Amino acid dipepetide frequency for Candidatus Erwinia dacicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.213AlaAla: 10.213 ± 0.141
1.081AlaCys: 1.081 ± 0.039
5.172AlaAsp: 5.172 ± 0.097
6.216AlaGlu: 6.216 ± 0.102
3.278AlaPhe: 3.278 ± 0.071
7.13AlaGly: 7.13 ± 0.11
1.757AlaHis: 1.757 ± 0.055
5.353AlaIle: 5.353 ± 0.101
4.288AlaLys: 4.288 ± 0.078
10.899AlaLeu: 10.899 ± 0.132
3.127AlaMet: 3.127 ± 0.066
3.062AlaAsn: 3.062 ± 0.078
3.35AlaPro: 3.35 ± 0.079
4.347AlaGln: 4.347 ± 0.085
5.58AlaArg: 5.58 ± 0.103
5.527AlaSer: 5.527 ± 0.094
4.731AlaThr: 4.731 ± 0.096
6.643AlaVal: 6.643 ± 0.105
1.259AlaTrp: 1.259 ± 0.047
2.125AlaTyr: 2.125 ± 0.058
0.004AlaXaa: 0.004 ± 0.002
Cys
0.968CysAla: 0.968 ± 0.036
0.25CysCys: 0.25 ± 0.018
0.615CysAsp: 0.615 ± 0.03
0.612CysGlu: 0.612 ± 0.029
0.426CysPhe: 0.426 ± 0.026
1.058CysGly: 1.058 ± 0.04
0.33CysHis: 0.33 ± 0.021
0.618CysIle: 0.618 ± 0.034
0.44CysLys: 0.44 ± 0.021
1.112CysLeu: 1.112 ± 0.041
0.281CysMet: 0.281 ± 0.019
0.345CysAsn: 0.345 ± 0.022
0.516CysPro: 0.516 ± 0.028
0.501CysGln: 0.501 ± 0.027
0.796CysArg: 0.796 ± 0.035
0.714CysSer: 0.714 ± 0.032
0.524CysThr: 0.524 ± 0.026
0.737CysVal: 0.737 ± 0.032
0.19CysTrp: 0.19 ± 0.017
0.348CysTyr: 0.348 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
5.306AspAla: 5.306 ± 0.095
0.561AspCys: 0.561 ± 0.028
3.004AspAsp: 3.004 ± 0.066
3.673AspGlu: 3.673 ± 0.066
2.14AspPhe: 2.14 ± 0.054
4.084AspGly: 4.084 ± 0.078
1.029AspHis: 1.029 ± 0.039
3.524AspIle: 3.524 ± 0.072
2.747AspLys: 2.747 ± 0.07
4.889AspLeu: 4.889 ± 0.088
1.428AspMet: 1.428 ± 0.044
2.156AspAsn: 2.156 ± 0.052
1.981AspPro: 1.981 ± 0.053
1.725AspGln: 1.725 ± 0.048
3.02AspArg: 3.02 ± 0.064
3.084AspSer: 3.084 ± 0.071
2.582AspThr: 2.582 ± 0.063
3.959AspVal: 3.959 ± 0.085
0.841AspTrp: 0.841 ± 0.032
1.9AspTyr: 1.9 ± 0.055
0.001AspXaa: 0.001 ± 0.001
Glu
5.632GluAla: 5.632 ± 0.092
0.545GluCys: 0.545 ± 0.03
2.648GluAsp: 2.648 ± 0.07
3.431GluGlu: 3.431 ± 0.079
1.96GluPhe: 1.96 ± 0.049
3.498GluGly: 3.498 ± 0.07
1.374GluHis: 1.374 ± 0.045
3.482GluIle: 3.482 ± 0.065
3.443GluLys: 3.443 ± 0.077
6.483GluLeu: 6.483 ± 0.108
1.978GluMet: 1.978 ± 0.051
2.356GluAsn: 2.356 ± 0.051
2.002GluPro: 2.002 ± 0.052
3.482GluGln: 3.482 ± 0.082
4.082GluArg: 4.082 ± 0.095
3.255GluSer: 3.255 ± 0.062
2.978GluThr: 2.978 ± 0.07
4.025GluVal: 4.025 ± 0.088
0.794GluTrp: 0.794 ± 0.03
1.523GluTyr: 1.523 ± 0.044
0.003GluXaa: 0.003 ± 0.002
Phe
3.317PheAla: 3.317 ± 0.072
0.578PheCys: 0.578 ± 0.028
2.377PheAsp: 2.377 ± 0.055
1.887PheGlu: 1.887 ± 0.052
1.488PhePhe: 1.488 ± 0.055
2.804PheGly: 2.804 ± 0.07
0.788PheHis: 0.788 ± 0.034
2.359PheIle: 2.359 ± 0.076
1.567PheLys: 1.567 ± 0.05
2.981PheLeu: 2.981 ± 0.082
1.03PheMet: 1.03 ± 0.037
1.794PheAsn: 1.794 ± 0.047
1.414PhePro: 1.414 ± 0.039
1.088PheGln: 1.088 ± 0.038
1.995PheArg: 1.995 ± 0.057
3.094PheSer: 3.094 ± 0.07
2.2PheThr: 2.2 ± 0.054
2.27PheVal: 2.27 ± 0.062
0.572PheTrp: 0.572 ± 0.03
1.146PheTyr: 1.146 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
5.747GlyAla: 5.747 ± 0.107
0.934GlyCys: 0.934 ± 0.036
3.747GlyAsp: 3.747 ± 0.077
4.414GlyGlu: 4.414 ± 0.085
3.04GlyPhe: 3.04 ± 0.082
5.087GlyGly: 5.087 ± 0.109
1.685GlyHis: 1.685 ± 0.049
4.723GlyIle: 4.723 ± 0.083
4.402GlyLys: 4.402 ± 0.082
6.515GlyLeu: 6.515 ± 0.104
2.367GlyMet: 2.367 ± 0.063
2.839GlyAsn: 2.839 ± 0.065
1.71GlyPro: 1.71 ± 0.046
3.064GlyGln: 3.064 ± 0.059
4.112GlyArg: 4.112 ± 0.073
4.127GlySer: 4.127 ± 0.085
3.696GlyThr: 3.696 ± 0.071
5.241GlyVal: 5.241 ± 0.076
1.217GlyTrp: 1.217 ± 0.047
2.362GlyTyr: 2.362 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.834HisAla: 1.834 ± 0.059
0.355HisCys: 0.355 ± 0.022
1.16HisAsp: 1.16 ± 0.048
1.146HisGlu: 1.146 ± 0.04
0.945HisPhe: 0.945 ± 0.037
1.757HisGly: 1.757 ± 0.044
0.74HisHis: 0.74 ± 0.032
1.235HisIle: 1.235 ± 0.042
0.843HisLys: 0.843 ± 0.036
2.344HisLeu: 2.344 ± 0.066
0.6HisMet: 0.6 ± 0.029
0.882HisAsn: 0.882 ± 0.035
1.195HisPro: 1.195 ± 0.042
1.208HisGln: 1.208 ± 0.042
1.271HisArg: 1.271 ± 0.048
1.388HisSer: 1.388 ± 0.04
1.142HisThr: 1.142 ± 0.046
1.27HisVal: 1.27 ± 0.043
0.355HisTrp: 0.355 ± 0.022
0.814HisTyr: 0.814 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.972IleAla: 5.972 ± 0.091
0.691IleCys: 0.691 ± 0.032
3.736IleAsp: 3.736 ± 0.091
3.592IleGlu: 3.592 ± 0.071
2.002IlePhe: 2.002 ± 0.055
4.289IleGly: 4.289 ± 0.089
1.167IleHis: 1.167 ± 0.038
3.138IleIle: 3.138 ± 0.08
2.806IleLys: 2.806 ± 0.059
4.441IleLeu: 4.441 ± 0.095
1.363IleMet: 1.363 ± 0.045
2.674IleAsn: 2.674 ± 0.057
2.478IlePro: 2.478 ± 0.058
2.05IleGln: 2.05 ± 0.06
3.198IleArg: 3.198 ± 0.062
3.914IleSer: 3.914 ± 0.076
3.523IleThr: 3.523 ± 0.076
3.684IleVal: 3.684 ± 0.073
0.656IleTrp: 0.656 ± 0.029
1.486IleTyr: 1.486 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.778LysAla: 4.778 ± 0.08
0.37LysCys: 0.37 ± 0.023
2.312LysAsp: 2.312 ± 0.053
2.72LysGlu: 2.72 ± 0.071
1.369LysPhe: 1.369 ± 0.046
3.341LysGly: 3.341 ± 0.073
0.96LysHis: 0.96 ± 0.041
2.698LysIle: 2.698 ± 0.065
2.784LysLys: 2.784 ± 0.068
4.901LysLeu: 4.901 ± 0.085
1.446LysMet: 1.446 ± 0.049
2.088LysAsn: 2.088 ± 0.059
2.389LysPro: 2.389 ± 0.06
2.312LysGln: 2.312 ± 0.065
3.224LysArg: 3.224 ± 0.072
2.826LysSer: 2.826 ± 0.065
2.975LysThr: 2.975 ± 0.073
3.234LysVal: 3.234 ± 0.068
0.521LysTrp: 0.521 ± 0.029
1.246LysTyr: 1.246 ± 0.039
0.003LysXaa: 0.003 ± 0.003
Leu
10.463LeuAla: 10.463 ± 0.126
1.224LeuCys: 1.224 ± 0.041
5.258LeuAsp: 5.258 ± 0.103
5.584LeuGlu: 5.584 ± 0.096
3.713LeuPhe: 3.713 ± 0.089
6.522LeuGly: 6.522 ± 0.11
2.273LeuHis: 2.273 ± 0.059
5.497LeuIle: 5.497 ± 0.088
5.171LeuLys: 5.171 ± 0.09
10.674LeuLeu: 10.674 ± 0.159
3.081LeuMet: 3.081 ± 0.07
4.329LeuAsn: 4.329 ± 0.081
5.437LeuPro: 5.437 ± 0.088
4.456LeuGln: 4.456 ± 0.093
6.197LeuArg: 6.197 ± 0.101
7.274LeuSer: 7.274 ± 0.114
6.137LeuThr: 6.137 ± 0.098
6.607LeuVal: 6.607 ± 0.104
1.212LeuTrp: 1.212 ± 0.044
2.581LeuTyr: 2.581 ± 0.06
0.001LeuXaa: 0.001 ± 0.001
Met
3.0MetAla: 3.0 ± 0.065
0.209MetCys: 0.209 ± 0.017
1.277MetAsp: 1.277 ± 0.043
1.398MetGlu: 1.398 ± 0.042
0.923MetPhe: 0.923 ± 0.042
1.847MetGly: 1.847 ± 0.053
0.571MetHis: 0.571 ± 0.029
1.487MetIle: 1.487 ± 0.05
1.557MetLys: 1.557 ± 0.049
3.234MetLeu: 3.234 ± 0.067
0.912MetMet: 0.912 ± 0.037
1.16MetAsn: 1.16 ± 0.04
1.546MetPro: 1.546 ± 0.046
1.337MetGln: 1.337 ± 0.043
1.758MetArg: 1.758 ± 0.046
1.995MetSer: 1.995 ± 0.052
1.824MetThr: 1.824 ± 0.054
1.993MetVal: 1.993 ± 0.052
0.278MetTrp: 0.278 ± 0.017
0.543MetTyr: 0.543 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.615AsnAla: 3.615 ± 0.077
0.431AsnCys: 0.431 ± 0.027
2.061AsnAsp: 2.061 ± 0.056
2.077AsnGlu: 2.077 ± 0.059
1.344AsnPhe: 1.344 ± 0.041
3.119AsnGly: 3.119 ± 0.065
0.882AsnHis: 0.882 ± 0.032
2.387AsnIle: 2.387 ± 0.06
1.949AsnLys: 1.949 ± 0.055
3.608AsnLeu: 3.608 ± 0.069
0.951AsnMet: 0.951 ± 0.04
1.578AsnAsn: 1.578 ± 0.052
2.024AsnPro: 2.024 ± 0.055
1.655AsnGln: 1.655 ± 0.049
2.23AsnArg: 2.23 ± 0.065
2.352AsnSer: 2.352 ± 0.055
2.059AsnThr: 2.059 ± 0.052
2.528AsnVal: 2.528 ± 0.06
0.56AsnTrp: 0.56 ± 0.028
1.145AsnTyr: 1.145 ± 0.035
0.001AsnXaa: 0.001 ± 0.001
Pro
4.262ProAla: 4.262 ± 0.083
0.385ProCys: 0.385 ± 0.022
2.777ProAsp: 2.777 ± 0.062
3.489ProGlu: 3.489 ± 0.075
1.626ProPhe: 1.626 ± 0.04
2.848ProGly: 2.848 ± 0.069
1.003ProHis: 1.003 ± 0.037
1.82ProIle: 1.82 ± 0.052
1.794ProLys: 1.794 ± 0.051
4.603ProLeu: 4.603 ± 0.079
1.043ProMet: 1.043 ± 0.038
1.227ProAsn: 1.227 ± 0.046
1.64ProPro: 1.64 ± 0.052
1.993ProGln: 1.993 ± 0.057
1.904ProArg: 1.904 ± 0.056
2.389ProSer: 2.389 ± 0.056
1.974ProThr: 1.974 ± 0.053
3.721ProVal: 3.721 ± 0.072
0.586ProTrp: 0.586 ± 0.028
1.105ProTyr: 1.105 ± 0.035
0.001ProXaa: 0.001 ± 0.001
Gln
4.515GlnAla: 4.515 ± 0.081
0.436GlnCys: 0.436 ± 0.024
1.886GlnAsp: 1.886 ± 0.052
2.186GlnGlu: 2.186 ± 0.054
1.583GlnPhe: 1.583 ± 0.05
2.861GlnGly: 2.861 ± 0.07
1.253GlnHis: 1.253 ± 0.045
2.453GlnIle: 2.453 ± 0.06
1.953GlnLys: 1.953 ± 0.063
5.203GlnLeu: 5.203 ± 0.101
1.341GlnMet: 1.341 ± 0.04
1.55GlnAsn: 1.55 ± 0.046
2.096GlnPro: 2.096 ± 0.06
3.512GlnGln: 3.512 ± 0.101
3.303GlnArg: 3.303 ± 0.083
2.48GlnSer: 2.48 ± 0.063
2.277GlnThr: 2.277 ± 0.058
3.066GlnVal: 3.066 ± 0.072
0.667GlnTrp: 0.667 ± 0.029
1.257GlnTyr: 1.257 ± 0.039
0.004GlnXaa: 0.004 ± 0.002
Arg
4.864ArgAla: 4.864 ± 0.088
0.736ArgCys: 0.736 ± 0.037
3.233ArgAsp: 3.233 ± 0.072
4.024ArgGlu: 4.024 ± 0.088
2.509ArgPhe: 2.509 ± 0.056
3.592ArgGly: 3.592 ± 0.068
1.611ArgHis: 1.611 ± 0.056
3.439ArgIle: 3.439 ± 0.066
3.079ArgLys: 3.079 ± 0.073
6.643ArgLeu: 6.643 ± 0.108
1.775ArgMet: 1.775 ± 0.049
2.245ArgAsn: 2.245 ± 0.06
2.215ArgPro: 2.215 ± 0.059
3.289ArgGln: 3.289 ± 0.071
3.955ArgArg: 3.955 ± 0.094
3.252ArgSer: 3.252 ± 0.07
2.706ArgThr: 2.706 ± 0.063
3.974ArgVal: 3.974 ± 0.08
0.953ArgTrp: 0.953 ± 0.036
2.179ArgTyr: 2.179 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
5.943SerAla: 5.943 ± 0.094
0.649SerCys: 0.649 ± 0.034
3.523SerAsp: 3.523 ± 0.078
3.636SerGlu: 3.636 ± 0.067
2.329SerPhe: 2.329 ± 0.056
5.522SerGly: 5.522 ± 0.087
1.355SerHis: 1.355 ± 0.042
3.106SerIle: 3.106 ± 0.065
2.655SerLys: 2.655 ± 0.071
6.622SerLeu: 6.622 ± 0.108
1.663SerMet: 1.663 ± 0.047
2.135SerAsn: 2.135 ± 0.06
2.577SerPro: 2.577 ± 0.062
2.655SerGln: 2.655 ± 0.068
3.654SerArg: 3.654 ± 0.069
3.848SerSer: 3.848 ± 0.085
3.081SerThr: 3.081 ± 0.071
4.405SerVal: 4.405 ± 0.083
0.944SerTrp: 0.944 ± 0.036
1.648SerTyr: 1.648 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.989ThrAla: 4.989 ± 0.087
0.561ThrCys: 0.561 ± 0.031
2.938ThrAsp: 2.938 ± 0.059
2.834ThrGlu: 2.834 ± 0.062
1.949ThrPhe: 1.949 ± 0.045
4.504ThrGly: 4.504 ± 0.086
1.186ThrHis: 1.186 ± 0.04
2.991ThrIle: 2.991 ± 0.074
1.999ThrLys: 1.999 ± 0.057
6.68ThrLeu: 6.68 ± 0.107
1.327ThrMet: 1.327 ± 0.045
1.609ThrAsn: 1.609 ± 0.053
2.824ThrPro: 2.824 ± 0.062
2.072ThrGln: 2.072 ± 0.058
3.059ThrArg: 3.059 ± 0.062
3.077ThrSer: 3.077 ± 0.066
2.852ThrThr: 2.852 ± 0.071
3.985ThrVal: 3.985 ± 0.066
0.62ThrTrp: 0.62 ± 0.03
1.208ThrTyr: 1.208 ± 0.044
0.003ThrXaa: 0.003 ± 0.002
Val
6.5ValAla: 6.5 ± 0.102
0.751ValCys: 0.751 ± 0.031
3.827ValAsp: 3.827 ± 0.073
4.208ValGlu: 4.208 ± 0.086
2.433ValPhe: 2.433 ± 0.061
4.336ValGly: 4.336 ± 0.087
1.301ValHis: 1.301 ± 0.046
4.321ValIle: 4.321 ± 0.075
3.418ValLys: 3.418 ± 0.07
6.774ValLeu: 6.774 ± 0.099
2.103ValMet: 2.103 ± 0.052
2.984ValAsn: 2.984 ± 0.068
2.941ValPro: 2.941 ± 0.059
2.553ValGln: 2.553 ± 0.072
3.827ValArg: 3.827 ± 0.077
4.806ValSer: 4.806 ± 0.095
4.143ValThr: 4.143 ± 0.086
5.328ValVal: 5.328 ± 0.11
0.834ValTrp: 0.834 ± 0.037
1.799ValTyr: 1.799 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.949TrpAla: 0.949 ± 0.032
0.249TrpCys: 0.249 ± 0.018
0.561TrpAsp: 0.561 ± 0.031
0.582TrpGlu: 0.582 ± 0.028
0.585TrpPhe: 0.585 ± 0.034
0.763TrpGly: 0.763 ± 0.03
0.455TrpHis: 0.455 ± 0.025
0.702TrpIle: 0.702 ± 0.03
0.601TrpLys: 0.601 ± 0.031
2.039TrpLeu: 2.039 ± 0.062
0.393TrpMet: 0.393 ± 0.024
0.502TrpAsn: 0.502 ± 0.028
0.578TrpPro: 0.578 ± 0.029
0.997TrpGln: 0.997 ± 0.04
1.028TrpArg: 1.028 ± 0.041
0.78TrpSer: 0.78 ± 0.034
0.501TrpThr: 0.501 ± 0.029
0.86TrpVal: 0.86 ± 0.035
0.216TrpTrp: 0.216 ± 0.017
0.395TrpTyr: 0.395 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.274TyrAla: 2.274 ± 0.049
0.385TyrCys: 0.385 ± 0.025
1.52TyrAsp: 1.52 ± 0.045
1.266TyrGlu: 1.266 ± 0.042
1.105TyrPhe: 1.105 ± 0.041
2.069TyrGly: 2.069 ± 0.055
0.763TyrHis: 0.763 ± 0.034
1.526TyrIle: 1.526 ± 0.047
1.001TyrLys: 1.001 ± 0.038
3.04TyrLeu: 3.04 ± 0.059
0.637TyrMet: 0.637 ± 0.031
1.04TyrAsn: 1.04 ± 0.037
1.278TyrPro: 1.278 ± 0.044
1.589TyrGln: 1.589 ± 0.05
2.077TyrArg: 2.077 ± 0.056
1.765TyrSer: 1.765 ± 0.048
1.362TyrThr: 1.362 ± 0.044
1.654TyrVal: 1.654 ± 0.048
0.459TyrTrp: 0.459 ± 0.023
0.832TyrTyr: 0.832 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.001
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.001
0.0XaaLys: 0.0 ± 0.0
0.006XaaLeu: 0.006 ± 0.003
0.001XaaMet: 0.001 ± 0.002
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.003XaaArg: 0.003 ± 0.002
0.001XaaSer: 0.001 ± 0.002
0.001XaaThr: 0.001 ± 0.001
0.004XaaVal: 0.004 ± 0.002
0.001XaaTrp: 0.001 ± 0.002
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 3896 proteins (726939 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski