Amino acid dipepetide frequency for Salmonella phage Vi06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.774AlaAla: 8.774 ± 1.547
0.731AlaCys: 0.731 ± 0.249
5.758AlaAsp: 5.758 ± 0.648
4.387AlaGlu: 4.387 ± 0.679
2.376AlaPhe: 2.376 ± 0.452
6.854AlaGly: 6.854 ± 1.082
1.097AlaHis: 1.097 ± 0.243
4.844AlaIle: 4.844 ± 0.78
6.489AlaLys: 6.489 ± 0.741
8.591AlaLeu: 8.591 ± 0.97
2.925AlaMet: 2.925 ± 0.651
3.656AlaAsn: 3.656 ± 0.665
1.828AlaPro: 1.828 ± 0.372
3.93AlaGln: 3.93 ± 0.8
5.666AlaArg: 5.666 ± 0.592
6.032AlaSer: 6.032 ± 0.914
4.661AlaThr: 4.661 ± 0.501
5.666AlaVal: 5.666 ± 0.773
1.371AlaTrp: 1.371 ± 0.295
2.925AlaTyr: 2.925 ± 0.716
0.0AlaXaa: 0.0 ± 0.0
Cys
1.097CysAla: 1.097 ± 0.36
0.091CysCys: 0.091 ± 0.09
1.188CysAsp: 1.188 ± 0.445
0.366CysGlu: 0.366 ± 0.172
0.731CysPhe: 0.731 ± 0.333
0.823CysGly: 0.823 ± 0.379
0.64CysHis: 0.64 ± 0.266
0.548CysIle: 0.548 ± 0.255
1.097CysLys: 1.097 ± 0.4
0.548CysLeu: 0.548 ± 0.265
0.183CysMet: 0.183 ± 0.134
0.183CysAsn: 0.183 ± 0.136
0.548CysPro: 0.548 ± 0.195
0.64CysGln: 0.64 ± 0.276
0.457CysArg: 0.457 ± 0.207
0.823CysSer: 0.823 ± 0.322
0.548CysThr: 0.548 ± 0.21
1.279CysVal: 1.279 ± 0.382
0.366CysTrp: 0.366 ± 0.184
0.091CysTyr: 0.091 ± 0.102
0.0CysXaa: 0.0 ± 0.0
Asp
4.752AspAla: 4.752 ± 0.563
0.914AspCys: 0.914 ± 0.284
4.021AspAsp: 4.021 ± 0.777
3.747AspGlu: 3.747 ± 0.473
2.65AspPhe: 2.65 ± 0.447
6.397AspGly: 6.397 ± 0.778
0.274AspHis: 0.274 ± 0.172
3.564AspIle: 3.564 ± 0.461
3.93AspLys: 3.93 ± 0.556
3.838AspLeu: 3.838 ± 0.716
2.468AspMet: 2.468 ± 0.502
2.468AspAsn: 2.468 ± 0.539
2.925AspPro: 2.925 ± 0.744
2.468AspGln: 2.468 ± 0.494
3.107AspArg: 3.107 ± 0.531
4.204AspSer: 4.204 ± 0.671
3.473AspThr: 3.473 ± 0.521
3.93AspVal: 3.93 ± 0.654
0.914AspTrp: 0.914 ± 0.362
2.011AspTyr: 2.011 ± 0.451
0.0AspXaa: 0.0 ± 0.0
Glu
7.22GluAla: 7.22 ± 0.987
0.548GluCys: 0.548 ± 0.264
4.021GluAsp: 4.021 ± 0.631
6.123GluGlu: 6.123 ± 0.789
1.828GluPhe: 1.828 ± 0.396
4.935GluGly: 4.935 ± 0.598
1.371GluHis: 1.371 ± 0.327
2.559GluIle: 2.559 ± 0.496
2.742GluLys: 2.742 ± 0.598
5.483GluLeu: 5.483 ± 0.72
1.736GluMet: 1.736 ± 0.44
2.65GluAsn: 2.65 ± 0.458
1.645GluPro: 1.645 ± 0.522
3.199GluGln: 3.199 ± 0.936
3.381GluArg: 3.381 ± 0.424
4.752GluSer: 4.752 ± 0.558
3.381GluThr: 3.381 ± 0.466
5.575GluVal: 5.575 ± 0.978
1.005GluTrp: 1.005 ± 0.347
2.925GluTyr: 2.925 ± 0.509
0.0GluXaa: 0.0 ± 0.0
Phe
1.919PheAla: 1.919 ± 0.449
0.366PheCys: 0.366 ± 0.203
2.376PheAsp: 2.376 ± 0.444
2.65PheGlu: 2.65 ± 0.458
1.097PhePhe: 1.097 ± 0.306
3.199PheGly: 3.199 ± 0.564
0.274PheHis: 0.274 ± 0.152
1.279PheIle: 1.279 ± 0.296
2.468PheLys: 2.468 ± 0.49
2.559PheLeu: 2.559 ± 0.449
1.279PheMet: 1.279 ± 0.306
2.011PheAsn: 2.011 ± 0.588
1.462PhePro: 1.462 ± 0.371
1.279PheGln: 1.279 ± 0.314
1.736PheArg: 1.736 ± 0.375
2.285PheSer: 2.285 ± 0.452
2.65PheThr: 2.65 ± 0.426
1.645PheVal: 1.645 ± 0.303
0.183PheTrp: 0.183 ± 0.114
1.188PheTyr: 1.188 ± 0.303
0.0PheXaa: 0.0 ± 0.0
Gly
6.763GlyAla: 6.763 ± 1.125
1.097GlyCys: 1.097 ± 0.354
3.93GlyAsp: 3.93 ± 0.651
4.935GlyGlu: 4.935 ± 0.551
2.833GlyPhe: 2.833 ± 0.576
5.666GlyGly: 5.666 ± 0.897
2.011GlyHis: 2.011 ± 0.462
4.113GlyIle: 4.113 ± 0.665
5.666GlyLys: 5.666 ± 0.812
6.854GlyLeu: 6.854 ± 1.016
2.468GlyMet: 2.468 ± 0.463
3.564GlyAsn: 3.564 ± 0.583
1.097GlyPro: 1.097 ± 0.424
2.742GlyGln: 2.742 ± 0.438
5.483GlyArg: 5.483 ± 0.594
5.575GlySer: 5.575 ± 0.878
4.021GlyThr: 4.021 ± 0.51
4.478GlyVal: 4.478 ± 0.493
0.914GlyTrp: 0.914 ± 0.537
3.107GlyTyr: 3.107 ± 0.505
0.0GlyXaa: 0.0 ± 0.0
His
0.731HisAla: 0.731 ± 0.269
0.457HisCys: 0.457 ± 0.193
0.914HisAsp: 0.914 ± 0.228
1.828HisGlu: 1.828 ± 0.481
0.731HisPhe: 0.731 ± 0.272
1.645HisGly: 1.645 ± 0.357
0.457HisHis: 0.457 ± 0.219
1.097HisIle: 1.097 ± 0.34
1.462HisLys: 1.462 ± 0.393
2.468HisLeu: 2.468 ± 0.524
0.731HisMet: 0.731 ± 0.256
0.731HisAsn: 0.731 ± 0.218
0.274HisPro: 0.274 ± 0.151
0.091HisGln: 0.091 ± 0.089
1.188HisArg: 1.188 ± 0.306
0.548HisSer: 0.548 ± 0.207
0.731HisThr: 0.731 ± 0.304
1.097HisVal: 1.097 ± 0.312
0.548HisTrp: 0.548 ± 0.258
0.914HisTyr: 0.914 ± 0.275
0.0HisXaa: 0.0 ± 0.0
Ile
3.838IleAla: 3.838 ± 0.642
0.457IleCys: 0.457 ± 0.183
3.747IleAsp: 3.747 ± 0.589
3.016IleGlu: 3.016 ± 0.715
0.823IlePhe: 0.823 ± 0.219
4.021IleGly: 4.021 ± 0.624
0.914IleHis: 0.914 ± 0.364
2.833IleIle: 2.833 ± 0.633
4.021IleLys: 4.021 ± 0.646
4.204IleLeu: 4.204 ± 0.681
1.097IleMet: 1.097 ± 0.308
3.747IleAsn: 3.747 ± 0.554
3.107IlePro: 3.107 ± 0.493
0.914IleGln: 0.914 ± 0.307
4.021IleArg: 4.021 ± 0.647
3.199IleSer: 3.199 ± 0.346
3.016IleThr: 3.016 ± 0.397
2.833IleVal: 2.833 ± 0.499
0.823IleTrp: 0.823 ± 0.279
1.462IleTyr: 1.462 ± 0.312
0.0IleXaa: 0.0 ± 0.0
Lys
7.22LysAla: 7.22 ± 1.043
0.64LysCys: 0.64 ± 0.279
2.925LysAsp: 2.925 ± 0.507
4.57LysGlu: 4.57 ± 0.796
2.011LysPhe: 2.011 ± 0.383
5.575LysGly: 5.575 ± 0.735
1.828LysHis: 1.828 ± 0.487
2.376LysIle: 2.376 ± 0.475
4.478LysLys: 4.478 ± 1.066
4.295LysLeu: 4.295 ± 0.623
2.468LysMet: 2.468 ± 0.493
2.468LysAsn: 2.468 ± 0.335
2.742LysPro: 2.742 ± 0.642
2.376LysGln: 2.376 ± 0.515
4.204LysArg: 4.204 ± 0.702
3.747LysSer: 3.747 ± 0.466
3.199LysThr: 3.199 ± 0.445
4.295LysVal: 4.295 ± 0.706
0.548LysTrp: 0.548 ± 0.205
2.559LysTyr: 2.559 ± 0.351
0.0LysXaa: 0.0 ± 0.0
Leu
8.134LeuAla: 8.134 ± 1.358
0.548LeuCys: 0.548 ± 0.235
4.387LeuAsp: 4.387 ± 0.635
5.666LeuGlu: 5.666 ± 0.747
2.559LeuPhe: 2.559 ± 0.504
5.392LeuGly: 5.392 ± 0.767
1.554LeuHis: 1.554 ± 0.337
3.838LeuIle: 3.838 ± 0.527
5.301LeuLys: 5.301 ± 0.62
5.027LeuLeu: 5.027 ± 0.894
2.742LeuMet: 2.742 ± 0.502
4.387LeuAsn: 4.387 ± 0.6
3.29LeuPro: 3.29 ± 0.525
3.838LeuGln: 3.838 ± 0.636
5.575LeuArg: 5.575 ± 0.617
4.844LeuSer: 4.844 ± 0.747
5.209LeuThr: 5.209 ± 0.728
2.833LeuVal: 2.833 ± 0.55
0.914LeuTrp: 0.914 ± 0.277
2.285LeuTyr: 2.285 ± 0.521
0.0LeuXaa: 0.0 ± 0.0
Met
3.107MetAla: 3.107 ± 0.438
0.457MetCys: 0.457 ± 0.272
2.285MetAsp: 2.285 ± 0.393
1.736MetGlu: 1.736 ± 0.39
1.005MetPhe: 1.005 ± 0.393
2.833MetGly: 2.833 ± 0.698
0.366MetHis: 0.366 ± 0.165
1.462MetIle: 1.462 ± 0.298
1.371MetLys: 1.371 ± 0.302
3.656MetLeu: 3.656 ± 0.522
0.731MetMet: 0.731 ± 0.286
1.371MetAsn: 1.371 ± 0.357
1.188MetPro: 1.188 ± 0.262
1.097MetGln: 1.097 ± 0.299
1.645MetArg: 1.645 ± 0.292
2.011MetSer: 2.011 ± 0.419
1.919MetThr: 1.919 ± 0.425
3.199MetVal: 3.199 ± 0.567
0.091MetTrp: 0.091 ± 0.094
0.823MetTyr: 0.823 ± 0.29
0.0MetXaa: 0.0 ± 0.0
Asn
3.381AsnAla: 3.381 ± 0.515
0.64AsnCys: 0.64 ± 0.289
3.016AsnAsp: 3.016 ± 0.485
1.736AsnGlu: 1.736 ± 0.385
1.736AsnPhe: 1.736 ± 0.367
4.295AsnGly: 4.295 ± 0.735
1.371AsnHis: 1.371 ± 0.395
3.199AsnIle: 3.199 ± 0.588
1.645AsnLys: 1.645 ± 0.405
2.833AsnLeu: 2.833 ± 0.541
1.462AsnMet: 1.462 ± 0.342
1.554AsnAsn: 1.554 ± 0.37
2.833AsnPro: 2.833 ± 0.54
1.188AsnGln: 1.188 ± 0.348
1.554AsnArg: 1.554 ± 0.465
2.833AsnSer: 2.833 ± 0.644
2.925AsnThr: 2.925 ± 0.748
3.107AsnVal: 3.107 ± 0.602
0.274AsnTrp: 0.274 ± 0.157
2.376AsnTyr: 2.376 ± 0.437
0.0AsnXaa: 0.0 ± 0.0
Pro
2.65ProAla: 2.65 ± 0.367
0.457ProCys: 0.457 ± 0.221
2.468ProAsp: 2.468 ± 0.472
4.752ProGlu: 4.752 ± 0.734
1.371ProPhe: 1.371 ± 0.373
1.005ProGly: 1.005 ± 0.338
0.64ProHis: 0.64 ± 0.196
1.919ProIle: 1.919 ± 0.367
2.559ProLys: 2.559 ± 0.45
2.193ProLeu: 2.193 ± 0.469
1.645ProMet: 1.645 ± 0.41
1.919ProAsn: 1.919 ± 0.324
0.64ProPro: 0.64 ± 0.249
0.823ProGln: 0.823 ± 0.365
1.645ProArg: 1.645 ± 0.395
2.102ProSer: 2.102 ± 0.319
1.736ProThr: 1.736 ± 0.288
1.645ProVal: 1.645 ± 0.368
0.823ProTrp: 0.823 ± 0.181
1.097ProTyr: 1.097 ± 0.317
0.0ProXaa: 0.0 ± 0.0
Gln
4.021GlnAla: 4.021 ± 0.799
0.366GlnCys: 0.366 ± 0.217
2.285GlnAsp: 2.285 ± 0.432
2.285GlnGlu: 2.285 ± 0.494
2.468GlnPhe: 2.468 ± 0.328
2.376GlnGly: 2.376 ± 0.439
0.457GlnHis: 0.457 ± 0.244
1.645GlnIle: 1.645 ± 0.378
2.102GlnLys: 2.102 ± 0.508
3.381GlnLeu: 3.381 ± 0.537
1.005GlnMet: 1.005 ± 0.323
1.097GlnAsn: 1.097 ± 0.259
1.097GlnPro: 1.097 ± 0.339
1.462GlnGln: 1.462 ± 0.415
2.102GlnArg: 2.102 ± 0.568
2.011GlnSer: 2.011 ± 0.565
1.279GlnThr: 1.279 ± 0.428
2.833GlnVal: 2.833 ± 0.652
0.823GlnTrp: 0.823 ± 0.262
1.188GlnTyr: 1.188 ± 0.441
0.0GlnXaa: 0.0 ± 0.0
Arg
5.209ArgAla: 5.209 ± 0.651
1.097ArgCys: 1.097 ± 0.396
3.838ArgAsp: 3.838 ± 0.491
3.747ArgGlu: 3.747 ± 0.719
2.285ArgPhe: 2.285 ± 0.538
3.564ArgGly: 3.564 ± 0.629
1.188ArgHis: 1.188 ± 0.323
3.29ArgIle: 3.29 ± 0.578
3.381ArgLys: 3.381 ± 0.704
4.478ArgLeu: 4.478 ± 0.672
2.011ArgMet: 2.011 ± 0.392
2.376ArgAsn: 2.376 ± 0.606
2.193ArgPro: 2.193 ± 0.523
2.102ArgGln: 2.102 ± 0.452
3.107ArgArg: 3.107 ± 0.43
4.204ArgSer: 4.204 ± 0.487
3.29ArgThr: 3.29 ± 0.46
4.113ArgVal: 4.113 ± 0.656
1.005ArgTrp: 1.005 ± 0.33
2.285ArgTyr: 2.285 ± 0.496
0.0ArgXaa: 0.0 ± 0.0
Ser
5.483SerAla: 5.483 ± 0.8
0.914SerCys: 0.914 ± 0.352
5.392SerAsp: 5.392 ± 0.683
3.473SerGlu: 3.473 ± 0.482
2.193SerPhe: 2.193 ± 0.447
5.575SerGly: 5.575 ± 0.691
1.279SerHis: 1.279 ± 0.282
3.747SerIle: 3.747 ± 0.459
4.478SerLys: 4.478 ± 0.681
4.387SerLeu: 4.387 ± 0.615
1.645SerMet: 1.645 ± 0.388
2.376SerAsn: 2.376 ± 0.487
1.828SerPro: 1.828 ± 0.349
2.285SerGln: 2.285 ± 0.521
3.747SerArg: 3.747 ± 0.685
4.021SerSer: 4.021 ± 0.628
4.478SerThr: 4.478 ± 0.702
4.113SerVal: 4.113 ± 0.637
1.462SerTrp: 1.462 ± 0.457
2.285SerTyr: 2.285 ± 0.479
0.0SerXaa: 0.0 ± 0.0
Thr
4.752ThrAla: 4.752 ± 0.62
0.823ThrCys: 0.823 ± 0.339
2.742ThrAsp: 2.742 ± 0.622
4.021ThrGlu: 4.021 ± 0.764
1.828ThrPhe: 1.828 ± 0.54
4.844ThrGly: 4.844 ± 0.658
1.097ThrHis: 1.097 ± 0.295
3.838ThrIle: 3.838 ± 0.612
5.027ThrLys: 5.027 ± 0.523
4.752ThrLeu: 4.752 ± 0.612
1.554ThrMet: 1.554 ± 0.348
2.193ThrAsn: 2.193 ± 0.446
2.742ThrPro: 2.742 ± 0.499
2.468ThrGln: 2.468 ± 0.453
2.65ThrArg: 2.65 ± 0.448
4.204ThrSer: 4.204 ± 0.559
4.478ThrThr: 4.478 ± 0.848
4.113ThrVal: 4.113 ± 0.636
0.64ThrTrp: 0.64 ± 0.25
1.462ThrTyr: 1.462 ± 0.408
0.0ThrXaa: 0.0 ± 0.0
Val
4.844ValAla: 4.844 ± 0.8
0.457ValCys: 0.457 ± 0.212
3.656ValAsp: 3.656 ± 0.471
4.387ValGlu: 4.387 ± 0.904
2.193ValPhe: 2.193 ± 0.601
5.392ValGly: 5.392 ± 0.699
1.097ValHis: 1.097 ± 0.396
3.473ValIle: 3.473 ± 0.476
3.473ValLys: 3.473 ± 0.575
4.752ValLeu: 4.752 ± 0.604
2.742ValMet: 2.742 ± 0.465
2.742ValAsn: 2.742 ± 0.602
1.828ValPro: 1.828 ± 0.5
1.828ValGln: 1.828 ± 0.41
3.93ValArg: 3.93 ± 0.533
4.113ValSer: 4.113 ± 0.596
5.666ValThr: 5.666 ± 0.577
5.027ValVal: 5.027 ± 0.865
1.279ValTrp: 1.279 ± 0.317
2.559ValTyr: 2.559 ± 0.573
0.0ValXaa: 0.0 ± 0.0
Trp
1.097TrpAla: 1.097 ± 0.304
0.366TrpCys: 0.366 ± 0.164
0.548TrpAsp: 0.548 ± 0.206
1.097TrpGlu: 1.097 ± 0.282
0.457TrpPhe: 0.457 ± 0.242
0.914TrpGly: 0.914 ± 0.371
0.366TrpHis: 0.366 ± 0.222
0.548TrpIle: 0.548 ± 0.206
1.005TrpLys: 1.005 ± 0.382
1.371TrpLeu: 1.371 ± 0.363
0.64TrpMet: 0.64 ± 0.223
1.005TrpAsn: 1.005 ± 0.284
0.091TrpPro: 0.091 ± 0.095
0.457TrpGln: 0.457 ± 0.181
0.731TrpArg: 0.731 ± 0.306
1.645TrpSer: 1.645 ± 0.519
1.188TrpThr: 1.188 ± 0.266
0.914TrpVal: 0.914 ± 0.243
0.274TrpTrp: 0.274 ± 0.156
0.091TrpTyr: 0.091 ± 0.097
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.564TyrAla: 3.564 ± 0.571
0.823TyrCys: 0.823 ± 0.255
2.65TyrAsp: 2.65 ± 0.575
2.559TyrGlu: 2.559 ± 0.418
0.731TyrPhe: 0.731 ± 0.299
2.011TyrGly: 2.011 ± 0.447
0.366TyrHis: 0.366 ± 0.213
1.919TyrIle: 1.919 ± 0.387
1.828TyrLys: 1.828 ± 0.426
2.65TyrLeu: 2.65 ± 0.529
0.731TyrMet: 0.731 ± 0.282
1.462TyrAsn: 1.462 ± 0.321
0.731TyrPro: 0.731 ± 0.25
1.097TyrGln: 1.097 ± 0.355
2.833TyrArg: 2.833 ± 0.536
2.011TyrSer: 2.011 ± 0.428
2.376TyrThr: 2.376 ± 0.481
2.742TyrVal: 2.742 ± 0.561
0.548TyrTrp: 0.548 ± 0.274
0.548TyrTyr: 0.548 ± 0.314
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (10943 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski