Amino acid dipepetide frequency for Chytriomyces confervae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.3AlaAla: 10.3 ± 0.075	1.168AlaCys: 1.168 ± 0.015	4.293AlaAsp: 4.293 ± 0.032	4.882AlaGlu: 4.882 ± 0.034	3.49AlaPhe: 3.49 ± 0.025	5.474AlaGly: 5.474 ± 0.047	1.77AlaHis: 1.77 ± 0.02	4.436AlaIle: 4.436 ± 0.03	4.766AlaLys: 4.766 ± 0.039	8.083AlaLeu: 8.083 ± 0.044	2.099AlaMet: 2.099 ± 0.021	3.518AlaAsn: 3.518 ± 0.024	4.381AlaPro: 4.381 ± 0.041	3.236AlaGln: 3.236 ± 0.028	4.088AlaArg: 4.088 ± 0.028	8.456AlaSer: 8.456 ± 0.05	5.618AlaThr: 5.618 ± 0.038	6.511AlaVal: 6.511 ± 0.045	0.87AlaTrp: 0.87 ± 0.013	2.047AlaTyr: 2.047 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.097CysAla: 1.097 ± 0.015	0.269CysCys: 0.269 ± 0.008	0.661CysAsp: 0.661 ± 0.011	0.647CysGlu: 0.647 ± 0.012	0.654CysPhe: 0.654 ± 0.01	1.016CysGly: 1.016 ± 0.017	0.294CysHis: 0.294 ± 0.006	0.838CysIle: 0.838 ± 0.013	0.661CysLys: 0.661 ± 0.011	1.381CysLeu: 1.381 ± 0.018	0.318CysMet: 0.318 ± 0.009	0.525CysAsn: 0.525 ± 0.01	0.625CysPro: 0.625 ± 0.017	0.445CysGln: 0.445 ± 0.01	0.612CysArg: 0.612 ± 0.011	1.035CysSer: 1.035 ± 0.014	0.768CysThr: 0.768 ± 0.011	1.017CysVal: 1.017 ± 0.014	0.165CysTrp: 0.165 ± 0.006	0.346CysTyr: 0.346 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.459AspAla: 5.459 ± 0.033	0.678AspCys: 0.678 ± 0.013	3.582AspAsp: 3.582 ± 0.044	3.931AspGlu: 3.931 ± 0.036	2.279AspPhe: 2.279 ± 0.024	3.707AspGly: 3.707 ± 0.028	1.048AspHis: 1.048 ± 0.014	2.721AspIle: 2.721 ± 0.021	2.346AspLys: 2.346 ± 0.025	4.977AspLeu: 4.977 ± 0.03	1.33AspMet: 1.33 ± 0.014	1.707AspAsn: 1.707 ± 0.02	2.744AspPro: 2.744 ± 0.02	1.613AspGln: 1.613 ± 0.017	2.447AspArg: 2.447 ± 0.025	4.546AspSer: 4.546 ± 0.033	2.828AspThr: 2.828 ± 0.024	3.689AspVal: 3.689 ± 0.027	0.692AspTrp: 0.692 ± 0.013	1.381AspTyr: 1.381 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	4.958GluAla: 4.958 ± 0.045	0.733GluCys: 0.733 ± 0.011	3.476GluAsp: 3.476 ± 0.033	4.43GluGlu: 4.43 ± 0.051	2.325GluPhe: 2.325 ± 0.023	3.067GluGly: 3.067 ± 0.024	1.22GluHis: 1.22 ± 0.017	3.151GluIle: 3.151 ± 0.031	3.664GluLys: 3.664 ± 0.037	5.048GluLeu: 5.048 ± 0.04	1.684GluMet: 1.684 ± 0.02	2.525GluAsn: 2.525 ± 0.023	2.111GluPro: 2.111 ± 0.025	2.143GluGln: 2.143 ± 0.024	3.351GluArg: 3.351 ± 0.027	4.9GluSer: 4.9 ± 0.033	3.726GluThr: 3.726 ± 0.054	3.435GluVal: 3.435 ± 0.042	0.709GluTrp: 0.709 ± 0.011	1.603GluTyr: 1.603 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.302PheAla: 3.302 ± 0.026	0.617PheCys: 0.617 ± 0.011	2.466PheAsp: 2.466 ± 0.022	2.511PheGlu: 2.511 ± 0.021	1.664PhePhe: 1.664 ± 0.021	3.041PheGly: 3.041 ± 0.029	0.965PheHis: 0.965 ± 0.014	2.008PheIle: 2.008 ± 0.024	2.101PheLys: 2.101 ± 0.02	3.684PheLeu: 3.684 ± 0.028	1.061PheMet: 1.061 ± 0.014	1.791PheAsn: 1.791 ± 0.018	1.792PhePro: 1.792 ± 0.018	1.526PheGln: 1.526 ± 0.017	1.829PheArg: 1.829 ± 0.017	3.455PheSer: 3.455 ± 0.029	2.231PheThr: 2.231 ± 0.021	2.814PheVal: 2.814 ± 0.026	0.534PheTrp: 0.534 ± 0.01	1.202PheTyr: 1.202 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.178GlyAla: 5.178 ± 0.043	0.854GlyCys: 0.854 ± 0.014	3.19GlyAsp: 3.19 ± 0.024	2.99GlyGlu: 2.99 ± 0.03	2.813GlyPhe: 2.813 ± 0.026	5.654GlyGly: 5.654 ± 0.068	1.388GlyHis: 1.388 ± 0.02	3.398GlyIle: 3.398 ± 0.033	3.401GlyLys: 3.401 ± 0.028	5.361GlyLeu: 5.361 ± 0.038	1.565GlyMet: 1.565 ± 0.019	2.67GlyAsn: 2.67 ± 0.028	2.459GlyPro: 2.459 ± 0.024	1.955GlyGln: 1.955 ± 0.021	3.078GlyArg: 3.078 ± 0.026	5.713GlySer: 5.713 ± 0.045	3.54GlyThr: 3.54 ± 0.028	4.649GlyVal: 4.649 ± 0.036	0.828GlyTrp: 0.828 ± 0.012	1.773GlyTyr: 1.773 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.048HisAla: 2.048 ± 0.02	0.344HisCys: 0.344 ± 0.008	1.059HisAsp: 1.059 ± 0.016	1.233HisGlu: 1.233 ± 0.016	1.007HisPhe: 1.007 ± 0.014	1.408HisGly: 1.408 ± 0.02	0.779HisHis: 0.779 ± 0.015	1.129HisIle: 1.129 ± 0.013	0.96HisLys: 0.96 ± 0.014	2.351HisLeu: 2.351 ± 0.019	0.503HisMet: 0.503 ± 0.009	0.855HisAsn: 0.855 ± 0.014	1.406HisPro: 1.406 ± 0.02	1.041HisGln: 1.041 ± 0.016	1.189HisArg: 1.189 ± 0.016	2.059HisSer: 2.059 ± 0.025	1.159HisThr: 1.159 ± 0.013	1.658HisVal: 1.658 ± 0.016	0.262HisTrp: 0.262 ± 0.007	0.594HisTyr: 0.594 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.536IleAla: 4.536 ± 0.032	0.773IleCys: 0.773 ± 0.013	2.697IleAsp: 2.697 ± 0.024	2.998IleGlu: 2.998 ± 0.027	1.928IlePhe: 1.928 ± 0.021	3.046IleGly: 3.046 ± 0.031	1.346IleHis: 1.346 ± 0.015	2.464IleIle: 2.464 ± 0.024	2.513IleLys: 2.513 ± 0.023	4.951IleLeu: 4.951 ± 0.032	1.122IleMet: 1.122 ± 0.014	1.946IleAsn: 1.946 ± 0.019	3.202IlePro: 3.202 ± 0.026	2.205IleGln: 2.205 ± 0.023	2.553IleArg: 2.553 ± 0.022	4.389IleSer: 4.389 ± 0.033	2.728IleThr: 2.728 ± 0.02	3.644IleVal: 3.644 ± 0.031	0.556IleTrp: 0.556 ± 0.01	1.275IleTyr: 1.275 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.354LysAla: 4.354 ± 0.03	0.684LysCys: 0.684 ± 0.011	2.864LysAsp: 2.864 ± 0.029	3.549LysGlu: 3.549 ± 0.031	1.839LysPhe: 1.839 ± 0.019	2.922LysGly: 2.922 ± 0.027	1.213LysHis: 1.213 ± 0.016	2.559LysIle: 2.559 ± 0.024	4.045LysLys: 4.045 ± 0.046	4.915LysLeu: 4.915 ± 0.037	1.435LysMet: 1.435 ± 0.014	2.294LysAsn: 2.294 ± 0.022	2.644LysPro: 2.644 ± 0.029	2.197LysGln: 2.197 ± 0.022	3.344LysArg: 3.344 ± 0.028	4.52LysSer: 4.52 ± 0.033	3.267LysThr: 3.267 ± 0.026	3.169LysVal: 3.169 ± 0.025	0.605LysTrp: 0.605 ± 0.009	1.521LysTyr: 1.521 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.829LeuAla: 7.829 ± 0.04	1.331LeuCys: 1.331 ± 0.018	5.309LeuAsp: 5.309 ± 0.03	5.692LeuGlu: 5.692 ± 0.055	3.893LeuPhe: 3.893 ± 0.033	5.252LeuGly: 5.252 ± 0.033	2.246LeuHis: 2.246 ± 0.02	4.325LeuIle: 4.325 ± 0.033	5.455LeuLys: 5.455 ± 0.04	8.853LeuLeu: 8.853 ± 0.052	2.177LeuMet: 2.177 ± 0.02	3.951LeuAsn: 3.951 ± 0.027	4.648LeuPro: 4.648 ± 0.034	3.966LeuGln: 3.966 ± 0.031	4.87LeuArg: 4.87 ± 0.034	8.053LeuSer: 8.053 ± 0.043	4.949LeuThr: 4.949 ± 0.028	6.17LeuVal: 6.17 ± 0.036	0.964LeuTrp: 0.964 ± 0.016	2.307LeuTyr: 2.307 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.064MetAla: 2.064 ± 0.021	0.281MetCys: 0.281 ± 0.007	1.646MetAsp: 1.646 ± 0.018	1.468MetGlu: 1.468 ± 0.015	0.944MetPhe: 0.944 ± 0.013	1.508MetGly: 1.508 ± 0.016	0.631MetHis: 0.631 ± 0.012	1.119MetIle: 1.119 ± 0.014	1.382MetLys: 1.382 ± 0.014	2.072MetLeu: 2.072 ± 0.02	0.67MetMet: 0.67 ± 0.012	1.176MetAsn: 1.176 ± 0.016	1.17MetPro: 1.17 ± 0.016	1.08MetGln: 1.08 ± 0.013	1.318MetArg: 1.318 ± 0.015	2.05MetSer: 2.05 ± 0.021	1.336MetThr: 1.336 ± 0.015	1.336MetVal: 1.336 ± 0.014	0.243MetTrp: 0.243 ± 0.007	0.66MetTyr: 0.66 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	4.083AsnAla: 4.083 ± 0.029	0.563AsnCys: 0.563 ± 0.01	2.108AsnAsp: 2.108 ± 0.018	2.421AsnGlu: 2.421 ± 0.023	1.457AsnPhe: 1.457 ± 0.019	2.914AsnGly: 2.914 ± 0.03	0.968AsnHis: 0.968 ± 0.013	2.038AsnIle: 2.038 ± 0.02	1.843AsnLys: 1.843 ± 0.018	4.095AsnLeu: 4.095 ± 0.039	1.046AsnMet: 1.046 ± 0.013	2.063AsnAsn: 2.063 ± 0.032	2.596AsnPro: 2.596 ± 0.021	1.762AsnGln: 1.762 ± 0.02	1.963AsnArg: 1.963 ± 0.019	3.726AsnSer: 3.726 ± 0.03	2.425AsnThr: 2.425 ± 0.021	2.732AsnVal: 2.732 ± 0.022	0.461AsnTrp: 0.461 ± 0.009	1.084AsnTyr: 1.084 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.827ProAla: 4.827 ± 0.036	0.487ProCys: 0.487 ± 0.009	2.439ProAsp: 2.439 ± 0.02	2.851ProGlu: 2.851 ± 0.023	2.064ProPhe: 2.064 ± 0.021	2.644ProGly: 2.644 ± 0.026	1.13ProHis: 1.13 ± 0.015	2.537ProIle: 2.537 ± 0.02	2.517ProLys: 2.517 ± 0.024	4.315ProLeu: 4.315 ± 0.03	1.018ProMet: 1.018 ± 0.016	2.178ProAsn: 2.178 ± 0.022	3.855ProPro: 3.855 ± 0.06	2.123ProGln: 2.123 ± 0.025	2.143ProArg: 2.143 ± 0.022	5.358ProSer: 5.358 ± 0.041	3.54ProThr: 3.54 ± 0.029	3.697ProVal: 3.697 ± 0.035	0.465ProTrp: 0.465 ± 0.009	1.196ProTyr: 1.196 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	2.892GlnAla: 2.892 ± 0.022	0.483GlnCys: 0.483 ± 0.01	1.798GlnAsp: 1.798 ± 0.021	2.18GlnGlu: 2.18 ± 0.024	1.619GlnPhe: 1.619 ± 0.017	1.8GlnGly: 1.8 ± 0.023	1.038GlnHis: 1.038 ± 0.016	2.131GlnIle: 2.131 ± 0.021	2.078GlnLys: 2.078 ± 0.02	3.802GlnLeu: 3.802 ± 0.032	1.101GlnMet: 1.101 ± 0.013	1.704GlnAsn: 1.704 ± 0.02	2.189GlnPro: 2.189 ± 0.026	3.415GlnGln: 3.415 ± 0.075	2.201GlnArg: 2.201 ± 0.023	3.329GlnSer: 3.329 ± 0.026	2.387GlnThr: 2.387 ± 0.02	2.336GlnVal: 2.336 ± 0.022	0.42GlnTrp: 0.42 ± 0.008	1.074GlnTyr: 1.074 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.903ArgAla: 3.903 ± 0.029	0.636ArgCys: 0.636 ± 0.011	2.786ArgAsp: 2.786 ± 0.028	3.007ArgGlu: 3.007 ± 0.026	2.09ArgPhe: 2.09 ± 0.019	2.84ArgGly: 2.84 ± 0.027	1.191ArgHis: 1.191 ± 0.015	3.023ArgIle: 3.023 ± 0.024	3.165ArgLys: 3.165 ± 0.027	4.725ArgLeu: 4.725 ± 0.033	1.364ArgMet: 1.364 ± 0.016	2.301ArgAsn: 2.301 ± 0.02	2.171ArgPro: 2.171 ± 0.022	1.905ArgGln: 1.905 ± 0.021	3.486ArgArg: 3.486 ± 0.035	3.92ArgSer: 3.92 ± 0.033	2.686ArgThr: 2.686 ± 0.022	3.489ArgVal: 3.489 ± 0.024	0.54ArgTrp: 0.54 ± 0.009	1.32ArgTyr: 1.32 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	7.819SerAla: 7.819 ± 0.05	1.035SerCys: 1.035 ± 0.013	4.585SerAsp: 4.585 ± 0.032	4.444SerGlu: 4.444 ± 0.032	3.553SerPhe: 3.553 ± 0.03	5.72SerGly: 5.72 ± 0.045	2.021SerHis: 2.021 ± 0.023	4.769SerIle: 4.769 ± 0.034	4.841SerLys: 4.841 ± 0.036	8.204SerLeu: 8.204 ± 0.05	1.971SerMet: 1.971 ± 0.019	4.393SerAsn: 4.393 ± 0.036	4.497SerPro: 4.497 ± 0.04	3.258SerGln: 3.258 ± 0.026	4.197SerArg: 4.197 ± 0.033	9.678SerSer: 9.678 ± 0.085	5.856SerThr: 5.856 ± 0.059	6.006SerVal: 6.006 ± 0.036	0.838SerTrp: 0.838 ± 0.011	1.886SerTyr: 1.886 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.654ThrAla: 5.654 ± 0.034	0.812ThrCys: 0.812 ± 0.014	2.818ThrAsp: 2.818 ± 0.02	2.953ThrGlu: 2.953 ± 0.031	2.242ThrPhe: 2.242 ± 0.022	3.835ThrGly: 3.835 ± 0.032	1.398ThrHis: 1.398 ± 0.016	2.991ThrIle: 2.991 ± 0.024	2.695ThrLys: 2.695 ± 0.022	5.604ThrLeu: 5.604 ± 0.033	1.153ThrMet: 1.153 ± 0.013	2.367ThrAsn: 2.367 ± 0.02	3.759ThrPro: 3.759 ± 0.03	2.169ThrGln: 2.169 ± 0.018	2.82ThrArg: 2.82 ± 0.02	5.523ThrSer: 5.523 ± 0.057	4.419ThrThr: 4.419 ± 0.087	4.165ThrVal: 4.165 ± 0.048	0.607ThrTrp: 0.607 ± 0.011	1.384ThrTyr: 1.384 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	6.229ValAla: 6.229 ± 0.037	1.016ValCys: 1.016 ± 0.015	3.847ValAsp: 3.847 ± 0.027	4.134ValGlu: 4.134 ± 0.071	2.957ValPhe: 2.957 ± 0.028	4.25ValGly: 4.25 ± 0.034	1.549ValHis: 1.549 ± 0.016	3.204ValIle: 3.204 ± 0.028	3.593ValLys: 3.593 ± 0.028	6.366ValLeu: 6.366 ± 0.04	1.527ValMet: 1.527 ± 0.017	2.635ValAsn: 2.635 ± 0.025	3.536ValPro: 3.536 ± 0.027	2.585ValGln: 2.585 ± 0.024	3.141ValArg: 3.141 ± 0.025	5.947ValSer: 5.947 ± 0.04	3.741ValThr: 3.741 ± 0.033	5.171ValVal: 5.171 ± 0.061	0.8ValTrp: 0.8 ± 0.013	1.769ValTyr: 1.769 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.841TrpAla: 0.841 ± 0.014	0.175TrpCys: 0.175 ± 0.006	0.699TrpAsp: 0.699 ± 0.013	0.549TrpGlu: 0.549 ± 0.01	0.512TrpPhe: 0.512 ± 0.01	0.627TrpGly: 0.627 ± 0.011	0.242TrpHis: 0.242 ± 0.006	0.699TrpIle: 0.699 ± 0.011	0.665TrpLys: 0.665 ± 0.01	0.95TrpLeu: 0.95 ± 0.012	0.374TrpMet: 0.374 ± 0.008	0.588TrpAsn: 0.588 ± 0.009	0.364TrpPro: 0.364 ± 0.01	0.342TrpGln: 0.342 ± 0.009	0.622TrpArg: 0.622 ± 0.011	0.866TrpSer: 0.866 ± 0.012	0.75TrpThr: 0.75 ± 0.012	0.724TrpVal: 0.724 ± 0.012	0.209TrpTrp: 0.209 ± 0.007	0.308TrpTyr: 0.308 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.113TyrAla: 2.113 ± 0.02	0.432TyrCys: 0.432 ± 0.01	1.382TyrAsp: 1.382 ± 0.016	1.389TyrGlu: 1.389 ± 0.015	1.26TyrPhe: 1.26 ± 0.017	1.729TyrGly: 1.729 ± 0.022	0.607TyrHis: 0.607 ± 0.011	1.33TyrIle: 1.33 ± 0.016	1.252TyrLys: 1.252 ± 0.015	2.503TyrLeu: 2.503 ± 0.024	0.635TyrMet: 0.635 ± 0.01	1.162TyrAsn: 1.162 ± 0.015	1.235TyrPro: 1.235 ± 0.016	1.015TyrGln: 1.015 ± 0.015	1.3TyrArg: 1.3 ± 0.016	2.05TyrSer: 2.05 ± 0.021	1.414TyrThr: 1.414 ± 0.017	1.586TyrVal: 1.586 ± 0.018	0.338TyrTrp: 0.338 ± 0.009	0.85TyrTyr: 0.85 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10661 proteins (5997939 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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