Amino acid dipepetide frequency for Sulfobacillus sp. hq2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.337AlaAla: 10.337 ± 0.132
0.691AlaCys: 0.691 ± 0.028
4.585AlaAsp: 4.585 ± 0.071
4.893AlaGlu: 4.893 ± 0.08
3.627AlaPhe: 3.627 ± 0.07
7.305AlaGly: 7.305 ± 0.088
2.786AlaHis: 2.786 ± 0.059
6.086AlaIle: 6.086 ± 0.09
3.12AlaLys: 3.12 ± 0.061
12.618AlaLeu: 12.618 ± 0.127
3.096AlaMet: 3.096 ± 0.064
2.571AlaAsn: 2.571 ± 0.051
4.34AlaPro: 4.34 ± 0.067
5.349AlaGln: 5.349 ± 0.09
5.823AlaArg: 5.823 ± 0.088
5.613AlaSer: 5.613 ± 0.091
5.247AlaThr: 5.247 ± 0.083
8.591AlaVal: 8.591 ± 0.108
1.979AlaTrp: 1.979 ± 0.052
2.756AlaTyr: 2.756 ± 0.053
0.001AlaXaa: 0.001 ± 0.001
Cys
0.539CysAla: 0.539 ± 0.024
0.078CysCys: 0.078 ± 0.008
0.348CysAsp: 0.348 ± 0.021
0.341CysGlu: 0.341 ± 0.019
0.192CysPhe: 0.192 ± 0.014
0.747CysGly: 0.747 ± 0.029
0.244CysHis: 0.244 ± 0.016
0.245CysIle: 0.245 ± 0.017
0.115CysLys: 0.115 ± 0.011
0.569CysLeu: 0.569 ± 0.023
0.125CysMet: 0.125 ± 0.011
0.146CysAsn: 0.146 ± 0.012
0.494CysPro: 0.494 ± 0.027
0.333CysGln: 0.333 ± 0.019
0.455CysArg: 0.455 ± 0.025
0.329CysSer: 0.329 ± 0.018
0.325CysThr: 0.325 ± 0.019
0.424CysVal: 0.424 ± 0.025
0.093CysTrp: 0.093 ± 0.009
0.193CysTyr: 0.193 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.751AspAla: 4.751 ± 0.077
0.286AspCys: 0.286 ± 0.017
2.392AspAsp: 2.392 ± 0.059
2.67AspGlu: 2.67 ± 0.063
1.681AspPhe: 1.681 ± 0.033
3.385AspGly: 3.385 ± 0.07
1.432AspHis: 1.432 ± 0.04
2.894AspIle: 2.894 ± 0.053
1.332AspLys: 1.332 ± 0.039
5.115AspLeu: 5.115 ± 0.075
1.297AspMet: 1.297 ± 0.04
1.226AspAsn: 1.226 ± 0.034
2.96AspPro: 2.96 ± 0.055
2.042AspGln: 2.042 ± 0.046
3.122AspArg: 3.122 ± 0.067
2.114AspSer: 2.114 ± 0.05
2.455AspThr: 2.455 ± 0.051
4.18AspVal: 4.18 ± 0.07
0.903AspTrp: 0.903 ± 0.032
1.421AspTyr: 1.421 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.677GluAla: 5.677 ± 0.091
0.274GluCys: 0.274 ± 0.018
2.591GluAsp: 2.591 ± 0.064
3.366GluGlu: 3.366 ± 0.075
1.547GluPhe: 1.547 ± 0.036
3.586GluGly: 3.586 ± 0.064
1.385GluHis: 1.385 ± 0.046
2.835GluIle: 2.835 ± 0.062
1.809GluLys: 1.809 ± 0.047
4.606GluLeu: 4.606 ± 0.079
1.5GluMet: 1.5 ± 0.042
1.397GluAsn: 1.397 ± 0.038
2.305GluPro: 2.305 ± 0.047
2.468GluGln: 2.468 ± 0.068
3.864GluArg: 3.864 ± 0.069
2.743GluSer: 2.743 ± 0.055
2.876GluThr: 2.876 ± 0.053
3.808GluVal: 3.808 ± 0.066
1.039GluTrp: 1.039 ± 0.033
1.267GluTyr: 1.267 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.259PheAla: 3.259 ± 0.065
0.267PheCys: 0.267 ± 0.014
1.893PheAsp: 1.893 ± 0.043
1.534PheGlu: 1.534 ± 0.038
1.504PhePhe: 1.504 ± 0.045
3.216PheGly: 3.216 ± 0.063
1.053PheHis: 1.053 ± 0.04
1.852PheIle: 1.852 ± 0.05
0.798PheLys: 0.798 ± 0.026
3.756PheLeu: 3.756 ± 0.073
0.843PheMet: 0.843 ± 0.029
1.068PheAsn: 1.068 ± 0.032
1.758PhePro: 1.758 ± 0.045
1.346PheGln: 1.346 ± 0.03
1.981PheArg: 1.981 ± 0.045
2.325PheSer: 2.325 ± 0.055
1.921PheThr: 1.921 ± 0.041
2.929PheVal: 2.929 ± 0.056
0.857PheTrp: 0.857 ± 0.03
1.146PheTyr: 1.146 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
6.868GlyAla: 6.868 ± 0.103
0.615GlyCys: 0.615 ± 0.03
3.187GlyAsp: 3.187 ± 0.062
3.39GlyGlu: 3.39 ± 0.061
3.299GlyPhe: 3.299 ± 0.062
5.705GlyGly: 5.705 ± 0.107
2.402GlyHis: 2.402 ± 0.049
5.235GlyIle: 5.235 ± 0.082
2.413GlyLys: 2.413 ± 0.057
8.655GlyLeu: 8.655 ± 0.114
2.374GlyMet: 2.374 ± 0.053
1.9GlyAsn: 1.9 ± 0.051
3.745GlyPro: 3.745 ± 0.066
3.785GlyGln: 3.785 ± 0.069
4.634GlyArg: 4.634 ± 0.067
4.525GlySer: 4.525 ± 0.07
4.671GlyThr: 4.671 ± 0.071
6.222GlyVal: 6.222 ± 0.09
1.62GlyTrp: 1.62 ± 0.043
2.659GlyTyr: 2.659 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
2.628HisAla: 2.628 ± 0.051
0.237HisCys: 0.237 ± 0.014
1.505HisAsp: 1.505 ± 0.044
1.417HisGlu: 1.417 ± 0.038
1.013HisPhe: 1.013 ± 0.034
2.339HisGly: 2.339 ± 0.052
1.209HisHis: 1.209 ± 0.038
1.559HisIle: 1.559 ± 0.038
0.746HisLys: 0.746 ± 0.028
3.043HisLeu: 3.043 ± 0.06
0.694HisMet: 0.694 ± 0.025
0.769HisAsn: 0.769 ± 0.026
1.92HisPro: 1.92 ± 0.046
1.39HisGln: 1.39 ± 0.037
1.826HisArg: 1.826 ± 0.044
1.371HisSer: 1.371 ± 0.039
1.41HisThr: 1.41 ± 0.037
2.338HisVal: 2.338 ± 0.054
0.716HisTrp: 0.716 ± 0.031
0.922HisTyr: 0.922 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.25IleAla: 6.25 ± 0.078
0.325IleCys: 0.325 ± 0.017
2.857IleAsp: 2.857 ± 0.062
2.835IleGlu: 2.835 ± 0.057
2.005IlePhe: 2.005 ± 0.055
4.876IleGly: 4.876 ± 0.073
1.481IleHis: 1.481 ± 0.038
3.07IleIle: 3.07 ± 0.068
1.433IleLys: 1.433 ± 0.036
5.632IleLeu: 5.632 ± 0.073
1.326IleMet: 1.326 ± 0.04
1.558IleAsn: 1.558 ± 0.046
3.265IlePro: 3.265 ± 0.062
2.161IleGln: 2.161 ± 0.049
3.355IleArg: 3.355 ± 0.068
2.975IleSer: 2.975 ± 0.066
3.237IleThr: 3.237 ± 0.052
4.87IleVal: 4.87 ± 0.078
0.947IleTrp: 0.947 ± 0.034
1.407IleTyr: 1.407 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
3.201LysAla: 3.201 ± 0.063
0.13LysCys: 0.13 ± 0.013
1.601LysAsp: 1.601 ± 0.048
1.899LysGlu: 1.899 ± 0.052
0.772LysPhe: 0.772 ± 0.03
2.127LysGly: 2.127 ± 0.051
0.676LysHis: 0.676 ± 0.023
1.666LysIle: 1.666 ± 0.04
1.263LysLys: 1.263 ± 0.046
2.369LysLeu: 2.369 ± 0.058
0.852LysMet: 0.852 ± 0.027
0.988LysAsn: 0.988 ± 0.036
1.669LysPro: 1.669 ± 0.04
1.16LysGln: 1.16 ± 0.035
2.083LysArg: 2.083 ± 0.047
1.736LysSer: 1.736 ± 0.048
2.156LysThr: 2.156 ± 0.05
2.283LysVal: 2.283 ± 0.051
0.517LysTrp: 0.517 ± 0.022
0.697LysTyr: 0.697 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
11.918LeuAla: 11.918 ± 0.125
0.638LeuCys: 0.638 ± 0.028
4.905LeuAsp: 4.905 ± 0.085
5.365LeuGlu: 5.365 ± 0.099
3.723LeuPhe: 3.723 ± 0.083
8.581LeuGly: 8.581 ± 0.097
2.601LeuHis: 2.601 ± 0.052
5.578LeuIle: 5.578 ± 0.08
3.389LeuLys: 3.389 ± 0.065
10.69LeuLeu: 10.69 ± 0.147
2.766LeuMet: 2.766 ± 0.056
2.966LeuAsn: 2.966 ± 0.057
5.748LeuPro: 5.748 ± 0.091
3.888LeuGln: 3.888 ± 0.063
5.936LeuArg: 5.936 ± 0.091
7.342LeuSer: 7.342 ± 0.087
6.743LeuThr: 6.743 ± 0.093
7.835LeuVal: 7.835 ± 0.098
2.466LeuTrp: 2.466 ± 0.058
2.821LeuTyr: 2.821 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
3.651MetAla: 3.651 ± 0.061
0.113MetCys: 0.113 ± 0.011
1.259MetAsp: 1.259 ± 0.04
1.397MetGlu: 1.397 ± 0.044
0.678MetPhe: 0.678 ± 0.028
2.369MetGly: 2.369 ± 0.047
0.634MetHis: 0.634 ± 0.024
1.422MetIle: 1.422 ± 0.041
0.887MetLys: 0.887 ± 0.034
2.268MetLeu: 2.268 ± 0.059
0.829MetMet: 0.829 ± 0.032
0.863MetAsn: 0.863 ± 0.027
1.465MetPro: 1.465 ± 0.043
1.01MetGln: 1.01 ± 0.033
1.72MetArg: 1.72 ± 0.044
1.458MetSer: 1.458 ± 0.037
1.905MetThr: 1.905 ± 0.043
2.385MetVal: 2.385 ± 0.053
0.336MetTrp: 0.336 ± 0.018
0.436MetTyr: 0.436 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.839AsnAla: 2.839 ± 0.059
0.139AsnCys: 0.139 ± 0.013
1.19AsnAsp: 1.19 ± 0.038
1.098AsnGlu: 1.098 ± 0.036
0.951AsnPhe: 0.951 ± 0.034
2.185AsnGly: 2.185 ± 0.059
0.822AsnHis: 0.822 ± 0.03
1.439AsnIle: 1.439 ± 0.04
0.792AsnLys: 0.792 ± 0.035
2.691AsnLeu: 2.691 ± 0.056
0.673AsnMet: 0.673 ± 0.026
0.773AsnAsn: 0.773 ± 0.03
2.325AsnPro: 2.325 ± 0.046
1.329AsnGln: 1.329 ± 0.039
1.738AsnArg: 1.738 ± 0.047
1.297AsnSer: 1.297 ± 0.04
1.519AsnThr: 1.519 ± 0.041
2.021AsnVal: 2.021 ± 0.045
0.496AsnTrp: 0.496 ± 0.024
0.727AsnTyr: 0.727 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
4.787ProAla: 4.787 ± 0.074
0.277ProCys: 0.277 ± 0.017
3.059ProAsp: 3.059 ± 0.066
3.273ProGlu: 3.273 ± 0.056
1.972ProPhe: 1.972 ± 0.048
4.101ProGly: 4.101 ± 0.07
1.757ProHis: 1.757 ± 0.046
2.65ProIle: 2.65 ± 0.05
1.746ProLys: 1.746 ± 0.046
5.661ProLeu: 5.661 ± 0.086
1.271ProMet: 1.271 ± 0.035
1.561ProAsn: 1.561 ± 0.046
2.511ProPro: 2.511 ± 0.058
2.428ProGln: 2.428 ± 0.053
2.715ProArg: 2.715 ± 0.055
3.498ProSer: 3.498 ± 0.069
2.962ProThr: 2.962 ± 0.055
4.827ProVal: 4.827 ± 0.072
1.28ProTrp: 1.28 ± 0.043
1.692ProTyr: 1.692 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
5.316GlnAla: 5.316 ± 0.079
0.301GlnCys: 0.301 ± 0.016
2.19GlnAsp: 2.19 ± 0.047
2.862GlnGlu: 2.862 ± 0.061
1.431GlnPhe: 1.431 ± 0.044
3.729GlnGly: 3.729 ± 0.061
1.258GlnHis: 1.258 ± 0.034
2.285GlnIle: 2.285 ± 0.051
1.562GlnLys: 1.562 ± 0.047
4.017GlnLeu: 4.017 ± 0.07
1.12GlnMet: 1.12 ± 0.034
1.292GlnAsn: 1.292 ± 0.038
1.991GlnPro: 1.991 ± 0.044
2.306GlnGln: 2.306 ± 0.053
2.725GlnArg: 2.725 ± 0.06
2.571GlnSer: 2.571 ± 0.064
2.599GlnThr: 2.599 ± 0.057
3.1GlnVal: 3.1 ± 0.064
1.298GlnTrp: 1.298 ± 0.038
1.289GlnTyr: 1.289 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
5.176ArgAla: 5.176 ± 0.084
0.382ArgCys: 0.382 ± 0.022
2.906ArgAsp: 2.906 ± 0.062
3.435ArgGlu: 3.435 ± 0.065
2.219ArgPhe: 2.219 ± 0.05
3.816ArgGly: 3.816 ± 0.075
2.131ArgHis: 2.131 ± 0.054
3.722ArgIle: 3.722 ± 0.068
1.823ArgLys: 1.823 ± 0.051
7.005ArgLeu: 7.005 ± 0.109
1.802ArgMet: 1.802 ± 0.044
1.404ArgAsn: 1.404 ± 0.039
3.065ArgPro: 3.065 ± 0.061
3.376ArgGln: 3.376 ± 0.061
4.511ArgArg: 4.511 ± 0.092
2.971ArgSer: 2.971 ± 0.059
3.199ArgThr: 3.199 ± 0.063
4.655ArgVal: 4.655 ± 0.074
1.379ArgTrp: 1.379 ± 0.039
2.165ArgTyr: 2.165 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.459SerAla: 5.459 ± 0.092
0.378SerCys: 0.378 ± 0.022
2.299SerAsp: 2.299 ± 0.055
2.493SerGlu: 2.493 ± 0.058
1.948SerPhe: 1.948 ± 0.042
4.831SerGly: 4.831 ± 0.077
1.867SerHis: 1.867 ± 0.046
2.639SerIle: 2.639 ± 0.052
1.378SerLys: 1.378 ± 0.036
6.62SerLeu: 6.62 ± 0.086
1.608SerMet: 1.608 ± 0.045
1.416SerAsn: 1.416 ± 0.037
3.455SerPro: 3.455 ± 0.065
2.775SerGln: 2.775 ± 0.06
3.6SerArg: 3.6 ± 0.072
3.739SerSer: 3.739 ± 0.092
3.209SerThr: 3.209 ± 0.064
4.57SerVal: 4.57 ± 0.08
1.19SerTrp: 1.19 ± 0.04
1.693SerTyr: 1.693 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.941ThrAla: 5.941 ± 0.092
0.351ThrCys: 0.351 ± 0.021
2.423ThrAsp: 2.423 ± 0.057
2.403ThrGlu: 2.403 ± 0.056
2.049ThrPhe: 2.049 ± 0.043
4.813ThrGly: 4.813 ± 0.07
1.555ThrHis: 1.555 ± 0.042
3.341ThrIle: 3.341 ± 0.055
1.555ThrLys: 1.555 ± 0.047
6.569ThrLeu: 6.569 ± 0.091
1.459ThrMet: 1.459 ± 0.042
1.42ThrAsn: 1.42 ± 0.044
3.621ThrPro: 3.621 ± 0.069
2.379ThrGln: 2.379 ± 0.056
3.052ThrArg: 3.052 ± 0.064
3.005ThrSer: 3.005 ± 0.059
3.61ThrThr: 3.61 ± 0.059
5.49ThrVal: 5.49 ± 0.089
1.219ThrTrp: 1.219 ± 0.034
1.477ThrTyr: 1.477 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
8.205ValAla: 8.205 ± 0.108
0.519ValCys: 0.519 ± 0.027
4.005ValAsp: 4.005 ± 0.06
4.035ValGlu: 4.035 ± 0.069
2.881ValPhe: 2.881 ± 0.059
6.158ValGly: 6.158 ± 0.093
1.99ValHis: 1.99 ± 0.04
4.78ValIle: 4.78 ± 0.07
2.512ValLys: 2.512 ± 0.061
8.653ValLeu: 8.653 ± 0.103
2.342ValMet: 2.342 ± 0.045
2.291ValAsn: 2.291 ± 0.051
4.53ValPro: 4.53 ± 0.065
3.061ValGln: 3.061 ± 0.054
4.621ValArg: 4.621 ± 0.065
5.021ValSer: 5.021 ± 0.08
4.974ValThr: 4.974 ± 0.085
7.392ValVal: 7.392 ± 0.1
1.384ValTrp: 1.384 ± 0.043
2.013ValTyr: 2.013 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.974TrpAla: 1.974 ± 0.05
0.117TrpCys: 0.117 ± 0.01
1.001TrpAsp: 1.001 ± 0.029
0.945TrpGlu: 0.945 ± 0.033
0.662TrpPhe: 0.662 ± 0.027
1.484TrpGly: 1.484 ± 0.038
0.69TrpHis: 0.69 ± 0.027
1.314TrpIle: 1.314 ± 0.04
0.575TrpLys: 0.575 ± 0.027
2.27TrpLeu: 2.27 ± 0.055
0.585TrpMet: 0.585 ± 0.024
0.664TrpAsn: 0.664 ± 0.027
1.175TrpPro: 1.175 ± 0.036
1.112TrpGln: 1.112 ± 0.034
1.342TrpArg: 1.342 ± 0.043
1.163TrpSer: 1.163 ± 0.037
1.294TrpThr: 1.294 ± 0.042
1.527TrpVal: 1.527 ± 0.042
0.469TrpTrp: 0.469 ± 0.025
0.466TrpTyr: 0.466 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.636TyrAla: 2.636 ± 0.058
0.216TyrCys: 0.216 ± 0.017
1.46TyrAsp: 1.46 ± 0.036
1.294TyrGlu: 1.294 ± 0.04
1.154TyrPhe: 1.154 ± 0.038
2.548TyrGly: 2.548 ± 0.046
1.08TyrHis: 1.08 ± 0.032
1.253TyrIle: 1.253 ± 0.037
0.596TyrLys: 0.596 ± 0.025
3.093TyrLeu: 3.093 ± 0.062
0.524TyrMet: 0.524 ± 0.025
0.771TyrAsn: 0.771 ± 0.031
1.688TyrPro: 1.688 ± 0.046
1.542TyrGln: 1.542 ± 0.045
2.036TyrArg: 2.036 ± 0.042
1.373TyrSer: 1.373 ± 0.039
1.422TyrThr: 1.422 ± 0.04
1.921TyrVal: 1.921 ± 0.042
0.641TyrTrp: 0.641 ± 0.026
0.901TyrTyr: 0.901 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.001XaaCys: 0.001 ± 0.001
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3298 proteins (984618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski