Amino acid dipepetide frequency for Dyella psychrodurans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.405AlaAla: 14.405 ± 0.147	1.208AlaCys: 1.208 ± 0.033	6.274AlaAsp: 6.274 ± 0.083	5.729AlaGlu: 5.729 ± 0.087	3.941AlaPhe: 3.941 ± 0.063	9.254AlaGly: 9.254 ± 0.095	2.808AlaHis: 2.808 ± 0.049	5.709AlaIle: 5.709 ± 0.082	3.838AlaLys: 3.838 ± 0.061	13.571AlaLeu: 13.571 ± 0.132	3.346AlaMet: 3.346 ± 0.06	3.455AlaAsn: 3.455 ± 0.066	5.398AlaPro: 5.398 ± 0.091	5.21AlaGln: 5.21 ± 0.074	7.437AlaArg: 7.437 ± 0.079	7.019AlaSer: 7.019 ± 0.094	6.278AlaThr: 6.278 ± 0.083	8.064AlaVal: 8.064 ± 0.084	1.881AlaTrp: 1.881 ± 0.04	2.75AlaTyr: 2.75 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	1.074CysAla: 1.074 ± 0.032	0.113CysCys: 0.113 ± 0.009	0.513CysAsp: 0.513 ± 0.022	0.452CysGlu: 0.452 ± 0.02	0.311CysPhe: 0.311 ± 0.015	0.906CysGly: 0.906 ± 0.029	0.265CysHis: 0.265 ± 0.016	0.372CysIle: 0.372 ± 0.018	0.239CysLys: 0.239 ± 0.015	0.859CysLeu: 0.859 ± 0.027	0.244CysMet: 0.244 ± 0.014	0.256CysAsn: 0.256 ± 0.015	0.398CysPro: 0.398 ± 0.019	0.241CysGln: 0.241 ± 0.014	0.535CysArg: 0.535 ± 0.019	0.528CysSer: 0.528 ± 0.021	0.485CysThr: 0.485 ± 0.021	0.724CysVal: 0.724 ± 0.026	0.133CysTrp: 0.133 ± 0.01	0.245CysTyr: 0.245 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.324AspAla: 7.324 ± 0.09	0.424AspCys: 0.424 ± 0.021	3.318AspAsp: 3.318 ± 0.058	3.082AspGlu: 3.082 ± 0.052	2.097AspPhe: 2.097 ± 0.044	4.91AspGly: 4.91 ± 0.068	1.392AspHis: 1.392 ± 0.032	2.842AspIle: 2.842 ± 0.051	1.666AspLys: 1.666 ± 0.043	5.384AspLeu: 5.384 ± 0.073	1.26AspMet: 1.26 ± 0.038	1.597AspAsn: 1.597 ± 0.035	3.201AspPro: 3.201 ± 0.06	1.939AspGln: 1.939 ± 0.038	3.471AspArg: 3.471 ± 0.059	2.702AspSer: 2.702 ± 0.045	2.965AspThr: 2.965 ± 0.051	4.604AspVal: 4.604 ± 0.06	1.042AspTrp: 1.042 ± 0.027	1.752AspTyr: 1.752 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.678GluAla: 5.678 ± 0.08	0.373GluCys: 0.373 ± 0.019	2.178GluAsp: 2.178 ± 0.04	2.348GluGlu: 2.348 ± 0.057	1.547GluPhe: 1.547 ± 0.034	3.438GluGly: 3.438 ± 0.059	1.549GluHis: 1.549 ± 0.033	2.32GluIle: 2.32 ± 0.039	1.719GluLys: 1.719 ± 0.041	5.547GluLeu: 5.547 ± 0.081	1.042GluMet: 1.042 ± 0.029	1.388GluAsn: 1.388 ± 0.037	2.214GluPro: 2.214 ± 0.041	2.551GluGln: 2.551 ± 0.048	4.383GluArg: 4.383 ± 0.07	2.709GluSer: 2.709 ± 0.051	2.528GluThr: 2.528 ± 0.047	3.378GluVal: 3.378 ± 0.059	0.717GluTrp: 0.717 ± 0.023	1.138GluTyr: 1.138 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.137PheAla: 4.137 ± 0.061	0.344PheCys: 0.344 ± 0.017	2.526PheAsp: 2.526 ± 0.048	1.737PheGlu: 1.737 ± 0.04	1.352PhePhe: 1.352 ± 0.038	3.437PheGly: 3.437 ± 0.064	0.892PheHis: 0.892 ± 0.027	1.474PheIle: 1.474 ± 0.034	1.058PheLys: 1.058 ± 0.033	3.078PheLeu: 3.078 ± 0.052	0.738PheMet: 0.738 ± 0.023	1.281PheAsn: 1.281 ± 0.038	1.522PhePro: 1.522 ± 0.033	1.149PheGln: 1.149 ± 0.03	1.975PheArg: 1.975 ± 0.048	2.183PheSer: 2.183 ± 0.048	1.962PheThr: 1.962 ± 0.044	2.723PheVal: 2.723 ± 0.053	0.543PheTrp: 0.543 ± 0.024	1.009PheTyr: 1.009 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.108GlyAla: 8.108 ± 0.102	0.871GlyCys: 0.871 ± 0.026	4.4GlyAsp: 4.4 ± 0.057	4.086GlyGlu: 4.086 ± 0.057	3.261GlyPhe: 3.261 ± 0.054	6.571GlyGly: 6.571 ± 0.097	2.218GlyHis: 2.218 ± 0.04	4.263GlyIle: 4.263 ± 0.055	3.197GlyLys: 3.197 ± 0.056	7.973GlyLeu: 7.973 ± 0.085	2.266GlyMet: 2.266 ± 0.044	2.679GlyAsn: 2.679 ± 0.057	2.949GlyPro: 2.949 ± 0.056	3.206GlyGln: 3.206 ± 0.057	4.904GlyArg: 4.904 ± 0.063	5.031GlySer: 5.031 ± 0.091	4.68GlyThr: 4.68 ± 0.079	6.362GlyVal: 6.362 ± 0.074	1.544GlyTrp: 1.544 ± 0.033	2.594GlyTyr: 2.594 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	3.345HisAla: 3.345 ± 0.06	0.253HisCys: 0.253 ± 0.012	1.637HisAsp: 1.637 ± 0.039	1.288HisGlu: 1.288 ± 0.032	0.987HisPhe: 0.987 ± 0.032	2.501HisGly: 2.501 ± 0.046	0.762HisHis: 0.762 ± 0.03	1.123HisIle: 1.123 ± 0.029	0.602HisLys: 0.602 ± 0.024	2.473HisLeu: 2.473 ± 0.047	0.682HisMet: 0.682 ± 0.021	0.597HisAsn: 0.597 ± 0.021	1.586HisPro: 1.586 ± 0.035	0.81HisGln: 0.81 ± 0.022	1.751HisArg: 1.751 ± 0.036	1.195HisSer: 1.195 ± 0.032	1.202HisThr: 1.202 ± 0.03	1.941HisVal: 1.941 ± 0.04	0.491HisTrp: 0.491 ± 0.021	0.819HisTyr: 0.819 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.579IleAla: 6.579 ± 0.078	0.448IleCys: 0.448 ± 0.02	3.516IleAsp: 3.516 ± 0.05	2.916IleGlu: 2.916 ± 0.052	1.415IlePhe: 1.415 ± 0.033	4.622IleGly: 4.622 ± 0.071	1.045IleHis: 1.045 ± 0.026	1.639IleIle: 1.639 ± 0.038	1.392IleLys: 1.392 ± 0.029	3.353IleLeu: 3.353 ± 0.061	0.732IleMet: 0.732 ± 0.025	1.609IleAsn: 1.609 ± 0.034	2.276IlePro: 2.276 ± 0.04	1.416IleGln: 1.416 ± 0.031	2.772IleArg: 2.772 ± 0.053	2.759IleSer: 2.759 ± 0.047	2.762IleThr: 2.762 ± 0.048	3.81IleVal: 3.81 ± 0.055	0.556IleTrp: 0.556 ± 0.023	1.163IleTyr: 1.163 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.594LysAla: 3.594 ± 0.055	0.16LysCys: 0.16 ± 0.01	1.691LysAsp: 1.691 ± 0.047	1.393LysGlu: 1.393 ± 0.037	0.836LysPhe: 0.836 ± 0.028	2.264LysGly: 2.264 ± 0.042	0.894LysHis: 0.894 ± 0.029	1.321LysIle: 1.321 ± 0.031	1.115LysLys: 1.115 ± 0.038	3.464LysLeu: 3.464 ± 0.055	0.685LysMet: 0.685 ± 0.026	0.911LysAsn: 0.911 ± 0.026	2.143LysPro: 2.143 ± 0.052	1.486LysGln: 1.486 ± 0.037	2.225LysArg: 2.225 ± 0.048	1.723LysSer: 1.723 ± 0.039	1.734LysThr: 1.734 ± 0.035	2.347LysVal: 2.347 ± 0.042	0.345LysTrp: 0.345 ± 0.015	0.726LysTyr: 0.726 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.091LeuAla: 13.091 ± 0.121	1.046LeuCys: 1.046 ± 0.028	6.203LeuAsp: 6.203 ± 0.066	4.78LeuGlu: 4.78 ± 0.079	3.59LeuPhe: 3.59 ± 0.06	8.165LeuGly: 8.165 ± 0.097	2.711LeuHis: 2.711 ± 0.049	4.835LeuIle: 4.835 ± 0.063	3.462LeuLys: 3.462 ± 0.055	11.064LeuLeu: 11.064 ± 0.123	2.342LeuMet: 2.342 ± 0.045	2.934LeuAsn: 2.934 ± 0.053	6.034LeuPro: 6.034 ± 0.084	3.84LeuGln: 3.84 ± 0.059	7.473LeuArg: 7.473 ± 0.095	6.602LeuSer: 6.602 ± 0.072	5.453LeuThr: 5.453 ± 0.067	7.25LeuVal: 7.25 ± 0.088	1.355LeuTrp: 1.355 ± 0.041	2.35LeuTyr: 2.35 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.745MetAla: 2.745 ± 0.043	0.179MetCys: 0.179 ± 0.013	1.167MetAsp: 1.167 ± 0.031	0.969MetGlu: 0.969 ± 0.03	0.721MetPhe: 0.721 ± 0.024	1.597MetGly: 1.597 ± 0.037	0.681MetHis: 0.681 ± 0.023	1.022MetIle: 1.022 ± 0.032	0.866MetLys: 0.866 ± 0.027	2.714MetLeu: 2.714 ± 0.048	0.546MetMet: 0.546 ± 0.022	0.845MetAsn: 0.845 ± 0.025	1.487MetPro: 1.487 ± 0.032	1.064MetGln: 1.064 ± 0.027	1.74MetArg: 1.74 ± 0.04	1.773MetSer: 1.773 ± 0.031	1.513MetThr: 1.513 ± 0.034	1.592MetVal: 1.592 ± 0.037	0.286MetTrp: 0.286 ± 0.017	0.467MetTyr: 0.467 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.715AsnAla: 3.715 ± 0.064	0.232AsnCys: 0.232 ± 0.013	1.833AsnAsp: 1.833 ± 0.042	1.333AsnGlu: 1.333 ± 0.029	1.123AsnPhe: 1.123 ± 0.034	3.067AsnGly: 3.067 ± 0.066	0.668AsnHis: 0.668 ± 0.026	1.41AsnIle: 1.41 ± 0.036	0.797AsnLys: 0.797 ± 0.027	2.885AsnLeu: 2.885 ± 0.054	0.595AsnMet: 0.595 ± 0.022	1.108AsnAsn: 1.108 ± 0.039	1.966AsnPro: 1.966 ± 0.047	1.126AsnGln: 1.126 ± 0.032	1.785AsnArg: 1.785 ± 0.035	1.578AsnSer: 1.578 ± 0.05	1.756AsnThr: 1.756 ± 0.046	2.352AsnVal: 2.352 ± 0.047	0.529AsnTrp: 0.529 ± 0.021	0.968AsnTyr: 0.968 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	6.078ProAla: 6.078 ± 0.089	0.349ProCys: 0.349 ± 0.018	3.3ProAsp: 3.3 ± 0.057	2.812ProGlu: 2.812 ± 0.05	1.75ProPhe: 1.75 ± 0.04	4.283ProGly: 4.283 ± 0.059	1.217ProHis: 1.217 ± 0.031	2.191ProIle: 2.191 ± 0.043	1.516ProLys: 1.516 ± 0.035	5.032ProLeu: 5.032 ± 0.069	1.358ProMet: 1.358 ± 0.032	1.7ProAsn: 1.7 ± 0.044	2.666ProPro: 2.666 ± 0.071	2.122ProGln: 2.122 ± 0.042	2.831ProArg: 2.831 ± 0.051	3.211ProSer: 3.211 ± 0.057	2.72ProThr: 2.72 ± 0.057	3.971ProVal: 3.971 ± 0.057	0.907ProTrp: 0.907 ± 0.027	1.388ProTyr: 1.388 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.954GlnAla: 4.954 ± 0.073	0.286GlnCys: 0.286 ± 0.016	1.753GlnAsp: 1.753 ± 0.037	1.514GlnGlu: 1.514 ± 0.035	1.289GlnPhe: 1.289 ± 0.037	2.903GlnGly: 2.903 ± 0.051	1.184GlnHis: 1.184 ± 0.031	1.904GlnIle: 1.904 ± 0.037	1.124GlnLys: 1.124 ± 0.03	4.398GlnLeu: 4.398 ± 0.06	0.944GlnMet: 0.944 ± 0.027	1.118GlnAsn: 1.118 ± 0.033	2.267GlnPro: 2.267 ± 0.042	2.208GlnGln: 2.208 ± 0.055	3.209GlnArg: 3.209 ± 0.05	2.301GlnSer: 2.301 ± 0.042	2.023GlnThr: 2.023 ± 0.04	2.858GlnVal: 2.858 ± 0.05	0.635GlnTrp: 0.635 ± 0.024	1.006GlnTyr: 1.006 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.956ArgAla: 6.956 ± 0.101	0.584ArgCys: 0.584 ± 0.021	3.876ArgAsp: 3.876 ± 0.059	3.901ArgGlu: 3.901 ± 0.065	2.617ArgPhe: 2.617 ± 0.047	4.403ArgGly: 4.403 ± 0.058	1.987ArgHis: 1.987 ± 0.039	3.584ArgIle: 3.584 ± 0.053	2.106ArgLys: 2.106 ± 0.047	7.304ArgLeu: 7.304 ± 0.093	1.811ArgMet: 1.811 ± 0.038	1.898ArgAsn: 1.898 ± 0.04	2.815ArgPro: 2.815 ± 0.045	2.651ArgGln: 2.651 ± 0.051	5.068ArgArg: 5.068 ± 0.078	3.558ArgSer: 3.558 ± 0.053	3.148ArgThr: 3.148 ± 0.05	4.78ArgVal: 4.78 ± 0.065	1.214ArgTrp: 1.214 ± 0.029	2.101ArgTyr: 2.101 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.573SerAla: 6.573 ± 0.085	0.483SerCys: 0.483 ± 0.024	3.182SerAsp: 3.182 ± 0.056	2.704SerGlu: 2.704 ± 0.044	2.192SerPhe: 2.192 ± 0.041	5.389SerGly: 5.389 ± 0.093	1.467SerHis: 1.467 ± 0.03	2.808SerIle: 2.808 ± 0.055	1.719SerLys: 1.719 ± 0.034	6.075SerLeu: 6.075 ± 0.086	1.465SerMet: 1.465 ± 0.032	1.905SerAsn: 1.905 ± 0.053	3.043SerPro: 3.043 ± 0.05	2.208SerGln: 2.208 ± 0.043	3.482SerArg: 3.482 ± 0.056	3.911SerSer: 3.911 ± 0.087	3.545SerThr: 3.545 ± 0.065	4.364SerVal: 4.364 ± 0.065	0.902SerTrp: 0.902 ± 0.027	1.691SerTyr: 1.691 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.059ThrAla: 6.059 ± 0.085	0.453ThrCys: 0.453 ± 0.018	2.819ThrAsp: 2.819 ± 0.053	2.236ThrGlu: 2.236 ± 0.041	1.869ThrPhe: 1.869 ± 0.042	4.665ThrGly: 4.665 ± 0.071	1.397ThrHis: 1.397 ± 0.036	2.506ThrIle: 2.506 ± 0.047	1.333ThrLys: 1.333 ± 0.038	6.336ThrLeu: 6.336 ± 0.08	1.162ThrMet: 1.162 ± 0.029	1.659ThrAsn: 1.659 ± 0.048	3.604ThrPro: 3.604 ± 0.065	2.165ThrGln: 2.165 ± 0.046	3.256ThrArg: 3.256 ± 0.055	3.235ThrSer: 3.235 ± 0.062	3.191ThrThr: 3.191 ± 0.073	4.339ThrVal: 4.339 ± 0.067	0.822ThrTrp: 0.822 ± 0.028	1.589ThrTyr: 1.589 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	8.845ValAla: 8.845 ± 0.103	0.694ValCys: 0.694 ± 0.021	4.529ValAsp: 4.529 ± 0.058	3.684ValGlu: 3.684 ± 0.064	2.529ValPhe: 2.529 ± 0.043	5.44ValGly: 5.44 ± 0.071	1.829ValHis: 1.829 ± 0.036	3.672ValIle: 3.672 ± 0.058	2.101ValLys: 2.101 ± 0.05	8.184ValLeu: 8.184 ± 0.086	1.802ValMet: 1.802 ± 0.035	2.383ValAsn: 2.383 ± 0.051	3.776ValPro: 3.776 ± 0.051	2.632ValGln: 2.632 ± 0.054	4.761ValArg: 4.761 ± 0.069	4.536ValSer: 4.536 ± 0.07	4.327ValThr: 4.327 ± 0.06	5.882ValVal: 5.882 ± 0.085	0.968ValTrp: 0.968 ± 0.027	1.791ValTyr: 1.791 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.201TrpAla: 1.201 ± 0.028	0.157TrpCys: 0.157 ± 0.01	0.684TrpAsp: 0.684 ± 0.023	0.541TrpGlu: 0.541 ± 0.021	0.625TrpPhe: 0.625 ± 0.025	0.914TrpGly: 0.914 ± 0.032	0.488TrpHis: 0.488 ± 0.02	0.787TrpIle: 0.787 ± 0.024	0.493TrpLys: 0.493 ± 0.021	2.224TrpLeu: 2.224 ± 0.048	0.454TrpMet: 0.454 ± 0.018	0.601TrpAsn: 0.601 ± 0.02	0.746TrpPro: 0.746 ± 0.026	0.774TrpGln: 0.774 ± 0.022	1.293TrpArg: 1.293 ± 0.036	1.008TrpSer: 1.008 ± 0.03	0.875TrpThr: 0.875 ± 0.032	1.038TrpVal: 1.038 ± 0.031	0.293TrpTrp: 0.293 ± 0.015	0.433TrpTyr: 0.433 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.112TyrAla: 3.112 ± 0.048	0.236TyrCys: 0.236 ± 0.013	1.575TyrAsp: 1.575 ± 0.039	1.244TyrGlu: 1.244 ± 0.032	1.07TyrPhe: 1.07 ± 0.031	2.434TyrGly: 2.434 ± 0.05	0.592TyrHis: 0.592 ± 0.021	0.996TyrIle: 0.996 ± 0.028	0.712TyrLys: 0.712 ± 0.024	2.661TyrLeu: 2.661 ± 0.053	0.499TyrMet: 0.499 ± 0.021	0.901TyrAsn: 0.901 ± 0.036	1.311TyrPro: 1.311 ± 0.037	1.078TyrGln: 1.078 ± 0.033	2.011TyrArg: 2.011 ± 0.041	1.544TyrSer: 1.544 ± 0.048	1.55TyrThr: 1.55 ± 0.051	1.988TyrVal: 1.988 ± 0.04	0.467TyrTrp: 0.467 ± 0.019	0.846TyrTyr: 0.846 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4047 proteins (1326686 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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