Amino acid dipepetide frequency for Plasmodium vivax (strain Salvador I)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.565AlaAla: 4.565 ± 0.081	0.77AlaCys: 0.77 ± 0.017	3.16AlaAsp: 3.16 ± 0.042	3.846AlaGlu: 3.846 ± 0.066	1.662AlaPhe: 1.662 ± 0.022	3.071AlaGly: 3.071 ± 0.046	1.658AlaHis: 1.658 ± 0.028	2.289AlaIle: 2.289 ± 0.03	4.515AlaLys: 4.515 ± 0.058	3.824AlaLeu: 3.824 ± 0.036	0.819AlaMet: 0.819 ± 0.016	4.288AlaAsn: 4.288 ± 0.053	2.555AlaPro: 2.555 ± 0.036	1.975AlaGln: 1.975 ± 0.032	2.015AlaArg: 2.015 ± 0.037	4.428AlaSer: 4.428 ± 0.047	2.627AlaThr: 2.627 ± 0.034	2.584AlaVal: 2.584 ± 0.032	0.244AlaTrp: 0.244 ± 0.008	1.708AlaTyr: 1.708 ± 0.025	0.001AlaXaa: 0.001 ± 0.001
Cys	1.053CysAla: 1.053 ± 0.02	0.379CysCys: 0.379 ± 0.011	0.94CysAsp: 0.94 ± 0.02	1.223CysGlu: 1.223 ± 0.021	0.859CysPhe: 0.859 ± 0.016	1.028CysGly: 1.028 ± 0.02	0.419CysHis: 0.419 ± 0.013	1.208CysIle: 1.208 ± 0.022	1.417CysLys: 1.417 ± 0.025	1.754CysLeu: 1.754 ± 0.024	0.355CysMet: 0.355 ± 0.009	1.141CysAsn: 1.141 ± 0.02	0.675CysPro: 0.675 ± 0.02	0.478CysGln: 0.478 ± 0.012	0.826CysArg: 0.826 ± 0.016	1.691CysSer: 1.691 ± 0.025	0.958CysThr: 0.958 ± 0.017	1.188CysVal: 1.188 ± 0.02	0.089CysTrp: 0.089 ± 0.005	0.722CysTyr: 0.722 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.564AspAla: 3.564 ± 0.038	0.79AspCys: 0.79 ± 0.016	4.228AspAsp: 4.228 ± 0.065	5.338AspGlu: 5.338 ± 0.056	2.114AspPhe: 2.114 ± 0.029	3.703AspGly: 3.703 ± 0.045	1.442AspHis: 1.442 ± 0.023	3.353AspIle: 3.353 ± 0.041	3.857AspLys: 3.857 ± 0.046	4.163AspLeu: 4.163 ± 0.039	1.1AspMet: 1.1 ± 0.02	3.002AspAsn: 3.002 ± 0.035	1.984AspPro: 1.984 ± 0.029	1.643AspGln: 1.643 ± 0.027	2.285AspArg: 2.285 ± 0.038	3.997AspSer: 3.997 ± 0.038	2.158AspThr: 2.158 ± 0.025	3.629AspVal: 3.629 ± 0.043	0.295AspTrp: 0.295 ± 0.01	2.155AspTyr: 2.155 ± 0.028	0.002AspXaa: 0.002 ± 0.001
Glu	4.677GluAla: 4.677 ± 0.071	1.111GluCys: 1.111 ± 0.019	4.742GluAsp: 4.742 ± 0.048	9.979GluGlu: 9.979 ± 0.14	1.973GluPhe: 1.973 ± 0.026	5.576GluGly: 5.576 ± 0.066	1.752GluHis: 1.752 ± 0.025	3.77GluIle: 3.77 ± 0.052	8.342GluLys: 8.342 ± 0.089	5.033GluLeu: 5.033 ± 0.057	1.637GluMet: 1.637 ± 0.024	5.16GluAsn: 5.16 ± 0.059	1.868GluPro: 1.868 ± 0.034	2.984GluGln: 2.984 ± 0.044	4.371GluArg: 4.371 ± 0.048	4.587GluSer: 4.587 ± 0.044	2.789GluThr: 2.789 ± 0.032	3.899GluVal: 3.899 ± 0.053	0.502GluTrp: 0.502 ± 0.014	2.341GluTyr: 2.341 ± 0.029	0.001GluXaa: 0.001 ± 0.001
Phe	1.786PheAla: 1.786 ± 0.025	1.018PheCys: 1.018 ± 0.016	2.308PheAsp: 2.308 ± 0.029	2.388PheGlu: 2.388 ± 0.031	3.305PhePhe: 3.305 ± 0.051	1.717PheGly: 1.717 ± 0.032	1.148PheHis: 1.148 ± 0.019	2.768PheIle: 2.768 ± 0.033	3.0PheLys: 3.0 ± 0.035	5.1PheLeu: 5.1 ± 0.054	0.779PheMet: 0.779 ± 0.019	2.808PheAsn: 2.808 ± 0.035	1.477PhePro: 1.477 ± 0.022	1.233PheGln: 1.233 ± 0.019	1.563PheArg: 1.563 ± 0.025	3.498PheSer: 3.498 ± 0.036	1.724PheThr: 1.724 ± 0.024	2.426PheVal: 2.426 ± 0.033	0.269PheTrp: 0.269 ± 0.009	2.357PheTyr: 2.357 ± 0.031	0.001PheXaa: 0.001 ± 0.0
Gly	4.447GlyAla: 4.447 ± 0.069	0.831GlyCys: 0.831 ± 0.016	4.184GlyAsp: 4.184 ± 0.048	6.8GlyGlu: 6.8 ± 0.084	1.464GlyPhe: 1.464 ± 0.026	8.904GlyGly: 8.904 ± 0.123	1.442GlyHis: 1.442 ± 0.028	2.523GlyIle: 2.523 ± 0.031	5.381GlyLys: 5.381 ± 0.051	3.046GlyLeu: 3.046 ± 0.039	1.22GlyMet: 1.22 ± 0.028	4.048GlyAsn: 4.048 ± 0.052	1.619GlyPro: 1.619 ± 0.026	1.794GlyGln: 1.794 ± 0.029	3.562GlyArg: 3.562 ± 0.059	6.324GlySer: 6.324 ± 0.084	2.805GlyThr: 2.805 ± 0.037	3.588GlyVal: 3.588 ± 0.05	0.295GlyTrp: 0.295 ± 0.01	1.661GlyTyr: 1.661 ± 0.028	0.001GlyXaa: 0.001 ± 0.0
His	1.329HisAla: 1.329 ± 0.023	0.444HisCys: 0.444 ± 0.012	1.161HisAsp: 1.161 ± 0.023	1.46HisGlu: 1.46 ± 0.024	1.613HisPhe: 1.613 ± 0.025	1.468HisGly: 1.468 ± 0.029	0.996HisHis: 0.996 ± 0.026	1.679HisIle: 1.679 ± 0.023	1.702HisLys: 1.702 ± 0.026	2.927HisLeu: 2.927 ± 0.03	0.716HisMet: 0.716 ± 0.016	1.622HisAsn: 1.622 ± 0.025	1.324HisPro: 1.324 ± 0.026	0.902HisGln: 0.902 ± 0.02	1.301HisArg: 1.301 ± 0.026	2.269HisSer: 2.269 ± 0.034	1.347HisThr: 1.347 ± 0.021	1.719HisVal: 1.719 ± 0.023	0.16HisTrp: 0.16 ± 0.006	1.018HisTyr: 1.018 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	2.11IleAla: 2.11 ± 0.029	1.422IleCys: 1.422 ± 0.023	2.939IleAsp: 2.939 ± 0.032	3.342IleGlu: 3.342 ± 0.045	3.295IlePhe: 3.295 ± 0.038	2.378IleGly: 2.378 ± 0.032	1.533IleHis: 1.533 ± 0.022	3.894IleIle: 3.894 ± 0.048	5.214IleLys: 5.214 ± 0.055	5.662IleLeu: 5.662 ± 0.057	0.979IleMet: 0.979 ± 0.016	4.424IleAsn: 4.424 ± 0.055	1.986IlePro: 1.986 ± 0.026	1.696IleGln: 1.696 ± 0.025	2.31IleArg: 2.31 ± 0.027	4.443IleSer: 4.443 ± 0.039	2.37IleThr: 2.37 ± 0.028	2.689IleVal: 2.689 ± 0.036	0.396IleTrp: 0.396 ± 0.012	2.87IleTyr: 2.87 ± 0.033	0.002IleXaa: 0.002 ± 0.001
Lys	3.62LysAla: 3.62 ± 0.062	1.679LysCys: 1.679 ± 0.027	4.156LysAsp: 4.156 ± 0.044	7.507LysGlu: 7.507 ± 0.09	2.834LysPhe: 2.834 ± 0.034	5.637LysGly: 5.637 ± 0.055	1.908LysHis: 1.908 ± 0.023	5.628LysIle: 5.628 ± 0.053	13.011LysLys: 13.011 ± 0.125	6.527LysLeu: 6.527 ± 0.058	2.268LysMet: 2.268 ± 0.026	7.762LysAsn: 7.762 ± 0.068	1.89LysPro: 1.89 ± 0.035	2.702LysGln: 2.702 ± 0.033	5.601LysArg: 5.601 ± 0.056	5.464LysSer: 5.464 ± 0.045	3.487LysThr: 3.487 ± 0.039	3.833LysVal: 3.833 ± 0.038	0.764LysTrp: 0.764 ± 0.018	3.872LysTyr: 3.872 ± 0.043	0.004LysXaa: 0.004 ± 0.002
Leu	3.375LeuAla: 3.375 ± 0.037	1.925LeuCys: 1.925 ± 0.028	3.564LeuAsp: 3.564 ± 0.037	4.662LeuGlu: 4.662 ± 0.053	4.767LeuPhe: 4.767 ± 0.056	3.618LeuGly: 3.618 ± 0.042	2.585LeuHis: 2.585 ± 0.031	4.767LeuIle: 4.767 ± 0.049	7.734LeuLys: 7.734 ± 0.07	8.742LeuLeu: 8.742 ± 0.077	1.556LeuMet: 1.556 ± 0.021	6.224LeuAsn: 6.224 ± 0.058	3.141LeuPro: 3.141 ± 0.036	3.0LeuGln: 3.0 ± 0.036	4.005LeuArg: 4.005 ± 0.041	6.967LeuSer: 6.967 ± 0.054	3.647LeuThr: 3.647 ± 0.034	3.499LeuVal: 3.499 ± 0.037	0.541LeuTrp: 0.541 ± 0.016	3.82LeuTyr: 3.82 ± 0.041	0.001LeuXaa: 0.001 ± 0.001
Met	0.931MetAla: 0.931 ± 0.018	0.429MetCys: 0.429 ± 0.012	1.094MetAsp: 1.094 ± 0.018	1.569MetGlu: 1.569 ± 0.022	0.714MetPhe: 0.714 ± 0.016	1.32MetGly: 1.32 ± 0.028	0.642MetHis: 0.642 ± 0.013	0.911MetIle: 0.911 ± 0.017	2.072MetLys: 2.072 ± 0.029	1.6MetLeu: 1.6 ± 0.023	0.505MetMet: 0.505 ± 0.013	1.908MetAsn: 1.908 ± 0.037	0.643MetPro: 0.643 ± 0.019	0.764MetGln: 0.764 ± 0.017	0.981MetArg: 0.981 ± 0.019	1.555MetSer: 1.555 ± 0.025	0.724MetThr: 0.724 ± 0.016	0.828MetVal: 0.828 ± 0.015	0.138MetTrp: 0.138 ± 0.006	0.846MetTyr: 0.846 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	3.805AsnAla: 3.805 ± 0.049	1.407AsnCys: 1.407 ± 0.025	4.025AsnAsp: 4.025 ± 0.048	5.774AsnGlu: 5.774 ± 0.061	3.53AsnPhe: 3.53 ± 0.041	4.678AsnGly: 4.678 ± 0.063	1.671AsnHis: 1.671 ± 0.027	4.728AsnIle: 4.728 ± 0.06	5.612AsnLys: 5.612 ± 0.052	5.953AsnLeu: 5.953 ± 0.062	1.654AsnMet: 1.654 ± 0.036	5.08AsnAsn: 5.08 ± 0.079	2.316AsnPro: 2.316 ± 0.034	2.082AsnGln: 2.082 ± 0.03	3.171AsnArg: 3.171 ± 0.039	5.574AsnSer: 5.574 ± 0.061	2.764AsnThr: 2.764 ± 0.035	4.697AsnVal: 4.697 ± 0.051	0.436AsnTrp: 0.436 ± 0.013	3.482AsnTyr: 3.482 ± 0.04	0.002AsnXaa: 0.002 ± 0.001
Pro	1.747ProAla: 1.747 ± 0.031	0.602ProCys: 0.602 ± 0.017	1.418ProAsp: 1.418 ± 0.023	1.842ProGlu: 1.842 ± 0.033	1.741ProPhe: 1.741 ± 0.029	1.928ProGly: 1.928 ± 0.03	1.325ProHis: 1.325 ± 0.024	1.643ProIle: 1.643 ± 0.025	2.329ProLys: 2.329 ± 0.033	3.285ProLeu: 3.285 ± 0.041	0.628ProMet: 0.628 ± 0.017	2.648ProAsn: 2.648 ± 0.043	3.248ProPro: 3.248 ± 0.055	1.528ProGln: 1.528 ± 0.032	1.629ProArg: 1.629 ± 0.029	3.537ProSer: 3.537 ± 0.042	1.829ProThr: 1.829 ± 0.027	1.726ProVal: 1.726 ± 0.029	0.219ProTrp: 0.219 ± 0.008	1.228ProTyr: 1.228 ± 0.024	0.001ProXaa: 0.001 ± 0.001
Gln	1.416GlnAla: 1.416 ± 0.026	0.458GlnCys: 0.458 ± 0.011	1.255GlnAsp: 1.255 ± 0.021	2.227GlnGlu: 2.227 ± 0.036	1.145GlnPhe: 1.145 ± 0.02	2.073GlnGly: 2.073 ± 0.031	0.861GlnHis: 0.861 ± 0.019	1.966GlnIle: 1.966 ± 0.026	3.166GlnLys: 3.166 ± 0.038	2.784GlnLeu: 2.784 ± 0.033	1.089GlnMet: 1.089 ± 0.018	2.743GlnAsn: 2.743 ± 0.038	1.241GlnPro: 1.241 ± 0.029	1.491GlnGln: 1.491 ± 0.042	1.906GlnArg: 1.906 ± 0.03	2.4GlnSer: 2.4 ± 0.027	1.561GlnThr: 1.561 ± 0.025	1.747GlnVal: 1.747 ± 0.022	0.259GlnTrp: 0.259 ± 0.009	0.978GlnTyr: 0.978 ± 0.019	0.001GlnXaa: 0.001 ± 0.0
Arg	2.319ArgAla: 2.319 ± 0.035	0.846ArgCys: 0.846 ± 0.017	2.683ArgAsp: 2.683 ± 0.04	4.06ArgGlu: 4.06 ± 0.039	1.44ArgPhe: 1.44 ± 0.024	4.427ArgGly: 4.427 ± 0.063	1.244ArgHis: 1.244 ± 0.023	2.366ArgIle: 2.366 ± 0.028	5.121ArgLys: 5.121 ± 0.052	2.911ArgLeu: 2.911 ± 0.037	0.959ArgMet: 0.959 ± 0.023	3.539ArgAsn: 3.539 ± 0.039	1.189ArgPro: 1.189 ± 0.024	1.443ArgGln: 1.443 ± 0.025	4.001ArgArg: 4.001 ± 0.062	4.249ArgSer: 4.249 ± 0.059	1.932ArgThr: 1.932 ± 0.026	2.384ArgVal: 2.384 ± 0.036	0.287ArgTrp: 0.287 ± 0.01	1.612ArgTyr: 1.612 ± 0.024	0.001ArgXaa: 0.001 ± 0.0
Ser	4.621SerAla: 4.621 ± 0.05	1.492SerCys: 1.492 ± 0.025	4.504SerAsp: 4.504 ± 0.04	5.206SerGlu: 5.206 ± 0.039	3.699SerPhe: 3.699 ± 0.036	6.476SerGly: 6.476 ± 0.082	2.222SerHis: 2.222 ± 0.033	4.201SerIle: 4.201 ± 0.044	5.753SerLys: 5.753 ± 0.05	6.359SerLeu: 6.359 ± 0.057	1.318SerMet: 1.318 ± 0.025	5.645SerAsn: 5.645 ± 0.062	3.233SerPro: 3.233 ± 0.043	2.397SerGln: 2.397 ± 0.03	3.507SerArg: 3.507 ± 0.044	8.6SerSer: 8.6 ± 0.093	3.734SerThr: 3.734 ± 0.039	4.149SerVal: 4.149 ± 0.045	0.41SerTrp: 0.41 ± 0.01	3.228SerTyr: 3.228 ± 0.031	0.002SerXaa: 0.002 ± 0.001
Thr	2.345ThrAla: 2.345 ± 0.031	0.899ThrCys: 0.899 ± 0.018	2.256ThrAsp: 2.256 ± 0.03	2.593ThrGlu: 2.593 ± 0.033	2.013ThrPhe: 2.013 ± 0.025	2.325ThrGly: 2.325 ± 0.034	1.531ThrHis: 1.531 ± 0.027	2.29ThrIle: 2.29 ± 0.028	3.309ThrLys: 3.309 ± 0.041	3.679ThrLeu: 3.679 ± 0.031	0.687ThrMet: 0.687 ± 0.014	3.322ThrAsn: 3.322 ± 0.035	2.421ThrPro: 2.421 ± 0.035	1.575ThrGln: 1.575 ± 0.02	1.616ThrArg: 1.616 ± 0.023	3.65ThrSer: 3.65 ± 0.038	2.223ThrThr: 2.223 ± 0.032	2.08ThrVal: 2.08 ± 0.027	0.283ThrTrp: 0.283 ± 0.009	1.896ThrTyr: 1.896 ± 0.028	0.002ThrXaa: 0.002 ± 0.001
Val	2.674ValAla: 2.674 ± 0.031	1.071ValCys: 1.071 ± 0.019	3.221ValAsp: 3.221 ± 0.033	4.088ValGlu: 4.088 ± 0.064	2.002ValPhe: 2.002 ± 0.03	3.262ValGly: 3.262 ± 0.042	1.616ValHis: 1.616 ± 0.021	2.771ValIle: 2.771 ± 0.035	4.826ValLys: 4.826 ± 0.041	4.36ValLeu: 4.36 ± 0.043	0.892ValMet: 0.892 ± 0.017	3.7ValAsn: 3.7 ± 0.036	1.915ValPro: 1.915 ± 0.032	1.811ValGln: 1.811 ± 0.022	2.405ValArg: 2.405 ± 0.028	4.192ValSer: 4.192 ± 0.042	2.332ValThr: 2.332 ± 0.027	2.829ValVal: 2.829 ± 0.036	0.283ValTrp: 0.283 ± 0.01	2.187ValTyr: 2.187 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	0.268TrpAla: 0.268 ± 0.009	0.124TrpCys: 0.124 ± 0.006	0.348TrpAsp: 0.348 ± 0.011	0.441TrpGlu: 0.441 ± 0.014	0.244TrpPhe: 0.244 ± 0.009	0.499TrpGly: 0.499 ± 0.014	0.129TrpHis: 0.129 ± 0.006	0.346TrpIle: 0.346 ± 0.01	0.666TrpLys: 0.666 ± 0.018	0.531TrpLeu: 0.531 ± 0.012	0.136TrpMet: 0.136 ± 0.007	0.444TrpAsn: 0.444 ± 0.013	0.157TrpPro: 0.157 ± 0.007	0.15TrpGln: 0.15 ± 0.006	0.373TrpArg: 0.373 ± 0.012	0.461TrpSer: 0.461 ± 0.013	0.238TrpThr: 0.238 ± 0.009	0.394TrpVal: 0.394 ± 0.011	0.053TrpTrp: 0.053 ± 0.004	0.189TrpTyr: 0.189 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.952TyrAla: 1.952 ± 0.026	0.706TyrCys: 0.706 ± 0.016	2.614TyrAsp: 2.614 ± 0.031	2.749TyrGlu: 2.749 ± 0.035	2.259TyrPhe: 2.259 ± 0.031	1.853TyrGly: 1.853 ± 0.037	1.033TyrHis: 1.033 ± 0.02	2.852TyrIle: 2.852 ± 0.041	3.124TyrLys: 3.124 ± 0.034	3.896TyrLeu: 3.896 ± 0.043	0.877TyrMet: 0.877 ± 0.016	2.93TyrAsn: 2.93 ± 0.042	1.197TyrPro: 1.197 ± 0.02	1.117TyrGln: 1.117 ± 0.02	1.588TyrArg: 1.588 ± 0.024	2.869TyrSer: 2.869 ± 0.036	1.747TyrThr: 1.747 ± 0.024	2.547TyrVal: 2.547 ± 0.03	0.264TyrTrp: 0.264 ± 0.009	2.01TyrTyr: 2.01 ± 0.031	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.003XaaTyr: 0.003 ± 0.001	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 5389 proteins (3748164 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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