Amino acid dipepetide frequency for Aurantimonas aggregata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.685AlaAla: 19.685 ± 0.208	1.033AlaCys: 1.033 ± 0.03	7.591AlaAsp: 7.591 ± 0.087	8.714AlaGlu: 8.714 ± 0.109	4.885AlaPhe: 4.885 ± 0.06	12.064AlaGly: 12.064 ± 0.12	2.071AlaHis: 2.071 ± 0.038	7.076AlaIle: 7.076 ± 0.082	3.268AlaLys: 3.268 ± 0.067	13.659AlaLeu: 13.659 ± 0.139	3.788AlaMet: 3.788 ± 0.06	2.687AlaAsn: 2.687 ± 0.05	6.012AlaPro: 6.012 ± 0.097	3.351AlaGln: 3.351 ± 0.052	8.979AlaArg: 8.979 ± 0.096	6.855AlaSer: 6.855 ± 0.082	6.647AlaThr: 6.647 ± 0.075	9.612AlaVal: 9.612 ± 0.098	1.484AlaTrp: 1.484 ± 0.041	2.613AlaTyr: 2.613 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.851CysAla: 0.851 ± 0.025	0.108CysCys: 0.108 ± 0.009	0.508CysAsp: 0.508 ± 0.016	0.43CysGlu: 0.43 ± 0.018	0.309CysPhe: 0.309 ± 0.014	0.91CysGly: 0.91 ± 0.032	0.25CysHis: 0.25 ± 0.013	0.351CysIle: 0.351 ± 0.017	0.136CysLys: 0.136 ± 0.01	0.792CysLeu: 0.792 ± 0.028	0.129CysMet: 0.129 ± 0.01	0.184CysAsn: 0.184 ± 0.013	0.424CysPro: 0.424 ± 0.017	0.213CysGln: 0.213 ± 0.014	0.651CysArg: 0.651 ± 0.023	0.375CysSer: 0.375 ± 0.019	0.36CysThr: 0.36 ± 0.018	0.554CysVal: 0.554 ± 0.02	0.094CysTrp: 0.094 ± 0.008	0.158CysTyr: 0.158 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.471AspAla: 7.471 ± 0.095	0.46AspCys: 0.46 ± 0.019	3.545AspAsp: 3.545 ± 0.092	3.78AspGlu: 3.78 ± 0.059	2.131AspPhe: 2.131 ± 0.044	5.793AspGly: 5.793 ± 0.08	1.216AspHis: 1.216 ± 0.032	3.002AspIle: 3.002 ± 0.042	1.364AspLys: 1.364 ± 0.036	6.065AspLeu: 6.065 ± 0.071	1.379AspMet: 1.379 ± 0.03	1.185AspAsn: 1.185 ± 0.032	3.81AspPro: 3.81 ± 0.059	1.637AspGln: 1.637 ± 0.034	4.931AspArg: 4.931 ± 0.068	2.116AspSer: 2.116 ± 0.041	2.638AspThr: 2.638 ± 0.058	4.308AspVal: 4.308 ± 0.061	0.964AspTrp: 0.964 ± 0.026	1.402AspTyr: 1.402 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.925GluAla: 8.925 ± 0.099	0.33GluCys: 0.33 ± 0.016	3.006GluAsp: 3.006 ± 0.047	3.397GluGlu: 3.397 ± 0.063	1.746GluPhe: 1.746 ± 0.038	4.685GluGly: 4.685 ± 0.051	1.125GluHis: 1.125 ± 0.031	3.677GluIle: 3.677 ± 0.061	1.977GluLys: 1.977 ± 0.042	5.092GluLeu: 5.092 ± 0.063	1.636GluMet: 1.636 ± 0.039	1.546GluAsn: 1.546 ± 0.034	3.151GluPro: 3.151 ± 0.057	1.804GluGln: 1.804 ± 0.043	5.5GluArg: 5.5 ± 0.069	2.534GluSer: 2.534 ± 0.041	4.027GluThr: 4.027 ± 0.055	3.614GluVal: 3.614 ± 0.05	0.721GluTrp: 0.721 ± 0.021	0.962GluTyr: 0.962 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	5.087PheAla: 5.087 ± 0.062	0.379PheCys: 0.379 ± 0.016	2.716PheAsp: 2.716 ± 0.049	2.218PheGlu: 2.218 ± 0.045	1.464PhePhe: 1.464 ± 0.036	3.858PheGly: 3.858 ± 0.053	0.763PheHis: 0.763 ± 0.024	1.607PheIle: 1.607 ± 0.032	0.807PheLys: 0.807 ± 0.025	3.577PheLeu: 3.577 ± 0.057	0.772PheMet: 0.772 ± 0.024	0.873PheAsn: 0.873 ± 0.028	1.641PhePro: 1.641 ± 0.036	1.035PheGln: 1.035 ± 0.029	2.347PheArg: 2.347 ± 0.037	2.118PheSer: 2.118 ± 0.043	1.856PheThr: 1.856 ± 0.036	3.145PheVal: 3.145 ± 0.052	0.501PheTrp: 0.501 ± 0.02	0.867PheTyr: 0.867 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.925GlyAla: 9.925 ± 0.106	0.857GlyCys: 0.857 ± 0.027	4.933GlyAsp: 4.933 ± 0.099	5.469GlyGlu: 5.469 ± 0.066	3.8GlyPhe: 3.8 ± 0.057	7.683GlyGly: 7.683 ± 0.106	1.91GlyHis: 1.91 ± 0.037	4.812GlyIle: 4.812 ± 0.058	2.666GlyLys: 2.666 ± 0.051	9.186GlyLeu: 9.186 ± 0.092	2.377GlyMet: 2.377 ± 0.044	2.015GlyAsn: 2.015 ± 0.05	3.743GlyPro: 3.743 ± 0.055	2.704GlyGln: 2.704 ± 0.045	6.731GlyArg: 6.731 ± 0.074	4.868GlySer: 4.868 ± 0.063	4.981GlyThr: 4.981 ± 0.074	6.204GlyVal: 6.204 ± 0.066	1.329GlyTrp: 1.329 ± 0.031	2.249GlyTyr: 2.249 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.239HisAla: 2.239 ± 0.04	0.206HisCys: 0.206 ± 0.013	1.226HisAsp: 1.226 ± 0.029	0.992HisGlu: 0.992 ± 0.028	0.763HisPhe: 0.763 ± 0.026	1.905HisGly: 1.905 ± 0.047	0.549HisHis: 0.549 ± 0.021	0.741HisIle: 0.741 ± 0.023	0.342HisLys: 0.342 ± 0.016	2.009HisLeu: 2.009 ± 0.038	0.439HisMet: 0.439 ± 0.018	0.368HisAsn: 0.368 ± 0.017	1.253HisPro: 1.253 ± 0.031	0.559HisGln: 0.559 ± 0.021	1.493HisArg: 1.493 ± 0.037	0.84HisSer: 0.84 ± 0.027	0.679HisThr: 0.679 ± 0.023	1.525HisVal: 1.525 ± 0.032	0.287HisTrp: 0.287 ± 0.014	0.499HisTyr: 0.499 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.746IleAla: 7.746 ± 0.085	0.464IleCys: 0.464 ± 0.02	3.68IleAsp: 3.68 ± 0.052	3.649IleGlu: 3.649 ± 0.048	1.733IlePhe: 1.733 ± 0.039	5.142IleGly: 5.142 ± 0.076	0.874IleHis: 0.874 ± 0.025	2.116IleIle: 2.116 ± 0.046	1.097IleLys: 1.097 ± 0.029	4.679IleLeu: 4.679 ± 0.062	0.915IleMet: 0.915 ± 0.024	1.229IleAsn: 1.229 ± 0.037	2.274IlePro: 2.274 ± 0.04	1.14IleGln: 1.14 ± 0.027	3.347IleArg: 3.347 ± 0.047	2.514IleSer: 2.514 ± 0.046	2.428IleThr: 2.428 ± 0.044	4.809IleVal: 4.809 ± 0.072	0.538IleTrp: 0.538 ± 0.02	1.089IleTyr: 1.089 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.584LysAla: 3.584 ± 0.055	0.126LysCys: 0.126 ± 0.01	1.392LysAsp: 1.392 ± 0.036	1.238LysGlu: 1.238 ± 0.032	0.65LysPhe: 0.65 ± 0.022	2.262LysGly: 2.262 ± 0.05	0.478LysHis: 0.478 ± 0.018	1.399LysIle: 1.399 ± 0.036	0.847LysLys: 0.847 ± 0.028	2.602LysLeu: 2.602 ± 0.044	0.592LysMet: 0.592 ± 0.024	0.655LysAsn: 0.655 ± 0.023	1.665LysPro: 1.665 ± 0.032	0.756LysGln: 0.756 ± 0.025	2.152LysArg: 2.152 ± 0.039	1.469LysSer: 1.469 ± 0.035	1.54LysThr: 1.54 ± 0.041	1.921LysVal: 1.921 ± 0.044	0.285LysTrp: 0.285 ± 0.014	0.423LysTyr: 0.423 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.851LeuAla: 14.851 ± 0.145	0.834LeuCys: 0.834 ± 0.025	6.101LeuAsp: 6.101 ± 0.079	5.193LeuGlu: 5.193 ± 0.069	3.763LeuPhe: 3.763 ± 0.058	8.445LeuGly: 8.445 ± 0.097	1.673LeuHis: 1.673 ± 0.041	4.742LeuIle: 4.742 ± 0.072	3.04LeuLys: 3.04 ± 0.046	9.553LeuLeu: 9.553 ± 0.123	2.231LeuMet: 2.231 ± 0.04	2.195LeuAsn: 2.195 ± 0.039	5.546LeuPro: 5.546 ± 0.072	2.524LeuGln: 2.524 ± 0.049	6.768LeuArg: 6.768 ± 0.082	6.375LeuSer: 6.375 ± 0.071	5.55LeuThr: 5.55 ± 0.068	8.181LeuVal: 8.181 ± 0.083	1.12LeuTrp: 1.12 ± 0.03	1.956LeuTyr: 1.956 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.295MetAla: 3.295 ± 0.054	0.119MetCys: 0.119 ± 0.009	1.122MetAsp: 1.122 ± 0.034	1.102MetGlu: 1.102 ± 0.029	0.697MetPhe: 0.697 ± 0.024	1.785MetGly: 1.785 ± 0.038	0.391MetHis: 0.391 ± 0.017	1.434MetIle: 1.434 ± 0.035	0.817MetLys: 0.817 ± 0.024	2.527MetLeu: 2.527 ± 0.047	0.656MetMet: 0.656 ± 0.027	0.73MetAsn: 0.73 ± 0.028	1.525MetPro: 1.525 ± 0.036	0.834MetGln: 0.834 ± 0.025	1.891MetArg: 1.891 ± 0.037	1.615MetSer: 1.615 ± 0.029	1.798MetThr: 1.798 ± 0.037	1.72MetVal: 1.72 ± 0.038	0.178MetTrp: 0.178 ± 0.011	0.267MetTyr: 0.267 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.839AsnAla: 2.839 ± 0.044	0.211AsnCys: 0.211 ± 0.015	1.333AsnAsp: 1.333 ± 0.041	1.213AsnGlu: 1.213 ± 0.034	0.84AsnPhe: 0.84 ± 0.028	2.183AsnGly: 2.183 ± 0.051	0.426AsnHis: 0.426 ± 0.017	1.166AsnIle: 1.166 ± 0.032	0.498AsnLys: 0.498 ± 0.019	2.217AsnLeu: 2.217 ± 0.044	0.507AsnMet: 0.507 ± 0.02	0.534AsnAsn: 0.534 ± 0.02	1.596AsnPro: 1.596 ± 0.036	0.667AsnGln: 0.667 ± 0.023	1.728AsnArg: 1.728 ± 0.041	1.031AsnSer: 1.031 ± 0.033	1.023AsnThr: 1.023 ± 0.03	1.818AsnVal: 1.818 ± 0.035	0.353AsnTrp: 0.353 ± 0.018	0.601AsnTyr: 0.601 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.117ProAla: 7.117 ± 0.099	0.281ProCys: 0.281 ± 0.017	3.779ProAsp: 3.779 ± 0.048	3.824ProGlu: 3.824 ± 0.054	2.05ProPhe: 2.05 ± 0.035	4.768ProGly: 4.768 ± 0.069	0.996ProHis: 0.996 ± 0.029	2.412ProIle: 2.412 ± 0.047	1.376ProLys: 1.376 ± 0.03	4.842ProLeu: 4.842 ± 0.061	1.232ProMet: 1.232 ± 0.028	1.242ProAsn: 1.242 ± 0.028	2.595ProPro: 2.595 ± 0.06	1.563ProGln: 1.563 ± 0.029	3.138ProArg: 3.138 ± 0.056	2.846ProSer: 2.846 ± 0.051	2.636ProThr: 2.636 ± 0.046	4.4ProVal: 4.4 ± 0.053	0.634ProTrp: 0.634 ± 0.023	1.125ProTyr: 1.125 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.875GlnAla: 3.875 ± 0.065	0.172GlnCys: 0.172 ± 0.012	1.38GlnAsp: 1.38 ± 0.033	1.426GlnGlu: 1.426 ± 0.036	0.984GlnPhe: 0.984 ± 0.026	2.126GlnGly: 2.126 ± 0.039	0.525GlnHis: 0.525 ± 0.019	1.721GlnIle: 1.721 ± 0.038	0.852GlnLys: 0.852 ± 0.029	2.606GlnLeu: 2.606 ± 0.04	0.835GlnMet: 0.835 ± 0.029	0.725GlnAsn: 0.725 ± 0.024	1.678GlnPro: 1.678 ± 0.036	1.052GlnGln: 1.052 ± 0.035	2.45GlnArg: 2.45 ± 0.051	1.617GlnSer: 1.617 ± 0.038	1.634GlnThr: 1.634 ± 0.036	1.926GlnVal: 1.926 ± 0.042	0.338GlnTrp: 0.338 ± 0.015	0.511GlnTyr: 0.511 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.826ArgAla: 7.826 ± 0.09	0.511ArgCys: 0.511 ± 0.021	4.369ArgAsp: 4.369 ± 0.065	4.451ArgGlu: 4.451 ± 0.065	3.24ArgPhe: 3.24 ± 0.048	5.07ArgGly: 5.07 ± 0.058	1.762ArgHis: 1.762 ± 0.045	4.098ArgIle: 4.098 ± 0.056	1.964ArgLys: 1.964 ± 0.039	8.581ArgLeu: 8.581 ± 0.094	1.969ArgMet: 1.969 ± 0.039	1.691ArgAsn: 1.691 ± 0.038	4.042ArgPro: 4.042 ± 0.052	2.768ArgGln: 2.768 ± 0.05	6.741ArgArg: 6.741 ± 0.085	4.072ArgSer: 4.072 ± 0.053	3.658ArgThr: 3.658 ± 0.054	4.813ArgVal: 4.813 ± 0.062	0.986ArgTrp: 0.986 ± 0.03	1.706ArgTyr: 1.706 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.161SerAla: 6.161 ± 0.061	0.379SerCys: 0.379 ± 0.017	3.069SerAsp: 3.069 ± 0.054	2.863SerGlu: 2.863 ± 0.051	2.35SerPhe: 2.35 ± 0.042	5.502SerGly: 5.502 ± 0.067	0.968SerHis: 0.968 ± 0.025	2.781SerIle: 2.781 ± 0.05	1.193SerLys: 1.193 ± 0.032	5.635SerLeu: 5.635 ± 0.061	1.271SerMet: 1.271 ± 0.032	1.157SerAsn: 1.157 ± 0.033	2.908SerPro: 2.908 ± 0.045	1.567SerGln: 1.567 ± 0.038	3.888SerArg: 3.888 ± 0.06	2.755SerSer: 2.755 ± 0.048	2.542SerThr: 2.542 ± 0.052	3.976SerVal: 3.976 ± 0.048	0.718SerTrp: 0.718 ± 0.024	1.173SerTyr: 1.173 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.613ThrAla: 6.613 ± 0.077	0.374ThrCys: 0.374 ± 0.018	2.863ThrAsp: 2.863 ± 0.05	2.798ThrGlu: 2.798 ± 0.049	1.889ThrPhe: 1.889 ± 0.047	5.288ThrGly: 5.288 ± 0.065	0.926ThrHis: 0.926 ± 0.025	3.199ThrIle: 3.199 ± 0.054	1.196ThrLys: 1.196 ± 0.031	5.874ThrLeu: 5.874 ± 0.066	1.232ThrMet: 1.232 ± 0.028	1.146ThrAsn: 1.146 ± 0.028	3.261ThrPro: 3.261 ± 0.055	1.269ThrGln: 1.269 ± 0.026	3.377ThrArg: 3.377 ± 0.048	2.722ThrSer: 2.722 ± 0.043	2.89ThrThr: 2.89 ± 0.048	4.644ThrVal: 4.644 ± 0.072	0.539ThrTrp: 0.539 ± 0.023	1.13ThrTyr: 1.13 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.375ValAla: 10.375 ± 0.101	0.6ValCys: 0.6 ± 0.02	4.531ValAsp: 4.531 ± 0.065	4.868ValGlu: 4.868 ± 0.069	2.949ValPhe: 2.949 ± 0.054	6.088ValGly: 6.088 ± 0.076	1.306ValHis: 1.306 ± 0.039	3.749ValIle: 3.749 ± 0.049	1.781ValLys: 1.781 ± 0.042	7.389ValLeu: 7.389 ± 0.097	1.831ValMet: 1.831 ± 0.04	1.752ValAsn: 1.752 ± 0.044	4.009ValPro: 4.009 ± 0.058	1.79ValGln: 1.79 ± 0.038	5.188ValArg: 5.188 ± 0.063	4.331ValSer: 4.331 ± 0.056	4.613ValThr: 4.613 ± 0.062	6.328ValVal: 6.328 ± 0.084	0.919ValTrp: 0.919 ± 0.029	1.456ValTyr: 1.456 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.134TrpAla: 1.134 ± 0.028	0.129TrpCys: 0.129 ± 0.01	0.609TrpAsp: 0.609 ± 0.022	0.57TrpGlu: 0.57 ± 0.02	0.534TrpPhe: 0.534 ± 0.022	0.78TrpGly: 0.78 ± 0.024	0.308TrpHis: 0.308 ± 0.015	0.608TrpIle: 0.608 ± 0.022	0.352TrpLys: 0.352 ± 0.018	1.605TrpLeu: 1.605 ± 0.04	0.342TrpMet: 0.342 ± 0.015	0.394TrpAsn: 0.394 ± 0.018	0.646TrpPro: 0.646 ± 0.021	0.551TrpGln: 0.551 ± 0.023	1.18TrpArg: 1.18 ± 0.032	0.79TrpSer: 0.79 ± 0.027	0.775TrpThr: 0.775 ± 0.023	0.725TrpVal: 0.725 ± 0.021	0.228TrpTrp: 0.228 ± 0.013	0.263TrpTyr: 0.263 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.475TyrAla: 2.475 ± 0.041	0.215TyrCys: 0.215 ± 0.012	1.443TyrAsp: 1.443 ± 0.037	1.26TyrGlu: 1.26 ± 0.03	0.854TyrPhe: 0.854 ± 0.025	2.101TyrGly: 2.101 ± 0.049	0.401TyrHis: 0.401 ± 0.017	0.773TyrIle: 0.773 ± 0.029	0.462TyrLys: 0.462 ± 0.018	2.148TyrLeu: 2.148 ± 0.044	0.368TyrMet: 0.368 ± 0.016	0.478TyrAsn: 0.478 ± 0.019	1.077TyrPro: 1.077 ± 0.026	0.65TyrGln: 0.65 ± 0.02	1.839TyrArg: 1.839 ± 0.039	1.013TyrSer: 1.013 ± 0.028	0.958TyrThr: 0.958 ± 0.027	1.629TyrVal: 1.629 ± 0.033	0.305TyrTrp: 0.305 ± 0.013	0.554TyrTyr: 0.554 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4495 proteins (1392481 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---