Amino acid dipepetide frequency for [Candida] intermedia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.192AlaAla: 5.192 ± 0.076	0.726AlaCys: 0.726 ± 0.016	3.319AlaAsp: 3.319 ± 0.041	4.056AlaGlu: 4.056 ± 0.076	2.586AlaPhe: 2.586 ± 0.036	3.675AlaGly: 3.675 ± 0.057	1.268AlaHis: 1.268 ± 0.023	3.852AlaIle: 3.852 ± 0.04	4.291AlaLys: 4.291 ± 0.05	6.407AlaLeu: 6.407 ± 0.052	1.379AlaMet: 1.379 ± 0.022	3.244AlaAsn: 3.244 ± 0.04	3.039AlaPro: 3.039 ± 0.055	2.402AlaGln: 2.402 ± 0.035	2.903AlaArg: 2.903 ± 0.034	6.093AlaSer: 6.093 ± 0.256	4.054AlaThr: 4.054 ± 0.056	4.145AlaVal: 4.145 ± 0.05	0.599AlaTrp: 0.599 ± 0.016	1.92AlaTyr: 1.92 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.639CysAla: 0.639 ± 0.015	0.226CysCys: 0.226 ± 0.01	0.661CysAsp: 0.661 ± 0.018	0.593CysGlu: 0.593 ± 0.018	0.599CysPhe: 0.599 ± 0.013	0.843CysGly: 0.843 ± 0.021	0.282CysHis: 0.282 ± 0.01	0.705CysIle: 0.705 ± 0.015	0.596CysLys: 0.596 ± 0.015	1.25CysLeu: 1.25 ± 0.026	0.239CysMet: 0.239 ± 0.011	0.515CysAsn: 0.515 ± 0.014	0.493CysPro: 0.493 ± 0.016	0.374CysGln: 0.374 ± 0.012	0.481CysArg: 0.481 ± 0.013	0.817CysSer: 0.817 ± 0.018	0.577CysThr: 0.577 ± 0.016	0.751CysVal: 0.751 ± 0.019	0.164CysTrp: 0.164 ± 0.007	0.41CysTyr: 0.41 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.678AspAla: 3.678 ± 0.113	0.562AspCys: 0.562 ± 0.016	4.477AspAsp: 4.477 ± 0.059	5.014AspGlu: 5.014 ± 0.079	2.833AspPhe: 2.833 ± 0.038	3.148AspGly: 3.148 ± 0.053	1.219AspHis: 1.219 ± 0.022	3.667AspIle: 3.667 ± 0.041	3.323AspLys: 3.323 ± 0.039	6.131AspLeu: 6.131 ± 0.056	1.204AspMet: 1.204 ± 0.021	2.604AspAsn: 2.604 ± 0.036	2.561AspPro: 2.561 ± 0.033	1.834AspGln: 1.834 ± 0.028	2.147AspArg: 2.147 ± 0.029	5.023AspSer: 5.023 ± 0.073	2.945AspThr: 2.945 ± 0.037	3.892AspVal: 3.892 ± 0.052	0.639AspTrp: 0.639 ± 0.016	2.217AspTyr: 2.217 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	4.262GluAla: 4.262 ± 0.182	0.63GluCys: 0.63 ± 0.018	4.427GluAsp: 4.427 ± 0.056	5.973GluGlu: 5.973 ± 0.085	2.807GluPhe: 2.807 ± 0.041	2.939GluGly: 2.939 ± 0.04	1.314GluHis: 1.314 ± 0.026	4.0GluIle: 4.0 ± 0.045	4.962GluLys: 4.962 ± 0.065	6.801GluLeu: 6.801 ± 0.076	1.382GluMet: 1.382 ± 0.02	3.469GluAsn: 3.469 ± 0.038	2.222GluPro: 2.222 ± 0.041	2.403GluGln: 2.403 ± 0.037	2.822GluArg: 2.822 ± 0.035	5.236GluSer: 5.236 ± 0.092	3.778GluThr: 3.778 ± 0.094	4.254GluVal: 4.254 ± 0.063	0.664GluTrp: 0.664 ± 0.016	2.191GluTyr: 2.191 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	2.838PheAla: 2.838 ± 0.037	0.55PheCys: 0.55 ± 0.014	2.878PheAsp: 2.878 ± 0.035	2.733PheGlu: 2.733 ± 0.037	2.113PhePhe: 2.113 ± 0.042	2.993PheGly: 2.993 ± 0.051	1.032PheHis: 1.032 ± 0.019	2.395PheIle: 2.395 ± 0.036	2.611PheLys: 2.611 ± 0.035	4.291PheLeu: 4.291 ± 0.048	0.954PheMet: 0.954 ± 0.02	2.34PheAsn: 2.34 ± 0.03	1.936PhePro: 1.936 ± 0.037	1.64PheGln: 1.64 ± 0.024	1.805PheArg: 1.805 ± 0.026	3.546PheSer: 3.546 ± 0.04	2.52PheThr: 2.52 ± 0.045	2.989PheVal: 2.989 ± 0.041	0.53PheTrp: 0.53 ± 0.016	1.499PheTyr: 1.499 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	3.74GlyAla: 3.74 ± 0.063	0.706GlyCys: 0.706 ± 0.015	3.121GlyAsp: 3.121 ± 0.041	3.228GlyGlu: 3.228 ± 0.046	2.606GlyPhe: 2.606 ± 0.033	3.79GlyGly: 3.79 ± 0.061	1.245GlyHis: 1.245 ± 0.025	3.336GlyIle: 3.336 ± 0.04	3.41GlyLys: 3.41 ± 0.04	5.282GlyLeu: 5.282 ± 0.053	1.139GlyMet: 1.139 ± 0.023	2.754GlyAsn: 2.754 ± 0.039	2.096GlyPro: 2.096 ± 0.043	1.913GlyGln: 1.913 ± 0.035	2.33GlyArg: 2.33 ± 0.031	5.305GlySer: 5.305 ± 0.11	3.318GlyThr: 3.318 ± 0.086	3.777GlyVal: 3.777 ± 0.06	0.669GlyTrp: 0.669 ± 0.016	2.059GlyTyr: 2.059 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.148HisAla: 1.148 ± 0.021	0.26HisCys: 0.26 ± 0.01	1.225HisAsp: 1.225 ± 0.025	1.335HisGlu: 1.335 ± 0.022	1.034HisPhe: 1.034 ± 0.019	1.26HisGly: 1.26 ± 0.025	0.756HisHis: 0.756 ± 0.022	1.291HisIle: 1.291 ± 0.019	1.251HisLys: 1.251 ± 0.024	2.389HisLeu: 2.389 ± 0.032	0.427HisMet: 0.427 ± 0.011	1.054HisAsn: 1.054 ± 0.02	1.135HisPro: 1.135 ± 0.021	0.957HisGln: 0.957 ± 0.024	1.001HisArg: 1.001 ± 0.018	1.792HisSer: 1.792 ± 0.033	1.078HisThr: 1.078 ± 0.017	1.272HisVal: 1.272 ± 0.021	0.223HisTrp: 0.223 ± 0.009	0.829HisTyr: 0.829 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.786IleAla: 3.786 ± 0.047	0.738IleCys: 0.738 ± 0.016	3.661IleAsp: 3.661 ± 0.038	3.664IleGlu: 3.664 ± 0.042	2.489IlePhe: 2.489 ± 0.037	3.105IleGly: 3.105 ± 0.042	1.325IleHis: 1.325 ± 0.022	3.163IleIle: 3.163 ± 0.041	3.418IleLys: 3.418 ± 0.04	5.669IleLeu: 5.669 ± 0.057	1.175IleMet: 1.175 ± 0.022	2.896IleAsn: 2.896 ± 0.038	2.942IlePro: 2.942 ± 0.035	2.06IleGln: 2.06 ± 0.028	2.529IleArg: 2.529 ± 0.03	4.914IleSer: 4.914 ± 0.065	3.261IleThr: 3.261 ± 0.04	3.959IleVal: 3.959 ± 0.055	0.595IleTrp: 0.595 ± 0.015	1.882IleTyr: 1.882 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.866LysAla: 3.866 ± 0.045	0.676LysCys: 0.676 ± 0.016	3.645LysAsp: 3.645 ± 0.041	4.546LysGlu: 4.546 ± 0.061	2.869LysPhe: 2.869 ± 0.037	2.826LysGly: 2.826 ± 0.04	1.41LysHis: 1.41 ± 0.023	3.672LysIle: 3.672 ± 0.04	5.39LysLys: 5.39 ± 0.073	7.098LysLeu: 7.098 ± 0.061	1.25LysMet: 1.25 ± 0.021	3.184LysAsn: 3.184 ± 0.04	2.785LysPro: 2.785 ± 0.038	2.471LysGln: 2.471 ± 0.034	3.28LysArg: 3.28 ± 0.041	4.95LysSer: 4.95 ± 0.054	3.394LysThr: 3.394 ± 0.038	4.223LysVal: 4.223 ± 0.037	0.721LysTrp: 0.721 ± 0.017	2.438LysTyr: 2.438 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	7.211LeuAla: 7.211 ± 0.055	1.224LeuCys: 1.224 ± 0.025	5.86LeuAsp: 5.86 ± 0.049	6.44LeuGlu: 6.44 ± 0.067	4.191LeuPhe: 4.191 ± 0.052	5.403LeuGly: 5.403 ± 0.044	2.179LeuHis: 2.179 ± 0.029	5.424LeuIle: 5.424 ± 0.06	6.73LeuLys: 6.73 ± 0.06	10.245LeuLeu: 10.245 ± 0.093	2.1LeuMet: 2.1 ± 0.027	5.098LeuAsn: 5.098 ± 0.048	4.889LeuPro: 4.889 ± 0.049	4.067LeuGln: 4.067 ± 0.048	4.935LeuArg: 4.935 ± 0.05	8.6LeuSer: 8.6 ± 0.089	5.74LeuThr: 5.74 ± 0.049	6.558LeuVal: 6.558 ± 0.056	0.982LeuTrp: 0.982 ± 0.02	3.032LeuTyr: 3.032 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	1.618MetAla: 1.618 ± 0.026	0.257MetCys: 0.257 ± 0.01	1.29MetAsp: 1.29 ± 0.023	1.264MetGlu: 1.264 ± 0.023	0.913MetPhe: 0.913 ± 0.021	1.193MetGly: 1.193 ± 0.023	0.354MetHis: 0.354 ± 0.012	1.077MetIle: 1.077 ± 0.022	1.329MetLys: 1.329 ± 0.022	1.955MetLeu: 1.955 ± 0.025	0.502MetMet: 0.502 ± 0.015	1.082MetAsn: 1.082 ± 0.026	0.908MetPro: 0.908 ± 0.021	0.62MetGln: 0.62 ± 0.016	0.896MetArg: 0.896 ± 0.02	2.012MetSer: 2.012 ± 0.029	1.121MetThr: 1.121 ± 0.021	1.325MetVal: 1.325 ± 0.021	0.197MetTrp: 0.197 ± 0.009	0.636MetTyr: 0.636 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.106AsnAla: 3.106 ± 0.04	0.543AsnCys: 0.543 ± 0.014	2.982AsnAsp: 2.982 ± 0.035	3.256AsnGlu: 3.256 ± 0.038	2.356AsnPhe: 2.356 ± 0.028	3.14AsnGly: 3.14 ± 0.045	1.123AsnHis: 1.123 ± 0.023	2.894AsnIle: 2.894 ± 0.034	2.825AsnLys: 2.825 ± 0.031	5.174AsnLeu: 5.174 ± 0.052	1.097AsnMet: 1.097 ± 0.025	2.526AsnAsn: 2.526 ± 0.044	2.296AsnPro: 2.296 ± 0.033	1.849AsnGln: 1.849 ± 0.034	1.943AsnArg: 1.943 ± 0.032	4.408AsnSer: 4.408 ± 0.073	2.747AsnThr: 2.747 ± 0.065	3.184AsnVal: 3.184 ± 0.033	0.574AsnTrp: 0.574 ± 0.015	1.928AsnTyr: 1.928 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	2.823ProAla: 2.823 ± 0.041	0.345ProCys: 0.345 ± 0.012	2.372ProAsp: 2.372 ± 0.032	3.352ProGlu: 3.352 ± 0.054	1.874ProPhe: 1.874 ± 0.027	2.372ProGly: 2.372 ± 0.047	1.017ProHis: 1.017 ± 0.02	2.513ProIle: 2.513 ± 0.032	2.872ProLys: 2.872 ± 0.038	4.404ProLeu: 4.404 ± 0.048	0.833ProMet: 0.833 ± 0.019	2.189ProAsn: 2.189 ± 0.033	2.711ProPro: 2.711 ± 0.066	2.09ProGln: 2.09 ± 0.037	1.871ProArg: 1.871 ± 0.03	3.942ProSer: 3.942 ± 0.05	2.85ProThr: 2.85 ± 0.037	3.173ProVal: 3.173 ± 0.042	0.449ProTrp: 0.449 ± 0.019	1.413ProTyr: 1.413 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	2.287GlnAla: 2.287 ± 0.039	0.382GlnCys: 0.382 ± 0.012	1.841GlnAsp: 1.841 ± 0.026	2.365GlnGlu: 2.365 ± 0.037	1.731GlnPhe: 1.731 ± 0.029	1.793GlnGly: 1.793 ± 0.036	0.872GlnHis: 0.872 ± 0.021	2.195GlnIle: 2.195 ± 0.028	2.517GlnLys: 2.517 ± 0.035	4.202GlnLeu: 4.202 ± 0.044	0.907GlnMet: 0.907 ± 0.021	1.975GlnAsn: 1.975 ± 0.031	1.693GlnPro: 1.693 ± 0.031	2.391GlnGln: 2.391 ± 0.087	1.763GlnArg: 1.763 ± 0.027	2.8GlnSer: 2.8 ± 0.046	1.996GlnThr: 1.996 ± 0.029	2.35GlnVal: 2.35 ± 0.034	0.409GlnTrp: 0.409 ± 0.011	1.37GlnTyr: 1.37 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.853ArgAla: 2.853 ± 0.03	0.486ArgCys: 0.486 ± 0.014	2.399ArgAsp: 2.399 ± 0.034	2.764ArgGlu: 2.764 ± 0.039	1.948ArgPhe: 1.948 ± 0.027	2.195ArgGly: 2.195 ± 0.034	1.007ArgHis: 1.007 ± 0.018	2.587ArgIle: 2.587 ± 0.031	3.437ArgLys: 3.437 ± 0.045	4.547ArgLeu: 4.547 ± 0.049	0.995ArgMet: 0.995 ± 0.017	2.272ArgAsn: 2.272 ± 0.027	1.817ArgPro: 1.817 ± 0.03	1.763ArgGln: 1.763 ± 0.027	2.728ArgArg: 2.728 ± 0.037	3.456ArgSer: 3.456 ± 0.052	2.295ArgThr: 2.295 ± 0.032	2.607ArgVal: 2.607 ± 0.035	0.472ArgTrp: 0.472 ± 0.014	1.513ArgTyr: 1.513 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	5.459SerAla: 5.459 ± 0.095	0.777SerCys: 0.777 ± 0.02	5.047SerAsp: 5.047 ± 0.127	5.451SerGlu: 5.451 ± 0.156	3.593SerPhe: 3.593 ± 0.052	5.4SerGly: 5.4 ± 0.127	1.851SerHis: 1.851 ± 0.028	4.93SerIle: 4.93 ± 0.062	5.43SerLys: 5.43 ± 0.054	8.442SerLeu: 8.442 ± 0.083	1.693SerMet: 1.693 ± 0.027	4.219SerAsn: 4.219 ± 0.052	3.931SerPro: 3.931 ± 0.054	3.265SerGln: 3.265 ± 0.047	3.768SerArg: 3.768 ± 0.042	9.354SerSer: 9.354 ± 0.223	5.828SerThr: 5.828 ± 0.116	5.302SerVal: 5.302 ± 0.058	0.822SerTrp: 0.822 ± 0.019	2.513SerTyr: 2.513 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	3.575ThrAla: 3.575 ± 0.055	0.639ThrCys: 0.639 ± 0.017	3.051ThrAsp: 3.051 ± 0.071	3.386ThrGlu: 3.386 ± 0.073	2.567ThrPhe: 2.567 ± 0.034	3.454ThrGly: 3.454 ± 0.065	1.142ThrHis: 1.142 ± 0.025	3.387ThrIle: 3.387 ± 0.037	3.576ThrLys: 3.576 ± 0.034	5.502ThrLeu: 5.502 ± 0.047	1.077ThrMet: 1.077 ± 0.019	3.056ThrAsn: 3.056 ± 0.069	3.137ThrPro: 3.137 ± 0.057	1.946ThrGln: 1.946 ± 0.032	2.314ThrArg: 2.314 ± 0.026	5.906ThrSer: 5.906 ± 0.147	4.873ThrThr: 4.873 ± 0.328	3.806ThrVal: 3.806 ± 0.076	0.682ThrTrp: 0.682 ± 0.043	1.861ThrTyr: 1.861 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.568ValAla: 4.568 ± 0.044	0.82ValCys: 0.82 ± 0.019	4.143ValAsp: 4.143 ± 0.06	4.496ValGlu: 4.496 ± 0.06	2.887ValPhe: 2.887 ± 0.034	3.604ValGly: 3.604 ± 0.046	1.329ValHis: 1.329 ± 0.021	3.655ValIle: 3.655 ± 0.049	3.972ValLys: 3.972 ± 0.039	6.387ValLeu: 6.387 ± 0.056	1.248ValMet: 1.248 ± 0.021	3.078ValAsn: 3.078 ± 0.037	3.161ValPro: 3.161 ± 0.035	2.138ValGln: 2.138 ± 0.028	2.705ValArg: 2.705 ± 0.04	5.515ValSer: 5.515 ± 0.067	3.93ValThr: 3.93 ± 0.087	4.875ValVal: 4.875 ± 0.056	0.666ValTrp: 0.666 ± 0.014	2.068ValTyr: 2.068 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	0.616TrpAla: 0.616 ± 0.016	0.202TrpCys: 0.202 ± 0.008	0.646TrpAsp: 0.646 ± 0.018	0.596TrpGlu: 0.596 ± 0.015	0.508TrpPhe: 0.508 ± 0.015	0.604TrpGly: 0.604 ± 0.018	0.216TrpHis: 0.216 ± 0.008	0.636TrpIle: 0.636 ± 0.016	0.776TrpLys: 0.776 ± 0.016	1.073TrpLeu: 1.073 ± 0.022	0.236TrpMet: 0.236 ± 0.009	0.609TrpAsn: 0.609 ± 0.016	0.329TrpPro: 0.329 ± 0.012	0.349TrpGln: 0.349 ± 0.011	0.539TrpArg: 0.539 ± 0.016	0.774TrpSer: 0.774 ± 0.019	0.717TrpThr: 0.717 ± 0.041	0.636TrpVal: 0.636 ± 0.016	0.176TrpTrp: 0.176 ± 0.009	0.404TrpTyr: 0.404 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.882TyrAla: 1.882 ± 0.027	0.467TyrCys: 0.467 ± 0.011	2.075TyrAsp: 2.075 ± 0.029	2.023TyrGlu: 2.023 ± 0.026	1.689TyrPhe: 1.689 ± 0.028	2.088TyrGly: 2.088 ± 0.03	0.778TyrHis: 0.778 ± 0.018	1.853TyrIle: 1.853 ± 0.03	1.976TyrLys: 1.976 ± 0.027	3.659TyrLeu: 3.659 ± 0.039	0.71TyrMet: 0.71 ± 0.017	1.786TyrAsn: 1.786 ± 0.03	1.384TyrPro: 1.384 ± 0.025	1.311TyrGln: 1.311 ± 0.025	1.383TyrArg: 1.383 ± 0.021	2.633TyrSer: 2.633 ± 0.036	1.912TyrThr: 1.912 ± 0.051	2.168TyrVal: 2.168 ± 0.042	0.408TyrTrp: 0.408 ± 0.014	1.382TyrTyr: 1.382 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5921 proteins (2935372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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