Amino acid dipepetide frequency for Cruoricaptor ignavus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.473AlaAla: 6.473 ± 0.142
0.53AlaCys: 0.53 ± 0.031
4.248AlaAsp: 4.248 ± 0.085
6.432AlaGlu: 6.432 ± 0.134
3.418AlaPhe: 3.418 ± 0.08
5.264AlaGly: 5.264 ± 0.102
1.157AlaHis: 1.157 ± 0.044
4.606AlaIle: 4.606 ± 0.106
5.597AlaLys: 5.597 ± 0.106
6.711AlaLeu: 6.711 ± 0.106
1.953AlaMet: 1.953 ± 0.064
3.382AlaAsn: 3.382 ± 0.071
2.106AlaPro: 2.106 ± 0.054
2.945AlaGln: 2.945 ± 0.072
2.852AlaArg: 2.852 ± 0.069
3.938AlaSer: 3.938 ± 0.077
3.325AlaThr: 3.325 ± 0.077
5.2AlaVal: 5.2 ± 0.092
0.655AlaTrp: 0.655 ± 0.03
2.46AlaTyr: 2.46 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.562CysAla: 0.562 ± 0.028
0.104CysCys: 0.104 ± 0.013
0.388CysAsp: 0.388 ± 0.021
0.486CysGlu: 0.486 ± 0.026
0.328CysPhe: 0.328 ± 0.026
0.733CysGly: 0.733 ± 0.038
0.149CysHis: 0.149 ± 0.019
0.589CysIle: 0.589 ± 0.031
0.386CysLys: 0.386 ± 0.024
0.594CysLeu: 0.594 ± 0.031
0.13CysMet: 0.13 ± 0.012
0.357CysAsn: 0.357 ± 0.02
0.31CysPro: 0.31 ± 0.029
0.206CysGln: 0.206 ± 0.02
0.334CysArg: 0.334 ± 0.024
0.474CysSer: 0.474 ± 0.03
0.354CysThr: 0.354 ± 0.024
0.436CysVal: 0.436 ± 0.026
0.056CysTrp: 0.056 ± 0.01
0.238CysTyr: 0.238 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.245AspAla: 4.245 ± 0.092
0.366AspCys: 0.366 ± 0.024
2.716AspAsp: 2.716 ± 0.065
4.628AspGlu: 4.628 ± 0.106
4.213AspPhe: 4.213 ± 0.08
3.749AspGly: 3.749 ± 0.1
0.728AspHis: 0.728 ± 0.033
3.783AspIle: 3.783 ± 0.075
3.483AspLys: 3.483 ± 0.079
4.93AspLeu: 4.93 ± 0.082
1.053AspMet: 1.053 ± 0.041
2.479AspAsn: 2.479 ± 0.062
1.606AspPro: 1.606 ± 0.055
1.154AspGln: 1.154 ± 0.046
2.201AspArg: 2.201 ± 0.073
2.788AspSer: 2.788 ± 0.067
2.19AspThr: 2.19 ± 0.055
3.306AspVal: 3.306 ± 0.069
0.764AspTrp: 0.764 ± 0.033
2.661AspTyr: 2.661 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.755GluAla: 4.755 ± 0.109
0.37GluCys: 0.37 ± 0.024
3.524GluAsp: 3.524 ± 0.076
5.417GluGlu: 5.417 ± 0.105
3.74GluPhe: 3.74 ± 0.066
4.012GluGly: 4.012 ± 0.087
0.999GluHis: 0.999 ± 0.042
6.909GluIle: 6.909 ± 0.111
6.952GluLys: 6.952 ± 0.121
6.108GluLeu: 6.108 ± 0.105
1.919GluMet: 1.919 ± 0.056
5.708GluAsn: 5.708 ± 0.096
1.831GluPro: 1.831 ± 0.057
2.466GluGln: 2.466 ± 0.054
3.272GluArg: 3.272 ± 0.071
3.296GluSer: 3.296 ± 0.069
3.579GluThr: 3.579 ± 0.079
4.378GluVal: 4.378 ± 0.087
0.693GluTrp: 0.693 ± 0.031
2.295GluTyr: 2.295 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.87PheAla: 3.87 ± 0.088
0.506PheCys: 0.506 ± 0.024
3.0PheAsp: 3.0 ± 0.068
3.388PheGlu: 3.388 ± 0.074
2.977PhePhe: 2.977 ± 0.086
4.004PheGly: 4.004 ± 0.086
0.873PheHis: 0.873 ± 0.033
3.609PheIle: 3.609 ± 0.082
2.984PheLys: 2.984 ± 0.063
4.946PheLeu: 4.946 ± 0.107
1.163PheMet: 1.163 ± 0.041
2.62PheAsn: 2.62 ± 0.065
1.978PhePro: 1.978 ± 0.058
1.84PheGln: 1.84 ± 0.049
2.732PheArg: 2.732 ± 0.059
4.397PheSer: 4.397 ± 0.096
2.877PheThr: 2.877 ± 0.072
3.259PheVal: 3.259 ± 0.066
0.689PheTrp: 0.689 ± 0.035
2.166PheTyr: 2.166 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
4.66GlyAla: 4.66 ± 0.098
0.568GlyCys: 0.568 ± 0.029
3.341GlyAsp: 3.341 ± 0.083
4.372GlyGlu: 4.372 ± 0.091
3.705GlyPhe: 3.705 ± 0.093
4.93GlyGly: 4.93 ± 0.112
1.062GlyHis: 1.062 ± 0.044
5.512GlyIle: 5.512 ± 0.096
5.695GlyLys: 5.695 ± 0.101
5.335GlyLeu: 5.335 ± 0.1
1.685GlyMet: 1.685 ± 0.054
3.894GlyAsn: 3.894 ± 0.096
1.167GlyPro: 1.167 ± 0.037
2.079GlyGln: 2.079 ± 0.059
3.105GlyArg: 3.105 ± 0.08
4.026GlySer: 4.026 ± 0.08
3.749GlyThr: 3.749 ± 0.089
4.239GlyVal: 4.239 ± 0.085
0.812GlyTrp: 0.812 ± 0.033
2.864GlyTyr: 2.864 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
0.974HisAla: 0.974 ± 0.033
0.187HisCys: 0.187 ± 0.018
0.802HisAsp: 0.802 ± 0.035
0.984HisGlu: 0.984 ± 0.04
1.157HisPhe: 1.157 ± 0.042
1.113HisGly: 1.113 ± 0.042
0.467HisHis: 0.467 ± 0.032
1.395HisIle: 1.395 ± 0.044
0.962HisLys: 0.962 ± 0.044
1.744HisLeu: 1.744 ± 0.056
0.275HisMet: 0.275 ± 0.023
0.824HisAsn: 0.824 ± 0.035
0.872HisPro: 0.872 ± 0.039
0.711HisGln: 0.711 ± 0.031
0.866HisArg: 0.866 ± 0.039
1.164HisSer: 1.164 ± 0.048
0.838HisThr: 0.838 ± 0.034
0.386HisVal: 0.386 ± 0.027
0.224HisTrp: 0.224 ± 0.018
0.819HisTyr: 0.819 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.323IleAla: 5.323 ± 0.095
0.623IleCys: 0.623 ± 0.033
4.078IleAsp: 4.078 ± 0.097
4.777IleGlu: 4.777 ± 0.088
3.952IlePhe: 3.952 ± 0.085
4.777IleGly: 4.777 ± 0.091
1.197IleHis: 1.197 ± 0.041
5.324IleIle: 5.324 ± 0.11
4.507IleLys: 4.507 ± 0.086
7.059IleLeu: 7.059 ± 0.123
1.295IleMet: 1.295 ± 0.049
3.79IleAsn: 3.79 ± 0.075
3.252IlePro: 3.252 ± 0.064
2.308IleGln: 2.308 ± 0.064
3.217IleArg: 3.217 ± 0.073
6.148IleSer: 6.148 ± 0.1
3.968IleThr: 3.968 ± 0.08
4.138IleVal: 4.138 ± 0.08
0.635IleTrp: 0.635 ± 0.032
2.705IleTyr: 2.705 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.896LysAla: 4.896 ± 0.089
0.37LysCys: 0.37 ± 0.026
4.09LysAsp: 4.09 ± 0.1
5.0LysGlu: 5.0 ± 0.1
3.869LysPhe: 3.869 ± 0.074
4.09LysGly: 4.09 ± 0.079
1.119LysHis: 1.119 ± 0.042
6.979LysIle: 6.979 ± 0.125
6.054LysLys: 6.054 ± 0.112
6.125LysLeu: 6.125 ± 0.1
2.158LysMet: 2.158 ± 0.053
5.532LysAsn: 5.532 ± 0.099
2.794LysPro: 2.794 ± 0.068
2.32LysGln: 2.32 ± 0.064
2.781LysArg: 2.781 ± 0.066
4.387LysSer: 4.387 ± 0.085
4.287LysThr: 4.287 ± 0.085
4.362LysVal: 4.362 ± 0.088
0.663LysTrp: 0.663 ± 0.035
2.804LysTyr: 2.804 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
6.838LeuAla: 6.838 ± 0.105
0.698LeuCys: 0.698 ± 0.033
4.592LeuAsp: 4.592 ± 0.073
6.069LeuGlu: 6.069 ± 0.095
4.181LeuPhe: 4.181 ± 0.093
6.025LeuGly: 6.025 ± 0.102
1.602LeuHis: 1.602 ± 0.054
5.961LeuIle: 5.961 ± 0.109
7.4LeuLys: 7.4 ± 0.119
8.278LeuLeu: 8.278 ± 0.159
2.395LeuMet: 2.395 ± 0.06
5.115LeuAsn: 5.115 ± 0.091
4.001LeuPro: 4.001 ± 0.078
3.849LeuGln: 3.849 ± 0.073
4.106LeuArg: 4.106 ± 0.09
6.637LeuSer: 6.637 ± 0.11
4.34LeuThr: 4.34 ± 0.087
4.93LeuVal: 4.93 ± 0.1
0.813LeuTrp: 0.813 ± 0.038
2.937LeuTyr: 2.937 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
1.855MetAla: 1.855 ± 0.048
0.12MetCys: 0.12 ± 0.014
1.204MetAsp: 1.204 ± 0.046
1.602MetGlu: 1.602 ± 0.051
0.926MetPhe: 0.926 ± 0.043
1.448MetGly: 1.448 ± 0.048
0.445MetHis: 0.445 ± 0.027
1.529MetIle: 1.529 ± 0.047
2.264MetLys: 2.264 ± 0.063
2.292MetLeu: 2.292 ± 0.07
0.724MetMet: 0.724 ± 0.034
1.426MetAsn: 1.426 ± 0.04
1.058MetPro: 1.058 ± 0.043
1.09MetGln: 1.09 ± 0.039
1.207MetArg: 1.207 ± 0.047
1.336MetSer: 1.336 ± 0.044
1.153MetThr: 1.153 ± 0.048
1.36MetVal: 1.36 ± 0.042
0.178MetTrp: 0.178 ± 0.014
0.622MetTyr: 0.622 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.232AsnAla: 4.232 ± 0.096
0.388AsnCys: 0.388 ± 0.026
2.605AsnAsp: 2.605 ± 0.071
3.514AsnGlu: 3.514 ± 0.074
3.79AsnPhe: 3.79 ± 0.082
3.837AsnGly: 3.837 ± 0.08
0.987AsnHis: 0.987 ± 0.039
4.254AsnIle: 4.254 ± 0.093
3.198AsnLys: 3.198 ± 0.078
5.715AsnLeu: 5.715 ± 0.091
1.104AsnMet: 1.104 ± 0.043
2.835AsnAsn: 2.835 ± 0.083
3.05AsnPro: 3.05 ± 0.077
2.174AsnGln: 2.174 ± 0.067
2.422AsnArg: 2.422 ± 0.06
3.65AsnSer: 3.65 ± 0.083
2.68AsnThr: 2.68 ± 0.071
2.975AsnVal: 2.975 ± 0.067
0.679AsnTrp: 0.679 ± 0.031
2.604AsnTyr: 2.604 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
2.779ProAla: 2.779 ± 0.072
0.218ProCys: 0.218 ± 0.016
2.095ProAsp: 2.095 ± 0.054
3.622ProGlu: 3.622 ± 0.071
1.739ProPhe: 1.739 ± 0.054
2.273ProGly: 2.273 ± 0.054
0.677ProHis: 0.677 ± 0.033
2.105ProIle: 2.105 ± 0.058
2.937ProLys: 2.937 ± 0.057
3.015ProLeu: 3.015 ± 0.067
0.875ProMet: 0.875 ± 0.033
2.03ProAsn: 2.03 ± 0.052
0.922ProPro: 0.922 ± 0.046
1.527ProGln: 1.527 ± 0.055
1.194ProArg: 1.194 ± 0.043
1.954ProSer: 1.954 ± 0.053
1.837ProThr: 1.837 ± 0.054
2.691ProVal: 2.691 ± 0.065
0.364ProTrp: 0.364 ± 0.027
1.488ProTyr: 1.488 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.332GlnAla: 2.332 ± 0.06
0.19GlnCys: 0.19 ± 0.018
1.804GlnAsp: 1.804 ± 0.056
2.525GlnGlu: 2.525 ± 0.065
1.713GlnPhe: 1.713 ± 0.051
2.043GlnGly: 2.043 ± 0.052
0.658GlnHis: 0.658 ± 0.031
2.751GlnIle: 2.751 ± 0.074
3.326GlnLys: 3.326 ± 0.07
3.271GlnLeu: 3.271 ± 0.073
1.018GlnMet: 1.018 ± 0.035
2.604GlnAsn: 2.604 ± 0.07
1.33GlnPro: 1.33 ± 0.042
1.807GlnGln: 1.807 ± 0.064
1.754GlnArg: 1.754 ± 0.06
2.083GlnSer: 2.083 ± 0.056
1.875GlnThr: 1.875 ± 0.053
1.902GlnVal: 1.902 ± 0.052
0.379GlnTrp: 0.379 ± 0.023
1.318GlnTyr: 1.318 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.83ArgAla: 2.83 ± 0.067
0.259ArgCys: 0.259 ± 0.022
2.22ArgAsp: 2.22 ± 0.055
3.609ArgGlu: 3.609 ± 0.083
2.335ArgPhe: 2.335 ± 0.06
2.4ArgGly: 2.4 ± 0.059
0.875ArgHis: 0.875 ± 0.036
3.426ArgIle: 3.426 ± 0.072
3.818ArgLys: 3.818 ± 0.08
3.995ArgLeu: 3.995 ± 0.091
1.229ArgMet: 1.229 ± 0.047
2.835ArgAsn: 2.835 ± 0.069
1.431ArgPro: 1.431 ± 0.042
1.758ArgGln: 1.758 ± 0.056
2.377ArgArg: 2.377 ± 0.065
2.174ArgSer: 2.174 ± 0.065
2.108ArgThr: 2.108 ± 0.058
2.342ArgVal: 2.342 ± 0.07
0.471ArgTrp: 0.471 ± 0.026
1.723ArgTyr: 1.723 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.137SerAla: 5.137 ± 0.083
0.537SerCys: 0.537 ± 0.033
3.375SerAsp: 3.375 ± 0.067
4.668SerGlu: 4.668 ± 0.096
3.293SerPhe: 3.293 ± 0.08
5.262SerGly: 5.262 ± 0.088
1.036SerHis: 1.036 ± 0.043
3.815SerIle: 3.815 ± 0.083
3.922SerLys: 3.922 ± 0.077
5.819SerLeu: 5.819 ± 0.105
1.242SerMet: 1.242 ± 0.048
2.719SerAsn: 2.719 ± 0.062
2.286SerPro: 2.286 ± 0.064
2.494SerGln: 2.494 ± 0.068
2.791SerArg: 2.791 ± 0.073
3.587SerSer: 3.587 ± 0.085
2.969SerThr: 2.969 ± 0.072
4.277SerVal: 4.277 ± 0.083
0.734SerTrp: 0.734 ± 0.038
2.241SerTyr: 2.241 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.028ThrAla: 4.028 ± 0.086
0.278ThrCys: 0.278 ± 0.021
2.956ThrAsp: 2.956 ± 0.067
3.777ThrGlu: 3.777 ± 0.092
2.411ThrPhe: 2.411 ± 0.068
3.914ThrGly: 3.914 ± 0.093
0.869ThrHis: 0.869 ± 0.038
3.356ThrIle: 3.356 ± 0.08
3.388ThrLys: 3.388 ± 0.067
4.502ThrLeu: 4.502 ± 0.088
1.078ThrMet: 1.078 ± 0.043
2.452ThrAsn: 2.452 ± 0.072
2.215ThrPro: 2.215 ± 0.068
1.67ThrGln: 1.67 ± 0.061
1.741ThrArg: 1.741 ± 0.055
2.886ThrSer: 2.886 ± 0.07
2.747ThrThr: 2.747 ± 0.082
3.54ThrVal: 3.54 ± 0.072
0.421ThrTrp: 0.421 ± 0.021
1.85ThrTyr: 1.85 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
4.224ValAla: 4.224 ± 0.084
0.462ValCys: 0.462 ± 0.027
3.142ValAsp: 3.142 ± 0.07
4.216ValGlu: 4.216 ± 0.079
3.183ValPhe: 3.183 ± 0.075
3.708ValGly: 3.708 ± 0.086
0.9ValHis: 0.9 ± 0.041
4.113ValIle: 4.113 ± 0.086
4.499ValLys: 4.499 ± 0.08
5.664ValLeu: 5.664 ± 0.098
1.553ValMet: 1.553 ± 0.047
3.252ValAsn: 3.252 ± 0.075
2.428ValPro: 2.428 ± 0.06
2.136ValGln: 2.136 ± 0.059
2.607ValArg: 2.607 ± 0.073
4.125ValSer: 4.125 ± 0.076
2.735ValThr: 2.735 ± 0.075
3.894ValVal: 3.894 ± 0.091
0.604ValTrp: 0.604 ± 0.034
2.22ValTyr: 2.22 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.701TrpAla: 0.701 ± 0.033
0.101TrpCys: 0.101 ± 0.013
0.628TrpAsp: 0.628 ± 0.031
0.721TrpGlu: 0.721 ± 0.032
0.538TrpPhe: 0.538 ± 0.032
0.591TrpGly: 0.591 ± 0.03
0.193TrpHis: 0.193 ± 0.018
0.689TrpIle: 0.689 ± 0.033
0.872TrpLys: 0.872 ± 0.038
1.055TrpLeu: 1.055 ± 0.036
0.322TrpMet: 0.322 ± 0.021
0.668TrpAsn: 0.668 ± 0.03
0.202TrpPro: 0.202 ± 0.018
0.553TrpGln: 0.553 ± 0.029
0.465TrpArg: 0.465 ± 0.028
0.505TrpSer: 0.505 ± 0.029
0.484TrpThr: 0.484 ± 0.027
0.568TrpVal: 0.568 ± 0.027
0.129TrpTrp: 0.129 ± 0.013
0.407TrpTyr: 0.407 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.536TyrAla: 2.536 ± 0.064
0.339TyrCys: 0.339 ± 0.023
2.237TyrAsp: 2.237 ± 0.069
2.421TyrGlu: 2.421 ± 0.067
2.411TyrPhe: 2.411 ± 0.059
2.624TyrGly: 2.624 ± 0.064
0.772TyrHis: 0.772 ± 0.035
2.37TyrIle: 2.37 ± 0.052
2.434TyrLys: 2.434 ± 0.07
3.609TyrLeu: 3.609 ± 0.084
0.666TyrMet: 0.666 ± 0.032
2.169TyrAsn: 2.169 ± 0.069
1.507TyrPro: 1.507 ± 0.051
1.596TyrGln: 1.596 ± 0.044
2.19TyrArg: 2.19 ± 0.06
2.651TyrSer: 2.651 ± 0.066
1.982TyrThr: 1.982 ± 0.064
1.483TyrVal: 1.483 ± 0.041
0.427TyrTrp: 0.427 ± 0.027
1.785TyrTyr: 1.785 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2166 proteins (683640 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski