Amino acid dipepetide frequency for Terrimonas sp. NS-102

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.823AlaAla: 6.823 ± 0.081
0.761AlaCys: 0.761 ± 0.024
4.39AlaAsp: 4.39 ± 0.052
4.298AlaGlu: 4.298 ± 0.064
3.667AlaPhe: 3.667 ± 0.051
6.192AlaGly: 6.192 ± 0.066
1.219AlaHis: 1.219 ± 0.029
5.524AlaIle: 5.524 ± 0.066
4.659AlaLys: 4.659 ± 0.06
6.987AlaLeu: 6.987 ± 0.074
1.743AlaMet: 1.743 ± 0.032
3.535AlaAsn: 3.535 ± 0.045
2.469AlaPro: 2.469 ± 0.04
2.692AlaGln: 2.692 ± 0.042
2.51AlaArg: 2.51 ± 0.041
4.442AlaSer: 4.442 ± 0.057
4.084AlaThr: 4.084 ± 0.056
5.199AlaVal: 5.199 ± 0.058
0.926AlaTrp: 0.926 ± 0.024
2.991AlaTyr: 2.991 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.537CysAla: 0.537 ± 0.017
0.169CysCys: 0.169 ± 0.01
0.423CysAsp: 0.423 ± 0.018
0.435CysGlu: 0.435 ± 0.016
0.499CysPhe: 0.499 ± 0.016
0.684CysGly: 0.684 ± 0.021
0.203CysHis: 0.203 ± 0.013
0.81CysIle: 0.81 ± 0.021
0.512CysLys: 0.512 ± 0.018
0.748CysLeu: 0.748 ± 0.022
0.211CysMet: 0.211 ± 0.01
0.47CysAsn: 0.47 ± 0.016
0.346CysPro: 0.346 ± 0.014
0.214CysGln: 0.214 ± 0.01
0.363CysArg: 0.363 ± 0.014
0.541CysSer: 0.541 ± 0.02
0.484CysThr: 0.484 ± 0.016
0.466CysVal: 0.466 ± 0.016
0.112CysTrp: 0.112 ± 0.008
0.383CysTyr: 0.383 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.12AspAla: 4.12 ± 0.055
0.394AspCys: 0.394 ± 0.014
2.718AspAsp: 2.718 ± 0.046
3.318AspGlu: 3.318 ± 0.052
2.923AspPhe: 2.923 ± 0.04
3.851AspGly: 3.851 ± 0.06
0.95AspHis: 0.95 ± 0.022
4.642AspIle: 4.642 ± 0.061
3.981AspLys: 3.981 ± 0.052
4.121AspLeu: 4.121 ± 0.061
1.221AspMet: 1.221 ± 0.031
3.011AspAsn: 3.011 ± 0.044
2.03AspPro: 2.03 ± 0.039
1.45AspGln: 1.45 ± 0.031
1.91AspArg: 1.91 ± 0.033
3.043AspSer: 3.043 ± 0.048
2.81AspThr: 2.81 ± 0.046
3.252AspVal: 3.252 ± 0.049
0.822AspTrp: 0.822 ± 0.025
2.454AspTyr: 2.454 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
4.267GluAla: 4.267 ± 0.065
0.357GluCys: 0.357 ± 0.014
2.698GluAsp: 2.698 ± 0.044
3.699GluGlu: 3.699 ± 0.063
2.158GluPhe: 2.158 ± 0.035
3.454GluGly: 3.454 ± 0.045
1.035GluHis: 1.035 ± 0.026
4.226GluIle: 4.226 ± 0.053
5.392GluLys: 5.392 ± 0.071
5.163GluLeu: 5.163 ± 0.064
1.519GluMet: 1.519 ± 0.033
3.389GluAsn: 3.389 ± 0.043
1.663GluPro: 1.663 ± 0.029
2.41GluGln: 2.41 ± 0.044
2.464GluArg: 2.464 ± 0.04
2.668GluSer: 2.668 ± 0.041
2.996GluThr: 2.996 ± 0.041
3.386GluVal: 3.386 ± 0.047
0.82GluTrp: 0.82 ± 0.026
2.155GluTyr: 2.155 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.292PheAla: 3.292 ± 0.045
0.495PheCys: 0.495 ± 0.017
2.818PheAsp: 2.818 ± 0.046
2.665PheGlu: 2.665 ± 0.039
2.75PhePhe: 2.75 ± 0.047
3.165PheGly: 3.165 ± 0.045
0.833PheHis: 0.833 ± 0.021
3.752PheIle: 3.752 ± 0.057
3.08PheLys: 3.08 ± 0.04
4.249PheLeu: 4.249 ± 0.058
1.061PheMet: 1.061 ± 0.027
2.957PheAsn: 2.957 ± 0.05
1.851PhePro: 1.851 ± 0.032
1.371PheGln: 1.371 ± 0.028
1.943PheArg: 1.943 ± 0.036
3.924PheSer: 3.924 ± 0.052
3.161PheThr: 3.161 ± 0.049
2.8PheVal: 2.8 ± 0.046
0.595PheTrp: 0.595 ± 0.021
2.086PheTyr: 2.086 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
4.756GlyAla: 4.756 ± 0.057
0.669GlyCys: 0.669 ± 0.021
3.505GlyAsp: 3.505 ± 0.054
3.535GlyGlu: 3.535 ± 0.051
3.504GlyPhe: 3.504 ± 0.05
4.983GlyGly: 4.983 ± 0.082
1.124GlyHis: 1.124 ± 0.027
5.671GlyIle: 5.671 ± 0.064
5.525GlyLys: 5.525 ± 0.065
5.909GlyLeu: 5.909 ± 0.063
1.716GlyMet: 1.716 ± 0.032
4.157GlyAsn: 4.157 ± 0.067
1.409GlyPro: 1.409 ± 0.031
1.986GlyGln: 1.986 ± 0.037
2.727GlyArg: 2.727 ± 0.044
4.325GlySer: 4.325 ± 0.07
4.096GlyThr: 4.096 ± 0.065
4.308GlyVal: 4.308 ± 0.057
1.11GlyTrp: 1.11 ± 0.027
3.336GlyTyr: 3.336 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.243HisAla: 1.243 ± 0.03
0.207HisCys: 0.207 ± 0.013
0.841HisAsp: 0.841 ± 0.023
0.968HisGlu: 0.968 ± 0.026
1.156HisPhe: 1.156 ± 0.025
1.136HisGly: 1.136 ± 0.028
0.54HisHis: 0.54 ± 0.02
1.495HisIle: 1.495 ± 0.031
1.107HisLys: 1.107 ± 0.025
1.797HisLeu: 1.797 ± 0.035
0.363HisMet: 0.363 ± 0.015
1.009HisAsn: 1.009 ± 0.026
0.973HisPro: 0.973 ± 0.025
0.673HisGln: 0.673 ± 0.019
0.733HisArg: 0.733 ± 0.019
1.111HisSer: 1.111 ± 0.025
1.07HisThr: 1.07 ± 0.021
0.928HisVal: 0.928 ± 0.023
0.291HisTrp: 0.291 ± 0.013
0.913HisTyr: 0.913 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.309IleAla: 6.309 ± 0.067
0.755IleCys: 0.755 ± 0.022
4.242IleAsp: 4.242 ± 0.051
4.3IleGlu: 4.3 ± 0.059
3.395IlePhe: 3.395 ± 0.055
4.629IleGly: 4.629 ± 0.063
1.376IleHis: 1.376 ± 0.032
5.779IleIle: 5.779 ± 0.071
5.131IleLys: 5.131 ± 0.061
6.264IleLeu: 6.264 ± 0.064
1.454IleMet: 1.454 ± 0.031
4.339IleAsn: 4.339 ± 0.048
3.377IlePro: 3.377 ± 0.041
2.503IleGln: 2.503 ± 0.04
3.122IleArg: 3.122 ± 0.044
5.32IleSer: 5.32 ± 0.066
5.039IleThr: 5.039 ± 0.067
4.502IleVal: 4.502 ± 0.057
0.796IleTrp: 0.796 ± 0.021
2.871IleTyr: 2.871 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
5.38LysAla: 5.38 ± 0.063
0.381LysCys: 0.381 ± 0.014
4.256LysAsp: 4.256 ± 0.062
4.948LysGlu: 4.948 ± 0.071
2.521LysPhe: 2.521 ± 0.038
4.576LysGly: 4.576 ± 0.055
1.372LysHis: 1.372 ± 0.029
5.342LysIle: 5.342 ± 0.058
6.341LysLys: 6.341 ± 0.07
5.819LysLeu: 5.819 ± 0.069
1.978LysMet: 1.978 ± 0.036
4.427LysAsn: 4.427 ± 0.051
2.857LysPro: 2.857 ± 0.038
3.08LysGln: 3.08 ± 0.042
2.809LysArg: 2.809 ± 0.045
3.865LysSer: 3.865 ± 0.053
4.151LysThr: 4.151 ± 0.049
4.114LysVal: 4.114 ± 0.058
1.011LysTrp: 1.011 ± 0.026
2.989LysTyr: 2.989 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
6.196LeuAla: 6.196 ± 0.074
0.865LeuCys: 0.865 ± 0.023
4.234LeuAsp: 4.234 ± 0.053
4.452LeuGlu: 4.452 ± 0.063
4.614LeuPhe: 4.614 ± 0.062
5.272LeuGly: 5.272 ± 0.067
1.84LeuHis: 1.84 ± 0.032
6.081LeuIle: 6.081 ± 0.069
6.833LeuLys: 6.833 ± 0.058
9.232LeuLeu: 9.232 ± 0.085
2.088LeuMet: 2.088 ± 0.036
5.167LeuAsn: 5.167 ± 0.065
4.203LeuPro: 4.203 ± 0.052
4.091LeuGln: 4.091 ± 0.055
3.579LeuArg: 3.579 ± 0.051
6.644LeuSer: 6.644 ± 0.065
5.254LeuThr: 5.254 ± 0.056
5.01LeuVal: 5.01 ± 0.052
1.026LeuTrp: 1.026 ± 0.027
3.5LeuTyr: 3.5 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
1.672MetAla: 1.672 ± 0.028
0.156MetCys: 0.156 ± 0.01
1.142MetAsp: 1.142 ± 0.027
1.333MetGlu: 1.333 ± 0.027
0.874MetPhe: 0.874 ± 0.022
1.427MetGly: 1.427 ± 0.029
0.524MetHis: 0.524 ± 0.018
1.534MetIle: 1.534 ± 0.032
2.028MetLys: 2.028 ± 0.036
2.336MetLeu: 2.336 ± 0.04
0.671MetMet: 0.671 ± 0.022
1.3MetAsn: 1.3 ± 0.025
1.152MetPro: 1.152 ± 0.024
1.184MetGln: 1.184 ± 0.027
1.034MetArg: 1.034 ± 0.023
1.315MetSer: 1.315 ± 0.028
1.04MetThr: 1.04 ± 0.028
1.341MetVal: 1.341 ± 0.028
0.236MetTrp: 0.236 ± 0.012
0.761MetTyr: 0.761 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
4.411AsnAla: 4.411 ± 0.052
0.432AsnCys: 0.432 ± 0.017
3.052AsnAsp: 3.052 ± 0.047
3.099AsnGlu: 3.099 ± 0.047
2.656AsnPhe: 2.656 ± 0.047
4.071AsnGly: 4.071 ± 0.067
0.899AsnHis: 0.899 ± 0.024
5.042AsnIle: 5.042 ± 0.059
3.959AsnLys: 3.959 ± 0.052
4.438AsnLeu: 4.438 ± 0.047
1.195AsnMet: 1.195 ± 0.027
3.774AsnAsn: 3.774 ± 0.061
2.7AsnPro: 2.7 ± 0.043
1.812AsnGln: 1.812 ± 0.035
2.344AsnArg: 2.344 ± 0.039
3.132AsnSer: 3.132 ± 0.047
3.589AsnThr: 3.589 ± 0.06
3.202AsnVal: 3.202 ± 0.047
0.791AsnTrp: 0.791 ± 0.023
2.55AsnTyr: 2.55 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.593ProAla: 3.593 ± 0.051
0.232ProCys: 0.232 ± 0.013
2.67ProAsp: 2.67 ± 0.044
2.74ProGlu: 2.74 ± 0.042
1.934ProPhe: 1.934 ± 0.031
3.26ProGly: 3.26 ± 0.046
0.702ProHis: 0.702 ± 0.022
1.88ProIle: 1.88 ± 0.033
1.967ProLys: 1.967 ± 0.037
3.372ProLeu: 3.372 ± 0.046
0.736ProMet: 0.736 ± 0.021
1.648ProAsn: 1.648 ± 0.029
1.25ProPro: 1.25 ± 0.039
1.432ProGln: 1.432 ± 0.03
1.175ProArg: 1.175 ± 0.029
2.383ProSer: 2.383 ± 0.043
1.731ProThr: 1.731 ± 0.033
3.837ProVal: 3.837 ± 0.054
0.492ProTrp: 0.492 ± 0.018
1.68ProTyr: 1.68 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
2.417GlnAla: 2.417 ± 0.041
0.241GlnCys: 0.241 ± 0.012
1.494GlnAsp: 1.494 ± 0.029
1.933GlnGlu: 1.933 ± 0.033
1.657GlnPhe: 1.657 ± 0.03
1.867GlnGly: 1.867 ± 0.035
0.934GlnHis: 0.934 ± 0.027
2.246GlnIle: 2.246 ± 0.031
2.947GlnLys: 2.947 ± 0.043
3.888GlnLeu: 3.888 ± 0.051
0.893GlnMet: 0.893 ± 0.024
1.979GlnAsn: 1.979 ± 0.036
1.55GlnPro: 1.55 ± 0.029
2.291GlnGln: 2.291 ± 0.048
1.537GlnArg: 1.537 ± 0.029
2.292GlnSer: 2.292 ± 0.034
2.12GlnThr: 2.12 ± 0.037
2.254GlnVal: 2.254 ± 0.041
0.544GlnTrp: 0.544 ± 0.016
1.699GlnTyr: 1.699 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.262ArgAla: 2.262 ± 0.039
0.264ArgCys: 0.264 ± 0.012
1.838ArgAsp: 1.838 ± 0.039
2.181ArgGlu: 2.181 ± 0.038
2.15ArgPhe: 2.15 ± 0.034
2.227ArgGly: 2.227 ± 0.035
0.748ArgHis: 0.748 ± 0.021
3.256ArgIle: 3.256 ± 0.045
3.151ArgLys: 3.151 ± 0.049
3.847ArgLeu: 3.847 ± 0.05
1.121ArgMet: 1.121 ± 0.026
2.473ArgAsn: 2.473 ± 0.035
1.269ArgPro: 1.269 ± 0.03
1.603ArgGln: 1.603 ± 0.037
1.731ArgArg: 1.731 ± 0.036
2.372ArgSer: 2.372 ± 0.04
2.014ArgThr: 2.014 ± 0.034
2.289ArgVal: 2.289 ± 0.037
0.6ArgTrp: 0.6 ± 0.021
1.907ArgTyr: 1.907 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
4.788SerAla: 4.788 ± 0.058
0.629SerCys: 0.629 ± 0.018
3.084SerAsp: 3.084 ± 0.04
2.944SerGlu: 2.944 ± 0.039
3.714SerPhe: 3.714 ± 0.057
5.214SerGly: 5.214 ± 0.068
1.033SerHis: 1.033 ± 0.026
4.818SerIle: 4.818 ± 0.054
3.863SerLys: 3.863 ± 0.05
6.008SerLeu: 6.008 ± 0.06
1.307SerMet: 1.307 ± 0.031
3.291SerAsn: 3.291 ± 0.051
2.451SerPro: 2.451 ± 0.04
1.837SerGln: 1.837 ± 0.032
2.506SerArg: 2.506 ± 0.039
4.294SerSer: 4.294 ± 0.072
3.421SerThr: 3.421 ± 0.056
4.264SerVal: 4.264 ± 0.056
0.859SerTrp: 0.859 ± 0.024
2.712SerTyr: 2.712 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.836ThrAla: 4.836 ± 0.065
0.423ThrCys: 0.423 ± 0.016
3.379ThrAsp: 3.379 ± 0.046
2.951ThrGlu: 2.951 ± 0.05
2.516ThrPhe: 2.516 ± 0.038
5.115ThrGly: 5.115 ± 0.065
1.008ThrHis: 1.008 ± 0.027
4.611ThrIle: 4.611 ± 0.053
3.21ThrLys: 3.21 ± 0.042
5.24ThrLeu: 5.24 ± 0.056
1.024ThrMet: 1.024 ± 0.024
2.989ThrAsn: 2.989 ± 0.048
2.573ThrPro: 2.573 ± 0.038
1.872ThrGln: 1.872 ± 0.03
2.009ThrArg: 2.009 ± 0.033
3.406ThrSer: 3.406 ± 0.051
3.548ThrThr: 3.548 ± 0.058
3.902ThrVal: 3.902 ± 0.059
0.723ThrTrp: 0.723 ± 0.022
2.344ThrTyr: 2.344 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
4.494ValAla: 4.494 ± 0.057
0.64ValCys: 0.64 ± 0.02
3.151ValAsp: 3.151 ± 0.05
3.322ValGlu: 3.322 ± 0.047
3.202ValPhe: 3.202 ± 0.05
3.439ValGly: 3.439 ± 0.049
1.075ValHis: 1.075 ± 0.026
4.812ValIle: 4.812 ± 0.057
4.579ValLys: 4.579 ± 0.05
5.792ValLeu: 5.792 ± 0.062
1.497ValMet: 1.497 ± 0.032
3.608ValAsn: 3.608 ± 0.048
2.464ValPro: 2.464 ± 0.034
2.149ValGln: 2.149 ± 0.041
2.252ValArg: 2.252 ± 0.038
4.414ValSer: 4.414 ± 0.057
3.661ValThr: 3.661 ± 0.056
4.022ValVal: 4.022 ± 0.059
0.781ValTrp: 0.781 ± 0.022
2.6ValTyr: 2.6 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.754TrpAla: 0.754 ± 0.022
0.139TrpCys: 0.139 ± 0.009
0.717TrpAsp: 0.717 ± 0.025
0.698TrpGlu: 0.698 ± 0.019
0.635TrpPhe: 0.635 ± 0.022
0.941TrpGly: 0.941 ± 0.026
0.324TrpHis: 0.324 ± 0.016
0.962TrpIle: 0.962 ± 0.027
1.044TrpLys: 1.044 ± 0.024
1.359TrpLeu: 1.359 ± 0.032
0.395TrpMet: 0.395 ± 0.017
0.834TrpAsn: 0.834 ± 0.027
0.34TrpPro: 0.34 ± 0.017
0.633TrpGln: 0.633 ± 0.02
0.615TrpArg: 0.615 ± 0.023
0.761TrpSer: 0.761 ± 0.021
0.645TrpThr: 0.645 ± 0.022
0.778TrpVal: 0.778 ± 0.022
0.246TrpTrp: 0.246 ± 0.012
0.573TrpTyr: 0.573 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.961TyrAla: 2.961 ± 0.041
0.399TyrCys: 0.399 ± 0.016
2.37TyrAsp: 2.37 ± 0.046
2.101TyrGlu: 2.101 ± 0.03
2.323TyrPhe: 2.323 ± 0.031
2.849TyrGly: 2.849 ± 0.047
0.813TyrHis: 0.813 ± 0.021
3.018TyrIle: 3.018 ± 0.04
2.909TyrLys: 2.909 ± 0.045
3.613TyrLeu: 3.613 ± 0.041
0.866TyrMet: 0.866 ± 0.022
2.794TyrAsn: 2.794 ± 0.05
1.789TyrPro: 1.789 ± 0.034
1.499TyrGln: 1.499 ± 0.032
1.942TyrArg: 1.942 ± 0.036
2.787TyrSer: 2.787 ± 0.044
2.762TyrThr: 2.762 ± 0.045
2.097TyrVal: 2.097 ± 0.035
0.612TyrTrp: 0.612 ± 0.02
2.115TyrTyr: 2.115 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5019 proteins (1778361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski