Amino acid dipepetide frequency for Aliiglaciecola lipolytica E3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.814AlaAla: 6.814 ± 0.092	0.902AlaCys: 0.902 ± 0.024	4.689AlaAsp: 4.689 ± 0.06	5.09AlaGlu: 5.09 ± 0.056	3.488AlaPhe: 3.488 ± 0.057	5.542AlaGly: 5.542 ± 0.065	1.542AlaHis: 1.542 ± 0.031	5.988AlaIle: 5.988 ± 0.075	5.165AlaLys: 5.165 ± 0.056	8.729AlaLeu: 8.729 ± 0.095	2.271AlaMet: 2.271 ± 0.046	4.102AlaAsn: 4.102 ± 0.059	2.638AlaPro: 2.638 ± 0.046	3.838AlaGln: 3.838 ± 0.058	3.17AlaArg: 3.17 ± 0.054	5.336AlaSer: 5.336 ± 0.071	4.256AlaThr: 4.256 ± 0.058	5.221AlaVal: 5.221 ± 0.072	0.899AlaTrp: 0.899 ± 0.031	2.35AlaTyr: 2.35 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.78CysAla: 0.78 ± 0.024	0.16CysCys: 0.16 ± 0.01	0.563CysAsp: 0.563 ± 0.019	0.667CysGlu: 0.667 ± 0.021	0.447CysPhe: 0.447 ± 0.018	0.751CysGly: 0.751 ± 0.027	0.327CysHis: 0.327 ± 0.018	0.641CysIle: 0.641 ± 0.024	0.456CysLys: 0.456 ± 0.018	0.983CysLeu: 0.983 ± 0.027	0.213CysMet: 0.213 ± 0.012	0.384CysAsn: 0.384 ± 0.015	0.383CysPro: 0.383 ± 0.019	0.46CysGln: 0.46 ± 0.019	0.402CysArg: 0.402 ± 0.016	0.714CysSer: 0.714 ± 0.024	0.446CysThr: 0.446 ± 0.017	0.618CysVal: 0.618 ± 0.021	0.121CysTrp: 0.121 ± 0.01	0.326CysTyr: 0.326 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.51AspAla: 4.51 ± 0.06	0.54AspCys: 0.54 ± 0.019	3.309AspAsp: 3.309 ± 0.055	3.921AspGlu: 3.921 ± 0.063	2.831AspPhe: 2.831 ± 0.05	3.801AspGly: 3.801 ± 0.066	0.993AspHis: 0.993 ± 0.029	4.167AspIle: 4.167 ± 0.058	3.398AspLys: 3.398 ± 0.058	5.457AspLeu: 5.457 ± 0.069	1.49AspMet: 1.49 ± 0.034	2.841AspAsn: 2.841 ± 0.049	2.229AspPro: 2.229 ± 0.038	2.026AspGln: 2.026 ± 0.041	2.071AspArg: 2.071 ± 0.037	3.728AspSer: 3.728 ± 0.054	2.797AspThr: 2.797 ± 0.046	4.05AspVal: 4.05 ± 0.063	0.88AspTrp: 0.88 ± 0.026	2.135AspTyr: 2.135 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	4.727GluAla: 4.727 ± 0.072	0.46GluCys: 0.46 ± 0.022	3.014GluAsp: 3.014 ± 0.049	3.394GluGlu: 3.394 ± 0.064	2.729GluPhe: 2.729 ± 0.045	3.297GluGly: 3.297 ± 0.053	1.521GluHis: 1.521 ± 0.035	4.111GluIle: 4.111 ± 0.053	3.952GluLys: 3.952 ± 0.058	6.908GluLeu: 6.908 ± 0.072	1.601GluMet: 1.601 ± 0.038	3.245GluAsn: 3.245 ± 0.048	1.867GluPro: 1.867 ± 0.039	4.021GluGln: 4.021 ± 0.067	2.74GluArg: 2.74 ± 0.046	3.939GluSer: 3.939 ± 0.058	3.083GluThr: 3.083 ± 0.043	4.007GluVal: 4.007 ± 0.059	0.696GluTrp: 0.696 ± 0.021	1.896GluTyr: 1.896 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.809PheAla: 3.809 ± 0.056	0.516PheCys: 0.516 ± 0.021	3.112PheAsp: 3.112 ± 0.049	2.889PheGlu: 2.889 ± 0.046	1.872PhePhe: 1.872 ± 0.043	3.191PheGly: 3.191 ± 0.052	0.82PheHis: 0.82 ± 0.027	2.94PheIle: 2.94 ± 0.058	2.271PheLys: 2.271 ± 0.04	3.645PheLeu: 3.645 ± 0.063	1.041PheMet: 1.041 ± 0.026	2.306PheAsn: 2.306 ± 0.041	1.511PhePro: 1.511 ± 0.029	1.332PheGln: 1.332 ± 0.031	1.581PheArg: 1.581 ± 0.038	3.626PheSer: 3.626 ± 0.049	2.475PheThr: 2.475 ± 0.049	2.998PheVal: 2.998 ± 0.05	0.622PheTrp: 0.622 ± 0.022	1.554PheTyr: 1.554 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.886GlyAla: 4.886 ± 0.063	0.799GlyCys: 0.799 ± 0.025	3.591GlyAsp: 3.591 ± 0.064	4.0GlyGlu: 4.0 ± 0.056	3.449GlyPhe: 3.449 ± 0.053	4.552GlyGly: 4.552 ± 0.086	1.458GlyHis: 1.458 ± 0.036	4.648GlyIle: 4.648 ± 0.061	3.953GlyLys: 3.953 ± 0.055	6.758GlyLeu: 6.758 ± 0.075	1.809GlyMet: 1.809 ± 0.043	2.942GlyAsn: 2.942 ± 0.055	1.683GlyPro: 1.683 ± 0.037	2.647GlyGln: 2.647 ± 0.038	2.695GlyArg: 2.695 ± 0.048	4.064GlySer: 4.064 ± 0.062	3.309GlyThr: 3.309 ± 0.06	4.792GlyVal: 4.792 ± 0.058	0.942GlyTrp: 0.942 ± 0.031	2.368GlyTyr: 2.368 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.602HisAla: 1.602 ± 0.038	0.313HisCys: 0.313 ± 0.016	1.055HisAsp: 1.055 ± 0.028	1.021HisGlu: 1.021 ± 0.03	1.158HisPhe: 1.158 ± 0.03	1.416HisGly: 1.416 ± 0.036	0.612HisHis: 0.612 ± 0.019	1.461HisIle: 1.461 ± 0.033	1.11HisLys: 1.11 ± 0.025	2.121HisLeu: 2.121 ± 0.043	0.475HisMet: 0.475 ± 0.018	0.985HisAsn: 0.985 ± 0.027	1.112HisPro: 1.112 ± 0.029	1.157HisGln: 1.157 ± 0.032	0.981HisArg: 0.981 ± 0.027	1.493HisSer: 1.493 ± 0.034	1.071HisThr: 1.071 ± 0.025	1.309HisVal: 1.309 ± 0.031	0.34HisTrp: 0.34 ± 0.017	0.846HisTyr: 0.846 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.13IleAla: 6.13 ± 0.069	0.736IleCys: 0.736 ± 0.022	4.611IleAsp: 4.611 ± 0.057	4.874IleGlu: 4.874 ± 0.064	2.526IlePhe: 2.526 ± 0.047	4.592IleGly: 4.592 ± 0.056	1.274IleHis: 1.274 ± 0.03	3.803IleIle: 3.803 ± 0.054	3.669IleLys: 3.669 ± 0.053	5.669IleLeu: 5.669 ± 0.068	1.27IleMet: 1.27 ± 0.028	3.452IleAsn: 3.452 ± 0.051	2.741IlePro: 2.741 ± 0.046	2.68IleGln: 2.68 ± 0.044	2.777IleArg: 2.777 ± 0.036	4.992IleSer: 4.992 ± 0.059	3.596IleThr: 3.596 ± 0.057	4.408IleVal: 4.408 ± 0.061	0.753IleTrp: 0.753 ± 0.024	1.849IleTyr: 1.849 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.491LysAla: 4.491 ± 0.063	0.359LysCys: 0.359 ± 0.018	2.803LysAsp: 2.803 ± 0.048	3.036LysGlu: 3.036 ± 0.051	1.834LysPhe: 1.834 ± 0.039	3.248LysGly: 3.248 ± 0.056	1.42LysHis: 1.42 ± 0.035	3.464LysIle: 3.464 ± 0.058	3.049LysLys: 3.049 ± 0.052	5.79LysLeu: 5.79 ± 0.073	1.459LysMet: 1.459 ± 0.035	2.687LysAsn: 2.687 ± 0.046	2.349LysPro: 2.349 ± 0.043	3.474LysGln: 3.474 ± 0.057	2.885LysArg: 2.885 ± 0.051	3.692LysSer: 3.692 ± 0.048	3.107LysThr: 3.107 ± 0.044	3.917LysVal: 3.917 ± 0.055	0.679LysTrp: 0.679 ± 0.021	1.629LysTyr: 1.629 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.35LeuAla: 9.35 ± 0.093	1.026LeuCys: 1.026 ± 0.03	5.789LeuAsp: 5.789 ± 0.067	5.92LeuGlu: 5.92 ± 0.068	4.429LeuPhe: 4.429 ± 0.065	6.424LeuGly: 6.424 ± 0.079	2.112LeuHis: 2.112 ± 0.044	6.575LeuIle: 6.575 ± 0.074	5.511LeuLys: 5.511 ± 0.062	10.136LeuLeu: 10.136 ± 0.121	2.408LeuMet: 2.408 ± 0.049	5.125LeuAsn: 5.125 ± 0.061	4.516LeuPro: 4.516 ± 0.055	4.196LeuGln: 4.196 ± 0.069	4.191LeuArg: 4.191 ± 0.055	7.976LeuSer: 7.976 ± 0.079	5.914LeuThr: 5.914 ± 0.06	6.724LeuVal: 6.724 ± 0.082	0.992LeuTrp: 0.992 ± 0.029	2.687LeuTyr: 2.687 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.183MetAla: 2.183 ± 0.039	0.19MetCys: 0.19 ± 0.011	1.213MetAsp: 1.213 ± 0.033	1.196MetGlu: 1.196 ± 0.029	0.946MetPhe: 0.946 ± 0.024	1.653MetGly: 1.653 ± 0.035	0.553MetHis: 0.553 ± 0.02	1.353MetIle: 1.353 ± 0.029	1.307MetLys: 1.307 ± 0.031	2.876MetLeu: 2.876 ± 0.05	0.648MetMet: 0.648 ± 0.022	1.001MetAsn: 1.001 ± 0.03	1.194MetPro: 1.194 ± 0.03	1.357MetGln: 1.357 ± 0.029	1.125MetArg: 1.125 ± 0.024	1.902MetSer: 1.902 ± 0.039	1.432MetThr: 1.432 ± 0.03	1.501MetVal: 1.501 ± 0.035	0.243MetTrp: 0.243 ± 0.011	0.547MetTyr: 0.547 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.865AsnAla: 3.865 ± 0.063	0.466AsnCys: 0.466 ± 0.017	2.604AsnAsp: 2.604 ± 0.051	2.69AsnGlu: 2.69 ± 0.039	1.848AsnPhe: 1.848 ± 0.037	3.249AsnGly: 3.249 ± 0.057	0.992AsnHis: 0.992 ± 0.028	3.351AsnIle: 3.351 ± 0.053	2.644AsnLys: 2.644 ± 0.045	4.743AsnLeu: 4.743 ± 0.065	1.185AsnMet: 1.185 ± 0.032	2.48AsnAsn: 2.48 ± 0.05	2.262AsnPro: 2.262 ± 0.046	2.764AsnGln: 2.764 ± 0.045	2.14AsnArg: 2.14 ± 0.04	3.117AsnSer: 3.117 ± 0.05	2.58AsnThr: 2.58 ± 0.043	3.109AsnVal: 3.109 ± 0.049	0.707AsnTrp: 0.707 ± 0.026	1.582AsnTyr: 1.582 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.853ProAla: 2.853 ± 0.051	0.28ProCys: 0.28 ± 0.014	2.562ProAsp: 2.562 ± 0.041	3.132ProGlu: 3.132 ± 0.047	1.803ProPhe: 1.803 ± 0.033	2.299ProGly: 2.299 ± 0.048	0.752ProHis: 0.752 ± 0.025	2.691ProIle: 2.691 ± 0.044	2.083ProLys: 2.083 ± 0.042	3.69ProLeu: 3.69 ± 0.053	0.894ProMet: 0.894 ± 0.027	2.0ProAsn: 2.0 ± 0.039	1.232ProPro: 1.232 ± 0.035	1.695ProGln: 1.695 ± 0.037	1.288ProArg: 1.288 ± 0.029	2.507ProSer: 2.507 ± 0.045	2.002ProThr: 2.002 ± 0.035	2.84ProVal: 2.84 ± 0.049	0.506ProTrp: 0.506 ± 0.02	1.17ProTyr: 1.17 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.096GlnAla: 4.096 ± 0.057	0.394GlnCys: 0.394 ± 0.02	2.216GlnAsp: 2.216 ± 0.038	2.455GlnGlu: 2.455 ± 0.049	1.975GlnPhe: 1.975 ± 0.039	2.836GlnGly: 2.836 ± 0.044	1.28GlnHis: 1.28 ± 0.032	3.085GlnIle: 3.085 ± 0.049	2.685GlnLys: 2.685 ± 0.048	5.249GlnLeu: 5.249 ± 0.064	1.107GlnMet: 1.107 ± 0.03	2.306GlnAsn: 2.306 ± 0.039	1.631GlnPro: 1.631 ± 0.035	3.652GlnGln: 3.652 ± 0.067	2.337GlnArg: 2.337 ± 0.048	3.241GlnSer: 3.241 ± 0.049	2.532GlnThr: 2.532 ± 0.05	3.139GlnVal: 3.139 ± 0.05	0.667GlnTrp: 0.667 ± 0.017	1.441GlnTyr: 1.441 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.181ArgAla: 3.181 ± 0.045	0.379ArgCys: 0.379 ± 0.017	2.305ArgAsp: 2.305 ± 0.045	2.597ArgGlu: 2.597 ± 0.048	2.253ArgPhe: 2.253 ± 0.043	2.336ArgGly: 2.336 ± 0.047	0.98ArgHis: 0.98 ± 0.029	3.061ArgIle: 3.061 ± 0.044	2.392ArgLys: 2.392 ± 0.043	4.612ArgLeu: 4.612 ± 0.065	1.086ArgMet: 1.086 ± 0.027	1.892ArgAsn: 1.892 ± 0.034	1.495ArgPro: 1.495 ± 0.032	2.041ArgGln: 2.041 ± 0.041	2.03ArgArg: 2.03 ± 0.044	2.584ArgSer: 2.584 ± 0.044	1.955ArgThr: 1.955 ± 0.036	2.845ArgVal: 2.845 ± 0.047	0.585ArgTrp: 0.585 ± 0.019	1.617ArgTyr: 1.617 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.579SerAla: 5.579 ± 0.071	0.658SerCys: 0.658 ± 0.021	4.022SerAsp: 4.022 ± 0.052	4.406SerGlu: 4.406 ± 0.055	3.038SerPhe: 3.038 ± 0.048	5.095SerGly: 5.095 ± 0.073	1.488SerHis: 1.488 ± 0.031	4.587SerIle: 4.587 ± 0.066	3.674SerLys: 3.674 ± 0.051	7.055SerLeu: 7.055 ± 0.072	1.718SerMet: 1.718 ± 0.036	3.097SerAsn: 3.097 ± 0.051	2.521SerPro: 2.521 ± 0.047	3.351SerGln: 3.351 ± 0.05	2.888SerArg: 2.888 ± 0.049	4.811SerSer: 4.811 ± 0.077	3.495SerThr: 3.495 ± 0.058	4.857SerVal: 4.857 ± 0.062	0.862SerTrp: 0.862 ± 0.023	2.069SerTyr: 2.069 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.224ThrAla: 4.224 ± 0.059	0.448ThrCys: 0.448 ± 0.021	3.162ThrAsp: 3.162 ± 0.048	3.196ThrGlu: 3.196 ± 0.048	2.322ThrPhe: 2.322 ± 0.037	3.885ThrGly: 3.885 ± 0.066	1.16ThrHis: 1.16 ± 0.029	3.361ThrIle: 3.361 ± 0.052	2.442ThrLys: 2.442 ± 0.048	5.931ThrLeu: 5.931 ± 0.071	1.076ThrMet: 1.076 ± 0.027	2.328ThrAsn: 2.328 ± 0.041	2.495ThrPro: 2.495 ± 0.039	2.556ThrGln: 2.556 ± 0.044	2.033ThrArg: 2.033 ± 0.042	3.595ThrSer: 3.595 ± 0.058	2.804ThrThr: 2.804 ± 0.05	3.544ThrVal: 3.544 ± 0.058	0.623ThrTrp: 0.623 ± 0.019	1.589ThrTyr: 1.589 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	5.727ValAla: 5.727 ± 0.062	0.714ValCys: 0.714 ± 0.022	4.231ValAsp: 4.231 ± 0.056	4.445ValGlu: 4.445 ± 0.068	2.943ValPhe: 2.943 ± 0.05	4.354ValGly: 4.354 ± 0.068	1.238ValHis: 1.238 ± 0.031	4.613ValIle: 4.613 ± 0.062	3.69ValLys: 3.69 ± 0.052	6.603ValLeu: 6.603 ± 0.074	1.695ValMet: 1.695 ± 0.036	3.477ValAsn: 3.477 ± 0.051	2.587ValPro: 2.587 ± 0.039	2.193ValGln: 2.193 ± 0.04	2.605ValArg: 2.605 ± 0.04	4.97ValSer: 4.97 ± 0.064	3.918ValThr: 3.918 ± 0.059	5.005ValVal: 5.005 ± 0.076	0.76ValTrp: 0.76 ± 0.028	1.867ValTyr: 1.867 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.792TrpAla: 0.792 ± 0.024	0.128TrpCys: 0.128 ± 0.009	0.634TrpAsp: 0.634 ± 0.023	0.561TrpGlu: 0.561 ± 0.021	0.614TrpPhe: 0.614 ± 0.022	0.771TrpGly: 0.771 ± 0.026	0.367TrpHis: 0.367 ± 0.018	0.745TrpIle: 0.745 ± 0.026	0.523TrpLys: 0.523 ± 0.019	1.659TrpLeu: 1.659 ± 0.039	0.35TrpMet: 0.35 ± 0.017	0.514TrpAsn: 0.514 ± 0.017	0.475TrpPro: 0.475 ± 0.019	1.003TrpGln: 1.003 ± 0.028	0.666TrpArg: 0.666 ± 0.023	0.766TrpSer: 0.766 ± 0.025	0.531TrpThr: 0.531 ± 0.02	0.85TrpVal: 0.85 ± 0.022	0.188TrpTrp: 0.188 ± 0.014	0.413TrpTyr: 0.413 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.428TyrAla: 2.428 ± 0.044	0.374TyrCys: 0.374 ± 0.017	1.688TyrAsp: 1.688 ± 0.036	1.717TyrGlu: 1.717 ± 0.037	1.608TyrPhe: 1.608 ± 0.037	2.053TyrGly: 2.053 ± 0.046	0.751TyrHis: 0.751 ± 0.024	1.757TyrIle: 1.757 ± 0.034	1.394TyrLys: 1.394 ± 0.032	3.389TyrLeu: 3.389 ± 0.055	0.625TyrMet: 0.625 ± 0.022	1.217TyrAsn: 1.217 ± 0.027	1.358TyrPro: 1.358 ± 0.035	1.883TyrGln: 1.883 ± 0.036	1.619TyrArg: 1.619 ± 0.039	2.216TyrSer: 2.216 ± 0.04	1.473TyrThr: 1.473 ± 0.034	1.899TyrVal: 1.899 ± 0.035	0.487TyrTrp: 0.487 ± 0.016	1.085TyrTyr: 1.085 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4327 proteins (1425066 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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