3.81AspSer: 3.81 ± 0.555
3.218AspThr: 3.218 ± 0.686
3.641AspVal: 3.641 ± 0.516
0.677AspTrp: 0.677 ± 0.226
2.71AspTyr: 2.71 ± 0.486
0.0AspXaa: 0.0 ± 0.0
Glu
5.673GluAla: 5.673 ± 0.927
0.339GluCys: 0.339 ± 0.16
4.234GluAsp: 4.234 ± 0.519
6.181GluGlu: 6.181 ± 0.776
3.133GluPhe: 3.133 ± 0.482
3.302GluGly: 3.302 ± 0.533
1.185GluHis: 1.185 ± 0.303
6.52GluIle: 6.52 ± 0.687
6.605GluLys: 6.605 ± 0.805
8.467GluLeu: 8.467 ± 1.011
2.286GluMet: 2.286 ± 0.437
3.641GluAsn: 3.641 ± 0.513
2.117GluPro: 2.117 ± 0.406
3.218GluGln: 3.218 ± 0.564
3.472GluArg: 3.472 ± 0.48
4.318GluSer: 4.318 ± 0.629
3.895GluThr: 3.895 ± 0.731
5.419GluVal: 5.419 ± 0.712
1.016GluTrp: 1.016 ± 0.3
2.71GluTyr: 2.71 ± 0.558
0.0GluXaa: 0.0 ± 0.0
Phe
3.472PheAla: 3.472 ± 0.697
0.423PheCys: 0.423 ± 0.194
2.54PheAsp: 2.54 ± 0.531
4.149PheGlu: 4.149 ± 0.591
1.185PhePhe: 1.185 ± 0.364
2.964PheGly: 2.964 ± 0.486
0.677PheHis: 0.677 ± 0.239
2.032PheIle: 2.032 ± 0.374
3.895PheLys: 3.895 ± 0.751
2.71PheLeu: 2.71 ± 0.528
0.762PheMet: 0.762 ± 0.23
3.048PheAsn: 3.048 ± 0.528
1.609PhePro: 1.609 ± 0.417
1.185PheGln: 1.185 ± 0.325
1.948PheArg: 1.948 ± 0.498
2.879PheSer: 2.879 ± 0.636
2.202PheThr: 2.202 ± 0.471
2.794PheVal: 2.794 ± 0.576
0.423PheTrp: 0.423 ± 0.209
2.032PheTyr: 2.032 ± 0.411
0.0PheXaa: 0.0 ± 0.0
Gly
3.048GlyAla: 3.048 ± 0.635
0.085GlyCys: 0.085 ± 0.097
3.218GlyAsp: 3.218 ± 0.479
4.234GlyGlu: 4.234 ± 0.456
3.387GlyPhe: 3.387 ± 0.555
4.403GlyGly: 4.403 ± 0.634
1.355GlyHis: 1.355 ± 0.406
3.641GlyIle: 3.641 ± 0.479
5.334GlyLys: 5.334 ± 0.639
5.673GlyLeu: 5.673 ± 0.995
2.371GlyMet: 2.371 ± 0.482
3.556GlyAsn: 3.556 ± 0.627
0.677GlyPro: 0.677 ± 0.194
2.964GlyGln: 2.964 ± 0.418
3.048GlyArg: 3.048 ± 0.503
3.81GlySer: 3.81 ± 0.591
4.064GlyThr: 4.064 ± 0.952
3.895GlyVal: 3.895 ± 0.565
0.593GlyTrp: 0.593 ± 0.186
3.048GlyTyr: 3.048 ± 0.54
0.0GlyXaa: 0.0 ± 0.0
His
1.101HisAla: 1.101 ± 0.357
0.254HisCys: 0.254 ± 0.139
1.185HisAsp: 1.185 ± 0.384
0.931HisGlu: 0.931 ± 0.289
0.847HisPhe: 0.847 ± 0.233
1.609HisGly: 1.609 ± 0.381
0.254HisHis: 0.254 ± 0.142
0.847HisIle: 0.847 ± 0.298
0.593HisLys: 0.593 ± 0.187
0.931HisLeu: 0.931 ± 0.329
0.593HisMet: 0.593 ± 0.204
0.931HisAsn: 0.931 ± 0.23
0.593HisPro: 0.593 ± 0.185
0.254HisGln: 0.254 ± 0.15
0.423HisArg: 0.423 ± 0.177
1.101HisSer: 1.101 ± 0.3
1.439HisThr: 1.439 ± 0.362
0.847HisVal: 0.847 ± 0.271
0.169HisTrp: 0.169 ± 0.104
0.508HisTyr: 0.508 ± 0.251
0.0HisXaa: 0.0 ± 0.0
Ile
4.911IleAla: 4.911 ± 0.674
0.508IleCys: 0.508 ± 0.204
4.318IleAsp: 4.318 ± 0.595
7.028IleGlu: 7.028 ± 0.637
2.456IlePhe: 2.456 ± 0.481
4.742IleGly: 4.742 ± 0.658
1.524IleHis: 1.524 ± 0.366
3.048IleIle: 3.048 ± 0.429
6.943IleLys: 6.943 ± 0.838
3.81IleLeu: 3.81 ± 0.489
1.185IleMet: 1.185 ± 0.27
4.318IleAsn: 4.318 ± 0.598
2.625IlePro: 2.625 ± 0.672
1.863IleGln: 1.863 ± 0.377
2.964IleArg: 2.964 ± 0.557
3.726IleSer: 3.726 ± 0.565
4.657IleThr: 4.657 ± 0.739
3.895IleVal: 3.895 ± 0.459
0.762IleTrp: 0.762 ± 0.222
2.032IleTyr: 2.032 ± 0.356
0.0IleXaa: 0.0 ± 0.0
Lys
7.451LysAla: 7.451 ± 0.98
0.423LysCys: 0.423 ± 0.233
4.742LysAsp: 4.742 ± 0.695
7.79LysGlu: 7.79 ± 0.787
2.794LysPhe: 2.794 ± 0.399
4.742LysGly: 4.742 ± 0.687
1.101LysHis: 1.101 ± 0.253
4.742LysIle: 4.742 ± 0.623
5.758LysLys: 5.758 ± 0.745
6.181LysLeu: 6.181 ± 0.769
1.778LysMet: 1.778 ± 0.423
4.403LysAsn: 4.403 ± 0.556
2.286LysPro: 2.286 ± 0.384
3.556LysGln: 3.556 ± 0.602
4.488LysArg: 4.488 ± 0.726
3.81LysSer: 3.81 ± 0.473
5.334LysThr: 5.334 ± 0.57
5.419LysVal: 5.419 ± 0.576
0.762LysTrp: 0.762 ± 0.284
2.54LysTyr: 2.54 ± 0.492
0.0LysXaa: 0.0 ± 0.0
Leu
7.621LeuAla: 7.621 ± 1.115
0.508LeuCys: 0.508 ± 0.186
5.588LeuAsp: 5.588 ± 0.755
7.113LeuGlu: 7.113 ± 1.03
2.879LeuPhe: 2.879 ± 0.507
4.657LeuGly: 4.657 ± 0.933
1.016LeuHis: 1.016 ± 0.27
5.673LeuIle: 5.673 ± 0.797
7.113LeuLys: 7.113 ± 0.72
6.605LeuLeu: 6.605 ± 0.833
1.693LeuMet: 1.693 ± 0.375
4.403LeuAsn: 4.403 ± 0.627
1.778LeuPro: 1.778 ± 0.344
1.948LeuGln: 1.948 ± 0.389
3.98LeuArg: 3.98 ± 0.563
4.996LeuSer: 4.996 ± 0.806
6.435LeuThr: 6.435 ± 0.805
4.826LeuVal: 4.826 ± 0.581
0.847LeuTrp: 0.847 ± 0.281
2.794LeuTyr: 2.794 ± 0.558
0.0LeuXaa: 0.0 ± 0.0
Met
2.625MetAla: 2.625 ± 0.495
0.0MetCys: 0.0 ± 0.0
1.693MetAsp: 1.693 ± 0.379
1.524MetGlu: 1.524 ± 0.325
0.762MetPhe: 0.762 ± 0.217
1.101MetGly: 1.101 ± 0.326
0.339MetHis: 0.339 ± 0.192
2.032MetIle: 2.032 ± 0.384
2.54MetLys: 2.54 ± 0.398
1.355MetLeu: 1.355 ± 0.358
0.847MetMet: 0.847 ± 0.266
1.948MetAsn: 1.948 ± 0.295
0.169MetPro: 0.169 ± 0.107
0.593MetGln: 0.593 ± 0.228
0.847MetArg: 0.847 ± 0.327
1.863MetSer: 1.863 ± 0.445
2.286MetThr: 2.286 ± 0.424
1.185MetVal: 1.185 ± 0.266
0.339MetTrp: 0.339 ± 0.171
1.016MetTyr: 1.016 ± 0.259
0.0MetXaa: 0.0 ± 0.0
Asn
3.726AsnAla: 3.726 ± 0.6
0.508AsnCys: 0.508 ± 0.181
2.964AsnAsp: 2.964 ± 0.564
3.81AsnGlu: 3.81 ± 0.544
2.794AsnPhe: 2.794 ± 0.486
5.419AsnGly: 5.419 ± 0.723
0.931AsnHis: 0.931 ± 0.266
2.625AsnIle: 2.625 ± 0.649
3.641AsnLys: 3.641 ± 0.487
4.488AsnLeu: 4.488 ± 0.738
1.016AsnMet: 1.016 ± 0.331
2.54AsnAsn: 2.54 ± 0.503
2.286AsnPro: 2.286 ± 0.458
3.556AsnGln: 3.556 ± 0.607
2.54AsnArg: 2.54 ± 0.422
3.133AsnSer: 3.133 ± 0.522
3.218AsnThr: 3.218 ± 0.613
4.064AsnVal: 4.064 ± 0.525
1.101AsnTrp: 1.101 ± 0.338
2.371AsnTyr: 2.371 ± 0.481
0.0AsnXaa: 0.0 ± 0.0
Pro
1.524ProAla: 1.524 ± 0.473
0.085ProCys: 0.085 ± 0.088
1.439ProAsp: 1.439 ± 0.385
2.032ProGlu: 2.032 ± 0.462
1.609ProPhe: 1.609 ± 0.367
0.677ProGly: 0.677 ± 0.277
0.085ProHis: 0.085 ± 0.097
2.117ProIle: 2.117 ± 0.406
2.371ProLys: 2.371 ± 0.551
2.032ProLeu: 2.032 ± 0.45
0.508ProMet: 0.508 ± 0.232
1.948ProAsn: 1.948 ± 0.436
0.593ProPro: 0.593 ± 0.209
0.762ProGln: 0.762 ± 0.294
1.524ProArg: 1.524 ± 0.356
1.778ProSer: 1.778 ± 0.48
1.355ProThr: 1.355 ± 0.311
2.032ProVal: 2.032 ± 0.373
0.254ProTrp: 0.254 ± 0.139
1.016ProTyr: 1.016 ± 0.248
0.0ProXaa: 0.0 ± 0.0
Gln
2.964GlnAla: 2.964 ± 0.535
0.254GlnCys: 0.254 ± 0.144
1.863GlnAsp: 1.863 ± 0.469
2.794GlnGlu: 2.794 ± 0.506
1.778GlnPhe: 1.778 ± 0.3
1.693GlnGly: 1.693 ± 0.395
0.339GlnHis: 0.339 ± 0.186
2.625GlnIle: 2.625 ± 0.497
3.387GlnLys: 3.387 ± 0.559
3.81GlnLeu: 3.81 ± 0.821
1.016GlnMet: 1.016 ± 0.27
1.524GlnAsn: 1.524 ± 0.352
1.185GlnPro: 1.185 ± 0.378
1.439GlnGln: 1.439 ± 0.323
2.286GlnArg: 2.286 ± 0.552
2.032GlnSer: 2.032 ± 0.358
2.117GlnThr: 2.117 ± 0.587
2.625GlnVal: 2.625 ± 0.386
0.508GlnTrp: 0.508 ± 0.162
1.101GlnTyr: 1.101 ± 0.307
0.0GlnXaa: 0.0 ± 0.0
Arg
2.625ArgAla: 2.625 ± 0.472
0.085ArgCys: 0.085 ± 0.097
2.54ArgAsp: 2.54 ± 0.628
3.387ArgGlu: 3.387 ± 0.53
2.286ArgPhe: 2.286 ± 0.562
2.202ArgGly: 2.202 ± 0.514
0.762ArgHis: 0.762 ± 0.216
3.556ArgIle: 3.556 ± 0.549
3.387ArgLys: 3.387 ± 0.599
4.488ArgLeu: 4.488 ± 0.617
1.27ArgMet: 1.27 ± 0.379
2.794ArgAsn: 2.794 ± 0.541
1.185ArgPro: 1.185 ± 0.341
1.778ArgGln: 1.778 ± 0.272
2.032ArgArg: 2.032 ± 0.381
2.032ArgSer: 2.032 ± 0.347
2.032ArgThr: 2.032 ± 0.624
2.794ArgVal: 2.794 ± 0.473
0.847ArgTrp: 0.847 ± 0.257
2.879ArgTyr: 2.879 ± 0.427
0.0ArgXaa: 0.0 ± 0.0
Ser
4.488SerAla: 4.488 ± 0.763
0.593SerCys: 0.593 ± 0.206
4.996SerAsp: 4.996 ± 0.667
3.641SerGlu: 3.641 ± 0.571
3.218SerPhe: 3.218 ± 0.434
4.403SerGly: 4.403 ± 0.927
0.677SerHis: 0.677 ± 0.244
3.302SerIle: 3.302 ± 0.528
4.826SerLys: 4.826 ± 0.7
5.504SerLeu: 5.504 ± 0.615
2.117SerMet: 2.117 ± 0.323
4.064SerAsn: 4.064 ± 0.491
1.778SerPro: 1.778 ± 0.413
2.71SerGln: 2.71 ± 0.438
1.609SerArg: 1.609 ± 0.353
5.334SerSer: 5.334 ± 0.736
4.234SerThr: 4.234 ± 1.002
3.556SerVal: 3.556 ± 0.485
0.762SerTrp: 0.762 ± 0.208
2.964SerTyr: 2.964 ± 0.501
0.0SerXaa: 0.0 ± 0.0
Thr
5.165ThrAla: 5.165 ± 0.688
0.169ThrCys: 0.169 ± 0.113
3.472ThrAsp: 3.472 ± 0.556
3.472ThrGlu: 3.472 ± 0.61
3.472ThrPhe: 3.472 ± 0.52
4.488ThrGly: 4.488 ± 0.758
0.762ThrHis: 0.762 ± 0.231
6.181ThrIle: 6.181 ± 0.934
4.318ThrLys: 4.318 ± 0.648
4.911ThrLeu: 4.911 ± 0.602
1.016ThrMet: 1.016 ± 0.259
2.371ThrAsn: 2.371 ± 0.495
0.847ThrPro: 0.847 ± 0.218
2.879ThrGln: 2.879 ± 0.653
1.778ThrArg: 1.778 ± 0.324
3.048ThrSer: 3.048 ± 0.958
3.556ThrThr: 3.556 ± 0.821
5.25ThrVal: 5.25 ± 0.974
1.101ThrTrp: 1.101 ± 0.259
2.54ThrTyr: 2.54 ± 0.617
0.0ThrXaa: 0.0 ± 0.0
Val
4.742ValAla: 4.742 ± 0.69
0.508ValCys: 0.508 ± 0.219
4.318ValAsp: 4.318 ± 0.613
4.318ValGlu: 4.318 ± 0.638
2.371ValPhe: 2.371 ± 0.497
4.572ValGly: 4.572 ± 0.537
0.931ValHis: 0.931 ± 0.319
4.657ValIle: 4.657 ± 0.61
4.742ValLys: 4.742 ± 0.684
5.673ValLeu: 5.673 ± 0.748
1.778ValMet: 1.778 ± 0.42
3.218ValAsn: 3.218 ± 0.506
1.693ValPro: 1.693 ± 0.309
1.524ValGln: 1.524 ± 0.285
2.71ValArg: 2.71 ± 0.555
5.165ValSer: 5.165 ± 0.692
3.387ValThr: 3.387 ± 0.572
5.08ValVal: 5.08 ± 0.772
0.762ValTrp: 0.762 ± 0.234
1.863ValTyr: 1.863 ± 0.371
0.0ValXaa: 0.0 ± 0.0
Trp
0.593TrpAla: 0.593 ± 0.251
0.085TrpCys: 0.085 ± 0.097
1.101TrpAsp: 1.101 ± 0.297
1.016TrpGlu: 1.016 ± 0.267
0.593TrpPhe: 0.593 ± 0.237
1.185TrpGly: 1.185 ± 0.299
0.085TrpHis: 0.085 ± 0.085
0.677TrpIle: 0.677 ± 0.202
0.677TrpLys: 0.677 ± 0.24
0.847TrpLeu: 0.847 ± 0.218
0.339TrpMet: 0.339 ± 0.148
0.931TrpAsn: 0.931 ± 0.275
0.0TrpPro: 0.0 ± 0.0
1.016TrpGln: 1.016 ± 0.311
0.847TrpArg: 0.847 ± 0.238
0.593TrpSer: 0.593 ± 0.22
1.016TrpThr: 1.016 ± 0.302
0.169TrpVal: 0.169 ± 0.132
0.169TrpTrp: 0.169 ± 0.11
0.423TrpTyr: 0.423 ± 0.235
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.625TyrAla: 2.625 ± 0.484
0.423TyrCys: 0.423 ± 0.178
2.625TyrAsp: 2.625 ± 0.527
1.693TyrGlu: 1.693 ± 0.293
1.016TyrPhe: 1.016 ± 0.296
2.032TyrGly: 2.032 ± 0.446
1.27TyrHis: 1.27 ± 0.301
2.794TyrIle: 2.794 ± 0.553
2.879TyrLys: 2.879 ± 0.545
4.403TyrLeu: 4.403 ± 0.583
0.677TyrMet: 0.677 ± 0.239
2.54TyrAsn: 2.54 ± 0.546
1.27TyrPro: 1.27 ± 0.326
2.032TyrGln: 2.032 ± 0.442
2.71TyrArg: 2.71 ± 0.376
3.048TyrSer: 3.048 ± 0.578
1.355TyrThr: 1.355 ± 0.335
1.948TyrVal: 1.948 ± 0.453
0.423TyrTrp: 0.423 ± 0.233
1.948TyrTyr: 1.948 ± 0.396
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (11811 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski