Amino acid dipepetide frequency for Anaerococcus octavius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.605AlaAla: 3.605 ± 0.102
0.553AlaCys: 0.553 ± 0.034
3.622AlaAsp: 3.622 ± 0.092
3.417AlaGlu: 3.417 ± 0.091
2.474AlaPhe: 2.474 ± 0.075
4.043AlaGly: 4.043 ± 0.094
0.814AlaHis: 0.814 ± 0.038
6.194AlaIle: 6.194 ± 0.118
4.945AlaLys: 4.945 ± 0.104
5.516AlaLeu: 5.516 ± 0.129
1.692AlaMet: 1.692 ± 0.054
3.786AlaAsn: 3.786 ± 0.095
1.459AlaPro: 1.459 ± 0.048
1.413AlaGln: 1.413 ± 0.043
2.217AlaArg: 2.217 ± 0.062
3.947AlaSer: 3.947 ± 0.09
2.967AlaThr: 2.967 ± 0.066
3.427AlaVal: 3.427 ± 0.091
0.306AlaTrp: 0.306 ± 0.022
2.525AlaTyr: 2.525 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.411CysAla: 0.411 ± 0.03
0.077CysCys: 0.077 ± 0.015
0.488CysAsp: 0.488 ± 0.03
0.441CysGlu: 0.441 ± 0.028
0.274CysPhe: 0.274 ± 0.024
0.744CysGly: 0.744 ± 0.036
0.166CysHis: 0.166 ± 0.016
0.522CysIle: 0.522 ± 0.032
0.527CysLys: 0.527 ± 0.036
0.553CysLeu: 0.553 ± 0.031
0.151CysMet: 0.151 ± 0.016
0.322CysAsn: 0.322 ± 0.025
0.323CysPro: 0.323 ± 0.025
0.216CysGln: 0.216 ± 0.02
0.198CysArg: 0.198 ± 0.018
0.378CysSer: 0.378 ± 0.027
0.318CysThr: 0.318 ± 0.026
0.399CysVal: 0.399 ± 0.027
0.055CysTrp: 0.055 ± 0.009
0.31CysTyr: 0.31 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.271AspAla: 3.271 ± 0.088
0.431AspCys: 0.431 ± 0.028
4.498AspAsp: 4.498 ± 0.11
5.947AspGlu: 5.947 ± 0.124
3.668AspPhe: 3.668 ± 0.073
3.981AspGly: 3.981 ± 0.094
0.989AspHis: 0.989 ± 0.043
6.731AspIle: 6.731 ± 0.115
6.673AspLys: 6.673 ± 0.137
6.62AspLeu: 6.62 ± 0.121
1.526AspMet: 1.526 ± 0.055
4.176AspAsn: 4.176 ± 0.109
2.024AspPro: 2.024 ± 0.057
2.094AspGln: 2.094 ± 0.07
2.418AspArg: 2.418 ± 0.068
3.692AspSer: 3.692 ± 0.083
2.924AspThr: 2.924 ± 0.082
3.583AspVal: 3.583 ± 0.078
0.424AspTrp: 0.424 ± 0.032
3.838AspTyr: 3.838 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
4.113GluAla: 4.113 ± 0.104
0.363GluCys: 0.363 ± 0.027
5.584GluAsp: 5.584 ± 0.127
6.709GluGlu: 6.709 ± 0.166
3.169GluPhe: 3.169 ± 0.078
3.576GluGly: 3.576 ± 0.083
0.785GluHis: 0.785 ± 0.037
7.504GluIle: 7.504 ± 0.124
8.247GluLys: 8.247 ± 0.128
6.257GluLeu: 6.257 ± 0.122
1.843GluMet: 1.843 ± 0.061
6.669GluAsn: 6.669 ± 0.123
1.264GluPro: 1.264 ± 0.046
1.745GluGln: 1.745 ± 0.06
2.402GluArg: 2.402 ± 0.087
3.877GluSer: 3.877 ± 0.087
3.126GluThr: 3.126 ± 0.08
4.705GluVal: 4.705 ± 0.094
0.351GluTrp: 0.351 ± 0.027
2.998GluTyr: 2.998 ± 0.095
0.0GluXaa: 0.0 ± 0.0
Phe
2.825PheAla: 2.825 ± 0.08
0.291PheCys: 0.291 ± 0.023
3.513PheAsp: 3.513 ± 0.078
2.994PheGlu: 2.994 ± 0.074
2.046PhePhe: 2.046 ± 0.106
2.748PheGly: 2.748 ± 0.073
0.491PheHis: 0.491 ± 0.028
4.176PheIle: 4.176 ± 0.087
3.495PheLys: 3.495 ± 0.077
4.098PheLeu: 4.098 ± 0.103
1.08PheMet: 1.08 ± 0.047
2.662PheAsn: 2.662 ± 0.07
1.206PhePro: 1.206 ± 0.043
0.871PheGln: 0.871 ± 0.037
1.362PheArg: 1.362 ± 0.052
3.078PheSer: 3.078 ± 0.089
2.556PheThr: 2.556 ± 0.06
2.825PheVal: 2.825 ± 0.076
0.26PheTrp: 0.26 ± 0.021
2.062PheTyr: 2.062 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
3.73GlyAla: 3.73 ± 0.098
0.532GlyCys: 0.532 ± 0.032
3.335GlyAsp: 3.335 ± 0.078
4.175GlyGlu: 4.175 ± 0.094
2.979GlyPhe: 2.979 ± 0.084
3.704GlyGly: 3.704 ± 0.11
0.997GlyHis: 0.997 ± 0.045
5.555GlyIle: 5.555 ± 0.12
5.571GlyLys: 5.571 ± 0.12
5.696GlyLeu: 5.696 ± 0.104
1.521GlyMet: 1.521 ± 0.059
3.177GlyAsn: 3.177 ± 0.082
1.304GlyPro: 1.304 ± 0.051
1.708GlyGln: 1.708 ± 0.058
2.038GlyArg: 2.038 ± 0.072
3.69GlySer: 3.69 ± 0.095
2.736GlyThr: 2.736 ± 0.069
3.961GlyVal: 3.961 ± 0.1
0.368GlyTrp: 0.368 ± 0.025
2.864GlyTyr: 2.864 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
0.69HisAla: 0.69 ± 0.03
0.13HisCys: 0.13 ± 0.015
0.871HisAsp: 0.871 ± 0.042
0.818HisGlu: 0.818 ± 0.041
0.635HisPhe: 0.635 ± 0.031
0.95HisGly: 0.95 ± 0.041
0.258HisHis: 0.258 ± 0.022
1.193HisIle: 1.193 ± 0.051
0.97HisLys: 0.97 ± 0.038
1.088HisLeu: 1.088 ± 0.048
0.315HisMet: 0.315 ± 0.027
0.717HisAsn: 0.717 ± 0.035
0.611HisPro: 0.611 ± 0.029
0.412HisGln: 0.412 ± 0.025
0.556HisArg: 0.556 ± 0.034
0.799HisSer: 0.799 ± 0.038
0.703HisThr: 0.703 ± 0.033
0.635HisVal: 0.635 ± 0.032
0.084HisTrp: 0.084 ± 0.012
0.513HisTyr: 0.513 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.843IleAla: 5.843 ± 0.12
0.734IleCys: 0.734 ± 0.037
7.029IleAsp: 7.029 ± 0.123
6.928IleGlu: 6.928 ± 0.125
4.469IlePhe: 4.469 ± 0.133
5.665IleGly: 5.665 ± 0.132
1.109IleHis: 1.109 ± 0.048
8.934IleIle: 8.934 ± 0.178
7.911IleLys: 7.911 ± 0.116
8.81IleLeu: 8.81 ± 0.176
2.161IleMet: 2.161 ± 0.063
6.247IleAsn: 6.247 ± 0.117
2.82IlePro: 2.82 ± 0.075
1.819IleGln: 1.819 ± 0.061
3.066IleArg: 3.066 ± 0.081
6.835IleSer: 6.835 ± 0.118
4.466IleThr: 4.466 ± 0.1
5.33IleVal: 5.33 ± 0.113
0.477IleTrp: 0.477 ± 0.032
3.913IleTyr: 3.913 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
5.129LysAla: 5.129 ± 0.108
0.452LysCys: 0.452 ± 0.029
7.171LysAsp: 7.171 ± 0.129
8.856LysGlu: 8.856 ± 0.158
3.119LysPhe: 3.119 ± 0.084
4.01LysGly: 4.01 ± 0.092
0.938LysHis: 0.938 ± 0.032
8.079LysIle: 8.079 ± 0.134
8.44LysLys: 8.44 ± 0.152
7.431LysLeu: 7.431 ± 0.118
2.01LysMet: 2.01 ± 0.057
7.124LysAsn: 7.124 ± 0.149
1.891LysPro: 1.891 ± 0.058
2.128LysGln: 2.128 ± 0.056
2.914LysArg: 2.914 ± 0.084
5.432LysSer: 5.432 ± 0.114
4.649LysThr: 4.649 ± 0.097
5.396LysVal: 5.396 ± 0.11
0.52LysTrp: 0.52 ± 0.032
3.94LysTyr: 3.94 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
6.265LeuAla: 6.265 ± 0.125
0.565LeuCys: 0.565 ± 0.032
6.625LeuAsp: 6.625 ± 0.12
6.531LeuGlu: 6.531 ± 0.129
3.641LeuPhe: 3.641 ± 0.104
5.68LeuGly: 5.68 ± 0.116
0.932LeuHis: 0.932 ± 0.042
8.378LeuIle: 8.378 ± 0.185
7.802LeuLys: 7.802 ± 0.123
7.839LeuLeu: 7.839 ± 0.157
2.294LeuMet: 2.294 ± 0.063
5.737LeuAsn: 5.737 ± 0.117
2.719LeuPro: 2.719 ± 0.074
1.971LeuGln: 1.971 ± 0.06
3.064LeuArg: 3.064 ± 0.085
6.808LeuSer: 6.808 ± 0.12
4.505LeuThr: 4.505 ± 0.09
5.41LeuVal: 5.41 ± 0.117
0.522LeuTrp: 0.522 ± 0.034
3.21LeuTyr: 3.21 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
1.81MetAla: 1.81 ± 0.059
0.152MetCys: 0.152 ± 0.016
1.747MetAsp: 1.747 ± 0.056
1.523MetGlu: 1.523 ± 0.054
0.862MetPhe: 0.862 ± 0.046
1.684MetGly: 1.684 ± 0.063
0.305MetHis: 0.305 ± 0.023
2.204MetIle: 2.204 ± 0.057
2.169MetLys: 2.169 ± 0.061
2.065MetLeu: 2.065 ± 0.076
0.601MetMet: 0.601 ± 0.033
1.511MetAsn: 1.511 ± 0.053
0.854MetPro: 0.854 ± 0.042
0.777MetGln: 0.777 ± 0.036
0.861MetArg: 0.861 ± 0.042
1.511MetSer: 1.511 ± 0.055
1.391MetThr: 1.391 ± 0.05
1.389MetVal: 1.389 ± 0.048
0.128MetTrp: 0.128 ± 0.014
0.79MetTyr: 0.79 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.189AsnAla: 3.189 ± 0.081
0.419AsnCys: 0.419 ± 0.031
4.123AsnAsp: 4.123 ± 0.08
4.965AsnGlu: 4.965 ± 0.096
2.91AsnPhe: 2.91 ± 0.079
3.632AsnGly: 3.632 ± 0.097
0.919AsnHis: 0.919 ± 0.04
6.763AsnIle: 6.763 ± 0.139
6.397AsnLys: 6.397 ± 0.134
6.38AsnLeu: 6.38 ± 0.118
1.613AsnMet: 1.613 ± 0.054
4.327AsnAsn: 4.327 ± 0.119
2.522AsnPro: 2.522 ± 0.078
2.108AsnGln: 2.108 ± 0.062
2.079AsnArg: 2.079 ± 0.058
3.612AsnSer: 3.612 ± 0.093
3.116AsnThr: 3.116 ± 0.08
3.35AsnVal: 3.35 ± 0.078
0.4AsnTrp: 0.4 ± 0.027
2.989AsnTyr: 2.989 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
1.6ProAla: 1.6 ± 0.058
0.202ProCys: 0.202 ± 0.02
1.873ProAsp: 1.873 ± 0.063
2.234ProGlu: 2.234 ± 0.078
1.273ProPhe: 1.273 ± 0.05
1.591ProGly: 1.591 ± 0.056
0.414ProHis: 0.414 ± 0.029
2.495ProIle: 2.495 ± 0.072
2.104ProLys: 2.104 ± 0.07
2.269ProLeu: 2.269 ± 0.058
0.642ProMet: 0.642 ± 0.032
1.62ProAsn: 1.62 ± 0.056
0.505ProPro: 0.505 ± 0.029
0.811ProGln: 0.811 ± 0.039
0.869ProArg: 0.869 ± 0.038
1.853ProSer: 1.853 ± 0.05
1.478ProThr: 1.478 ± 0.051
1.985ProVal: 1.985 ± 0.07
0.209ProTrp: 0.209 ± 0.019
1.27ProTyr: 1.27 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
1.976GlnAla: 1.976 ± 0.065
0.104GlnCys: 0.104 ± 0.013
1.376GlnAsp: 1.376 ± 0.046
1.887GlnGlu: 1.887 ± 0.064
0.89GlnPhe: 0.89 ± 0.039
1.48GlnGly: 1.48 ± 0.065
0.204GlnHis: 0.204 ± 0.018
2.618GlnIle: 2.618 ± 0.068
2.52GlnLys: 2.52 ± 0.076
2.063GlnLeu: 2.063 ± 0.068
0.789GlnMet: 0.789 ± 0.037
1.761GlnAsn: 1.761 ± 0.057
0.429GlnPro: 0.429 ± 0.026
0.613GlnGln: 0.613 ± 0.033
1.227GlnArg: 1.227 ± 0.055
1.487GlnSer: 1.487 ± 0.053
1.477GlnThr: 1.477 ± 0.054
1.685GlnVal: 1.685 ± 0.051
0.149GlnTrp: 0.149 ± 0.016
0.927GlnTyr: 0.927 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
1.956ArgAla: 1.956 ± 0.069
0.233ArgCys: 0.233 ± 0.022
2.248ArgAsp: 2.248 ± 0.072
2.842ArgGlu: 2.842 ± 0.086
1.526ArgPhe: 1.526 ± 0.054
1.793ArgGly: 1.793 ± 0.063
0.388ArgHis: 0.388 ± 0.024
2.984ArgIle: 2.984 ± 0.085
3.1ArgLys: 3.1 ± 0.091
3.075ArgLeu: 3.075 ± 0.094
0.85ArgMet: 0.85 ± 0.038
2.286ArgAsn: 2.286 ± 0.078
0.975ArgPro: 0.975 ± 0.051
1.129ArgGln: 1.129 ± 0.04
1.358ArgArg: 1.358 ± 0.059
1.992ArgSer: 1.992 ± 0.056
1.596ArgThr: 1.596 ± 0.054
1.981ArgVal: 1.981 ± 0.067
0.195ArgTrp: 0.195 ± 0.019
1.468ArgTyr: 1.468 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
3.353SerAla: 3.353 ± 0.085
0.433SerCys: 0.433 ± 0.031
4.075SerAsp: 4.075 ± 0.087
4.161SerGlu: 4.161 ± 0.084
3.244SerPhe: 3.244 ± 0.092
4.009SerGly: 4.009 ± 0.103
1.025SerHis: 1.025 ± 0.041
5.773SerIle: 5.773 ± 0.113
5.87SerLys: 5.87 ± 0.114
6.479SerLeu: 6.479 ± 0.13
1.48SerMet: 1.48 ± 0.047
3.8SerAsn: 3.8 ± 0.104
1.598SerPro: 1.598 ± 0.052
1.974SerGln: 1.974 ± 0.063
2.024SerArg: 2.024 ± 0.053
4.017SerSer: 4.017 ± 0.093
3.121SerThr: 3.121 ± 0.073
3.408SerVal: 3.408 ± 0.09
0.438SerTrp: 0.438 ± 0.034
3.141SerTyr: 3.141 ± 0.079
0.0SerXaa: 0.0 ± 0.0
Thr
2.852ThrAla: 2.852 ± 0.073
0.346ThrCys: 0.346 ± 0.025
3.251ThrAsp: 3.251 ± 0.089
2.915ThrGlu: 2.915 ± 0.08
2.279ThrPhe: 2.279 ± 0.072
3.504ThrGly: 3.504 ± 0.08
0.789ThrHis: 0.789 ± 0.039
4.828ThrIle: 4.828 ± 0.101
3.714ThrLys: 3.714 ± 0.089
4.383ThrLeu: 4.383 ± 0.087
1.16ThrMet: 1.16 ± 0.051
3.052ThrAsn: 3.052 ± 0.07
1.615ThrPro: 1.615 ± 0.06
1.114ThrGln: 1.114 ± 0.044
1.656ThrArg: 1.656 ± 0.053
3.454ThrSer: 3.454 ± 0.078
2.619ThrThr: 2.619 ± 0.073
2.897ThrVal: 2.897 ± 0.071
0.303ThrTrp: 0.303 ± 0.022
2.192ThrTyr: 2.192 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
3.725ValAla: 3.725 ± 0.098
0.505ValCys: 0.505 ± 0.032
4.45ValAsp: 4.45 ± 0.091
4.255ValGlu: 4.255 ± 0.099
2.767ValPhe: 2.767 ± 0.08
3.913ValGly: 3.913 ± 0.102
0.734ValHis: 0.734 ± 0.037
5.336ValIle: 5.336 ± 0.108
4.635ValLys: 4.635 ± 0.098
5.208ValLeu: 5.208 ± 0.106
1.435ValMet: 1.435 ± 0.055
3.702ValAsn: 3.702 ± 0.081
1.593ValPro: 1.593 ± 0.059
1.074ValGln: 1.074 ± 0.045
1.976ValArg: 1.976 ± 0.068
4.043ValSer: 4.043 ± 0.069
2.847ValThr: 2.847 ± 0.075
3.679ValVal: 3.679 ± 0.085
0.363ValTrp: 0.363 ± 0.024
2.327ValTyr: 2.327 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.387TrpAla: 0.387 ± 0.03
0.041TrpCys: 0.041 ± 0.008
0.435TrpAsp: 0.435 ± 0.029
0.346TrpGlu: 0.346 ± 0.026
0.262TrpPhe: 0.262 ± 0.028
0.417TrpGly: 0.417 ± 0.035
0.115TrpHis: 0.115 ± 0.015
0.578TrpIle: 0.578 ± 0.032
0.409TrpLys: 0.409 ± 0.028
0.496TrpLeu: 0.496 ± 0.028
0.186TrpMet: 0.186 ± 0.018
0.346TrpAsn: 0.346 ± 0.027
0.171TrpPro: 0.171 ± 0.02
0.272TrpGln: 0.272 ± 0.023
0.197TrpArg: 0.197 ± 0.017
0.33TrpSer: 0.33 ± 0.025
0.296TrpThr: 0.296 ± 0.026
0.32TrpVal: 0.32 ± 0.024
0.065TrpTrp: 0.065 ± 0.011
0.234TrpTyr: 0.234 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.193TyrAla: 2.193 ± 0.061
0.31TyrCys: 0.31 ± 0.023
3.196TyrAsp: 3.196 ± 0.073
3.343TyrGlu: 3.343 ± 0.08
2.152TyrPhe: 2.152 ± 0.068
2.515TyrGly: 2.515 ± 0.065
0.575TyrHis: 0.575 ± 0.034
3.718TyrIle: 3.718 ± 0.092
4.128TyrLys: 4.128 ± 0.095
4.173TyrLeu: 4.173 ± 0.09
0.982TyrMet: 0.982 ± 0.036
2.794TyrAsn: 2.794 ± 0.078
1.413TyrPro: 1.413 ± 0.054
1.412TyrGln: 1.412 ± 0.055
1.494TyrArg: 1.494 ± 0.049
2.589TyrSer: 2.589 ± 0.067
2.034TyrThr: 2.034 ± 0.056
2.204TyrVal: 2.204 ± 0.057
0.286TyrTrp: 0.286 ± 0.024
2.089TyrTyr: 2.089 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1795 proteins (584478 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski