Amino acid dipepetide frequency for Rhododendron williamsianum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.695AlaAla: 6.695 ± 0.04	1.298AlaCys: 1.298 ± 0.015	3.143AlaAsp: 3.143 ± 0.019	4.34AlaGlu: 4.34 ± 0.028	2.818AlaPhe: 2.818 ± 0.019	4.316AlaGly: 4.316 ± 0.027	1.309AlaHis: 1.309 ± 0.012	3.743AlaIle: 3.743 ± 0.022	3.837AlaLys: 3.837 ± 0.022	6.797AlaLeu: 6.797 ± 0.036	1.83AlaMet: 1.83 ± 0.014	2.565AlaAsn: 2.565 ± 0.017	2.781AlaPro: 2.781 ± 0.021	2.074AlaGln: 2.074 ± 0.018	3.412AlaArg: 3.412 ± 0.019	5.921AlaSer: 5.921 ± 0.029	3.629AlaThr: 3.629 ± 0.024	5.164AlaVal: 5.164 ± 0.026	0.79AlaTrp: 0.79 ± 0.01	1.829AlaTyr: 1.829 ± 0.014	0.085AlaXaa: 0.085 ± 0.003
Cys	1.036CysAla: 1.036 ± 0.013	0.545CysCys: 0.545 ± 0.007	0.862CysAsp: 0.862 ± 0.011	0.913CysGlu: 0.913 ± 0.011	0.944CysPhe: 0.944 ± 0.012	1.483CysGly: 1.483 ± 0.015	0.461CysHis: 0.461 ± 0.008	0.971CysIle: 0.971 ± 0.011	1.074CysLys: 1.074 ± 0.014	1.985CysLeu: 1.985 ± 0.015	0.44CysMet: 0.44 ± 0.007	0.845CysAsn: 0.845 ± 0.01	0.939CysPro: 0.939 ± 0.012	0.593CysGln: 0.593 ± 0.008	1.08CysArg: 1.08 ± 0.011	1.828CysSer: 1.828 ± 0.017	0.868CysThr: 0.868 ± 0.009	1.102CysVal: 1.102 ± 0.012	0.259CysTrp: 0.259 ± 0.005	0.567CysTyr: 0.567 ± 0.008	0.024CysXaa: 0.024 ± 0.001
Asp	3.49AspAla: 3.49 ± 0.019	0.988AspCys: 0.988 ± 0.011	3.619AspAsp: 3.619 ± 0.032	4.024AspGlu: 4.024 ± 0.028	2.38AspPhe: 2.38 ± 0.017	4.049AspGly: 4.049 ± 0.023	1.215AspHis: 1.215 ± 0.014	2.854AspIle: 2.854 ± 0.019	2.573AspLys: 2.573 ± 0.018	5.219AspLeu: 5.219 ± 0.027	1.362AspMet: 1.362 ± 0.012	1.968AspAsn: 1.968 ± 0.016	2.688AspPro: 2.688 ± 0.02	1.735AspGln: 1.735 ± 0.014	2.503AspArg: 2.503 ± 0.019	4.309AspSer: 4.309 ± 0.024	2.178AspThr: 2.178 ± 0.016	3.728AspVal: 3.728 ± 0.021	0.713AspTrp: 0.713 ± 0.011	1.563AspTyr: 1.563 ± 0.014	0.076AspXaa: 0.076 ± 0.003
Glu	4.927GluAla: 4.927 ± 0.031	0.898GluCys: 0.898 ± 0.012	3.976GluAsp: 3.976 ± 0.028	6.519GluGlu: 6.519 ± 0.049	2.41GluPhe: 2.41 ± 0.016	4.043GluGly: 4.043 ± 0.023	1.221GluHis: 1.221 ± 0.012	3.675GluIle: 3.675 ± 0.022	4.687GluLys: 4.687 ± 0.034	6.021GluLeu: 6.021 ± 0.033	1.875GluMet: 1.875 ± 0.017	3.002GluAsn: 3.002 ± 0.021	2.165GluPro: 2.165 ± 0.017	2.094GluGln: 2.094 ± 0.019	3.538GluArg: 3.538 ± 0.024	4.644GluSer: 4.644 ± 0.03	3.038GluThr: 3.038 ± 0.024	4.473GluVal: 4.473 ± 0.025	0.75GluTrp: 0.75 ± 0.01	1.591GluTyr: 1.591 ± 0.015	0.072GluXaa: 0.072 ± 0.003
Phe	2.594PheAla: 2.594 ± 0.017	0.965PheCys: 0.965 ± 0.01	2.471PheAsp: 2.471 ± 0.02	2.364PheGlu: 2.364 ± 0.016	1.941PhePhe: 1.941 ± 0.017	3.122PheGly: 3.122 ± 0.019	1.099PheHis: 1.099 ± 0.011	1.92PheIle: 1.92 ± 0.015	1.998PheLys: 1.998 ± 0.015	4.379PheLeu: 4.379 ± 0.025	0.926PheMet: 0.926 ± 0.009	1.675PheAsn: 1.675 ± 0.015	2.203PhePro: 2.203 ± 0.019	1.546PheGln: 1.546 ± 0.012	2.176PheArg: 2.176 ± 0.018	4.085PheSer: 4.085 ± 0.025	1.966PheThr: 1.966 ± 0.015	2.943PheVal: 2.943 ± 0.018	0.567PheTrp: 0.567 ± 0.007	1.256PheTyr: 1.256 ± 0.014	0.054PheXaa: 0.054 ± 0.002
Gly	4.019GlyAla: 4.019 ± 0.022	1.362GlyCys: 1.362 ± 0.013	3.695GlyAsp: 3.695 ± 0.022	3.987GlyGlu: 3.987 ± 0.022	3.394GlyPhe: 3.394 ± 0.022	6.218GlyGly: 6.218 ± 0.057	1.529GlyHis: 1.529 ± 0.014	3.666GlyIle: 3.666 ± 0.021	4.242GlyLys: 4.242 ± 0.026	6.211GlyLeu: 6.211 ± 0.033	1.631GlyMet: 1.631 ± 0.016	3.209GlyAsn: 3.209 ± 0.024	2.626GlyPro: 2.626 ± 0.022	2.077GlyGln: 2.077 ± 0.017	3.869GlyArg: 3.869 ± 0.024	6.136GlySer: 6.136 ± 0.029	3.26GlyThr: 3.26 ± 0.019	4.548GlyVal: 4.548 ± 0.024	0.943GlyTrp: 0.943 ± 0.011	2.121GlyTyr: 2.121 ± 0.019	0.084GlyXaa: 0.084 ± 0.003
His	1.393HisAla: 1.393 ± 0.014	0.496HisCys: 0.496 ± 0.008	1.11HisAsp: 1.11 ± 0.011	1.249HisGlu: 1.249 ± 0.013	1.056HisPhe: 1.056 ± 0.012	1.713HisGly: 1.713 ± 0.018	0.921HisHis: 0.921 ± 0.013	1.11HisIle: 1.11 ± 0.012	1.079HisLys: 1.079 ± 0.011	2.417HisLeu: 2.417 ± 0.018	0.523HisMet: 0.523 ± 0.008	0.911HisAsn: 0.911 ± 0.011	1.369HisPro: 1.369 ± 0.015	0.948HisGln: 0.948 ± 0.012	1.357HisArg: 1.357 ± 0.013	1.923HisSer: 1.923 ± 0.015	0.932HisThr: 0.932 ± 0.01	1.526HisVal: 1.526 ± 0.012	0.312HisTrp: 0.312 ± 0.006	0.675HisTyr: 0.675 ± 0.01	0.031HisXaa: 0.031 ± 0.002
Ile	3.569IleAla: 3.569 ± 0.022	1.094IleCys: 1.094 ± 0.011	2.821IleAsp: 2.821 ± 0.021	3.141IleGlu: 3.141 ± 0.02	2.161IlePhe: 2.161 ± 0.016	3.394IleGly: 3.394 ± 0.023	1.225IleHis: 1.225 ± 0.011	2.471IleIle: 2.471 ± 0.019	2.634IleLys: 2.634 ± 0.019	5.086IleLeu: 5.086 ± 0.029	1.083IleMet: 1.083 ± 0.011	1.918IleAsn: 1.918 ± 0.016	2.873IlePro: 2.873 ± 0.021	1.878IleGln: 1.878 ± 0.014	2.654IleArg: 2.654 ± 0.02	4.67IleSer: 4.67 ± 0.026	2.47IleThr: 2.47 ± 0.017	3.439IleVal: 3.439 ± 0.021	0.66IleTrp: 0.66 ± 0.009	1.448IleTyr: 1.448 ± 0.013	0.062IleXaa: 0.062 ± 0.003
Lys	3.992LysAla: 3.992 ± 0.023	0.906LysCys: 0.906 ± 0.01	3.059LysAsp: 3.059 ± 0.02	4.476LysGlu: 4.476 ± 0.029	2.089LysPhe: 2.089 ± 0.017	3.639LysGly: 3.639 ± 0.023	1.255LysHis: 1.255 ± 0.013	2.931LysIle: 2.931 ± 0.018	4.406LysLys: 4.406 ± 0.033	5.712LysLeu: 5.712 ± 0.028	1.48LysMet: 1.48 ± 0.014	2.375LysAsn: 2.375 ± 0.018	2.706LysPro: 2.706 ± 0.021	2.16LysGln: 2.16 ± 0.017	3.497LysArg: 3.497 ± 0.022	4.452LysSer: 4.452 ± 0.025	2.769LysThr: 2.769 ± 0.017	3.83LysVal: 3.83 ± 0.02	0.778LysTrp: 0.778 ± 0.011	1.524LysTyr: 1.524 ± 0.014	0.07LysXaa: 0.07 ± 0.003
Leu	6.585LeuAla: 6.585 ± 0.035	1.953LeuCys: 1.953 ± 0.014	5.178LeuAsp: 5.178 ± 0.028	6.44LeuGlu: 6.44 ± 0.037	4.013LeuPhe: 4.013 ± 0.024	6.092LeuGly: 6.092 ± 0.029	2.522LeuHis: 2.522 ± 0.017	4.573LeuIle: 4.573 ± 0.03	5.86LeuLys: 5.86 ± 0.031	10.309LeuLeu: 10.309 ± 0.051	2.206LeuMet: 2.206 ± 0.017	3.802LeuAsn: 3.802 ± 0.021	5.234LeuPro: 5.234 ± 0.031	4.065LeuGln: 4.065 ± 0.025	5.541LeuArg: 5.541 ± 0.031	8.738LeuSer: 8.738 ± 0.039	4.447LeuThr: 4.447 ± 0.025	6.788LeuVal: 6.788 ± 0.033	1.177LeuTrp: 1.177 ± 0.012	2.524LeuTyr: 2.524 ± 0.017	0.112LeuXaa: 0.112 ± 0.004
Met	2.052MetAla: 2.052 ± 0.015	0.322MetCys: 0.322 ± 0.005	1.463MetAsp: 1.463 ± 0.014	2.05MetGlu: 2.05 ± 0.016	0.827MetPhe: 0.827 ± 0.009	1.745MetGly: 1.745 ± 0.017	0.512MetHis: 0.512 ± 0.008	1.152MetIle: 1.152 ± 0.012	1.544MetLys: 1.544 ± 0.015	2.199MetLeu: 2.199 ± 0.015	0.666MetMet: 0.666 ± 0.009	0.958MetAsn: 0.958 ± 0.01	1.071MetPro: 1.071 ± 0.013	0.881MetGln: 0.881 ± 0.012	1.239MetArg: 1.239 ± 0.012	1.701MetSer: 1.701 ± 0.013	1.018MetThr: 1.018 ± 0.011	1.772MetVal: 1.772 ± 0.014	0.275MetTrp: 0.275 ± 0.006	0.624MetTyr: 0.624 ± 0.009	0.026MetXaa: 0.026 ± 0.002
Asn	2.67AsnAla: 2.67 ± 0.019	0.872AsnCys: 0.872 ± 0.012	1.95AsnAsp: 1.95 ± 0.015	2.365AsnGlu: 2.365 ± 0.018	1.843AsnPhe: 1.843 ± 0.014	3.374AsnGly: 3.374 ± 0.025	1.036AsnHis: 1.036 ± 0.012	2.147AsnIle: 2.147 ± 0.015	2.115AsnLys: 2.115 ± 0.016	4.404AsnLeu: 4.404 ± 0.028	1.013AsnMet: 1.013 ± 0.014	1.985AsnAsn: 1.985 ± 0.02	2.469AsnPro: 2.469 ± 0.02	1.591AsnGln: 1.591 ± 0.015	2.016AsnArg: 2.016 ± 0.017	3.834AsnSer: 3.834 ± 0.025	1.877AsnThr: 1.877 ± 0.015	2.76AsnVal: 2.76 ± 0.019	0.557AsnTrp: 0.557 ± 0.008	1.262AsnTyr: 1.262 ± 0.011	0.06AsnXaa: 0.06 ± 0.003
Pro	2.979ProAla: 2.979 ± 0.023	0.783ProCys: 0.783 ± 0.01	2.609ProAsp: 2.609 ± 0.021	3.126ProGlu: 3.126 ± 0.021	2.082ProPhe: 2.082 ± 0.016	2.759ProGly: 2.759 ± 0.022	1.154ProHis: 1.154 ± 0.015	2.318ProIle: 2.318 ± 0.018	2.657ProLys: 2.657 ± 0.017	4.48ProLeu: 4.48 ± 0.025	0.989ProMet: 0.989 ± 0.011	2.38ProAsn: 2.38 ± 0.017	4.231ProPro: 4.231 ± 0.058	1.779ProGln: 1.779 ± 0.019	2.45ProArg: 2.45 ± 0.019	5.223ProSer: 5.223 ± 0.034	2.733ProThr: 2.733 ± 0.02	3.217ProVal: 3.217 ± 0.021	0.607ProTrp: 0.607 ± 0.01	1.299ProTyr: 1.299 ± 0.014	0.073ProXaa: 0.073 ± 0.003
Gln	2.317GlnAla: 2.317 ± 0.019	0.559GlnCys: 0.559 ± 0.009	1.545GlnAsp: 1.545 ± 0.014	2.287GlnGlu: 2.287 ± 0.02	1.4GlnPhe: 1.4 ± 0.012	2.084GlnGly: 2.084 ± 0.015	0.82GlnHis: 0.82 ± 0.01	1.93GlnIle: 1.93 ± 0.017	2.204GlnLys: 2.204 ± 0.017	3.548GlnLeu: 3.548 ± 0.024	0.94GlnMet: 0.94 ± 0.011	1.662GlnAsn: 1.662 ± 0.015	1.704GlnPro: 1.704 ± 0.017	1.835GlnGln: 1.835 ± 0.03	2.054GlnArg: 2.054 ± 0.016	2.743GlnSer: 2.743 ± 0.017	1.675GlnThr: 1.675 ± 0.014	2.346GlnVal: 2.346 ± 0.015	0.472GlnTrp: 0.472 ± 0.008	0.904GlnTyr: 0.904 ± 0.011	0.033GlnXaa: 0.033 ± 0.002
Arg	3.39ArgAla: 3.39 ± 0.02	0.981ArgCys: 0.981 ± 0.011	2.731ArgAsp: 2.731 ± 0.019	3.518ArgGlu: 3.518 ± 0.025	2.248ArgPhe: 2.248 ± 0.017	3.499ArgGly: 3.499 ± 0.025	1.266ArgHis: 1.266 ± 0.014	2.826ArgIle: 2.826 ± 0.019	3.763ArgLys: 3.763 ± 0.026	5.106ArgLeu: 5.106 ± 0.029	1.305ArgMet: 1.305 ± 0.012	2.433ArgAsn: 2.433 ± 0.018	2.395ArgPro: 2.395 ± 0.016	1.774ArgGln: 1.774 ± 0.014	4.115ArgArg: 4.115 ± 0.026	4.378ArgSer: 4.378 ± 0.028	2.46ArgThr: 2.46 ± 0.02	3.595ArgVal: 3.595 ± 0.021	0.772ArgTrp: 0.772 ± 0.01	1.446ArgTyr: 1.446 ± 0.013	0.062ArgXaa: 0.062 ± 0.003
Ser	5.429SerAla: 5.429 ± 0.026	1.766SerCys: 1.766 ± 0.014	4.469SerAsp: 4.469 ± 0.024	4.812SerGlu: 4.812 ± 0.03	3.9SerPhe: 3.9 ± 0.023	6.283SerGly: 6.283 ± 0.037	1.95SerHis: 1.95 ± 0.014	4.372SerIle: 4.372 ± 0.024	4.672SerLys: 4.672 ± 0.027	8.817SerLeu: 8.817 ± 0.039	2.032SerMet: 2.032 ± 0.014	3.885SerAsn: 3.885 ± 0.023	4.709SerPro: 4.709 ± 0.031	2.845SerGln: 2.845 ± 0.022	4.493SerArg: 4.493 ± 0.028	10.699SerSer: 10.699 ± 0.054	4.71SerThr: 4.71 ± 0.027	5.435SerVal: 5.435 ± 0.027	1.185SerTrp: 1.185 ± 0.013	2.27SerTyr: 2.27 ± 0.019	0.12SerXaa: 0.12 ± 0.004
Thr	3.466ThrAla: 3.466 ± 0.021	0.911ThrCys: 0.911 ± 0.011	2.267ThrAsp: 2.267 ± 0.018	2.788ThrGlu: 2.788 ± 0.023	1.994ThrPhe: 1.994 ± 0.015	3.38ThrGly: 3.38 ± 0.022	1.021ThrHis: 1.021 ± 0.011	2.57ThrIle: 2.57 ± 0.019	2.501ThrLys: 2.501 ± 0.015	4.682ThrLeu: 4.682 ± 0.026	1.126ThrMet: 1.126 ± 0.011	1.997ThrAsn: 1.997 ± 0.016	2.634ThrPro: 2.634 ± 0.021	1.512ThrGln: 1.512 ± 0.013	2.372ThrArg: 2.372 ± 0.018	4.554ThrSer: 4.554 ± 0.027	3.069ThrThr: 3.069 ± 0.024	3.431ThrVal: 3.431 ± 0.024	0.633ThrTrp: 0.633 ± 0.008	1.389ThrTyr: 1.389 ± 0.016	0.064ThrXaa: 0.064 ± 0.003
Val	5.059ValAla: 5.059 ± 0.028	1.223ValCys: 1.223 ± 0.013	3.971ValAsp: 3.971 ± 0.022	4.791ValGlu: 4.791 ± 0.028	2.861ValPhe: 2.861 ± 0.02	4.586ValGly: 4.586 ± 0.029	1.521ValHis: 1.521 ± 0.014	3.435ValIle: 3.435 ± 0.022	3.867ValLys: 3.867 ± 0.021	6.706ValLeu: 6.706 ± 0.034	1.608ValMet: 1.608 ± 0.014	2.625ValAsn: 2.625 ± 0.019	3.285ValPro: 3.285 ± 0.022	2.303ValGln: 2.303 ± 0.017	3.327ValArg: 3.327 ± 0.021	5.666ValSer: 5.666 ± 0.026	3.274ValThr: 3.274 ± 0.019	5.539ValVal: 5.539 ± 0.028	0.796ValTrp: 0.796 ± 0.011	1.925ValTyr: 1.925 ± 0.014	0.083ValXaa: 0.083 ± 0.003
Trp	0.795TrpAla: 0.795 ± 0.01	0.236TrpCys: 0.236 ± 0.005	0.721TrpAsp: 0.721 ± 0.009	0.785TrpGlu: 0.785 ± 0.009	0.54TrpPhe: 0.54 ± 0.008	0.793TrpGly: 0.793 ± 0.011	0.299TrpHis: 0.299 ± 0.006	0.673TrpIle: 0.673 ± 0.009	0.92TrpLys: 0.92 ± 0.01	1.251TrpLeu: 1.251 ± 0.013	0.336TrpMet: 0.336 ± 0.006	0.684TrpAsn: 0.684 ± 0.01	0.505TrpPro: 0.505 ± 0.008	0.442TrpGln: 0.442 ± 0.007	0.847TrpArg: 0.847 ± 0.009	0.944TrpSer: 0.944 ± 0.012	0.648TrpThr: 0.648 ± 0.009	0.899TrpVal: 0.899 ± 0.008	0.268TrpTrp: 0.268 ± 0.007	0.344TrpTyr: 0.344 ± 0.007	0.013TrpXaa: 0.013 ± 0.001
Tyr	1.841TyrAla: 1.841 ± 0.014	0.638TyrCys: 0.638 ± 0.009	1.505TyrAsp: 1.505 ± 0.015	1.56TyrGlu: 1.56 ± 0.013	1.295TyrPhe: 1.295 ± 0.014	2.157TyrGly: 2.157 ± 0.019	0.684TyrHis: 0.684 ± 0.009	1.355TyrIle: 1.355 ± 0.014	1.401TyrLys: 1.401 ± 0.013	2.722TyrLeu: 2.722 ± 0.02	0.695TyrMet: 0.695 ± 0.01	1.268TyrAsn: 1.268 ± 0.012	1.281TyrPro: 1.281 ± 0.012	0.887TyrGln: 0.887 ± 0.01	1.457TyrArg: 1.457 ± 0.014	2.298TyrSer: 2.298 ± 0.017	1.282TyrThr: 1.282 ± 0.012	1.83TyrVal: 1.83 ± 0.015	0.411TyrTrp: 0.411 ± 0.008	0.95TyrTyr: 0.95 ± 0.012	0.032TyrXaa: 0.032 ± 0.002
Xaa	0.077XaaAla: 0.077 ± 0.003	0.025XaaCys: 0.025 ± 0.002	0.068XaaAsp: 0.068 ± 0.003	0.085XaaGlu: 0.085 ± 0.003	0.052XaaPhe: 0.052 ± 0.002	0.097XaaGly: 0.097 ± 0.003	0.029XaaHis: 0.029 ± 0.002	0.061XaaIle: 0.061 ± 0.003	0.075XaaLys: 0.075 ± 0.003	0.11XaaLeu: 0.11 ± 0.004	0.028XaaMet: 0.028 ± 0.002	0.053XaaAsn: 0.053 ± 0.002	0.061XaaPro: 0.061 ± 0.003	0.044XaaGln: 0.044 ± 0.002	0.064XaaArg: 0.064 ± 0.003	0.109XaaSer: 0.109 ± 0.004	0.058XaaThr: 0.058 ± 0.003	0.086XaaVal: 0.086 ± 0.003	0.017XaaTrp: 0.017 ± 0.001	0.035XaaTyr: 0.035 ± 0.002	0.074XaaXaa: 0.074 ± 0.016

Statistics based on 21355 proteins (8907007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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