Amino acid dipepetide frequency for Sedimentisphaera salicampi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.223AlaAla: 8.223 ± 0.144
0.989AlaCys: 0.989 ± 0.033
4.877AlaAsp: 4.877 ± 0.124
6.989AlaGlu: 6.989 ± 0.117
3.03AlaPhe: 3.03 ± 0.058
8.139AlaGly: 8.139 ± 0.167
1.028AlaHis: 1.028 ± 0.037
3.776AlaIle: 3.776 ± 0.08
4.312AlaLys: 4.312 ± 0.077
5.671AlaLeu: 5.671 ± 0.086
1.87AlaMet: 1.87 ± 0.055
2.823AlaAsn: 2.823 ± 0.063
2.46AlaPro: 2.46 ± 0.06
2.367AlaGln: 2.367 ± 0.057
3.283AlaArg: 3.283 ± 0.071
5.089AlaSer: 5.089 ± 0.091
2.134AlaThr: 2.134 ± 0.06
6.42AlaVal: 6.42 ± 0.099
0.771AlaTrp: 0.771 ± 0.034
2.274AlaTyr: 2.274 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.754CysAla: 0.754 ± 0.03
0.277CysCys: 0.277 ± 0.017
0.756CysAsp: 0.756 ± 0.032
0.901CysGlu: 0.901 ± 0.037
0.723CysPhe: 0.723 ± 0.029
1.468CysGly: 1.468 ± 0.051
0.21CysHis: 0.21 ± 0.016
0.886CysIle: 0.886 ± 0.032
0.775CysLys: 0.775 ± 0.03
1.11CysLeu: 1.11 ± 0.034
0.261CysMet: 0.261 ± 0.017
0.467CysAsn: 0.467 ± 0.022
0.715CysPro: 0.715 ± 0.039
0.35CysGln: 0.35 ± 0.02
0.899CysArg: 0.899 ± 0.033
1.257CysSer: 1.257 ± 0.036
0.634CysThr: 0.634 ± 0.025
0.813CysVal: 0.813 ± 0.031
0.217CysTrp: 0.217 ± 0.015
0.56CysTyr: 0.56 ± 0.039
0.0CysXaa: 0.0 ± 0.0
Asp
3.932AspAla: 3.932 ± 0.109
0.852AspCys: 0.852 ± 0.029
3.095AspAsp: 3.095 ± 0.079
4.09AspGlu: 4.09 ± 0.065
3.355AspPhe: 3.355 ± 0.07
4.646AspGly: 4.646 ± 0.105
0.85AspHis: 0.85 ± 0.03
4.582AspIle: 4.582 ± 0.075
4.12AspLys: 4.12 ± 0.086
4.788AspLeu: 4.788 ± 0.082
1.586AspMet: 1.586 ± 0.044
2.952AspAsn: 2.952 ± 0.071
2.607AspPro: 2.607 ± 0.076
1.537AspGln: 1.537 ± 0.045
2.26AspArg: 2.26 ± 0.05
4.513AspSer: 4.513 ± 0.099
2.848AspThr: 2.848 ± 0.073
3.732AspVal: 3.732 ± 0.073
1.002AspTrp: 1.002 ± 0.037
2.889AspTyr: 2.889 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.313GluAla: 5.313 ± 0.102
0.687GluCys: 0.687 ± 0.027
4.416GluAsp: 4.416 ± 0.08
5.139GluGlu: 5.139 ± 0.09
2.926GluPhe: 2.926 ± 0.058
5.19GluGly: 5.19 ± 0.084
1.158GluHis: 1.158 ± 0.04
5.396GluIle: 5.396 ± 0.084
6.525GluLys: 6.525 ± 0.11
6.583GluLeu: 6.583 ± 0.092
1.974GluMet: 1.974 ± 0.048
4.538GluAsn: 4.538 ± 0.085
2.682GluPro: 2.682 ± 0.054
2.949GluGln: 2.949 ± 0.068
3.091GluArg: 3.091 ± 0.076
4.27GluSer: 4.27 ± 0.077
3.567GluThr: 3.567 ± 0.068
4.037GluVal: 4.037 ± 0.072
0.846GluTrp: 0.846 ± 0.037
2.76GluTyr: 2.76 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
3.751PheAla: 3.751 ± 0.064
0.763PheCys: 0.763 ± 0.029
3.166PheAsp: 3.166 ± 0.065
3.297PheGlu: 3.297 ± 0.068
2.01PhePhe: 2.01 ± 0.049
3.19PheGly: 3.19 ± 0.067
0.656PheHis: 0.656 ± 0.027
2.803PheIle: 2.803 ± 0.063
2.37PheLys: 2.37 ± 0.048
3.498PheLeu: 3.498 ± 0.069
1.007PheMet: 1.007 ± 0.033
2.045PheAsn: 2.045 ± 0.048
1.533PhePro: 1.533 ± 0.041
1.17PheGln: 1.17 ± 0.037
1.933PheArg: 1.933 ± 0.05
3.719PheSer: 3.719 ± 0.074
2.55PheThr: 2.55 ± 0.055
2.632PheVal: 2.632 ± 0.053
0.688PheTrp: 0.688 ± 0.027
1.624PheTyr: 1.624 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.117GlyAla: 5.117 ± 0.11
1.208GlyCys: 1.208 ± 0.036
4.249GlyAsp: 4.249 ± 0.103
5.469GlyGlu: 5.469 ± 0.096
3.654GlyPhe: 3.654 ± 0.073
6.233GlyGly: 6.233 ± 0.199
1.303GlyHis: 1.303 ± 0.038
5.271GlyIle: 5.271 ± 0.093
5.448GlyLys: 5.448 ± 0.102
6.595GlyLeu: 6.595 ± 0.106
1.874GlyMet: 1.874 ± 0.054
3.125GlyAsn: 3.125 ± 0.083
1.955GlyPro: 1.955 ± 0.049
2.469GlyGln: 2.469 ± 0.059
3.929GlyArg: 3.929 ± 0.073
5.925GlySer: 5.925 ± 0.125
3.813GlyThr: 3.813 ± 0.087
4.469GlyVal: 4.469 ± 0.078
1.431GlyTrp: 1.431 ± 0.065
2.91GlyTyr: 2.91 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
0.885HisAla: 0.885 ± 0.031
0.284HisCys: 0.284 ± 0.017
0.728HisAsp: 0.728 ± 0.028
0.856HisGlu: 0.856 ± 0.033
0.884HisPhe: 0.884 ± 0.031
1.175HisGly: 1.175 ± 0.04
0.385HisHis: 0.385 ± 0.023
1.33HisIle: 1.33 ± 0.039
1.1HisLys: 1.1 ± 0.036
1.507HisLeu: 1.507 ± 0.037
0.334HisMet: 0.334 ± 0.016
0.8HisAsn: 0.8 ± 0.031
0.896HisPro: 0.896 ± 0.032
0.555HisGln: 0.555 ± 0.026
0.795HisArg: 0.795 ± 0.03
1.213HisSer: 1.213 ± 0.037
0.897HisThr: 0.897 ± 0.035
0.68HisVal: 0.68 ± 0.023
0.369HisTrp: 0.369 ± 0.02
0.771HisTyr: 0.771 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.2IleAla: 5.2 ± 0.098
1.034IleCys: 1.034 ± 0.035
4.625IleAsp: 4.625 ± 0.074
5.364IleGlu: 5.364 ± 0.086
2.665IlePhe: 2.665 ± 0.057
4.271IleGly: 4.271 ± 0.083
0.994IleHis: 0.994 ± 0.032
4.179IleIle: 4.179 ± 0.083
4.116IleLys: 4.116 ± 0.077
5.01IleLeu: 5.01 ± 0.096
1.341IleMet: 1.341 ± 0.044
3.083IleAsn: 3.083 ± 0.071
2.623IlePro: 2.623 ± 0.058
1.783IleGln: 1.783 ± 0.041
2.999IleArg: 2.999 ± 0.073
5.395IleSer: 5.395 ± 0.093
3.943IleThr: 3.943 ± 0.086
3.748IleVal: 3.748 ± 0.08
0.723IleTrp: 0.723 ± 0.026
2.262IleTyr: 2.262 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.246LysAla: 5.246 ± 0.084
0.679LysCys: 0.679 ± 0.032
3.78LysAsp: 3.78 ± 0.071
4.34LysGlu: 4.34 ± 0.086
2.386LysPhe: 2.386 ± 0.059
4.172LysGly: 4.172 ± 0.077
1.135LysHis: 1.135 ± 0.039
4.864LysIle: 4.864 ± 0.091
5.021LysLys: 5.021 ± 0.112
5.853LysLeu: 5.853 ± 0.095
1.662LysMet: 1.662 ± 0.044
3.486LysAsn: 3.486 ± 0.071
2.726LysPro: 2.726 ± 0.068
2.392LysGln: 2.392 ± 0.06
3.281LysArg: 3.281 ± 0.073
3.976LysSer: 3.976 ± 0.078
3.76LysThr: 3.76 ± 0.075
3.735LysVal: 3.735 ± 0.077
0.87LysTrp: 0.87 ± 0.031
2.433LysTyr: 2.433 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
6.786LeuAla: 6.786 ± 0.089
1.348LeuCys: 1.348 ± 0.052
4.936LeuAsp: 4.936 ± 0.08
6.453LeuGlu: 6.453 ± 0.107
3.513LeuPhe: 3.513 ± 0.076
5.885LeuGly: 5.885 ± 0.088
1.284LeuHis: 1.284 ± 0.035
5.297LeuIle: 5.297 ± 0.099
6.072LeuLys: 6.072 ± 0.107
7.299LeuLeu: 7.299 ± 0.117
1.885LeuMet: 1.885 ± 0.048
3.963LeuAsn: 3.963 ± 0.067
3.747LeuPro: 3.747 ± 0.064
2.309LeuGln: 2.309 ± 0.055
4.014LeuArg: 4.014 ± 0.08
7.091LeuSer: 7.091 ± 0.098
4.417LeuThr: 4.417 ± 0.088
4.507LeuVal: 4.507 ± 0.079
0.974LeuTrp: 0.974 ± 0.038
2.755LeuTyr: 2.755 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.052MetAla: 2.052 ± 0.051
0.256MetCys: 0.256 ± 0.016
1.257MetAsp: 1.257 ± 0.036
1.34MetGlu: 1.34 ± 0.037
0.918MetPhe: 0.918 ± 0.035
1.654MetGly: 1.654 ± 0.043
0.436MetHis: 0.436 ± 0.021
1.495MetIle: 1.495 ± 0.043
1.851MetLys: 1.851 ± 0.043
2.336MetLeu: 2.336 ± 0.064
0.596MetMet: 0.596 ± 0.027
1.18MetAsn: 1.18 ± 0.032
1.278MetPro: 1.278 ± 0.044
0.934MetGln: 0.934 ± 0.035
1.171MetArg: 1.171 ± 0.037
1.439MetSer: 1.439 ± 0.041
1.039MetThr: 1.039 ± 0.039
1.318MetVal: 1.318 ± 0.039
0.219MetTrp: 0.219 ± 0.016
0.66MetTyr: 0.66 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.382AsnAla: 3.382 ± 0.069
0.87AsnCys: 0.87 ± 0.048
2.39AsnAsp: 2.39 ± 0.057
2.858AsnGlu: 2.858 ± 0.063
2.15AsnPhe: 2.15 ± 0.048
3.623AsnGly: 3.623 ± 0.094
0.796AsnHis: 0.796 ± 0.031
3.351AsnIle: 3.351 ± 0.06
2.641AsnLys: 2.641 ± 0.051
4.018AsnLeu: 4.018 ± 0.063
1.158AsnMet: 1.158 ± 0.036
2.225AsnAsn: 2.225 ± 0.059
2.637AsnPro: 2.637 ± 0.06
1.557AsnGln: 1.557 ± 0.048
2.01AsnArg: 2.01 ± 0.05
3.44AsnSer: 3.44 ± 0.068
2.265AsnThr: 2.265 ± 0.05
2.811AsnVal: 2.811 ± 0.067
0.861AsnTrp: 0.861 ± 0.036
1.89AsnTyr: 1.89 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
3.678ProAla: 3.678 ± 0.064
0.481ProCys: 0.481 ± 0.021
3.031ProAsp: 3.031 ± 0.066
4.791ProGlu: 4.791 ± 0.076
1.72ProPhe: 1.72 ± 0.045
2.973ProGly: 2.973 ± 0.061
0.795ProHis: 0.795 ± 0.031
1.855ProIle: 1.855 ± 0.044
2.095ProLys: 2.095 ± 0.056
3.053ProLeu: 3.053 ± 0.06
0.76ProMet: 0.76 ± 0.031
1.81ProAsn: 1.81 ± 0.046
1.264ProPro: 1.264 ± 0.043
1.457ProGln: 1.457 ± 0.04
1.379ProArg: 1.379 ± 0.044
2.709ProSer: 2.709 ± 0.059
1.582ProThr: 1.582 ± 0.05
3.093ProVal: 3.093 ± 0.056
0.538ProTrp: 0.538 ± 0.025
1.485ProTyr: 1.485 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.658GlnAla: 2.658 ± 0.062
0.309GlnCys: 0.309 ± 0.017
1.758GlnAsp: 1.758 ± 0.045
2.008GlnGlu: 2.008 ± 0.051
1.236GlnPhe: 1.236 ± 0.033
2.211GlnGly: 2.211 ± 0.055
0.5GlnHis: 0.5 ± 0.022
2.52GlnIle: 2.52 ± 0.051
2.332GlnLys: 2.332 ± 0.06
2.739GlnLeu: 2.739 ± 0.063
0.913GlnMet: 0.913 ± 0.032
1.711GlnAsn: 1.711 ± 0.044
1.239GlnPro: 1.239 ± 0.039
1.5GlnGln: 1.5 ± 0.054
1.669GlnArg: 1.669 ± 0.049
1.906GlnSer: 1.906 ± 0.046
1.966GlnThr: 1.966 ± 0.041
1.793GlnVal: 1.793 ± 0.045
0.597GlnTrp: 0.597 ± 0.027
1.119GlnTyr: 1.119 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.893ArgAla: 2.893 ± 0.066
0.642ArgCys: 0.642 ± 0.028
2.53ArgAsp: 2.53 ± 0.052
3.389ArgGlu: 3.389 ± 0.076
2.306ArgPhe: 2.306 ± 0.055
2.874ArgGly: 2.874 ± 0.063
0.813ArgHis: 0.813 ± 0.031
3.439ArgIle: 3.439 ± 0.065
3.63ArgLys: 3.63 ± 0.073
4.38ArgLeu: 4.38 ± 0.077
1.191ArgMet: 1.191 ± 0.037
2.231ArgAsn: 2.231 ± 0.054
1.944ArgPro: 1.944 ± 0.053
1.632ArgGln: 1.632 ± 0.05
2.598ArgArg: 2.598 ± 0.069
2.634ArgSer: 2.634 ± 0.048
1.967ArgThr: 1.967 ± 0.048
2.646ArgVal: 2.646 ± 0.058
0.696ArgTrp: 0.696 ± 0.028
1.68ArgTyr: 1.68 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
5.287SerAla: 5.287 ± 0.088
0.898SerCys: 0.898 ± 0.032
4.575SerAsp: 4.575 ± 0.08
5.83SerGlu: 5.83 ± 0.096
3.44SerPhe: 3.44 ± 0.071
6.982SerGly: 6.982 ± 0.129
1.118SerHis: 1.118 ± 0.033
4.136SerIle: 4.136 ± 0.091
4.078SerLys: 4.078 ± 0.068
6.07SerLeu: 6.07 ± 0.089
1.552SerMet: 1.552 ± 0.046
2.863SerAsn: 2.863 ± 0.06
3.059SerPro: 3.059 ± 0.062
2.405SerGln: 2.405 ± 0.061
3.617SerArg: 3.617 ± 0.079
5.833SerSer: 5.833 ± 0.112
2.726SerThr: 2.726 ± 0.053
4.681SerVal: 4.681 ± 0.078
1.092SerTrp: 1.092 ± 0.043
2.36SerTyr: 2.36 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.431ThrAla: 4.431 ± 0.174
0.517ThrCys: 0.517 ± 0.027
3.047ThrAsp: 3.047 ± 0.08
3.347ThrGlu: 3.347 ± 0.068
2.112ThrPhe: 2.112 ± 0.052
4.602ThrGly: 4.602 ± 0.084
0.781ThrHis: 0.781 ± 0.026
3.11ThrIle: 3.11 ± 0.068
2.445ThrLys: 2.445 ± 0.051
4.16ThrLeu: 4.16 ± 0.08
0.898ThrMet: 0.898 ± 0.034
1.937ThrAsn: 1.937 ± 0.06
2.275ThrPro: 2.275 ± 0.047
1.337ThrGln: 1.337 ± 0.038
1.713ThrArg: 1.713 ± 0.045
3.133ThrSer: 3.133 ± 0.061
2.087ThrThr: 2.087 ± 0.061
3.706ThrVal: 3.706 ± 0.085
0.525ThrTrp: 0.525 ± 0.029
1.525ThrTyr: 1.525 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
3.506ValAla: 3.506 ± 0.079
1.12ValCys: 1.12 ± 0.038
3.658ValAsp: 3.658 ± 0.068
4.316ValGlu: 4.316 ± 0.079
3.133ValPhe: 3.133 ± 0.065
3.607ValGly: 3.607 ± 0.073
1.117ValHis: 1.117 ± 0.037
4.134ValIle: 4.134 ± 0.083
3.858ValLys: 3.858 ± 0.074
5.558ValLeu: 5.558 ± 0.088
1.515ValMet: 1.515 ± 0.045
3.092ValAsn: 3.092 ± 0.064
2.621ValPro: 2.621 ± 0.058
1.992ValGln: 1.992 ± 0.057
2.936ValArg: 2.936 ± 0.061
5.144ValSer: 5.144 ± 0.086
2.998ValThr: 2.998 ± 0.086
4.04ValVal: 4.04 ± 0.09
0.78ValTrp: 0.78 ± 0.032
2.432ValTyr: 2.432 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.949TrpAla: 0.949 ± 0.035
0.166TrpCys: 0.166 ± 0.014
0.989TrpAsp: 0.989 ± 0.047
0.861TrpGlu: 0.861 ± 0.037
0.564TrpPhe: 0.564 ± 0.023
0.964TrpGly: 0.964 ± 0.042
0.41TrpHis: 0.41 ± 0.023
0.744TrpIle: 0.744 ± 0.031
0.892TrpLys: 0.892 ± 0.035
1.336TrpLeu: 1.336 ± 0.04
0.317TrpMet: 0.317 ± 0.02
0.731TrpAsn: 0.731 ± 0.033
0.632TrpPro: 0.632 ± 0.028
0.722TrpGln: 0.722 ± 0.03
0.7TrpArg: 0.7 ± 0.031
0.853TrpSer: 0.853 ± 0.038
0.709TrpThr: 0.709 ± 0.031
0.738TrpVal: 0.738 ± 0.031
0.237TrpTrp: 0.237 ± 0.018
0.525TrpTyr: 0.525 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.482TyrAla: 2.482 ± 0.053
0.653TyrCys: 0.653 ± 0.028
2.374TyrAsp: 2.374 ± 0.065
2.407TyrGlu: 2.407 ± 0.058
1.678TyrPhe: 1.678 ± 0.043
2.589TyrGly: 2.589 ± 0.06
0.676TyrHis: 0.676 ± 0.03
2.189TyrIle: 2.189 ± 0.045
2.119TyrLys: 2.119 ± 0.055
2.97TyrLeu: 2.97 ± 0.058
0.735TyrMet: 0.735 ± 0.027
1.873TyrAsn: 1.873 ± 0.047
1.655TyrPro: 1.655 ± 0.042
1.266TyrGln: 1.266 ± 0.043
1.839TyrArg: 1.839 ± 0.043
3.063TyrSer: 3.063 ± 0.065
1.787TyrThr: 1.787 ± 0.054
1.955TyrVal: 1.955 ± 0.047
0.605TyrTrp: 0.605 ± 0.028
1.662TyrTyr: 1.662 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2335 proteins (937580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski