Amino acid dipepetide frequency for Trichomalopsis sarcophagae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.455AlaAla: 5.455 ± 0.051	1.208AlaCys: 1.208 ± 0.022	3.141AlaAsp: 3.141 ± 0.025	4.108AlaGlu: 4.108 ± 0.033	2.26AlaPhe: 2.26 ± 0.022	3.426AlaGly: 3.426 ± 0.033	1.346AlaHis: 1.346 ± 0.015	3.615AlaIle: 3.615 ± 0.025	4.047AlaLys: 4.047 ± 0.033	5.887AlaLeu: 5.887 ± 0.042	1.498AlaMet: 1.498 ± 0.018	2.936AlaAsn: 2.936 ± 0.023	2.728AlaPro: 2.728 ± 0.028	2.438AlaGln: 2.438 ± 0.024	3.373AlaArg: 3.373 ± 0.03	5.084AlaSer: 5.084 ± 0.04	3.676AlaThr: 3.676 ± 0.027	4.193AlaVal: 4.193 ± 0.032	0.606AlaTrp: 0.606 ± 0.011	1.762AlaTyr: 1.762 ± 0.02	0.007AlaXaa: 0.007 ± 0.001
Cys	1.128CysAla: 1.128 ± 0.016	0.5CysCys: 0.5 ± 0.01	1.085CysAsp: 1.085 ± 0.019	1.14CysGlu: 1.14 ± 0.019	0.786CysPhe: 0.786 ± 0.011	1.236CysGly: 1.236 ± 0.028	0.494CysHis: 0.494 ± 0.011	1.211CysIle: 1.211 ± 0.018	1.234CysLys: 1.234 ± 0.017	1.874CysLeu: 1.874 ± 0.023	0.428CysMet: 0.428 ± 0.008	1.005CysAsn: 1.005 ± 0.016	0.972CysPro: 0.972 ± 0.024	0.801CysGln: 0.801 ± 0.016	1.107CysArg: 1.107 ± 0.023	1.656CysSer: 1.656 ± 0.027	1.122CysThr: 1.122 ± 0.02	1.185CysVal: 1.185 ± 0.02	0.221CysTrp: 0.221 ± 0.006	0.613CysTyr: 0.613 ± 0.011	0.001CysXaa: 0.001 ± 0.0
Asp	3.153AspAla: 3.153 ± 0.028	1.052AspCys: 1.052 ± 0.017	3.971AspAsp: 3.971 ± 0.044	4.533AspGlu: 4.533 ± 0.041	2.278AspPhe: 2.278 ± 0.02	2.887AspGly: 2.887 ± 0.033	1.102AspHis: 1.102 ± 0.015	3.368AspIle: 3.368 ± 0.026	3.602AspLys: 3.602 ± 0.038	4.862AspLeu: 4.862 ± 0.033	1.194AspMet: 1.194 ± 0.014	2.771AspAsn: 2.771 ± 0.021	2.369AspPro: 2.369 ± 0.028	1.75AspGln: 1.75 ± 0.015	2.619AspArg: 2.619 ± 0.029	4.468AspSer: 4.468 ± 0.036	2.667AspThr: 2.667 ± 0.022	3.558AspVal: 3.558 ± 0.026	0.663AspTrp: 0.663 ± 0.014	1.937AspTyr: 1.937 ± 0.02	0.004AspXaa: 0.004 ± 0.001
Glu	4.254GluAla: 4.254 ± 0.032	1.171GluCys: 1.171 ± 0.023	4.191GluAsp: 4.191 ± 0.04	6.303GluGlu: 6.303 ± 0.076	2.258GluPhe: 2.258 ± 0.019	2.764GluGly: 2.764 ± 0.028	1.462GluHis: 1.462 ± 0.015	4.175GluIle: 4.175 ± 0.04	5.579GluLys: 5.579 ± 0.063	5.847GluLeu: 5.847 ± 0.041	1.584GluMet: 1.584 ± 0.016	4.096GluAsn: 4.096 ± 0.036	2.655GluPro: 2.655 ± 0.033	2.701GluGln: 2.701 ± 0.029	3.7GluArg: 3.7 ± 0.032	4.972GluSer: 4.972 ± 0.049	3.654GluThr: 3.654 ± 0.029	3.753GluVal: 3.753 ± 0.032	0.63GluTrp: 0.63 ± 0.012	1.967GluTyr: 1.967 ± 0.02	0.005GluXaa: 0.005 ± 0.001
Phe	2.275PheAla: 2.275 ± 0.02	0.867PheCys: 0.867 ± 0.013	2.244PheAsp: 2.244 ± 0.022	2.332PheGlu: 2.332 ± 0.022	1.74PhePhe: 1.74 ± 0.022	2.241PheGly: 2.241 ± 0.033	0.956PheHis: 0.956 ± 0.013	2.29PheIle: 2.29 ± 0.024	2.318PheLys: 2.318 ± 0.02	3.733PheLeu: 3.733 ± 0.034	0.851PheMet: 0.851 ± 0.011	1.931PheAsn: 1.931 ± 0.024	1.613PhePro: 1.613 ± 0.018	1.427PheGln: 1.427 ± 0.015	1.86PheArg: 1.86 ± 0.021	3.075PheSer: 3.075 ± 0.023	2.118PheThr: 2.118 ± 0.021	2.541PheVal: 2.541 ± 0.022	0.463PheTrp: 0.463 ± 0.009	1.463PheTyr: 1.463 ± 0.017	0.002PheXaa: 0.002 ± 0.001
Gly	3.163GlyAla: 3.163 ± 0.031	0.999GlyCys: 0.999 ± 0.016	2.623GlyAsp: 2.623 ± 0.025	3.006GlyGlu: 3.006 ± 0.03	2.14GlyPhe: 2.14 ± 0.022	3.633GlyGly: 3.633 ± 0.063	1.297GlyHis: 1.297 ± 0.018	3.087GlyIle: 3.087 ± 0.025	3.411GlyLys: 3.411 ± 0.029	4.421GlyLeu: 4.421 ± 0.037	1.144GlyMet: 1.144 ± 0.014	2.574GlyAsn: 2.574 ± 0.027	2.213GlyPro: 2.213 ± 0.043	1.935GlyGln: 1.935 ± 0.023	2.791GlyArg: 2.791 ± 0.028	4.381GlySer: 4.381 ± 0.044	2.858GlyThr: 2.858 ± 0.029	3.083GlyVal: 3.083 ± 0.027	0.609GlyTrp: 0.609 ± 0.011	1.841GlyTyr: 1.841 ± 0.022	0.004GlyXaa: 0.004 ± 0.001
His	1.311HisAla: 1.311 ± 0.015	0.574HisCys: 0.574 ± 0.013	1.103HisAsp: 1.103 ± 0.014	1.412HisGlu: 1.412 ± 0.015	1.019HisPhe: 1.019 ± 0.013	1.282HisGly: 1.282 ± 0.018	1.006HisHis: 1.006 ± 0.02	1.356HisIle: 1.356 ± 0.015	1.403HisLys: 1.403 ± 0.016	2.323HisLeu: 2.323 ± 0.021	0.564HisMet: 0.564 ± 0.01	1.12HisAsn: 1.12 ± 0.015	1.236HisPro: 1.236 ± 0.017	1.165HisGln: 1.165 ± 0.018	1.429HisArg: 1.429 ± 0.016	1.81HisSer: 1.81 ± 0.02	1.205HisThr: 1.205 ± 0.015	1.492HisVal: 1.492 ± 0.016	0.307HisTrp: 0.307 ± 0.006	0.851HisTyr: 0.851 ± 0.013	0.001HisXaa: 0.001 ± 0.0
Ile	3.703IleAla: 3.703 ± 0.028	1.267IleCys: 1.267 ± 0.018	3.437IleAsp: 3.437 ± 0.027	3.917IleGlu: 3.917 ± 0.032	2.539IlePhe: 2.539 ± 0.027	2.883IleGly: 2.883 ± 0.026	1.378IleHis: 1.378 ± 0.018	3.642IleIle: 3.642 ± 0.033	3.965IleLys: 3.965 ± 0.032	5.648IleLeu: 5.648 ± 0.044	1.277IleMet: 1.277 ± 0.016	3.14IleAsn: 3.14 ± 0.03	2.823IlePro: 2.823 ± 0.024	2.277IleGln: 2.277 ± 0.023	2.925IleArg: 2.925 ± 0.022	4.563IleSer: 4.563 ± 0.028	3.25IleThr: 3.25 ± 0.025	3.886IleVal: 3.886 ± 0.031	0.562IleTrp: 0.562 ± 0.011	1.889IleTyr: 1.889 ± 0.017	0.002IleXaa: 0.002 ± 0.001
Lys	3.743LysAla: 3.743 ± 0.029	1.308LysCys: 1.308 ± 0.023	3.688LysAsp: 3.688 ± 0.041	4.999LysGlu: 4.999 ± 0.054	2.447LysPhe: 2.447 ± 0.025	2.703LysGly: 2.703 ± 0.028	1.566LysHis: 1.566 ± 0.018	4.489LysIle: 4.489 ± 0.035	6.186LysLys: 6.186 ± 0.074	6.291LysLeu: 6.291 ± 0.042	1.613LysMet: 1.613 ± 0.016	3.865LysAsn: 3.865 ± 0.028	3.113LysPro: 3.113 ± 0.037	2.712LysGln: 2.712 ± 0.024	3.898LysArg: 3.898 ± 0.034	5.399LysSer: 5.399 ± 0.054	3.819LysThr: 3.819 ± 0.033	3.847LysVal: 3.847 ± 0.026	0.67LysTrp: 0.67 ± 0.011	2.269LysTyr: 2.269 ± 0.022	0.005LysXaa: 0.005 ± 0.001
Leu	5.976LeuAla: 5.976 ± 0.041	1.798LeuCys: 1.798 ± 0.022	4.904LeuAsp: 4.904 ± 0.034	6.177LeuGlu: 6.177 ± 0.046	3.437LeuPhe: 3.437 ± 0.03	4.417LeuGly: 4.417 ± 0.033	2.408LeuHis: 2.408 ± 0.025	4.942LeuIle: 4.942 ± 0.034	6.499LeuLys: 6.499 ± 0.045	9.246LeuLeu: 9.246 ± 0.063	2.101LeuMet: 2.101 ± 0.023	4.525LeuAsn: 4.525 ± 0.032	4.492LeuPro: 4.492 ± 0.034	4.378LeuGln: 4.378 ± 0.034	5.313LeuArg: 5.313 ± 0.035	7.17LeuSer: 7.17 ± 0.041	5.005LeuThr: 5.005 ± 0.03	5.358LeuVal: 5.358 ± 0.034	0.908LeuTrp: 0.908 ± 0.014	2.807LeuTyr: 2.807 ± 0.023	0.007LeuXaa: 0.007 ± 0.001
Met	1.544MetAla: 1.544 ± 0.016	0.424MetCys: 0.424 ± 0.008	1.257MetAsp: 1.257 ± 0.013	1.495MetGlu: 1.495 ± 0.016	0.848MetPhe: 0.848 ± 0.013	1.068MetGly: 1.068 ± 0.016	0.56MetHis: 0.56 ± 0.01	1.304MetIle: 1.304 ± 0.016	1.577MetLys: 1.577 ± 0.018	2.087MetLeu: 2.087 ± 0.019	0.643MetMet: 0.643 ± 0.011	1.122MetAsn: 1.122 ± 0.014	1.082MetPro: 1.082 ± 0.014	1.018MetGln: 1.018 ± 0.015	1.246MetArg: 1.246 ± 0.014	1.817MetSer: 1.817 ± 0.017	1.307MetThr: 1.307 ± 0.014	1.217MetVal: 1.217 ± 0.014	0.236MetTrp: 0.236 ± 0.006	0.737MetTyr: 0.737 ± 0.011	0.002MetXaa: 0.002 ± 0.001
Asn	3.128AsnAla: 3.128 ± 0.028	1.021AsnCys: 1.021 ± 0.015	2.885AsnAsp: 2.885 ± 0.024	3.461AsnGlu: 3.461 ± 0.03	2.133AsnPhe: 2.133 ± 0.024	2.818AsnGly: 2.818 ± 0.027	1.222AsnHis: 1.222 ± 0.017	3.337AsnIle: 3.337 ± 0.029	3.486AsnLys: 3.486 ± 0.033	4.717AsnLeu: 4.717 ± 0.035	1.134AsnMet: 1.134 ± 0.015	3.386AsnAsn: 3.386 ± 0.034	2.318AsnPro: 2.318 ± 0.024	2.024AsnGln: 2.024 ± 0.022	2.481AsnArg: 2.481 ± 0.02	4.322AsnSer: 4.322 ± 0.035	2.68AsnThr: 2.68 ± 0.024	3.372AsnVal: 3.372 ± 0.027	0.523AsnTrp: 0.523 ± 0.008	1.822AsnTyr: 1.822 ± 0.021	0.004AsnXaa: 0.004 ± 0.001
Pro	3.142ProAla: 3.142 ± 0.033	0.796ProCys: 0.796 ± 0.027	2.446ProAsp: 2.446 ± 0.023	3.312ProGlu: 3.312 ± 0.035	1.609ProPhe: 1.609 ± 0.021	2.623ProGly: 2.623 ± 0.048	1.042ProHis: 1.042 ± 0.015	2.626ProIle: 2.626 ± 0.023	2.96ProLys: 2.96 ± 0.031	3.947ProLeu: 3.947 ± 0.029	1.007ProMet: 1.007 ± 0.015	2.275ProAsn: 2.275 ± 0.024	3.546ProPro: 3.546 ± 0.051	2.06ProGln: 2.06 ± 0.029	2.544ProArg: 2.544 ± 0.024	4.033ProSer: 4.033 ± 0.045	2.936ProThr: 2.936 ± 0.029	3.113ProVal: 3.113 ± 0.03	0.474ProTrp: 0.474 ± 0.008	1.442ProTyr: 1.442 ± 0.018	0.005ProXaa: 0.005 ± 0.001
Gln	2.517GlnAla: 2.517 ± 0.022	0.767GlnCys: 0.767 ± 0.016	1.901GlnAsp: 1.901 ± 0.018	2.862GlnGlu: 2.862 ± 0.025	1.389GlnPhe: 1.389 ± 0.017	1.763GlnGly: 1.763 ± 0.024	1.167GlnHis: 1.167 ± 0.018	2.297GlnIle: 2.297 ± 0.023	2.713GlnLys: 2.713 ± 0.026	3.873GlnLeu: 3.873 ± 0.031	0.996GlnMet: 0.996 ± 0.014	2.24GlnAsn: 2.24 ± 0.022	2.158GlnPro: 2.158 ± 0.03	3.812GlnGln: 3.812 ± 0.093	2.465GlnArg: 2.465 ± 0.023	3.092GlnSer: 3.092 ± 0.032	2.203GlnThr: 2.203 ± 0.021	2.323GlnVal: 2.323 ± 0.023	0.432GlnTrp: 0.432 ± 0.008	1.252GlnTyr: 1.252 ± 0.017	0.004GlnXaa: 0.004 ± 0.001
Arg	3.165ArgAla: 3.165 ± 0.029	1.096ArgCys: 1.096 ± 0.019	2.891ArgAsp: 2.891 ± 0.031	3.535ArgGlu: 3.535 ± 0.03	2.04ArgPhe: 2.04 ± 0.019	2.784ArgGly: 2.784 ± 0.03	1.468ArgHis: 1.468 ± 0.019	3.102ArgIle: 3.102 ± 0.025	4.052ArgLys: 4.052 ± 0.031	5.041ArgLeu: 5.041 ± 0.034	1.247ArgMet: 1.247 ± 0.014	2.787ArgAsn: 2.787 ± 0.023	2.455ArgPro: 2.455 ± 0.029	2.268ArgGln: 2.268 ± 0.022	4.208ArgArg: 4.208 ± 0.044	4.285ArgSer: 4.285 ± 0.038	2.795ArgThr: 2.795 ± 0.024	3.046ArgVal: 3.046 ± 0.026	0.571ArgTrp: 0.571 ± 0.01	1.79ArgTyr: 1.79 ± 0.019	0.005ArgXaa: 0.005 ± 0.001
Ser	4.877SerAla: 4.877 ± 0.034	1.513SerCys: 1.513 ± 0.028	4.38SerAsp: 4.38 ± 0.037	5.014SerGlu: 5.014 ± 0.046	2.927SerPhe: 2.927 ± 0.024	4.391SerGly: 4.391 ± 0.039	1.768SerHis: 1.768 ± 0.019	4.617SerIle: 4.617 ± 0.032	5.262SerLys: 5.262 ± 0.047	7.2SerLeu: 7.2 ± 0.033	1.753SerMet: 1.753 ± 0.019	4.297SerAsn: 4.297 ± 0.035	4.182SerPro: 4.182 ± 0.049	3.216SerGln: 3.216 ± 0.029	4.437SerArg: 4.437 ± 0.039	8.842SerSer: 8.842 ± 0.083	5.207SerThr: 5.207 ± 0.04	4.742SerVal: 4.742 ± 0.033	0.851SerTrp: 0.851 ± 0.012	2.341SerTyr: 2.341 ± 0.025	0.006SerXaa: 0.006 ± 0.001
Thr	3.753ThrAla: 3.753 ± 0.026	1.132ThrCys: 1.132 ± 0.021	2.872ThrAsp: 2.872 ± 0.025	3.547ThrGlu: 3.547 ± 0.034	2.167ThrPhe: 2.167 ± 0.018	3.016ThrGly: 3.016 ± 0.024	1.159ThrHis: 1.159 ± 0.015	3.444ThrIle: 3.444 ± 0.024	3.544ThrLys: 3.544 ± 0.029	5.08ThrLeu: 5.08 ± 0.03	1.249ThrMet: 1.249 ± 0.013	2.779ThrAsn: 2.779 ± 0.023	3.137ThrPro: 3.137 ± 0.032	1.978ThrGln: 1.978 ± 0.02	2.785ThrArg: 2.785 ± 0.024	4.989ThrSer: 4.989 ± 0.041	4.068ThrThr: 4.068 ± 0.048	3.603ThrVal: 3.603 ± 0.03	0.608ThrTrp: 0.608 ± 0.011	1.683ThrTyr: 1.683 ± 0.019	0.004ThrXaa: 0.004 ± 0.001
Val	4.065ValAla: 4.065 ± 0.031	1.321ValCys: 1.321 ± 0.021	3.472ValAsp: 3.472 ± 0.025	3.998ValGlu: 3.998 ± 0.032	2.368ValPhe: 2.368 ± 0.024	2.987ValGly: 2.987 ± 0.026	1.464ValHis: 1.464 ± 0.017	3.577ValIle: 3.577 ± 0.028	3.998ValLys: 3.998 ± 0.033	5.641ValLeu: 5.641 ± 0.04	1.33ValMet: 1.33 ± 0.016	3.115ValAsn: 3.115 ± 0.026	3.011ValPro: 3.011 ± 0.025	2.537ValGln: 2.537 ± 0.025	3.032ValArg: 3.032 ± 0.021	4.618ValSer: 4.618 ± 0.034	3.654ValThr: 3.654 ± 0.027	4.054ValVal: 4.054 ± 0.029	0.637ValTrp: 0.637 ± 0.011	1.982ValTyr: 1.982 ± 0.018	0.005ValXaa: 0.005 ± 0.001
Trp	0.564TrpAla: 0.564 ± 0.012	0.216TrpCys: 0.216 ± 0.006	0.543TrpAsp: 0.543 ± 0.01	0.584TrpGlu: 0.584 ± 0.009	0.427TrpPhe: 0.427 ± 0.009	0.498TrpGly: 0.498 ± 0.01	0.261TrpHis: 0.261 ± 0.007	0.694TrpIle: 0.694 ± 0.012	0.746TrpLys: 0.746 ± 0.012	1.08TrpLeu: 1.08 ± 0.016	0.275TrpMet: 0.275 ± 0.007	0.587TrpAsn: 0.587 ± 0.011	0.438TrpPro: 0.438 ± 0.009	0.452TrpGln: 0.452 ± 0.009	0.665TrpArg: 0.665 ± 0.011	0.827TrpSer: 0.827 ± 0.014	0.598TrpThr: 0.598 ± 0.01	0.52TrpVal: 0.52 ± 0.01	0.161TrpTrp: 0.161 ± 0.005	0.381TrpTyr: 0.381 ± 0.009	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.873TyrAla: 1.873 ± 0.02	0.768TyrCys: 0.768 ± 0.013	1.772TyrAsp: 1.772 ± 0.018	1.981TyrGlu: 1.981 ± 0.02	1.524TyrPhe: 1.524 ± 0.018	1.79TyrGly: 1.79 ± 0.02	0.841TyrHis: 0.841 ± 0.013	1.795TyrIle: 1.795 ± 0.018	2.045TyrLys: 2.045 ± 0.022	3.067TyrLeu: 3.067 ± 0.027	0.701TyrMet: 0.701 ± 0.012	1.718TyrAsn: 1.718 ± 0.019	1.391TyrPro: 1.391 ± 0.019	1.273TyrGln: 1.273 ± 0.017	1.746TyrArg: 1.746 ± 0.019	2.414TyrSer: 2.414 ± 0.024	1.773TyrThr: 1.773 ± 0.02	1.973TyrVal: 1.973 ± 0.021	0.386TyrTrp: 0.386 ± 0.009	1.33TyrTyr: 1.33 ± 0.019	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.005XaaGlu: 0.005 ± 0.001	0.003XaaPhe: 0.003 ± 0.001	0.004XaaGly: 0.004 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.005XaaIle: 0.005 ± 0.001	0.005XaaLys: 0.005 ± 0.001	0.005XaaLeu: 0.005 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.005XaaPro: 0.005 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.007XaaArg: 0.007 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.004XaaThr: 0.004 ± 0.001	0.005XaaVal: 0.005 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.181XaaXaa: 0.181 ± 0.019

Statistics based on 16064 proteins (6836071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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