Amino acid dipepetide frequency for Limnothrix sp. P13C2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.746AlaAla: 12.746 ± 0.186
0.943AlaCys: 0.943 ± 0.03
5.576AlaAsp: 5.576 ± 0.081
6.116AlaGlu: 6.116 ± 0.099
2.991AlaPhe: 2.991 ± 0.057
7.415AlaGly: 7.415 ± 0.11
1.634AlaHis: 1.634 ± 0.033
8.624AlaIle: 8.624 ± 0.098
3.304AlaLys: 3.304 ± 0.053
11.694AlaLeu: 11.694 ± 0.128
2.092AlaMet: 2.092 ± 0.047
3.375AlaAsn: 3.375 ± 0.067
4.982AlaPro: 4.982 ± 0.112
5.647AlaGln: 5.647 ± 0.084
5.67AlaArg: 5.67 ± 0.082
5.019AlaSer: 5.019 ± 0.069
5.74AlaThr: 5.74 ± 0.084
6.665AlaVal: 6.665 ± 0.087
1.636AlaTrp: 1.636 ± 0.043
2.314AlaTyr: 2.314 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.781CysAla: 0.781 ± 0.029
0.16CysCys: 0.16 ± 0.012
0.642CysAsp: 0.642 ± 0.025
0.513CysGlu: 0.513 ± 0.019
0.389CysPhe: 0.389 ± 0.02
0.843CysGly: 0.843 ± 0.03
0.272CysHis: 0.272 ± 0.016
0.386CysIle: 0.386 ± 0.016
0.217CysLys: 0.217 ± 0.013
1.139CysLeu: 1.139 ± 0.036
0.144CysMet: 0.144 ± 0.01
0.294CysAsn: 0.294 ± 0.015
0.597CysPro: 0.597 ± 0.027
0.59CysGln: 0.59 ± 0.021
0.615CysArg: 0.615 ± 0.026
0.524CysSer: 0.524 ± 0.02
0.483CysThr: 0.483 ± 0.019
0.572CysVal: 0.572 ± 0.021
0.184CysTrp: 0.184 ± 0.014
0.354CysTyr: 0.354 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.004AspAla: 4.004 ± 0.07
0.676AspCys: 0.676 ± 0.022
2.572AspAsp: 2.572 ± 0.066
2.643AspGlu: 2.643 ± 0.063
2.236AspPhe: 2.236 ± 0.055
3.678AspGly: 3.678 ± 0.065
1.027AspHis: 1.027 ± 0.037
2.164AspIle: 2.164 ± 0.042
1.124AspLys: 1.124 ± 0.032
7.256AspLeu: 7.256 ± 0.11
0.708AspMet: 0.708 ± 0.021
1.3AspAsn: 1.3 ± 0.042
3.86AspPro: 3.86 ± 0.075
2.641AspGln: 2.641 ± 0.05
8.606AspArg: 8.606 ± 0.116
2.925AspSer: 2.925 ± 0.061
1.92AspThr: 1.92 ± 0.046
2.743AspVal: 2.743 ± 0.052
1.413AspTrp: 1.413 ± 0.035
1.765AspTyr: 1.765 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
6.506GluAla: 6.506 ± 0.085
0.406GluCys: 0.406 ± 0.018
2.397GluAsp: 2.397 ± 0.052
2.859GluGlu: 2.859 ± 0.068
2.183GluPhe: 2.183 ± 0.041
3.292GluGly: 3.292 ± 0.055
0.869GluHis: 0.869 ± 0.029
3.463GluIle: 3.463 ± 0.064
1.819GluLys: 1.819 ± 0.046
6.861GluLeu: 6.861 ± 0.082
1.118GluMet: 1.118 ± 0.034
1.634GluAsn: 1.634 ± 0.041
3.226GluPro: 3.226 ± 0.075
3.247GluGln: 3.247 ± 0.062
3.895GluArg: 3.895 ± 0.068
3.319GluSer: 3.319 ± 0.062
3.481GluThr: 3.481 ± 0.058
3.86GluVal: 3.86 ± 0.066
0.77GluTrp: 0.77 ± 0.026
1.226GluTyr: 1.226 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.235PheAla: 3.235 ± 0.057
0.505PheCys: 0.505 ± 0.022
2.293PheAsp: 2.293 ± 0.046
2.048PheGlu: 2.048 ± 0.045
1.318PhePhe: 1.318 ± 0.036
3.059PheGly: 3.059 ± 0.061
0.604PheHis: 0.604 ± 0.025
1.422PheIle: 1.422 ± 0.039
1.009PheLys: 1.009 ± 0.033
3.682PheLeu: 3.682 ± 0.07
0.637PheMet: 0.637 ± 0.024
1.231PheAsn: 1.231 ± 0.035
1.724PhePro: 1.724 ± 0.037
1.747PheGln: 1.747 ± 0.037
2.012PheArg: 2.012 ± 0.043
2.389PheSer: 2.389 ± 0.055
1.773PheThr: 1.773 ± 0.036
2.223PheVal: 2.223 ± 0.045
0.755PheTrp: 0.755 ± 0.025
1.127PheTyr: 1.127 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
6.752GlyAla: 6.752 ± 0.114
0.912GlyCys: 0.912 ± 0.029
4.57GlyAsp: 4.57 ± 0.076
3.84GlyGlu: 3.84 ± 0.066
2.951GlyPhe: 2.951 ± 0.058
5.594GlyGly: 5.594 ± 0.128
1.34GlyHis: 1.34 ± 0.039
4.113GlyIle: 4.113 ± 0.072
2.689GlyLys: 2.689 ± 0.058
8.66GlyLeu: 8.66 ± 0.119
1.584GlyMet: 1.584 ± 0.044
2.649GlyAsn: 2.649 ± 0.091
2.727GlyPro: 2.727 ± 0.055
4.221GlyGln: 4.221 ± 0.066
4.802GlyArg: 4.802 ± 0.071
4.856GlySer: 4.856 ± 0.088
3.86GlyThr: 3.86 ± 0.066
4.729GlyVal: 4.729 ± 0.08
1.586GlyTrp: 1.586 ± 0.047
2.17GlyTyr: 2.17 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.199HisAla: 1.199 ± 0.037
0.307HisCys: 0.307 ± 0.015
0.833HisAsp: 0.833 ± 0.033
0.962HisGlu: 0.962 ± 0.031
0.692HisPhe: 0.692 ± 0.024
1.379HisGly: 1.379 ± 0.036
0.661HisHis: 0.661 ± 0.032
0.674HisIle: 0.674 ± 0.023
0.457HisLys: 0.457 ± 0.021
2.299HisLeu: 2.299 ± 0.049
0.242HisMet: 0.242 ± 0.015
0.544HisAsn: 0.544 ± 0.022
1.522HisPro: 1.522 ± 0.042
1.126HisGln: 1.126 ± 0.034
1.365HisArg: 1.365 ± 0.035
0.969HisSer: 0.969 ± 0.03
0.666HisThr: 0.666 ± 0.023
0.862HisVal: 0.862 ± 0.025
0.54HisTrp: 0.54 ± 0.025
0.641HisTyr: 0.641 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.539IleAla: 7.539 ± 0.083
0.544IleCys: 0.544 ± 0.025
3.819IleAsp: 3.819 ± 0.055
3.95IleGlu: 3.95 ± 0.057
1.691IlePhe: 1.691 ± 0.042
4.396IleGly: 4.396 ± 0.076
1.05IleHis: 1.05 ± 0.033
1.892IleIle: 1.892 ± 0.042
1.341IleLys: 1.341 ± 0.035
5.152IleLeu: 5.152 ± 0.077
0.56IleMet: 0.56 ± 0.024
1.62IleAsn: 1.62 ± 0.04
2.816IlePro: 2.816 ± 0.048
2.517IleGln: 2.517 ± 0.039
2.984IleArg: 2.984 ± 0.051
2.939IleSer: 2.939 ± 0.054
2.843IleThr: 2.843 ± 0.056
3.781IleVal: 3.781 ± 0.072
0.693IleTrp: 0.693 ± 0.027
1.356IleTyr: 1.356 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.023LysAla: 3.023 ± 0.06
0.181LysCys: 0.181 ± 0.012
1.322LysAsp: 1.322 ± 0.031
1.437LysGlu: 1.437 ± 0.04
1.034LysPhe: 1.034 ± 0.029
1.992LysGly: 1.992 ± 0.047
0.531LysHis: 0.531 ± 0.02
1.838LysIle: 1.838 ± 0.048
1.056LysLys: 1.056 ± 0.036
3.395LysLeu: 3.395 ± 0.05
0.618LysMet: 0.618 ± 0.022
1.012LysAsn: 1.012 ± 0.035
1.945LysPro: 1.945 ± 0.045
1.462LysGln: 1.462 ± 0.044
1.873LysArg: 1.873 ± 0.041
1.768LysSer: 1.768 ± 0.042
2.077LysThr: 2.077 ± 0.049
2.032LysVal: 2.032 ± 0.042
0.287LysTrp: 0.287 ± 0.017
0.671LysTyr: 0.671 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
13.004LeuAla: 13.004 ± 0.141
1.052LeuCys: 1.052 ± 0.027
6.659LeuAsp: 6.659 ± 0.095
6.881LeuGlu: 6.881 ± 0.084
3.453LeuPhe: 3.453 ± 0.058
9.292LeuGly: 9.292 ± 0.12
1.936LeuHis: 1.936 ± 0.045
5.286LeuIle: 5.286 ± 0.075
3.962LeuLys: 3.962 ± 0.062
12.109LeuLeu: 12.109 ± 0.16
2.156LeuMet: 2.156 ± 0.05
3.755LeuAsn: 3.755 ± 0.056
6.709LeuPro: 6.709 ± 0.078
5.697LeuGln: 5.697 ± 0.081
7.186LeuArg: 7.186 ± 0.093
7.045LeuSer: 7.045 ± 0.091
6.322LeuThr: 6.322 ± 0.083
7.899LeuVal: 7.899 ± 0.093
1.902LeuTrp: 1.902 ± 0.049
2.488LeuTyr: 2.488 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.383MetAla: 2.383 ± 0.053
0.098MetCys: 0.098 ± 0.01
0.878MetAsp: 0.878 ± 0.027
0.945MetGlu: 0.945 ± 0.03
0.476MetPhe: 0.476 ± 0.021
1.582MetGly: 1.582 ± 0.039
0.278MetHis: 0.278 ± 0.016
0.776MetIle: 0.776 ± 0.027
0.597MetLys: 0.597 ± 0.024
1.802MetLeu: 1.802 ± 0.041
0.399MetMet: 0.399 ± 0.02
0.663MetAsn: 0.663 ± 0.024
1.089MetPro: 1.089 ± 0.031
0.862MetGln: 0.862 ± 0.027
1.087MetArg: 1.087 ± 0.035
1.16MetSer: 1.16 ± 0.036
1.301MetThr: 1.301 ± 0.033
1.461MetVal: 1.461 ± 0.04
0.127MetTrp: 0.127 ± 0.011
0.251MetTyr: 0.251 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.759AsnAla: 2.759 ± 0.063
0.359AsnCys: 0.359 ± 0.019
1.515AsnAsp: 1.515 ± 0.056
1.242AsnGlu: 1.242 ± 0.033
1.314AsnPhe: 1.314 ± 0.038
2.325AsnGly: 2.325 ± 0.055
0.701AsnHis: 0.701 ± 0.027
1.318AsnIle: 1.318 ± 0.036
0.677AsnLys: 0.677 ± 0.023
4.295AsnLeu: 4.295 ± 0.084
0.42AsnMet: 0.42 ± 0.019
1.057AsnAsn: 1.057 ± 0.037
2.793AsnPro: 2.793 ± 0.051
2.075AsnGln: 2.075 ± 0.047
2.388AsnArg: 2.388 ± 0.051
1.941AsnSer: 1.941 ± 0.049
1.477AsnThr: 1.477 ± 0.039
1.56AsnVal: 1.56 ± 0.04
0.628AsnTrp: 0.628 ± 0.024
0.862AsnTyr: 0.862 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
5.745ProAla: 5.745 ± 0.117
0.407ProCys: 0.407 ± 0.022
4.037ProAsp: 4.037 ± 0.067
4.266ProGlu: 4.266 ± 0.073
1.789ProPhe: 1.789 ± 0.038
3.888ProGly: 3.888 ± 0.07
1.007ProHis: 1.007 ± 0.028
3.595ProIle: 3.595 ± 0.06
1.865ProLys: 1.865 ± 0.046
5.698ProLeu: 5.698 ± 0.086
1.167ProMet: 1.167 ± 0.034
2.142ProAsn: 2.142 ± 0.049
3.325ProPro: 3.325 ± 0.083
2.835ProGln: 2.835 ± 0.061
2.556ProArg: 2.556 ± 0.049
3.466ProSer: 3.466 ± 0.075
3.495ProThr: 3.495 ± 0.079
3.917ProVal: 3.917 ± 0.07
0.953ProTrp: 0.953 ± 0.032
1.18ProTyr: 1.18 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
6.003GlnAla: 6.003 ± 0.087
0.382GlnCys: 0.382 ± 0.018
2.176GlnAsp: 2.176 ± 0.046
2.754GlnGlu: 2.754 ± 0.052
1.936GlnPhe: 1.936 ± 0.047
3.618GlnGly: 3.618 ± 0.064
0.85GlnHis: 0.85 ± 0.027
2.869GlnIle: 2.869 ± 0.06
1.652GlnLys: 1.652 ± 0.043
6.268GlnLeu: 6.268 ± 0.091
0.997GlnMet: 0.997 ± 0.028
1.524GlnAsn: 1.524 ± 0.043
3.49GlnPro: 3.49 ± 0.065
3.396GlnGln: 3.396 ± 0.088
3.826GlnArg: 3.826 ± 0.064
3.101GlnSer: 3.101 ± 0.055
2.939GlnThr: 2.939 ± 0.055
3.84GlnVal: 3.84 ± 0.054
1.004GlnTrp: 1.004 ± 0.034
1.006GlnTyr: 1.006 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
6.217ArgAla: 6.217 ± 0.087
0.642ArgCys: 0.642 ± 0.025
3.932ArgAsp: 3.932 ± 0.062
3.552ArgGlu: 3.552 ± 0.072
2.543ArgPhe: 2.543 ± 0.049
4.028ArgGly: 4.028 ± 0.069
1.179ArgHis: 1.179 ± 0.029
3.137ArgIle: 3.137 ± 0.049
1.742ArgLys: 1.742 ± 0.041
8.133ArgLeu: 8.133 ± 0.076
1.19ArgMet: 1.19 ± 0.032
1.914ArgAsn: 1.914 ± 0.039
3.821ArgPro: 3.821 ± 0.07
3.829ArgGln: 3.829 ± 0.072
4.317ArgArg: 4.317 ± 0.075
5.897ArgSer: 5.897 ± 0.076
2.824ArgThr: 2.824 ± 0.048
4.484ArgVal: 4.484 ± 0.059
1.495ArgTrp: 1.495 ± 0.038
2.057ArgTyr: 2.057 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
5.574SerAla: 5.574 ± 0.068
0.514SerCys: 0.514 ± 0.023
3.19SerAsp: 3.19 ± 0.067
3.178SerGlu: 3.178 ± 0.059
2.061SerPhe: 2.061 ± 0.044
5.103SerGly: 5.103 ± 0.079
1.169SerHis: 1.169 ± 0.036
3.376SerIle: 3.376 ± 0.051
1.566SerLys: 1.566 ± 0.038
7.128SerLeu: 7.128 ± 0.081
1.247SerMet: 1.247 ± 0.033
1.907SerAsn: 1.907 ± 0.045
4.115SerPro: 4.115 ± 0.076
3.048SerGln: 3.048 ± 0.053
3.676SerArg: 3.676 ± 0.063
3.681SerSer: 3.681 ± 0.078
3.277SerThr: 3.277 ± 0.052
3.694SerVal: 3.694 ± 0.065
0.945SerTrp: 0.945 ± 0.025
1.379SerTyr: 1.379 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.533ThrAla: 5.533 ± 0.08
0.476ThrCys: 0.476 ± 0.02
3.001ThrAsp: 3.001 ± 0.05
2.967ThrGlu: 2.967 ± 0.059
1.837ThrPhe: 1.837 ± 0.035
4.525ThrGly: 4.525 ± 0.075
0.968ThrHis: 0.968 ± 0.029
3.393ThrIle: 3.393 ± 0.073
1.368ThrLys: 1.368 ± 0.037
6.195ThrLeu: 6.195 ± 0.079
0.83ThrMet: 0.83 ± 0.028
1.638ThrAsn: 1.638 ± 0.043
3.286ThrPro: 3.286 ± 0.084
2.532ThrGln: 2.532 ± 0.055
2.664ThrArg: 2.664 ± 0.054
2.669ThrSer: 2.669 ± 0.048
2.977ThrThr: 2.977 ± 0.065
4.0ThrVal: 4.0 ± 0.059
0.797ThrTrp: 0.797 ± 0.025
1.403ThrTyr: 1.403 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
7.562ValAla: 7.562 ± 0.092
0.647ValCys: 0.647 ± 0.024
3.716ValAsp: 3.716 ± 0.059
3.831ValGlu: 3.831 ± 0.064
2.208ValPhe: 2.208 ± 0.055
5.07ValGly: 5.07 ± 0.081
0.993ValHis: 0.993 ± 0.029
3.238ValIle: 3.238 ± 0.052
2.056ValLys: 2.056 ± 0.043
7.393ValLeu: 7.393 ± 0.085
1.452ValMet: 1.452 ± 0.041
2.231ValAsn: 2.231 ± 0.044
3.237ValPro: 3.237 ± 0.058
3.196ValGln: 3.196 ± 0.051
4.035ValArg: 4.035 ± 0.061
3.796ValSer: 3.796 ± 0.059
3.915ValThr: 3.915 ± 0.055
5.112ValVal: 5.112 ± 0.076
0.955ValTrp: 0.955 ± 0.029
1.521ValTyr: 1.521 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.581TrpAla: 1.581 ± 0.044
0.143TrpCys: 0.143 ± 0.01
0.768TrpAsp: 0.768 ± 0.027
0.935TrpGlu: 0.935 ± 0.028
0.689TrpPhe: 0.689 ± 0.025
1.331TrpGly: 1.331 ± 0.041
0.337TrpHis: 0.337 ± 0.017
0.912TrpIle: 0.912 ± 0.031
0.428TrpLys: 0.428 ± 0.019
2.599TrpLeu: 2.599 ± 0.054
0.347TrpMet: 0.347 ± 0.018
0.497TrpAsn: 0.497 ± 0.025
0.677TrpPro: 0.677 ± 0.028
1.402TrpGln: 1.402 ± 0.04
1.191TrpArg: 1.191 ± 0.035
0.921TrpSer: 0.921 ± 0.028
0.7TrpThr: 0.7 ± 0.025
1.376TrpVal: 1.376 ± 0.039
0.359TrpTrp: 0.359 ± 0.019
0.333TrpTyr: 0.333 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.038TyrAla: 2.038 ± 0.043
0.347TyrCys: 0.347 ± 0.018
1.366TyrAsp: 1.366 ± 0.035
1.514TyrGlu: 1.514 ± 0.041
1.004TyrPhe: 1.004 ± 0.031
2.197TyrGly: 2.197 ± 0.045
0.531TyrHis: 0.531 ± 0.021
1.007TyrIle: 1.007 ± 0.029
0.625TyrLys: 0.625 ± 0.026
3.032TyrLeu: 3.032 ± 0.06
0.303TyrMet: 0.303 ± 0.015
0.719TyrAsn: 0.719 ± 0.032
1.393TyrPro: 1.393 ± 0.038
1.562TyrGln: 1.562 ± 0.039
2.184TyrArg: 2.184 ± 0.04
1.445TyrSer: 1.445 ± 0.041
0.989TyrThr: 0.989 ± 0.034
1.355TyrVal: 1.355 ± 0.031
0.494TyrTrp: 0.494 ± 0.021
0.763TyrTyr: 0.763 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3670 proteins (1208963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski