Amino acid dipepetide frequency for Desulfotomaculum arcticum DSM 17038

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.923AlaAla: 8.923 ± 0.109	1.035AlaCys: 1.035 ± 0.026	4.021AlaAsp: 4.021 ± 0.061	5.348AlaGlu: 5.348 ± 0.063	2.962AlaPhe: 2.962 ± 0.051	8.219AlaGly: 8.219 ± 0.094	1.203AlaHis: 1.203 ± 0.028	5.644AlaIle: 5.644 ± 0.067	4.2AlaLys: 4.2 ± 0.054	8.723AlaLeu: 8.723 ± 0.086	2.38AlaMet: 2.38 ± 0.042	2.766AlaAsn: 2.766 ± 0.05	2.614AlaPro: 2.614 ± 0.045	2.592AlaGln: 2.592 ± 0.047	4.779AlaArg: 4.779 ± 0.072	4.095AlaSer: 4.095 ± 0.062	3.567AlaThr: 3.567 ± 0.057	7.203AlaVal: 7.203 ± 0.085	0.786AlaTrp: 0.786 ± 0.028	2.369AlaTyr: 2.369 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.91CysAla: 0.91 ± 0.029	0.252CysCys: 0.252 ± 0.012	0.567CysAsp: 0.567 ± 0.021	0.589CysGlu: 0.589 ± 0.022	0.527CysPhe: 0.527 ± 0.017	1.367CysGly: 1.367 ± 0.033	0.295CysHis: 0.295 ± 0.013	0.78CysIle: 0.78 ± 0.024	0.543CysLys: 0.543 ± 0.021	1.134CysLeu: 1.134 ± 0.032	0.315CysMet: 0.315 ± 0.015	0.473CysAsn: 0.473 ± 0.016	0.773CysPro: 0.773 ± 0.025	0.383CysGln: 0.383 ± 0.017	0.81CysArg: 0.81 ± 0.027	0.796CysSer: 0.796 ± 0.027	0.619CysThr: 0.619 ± 0.019	0.667CysVal: 0.667 ± 0.022	0.116CysTrp: 0.116 ± 0.009	0.406CysTyr: 0.406 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.548AspAla: 3.548 ± 0.05	0.621AspCys: 0.621 ± 0.018	2.384AspAsp: 2.384 ± 0.051	3.382AspGlu: 3.382 ± 0.051	2.254AspPhe: 2.254 ± 0.039	3.605AspGly: 3.605 ± 0.06	0.846AspHis: 0.846 ± 0.023	4.26AspIle: 4.26 ± 0.058	3.016AspLys: 3.016 ± 0.046	5.387AspLeu: 5.387 ± 0.071	1.43AspMet: 1.43 ± 0.032	2.271AspAsn: 2.271 ± 0.04	2.3AspPro: 2.3 ± 0.043	1.746AspGln: 1.746 ± 0.038	2.678AspArg: 2.678 ± 0.04	2.433AspSer: 2.433 ± 0.041	2.376AspThr: 2.376 ± 0.049	3.505AspVal: 3.505 ± 0.045	0.572AspTrp: 0.572 ± 0.019	2.056AspTyr: 2.056 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.385GluAla: 5.385 ± 0.071	0.574GluCys: 0.574 ± 0.018	3.114GluAsp: 3.114 ± 0.047	4.862GluGlu: 4.862 ± 0.067	2.215GluPhe: 2.215 ± 0.034	3.85GluGly: 3.85 ± 0.05	1.195GluHis: 1.195 ± 0.028	5.411GluIle: 5.411 ± 0.06	5.303GluLys: 5.303 ± 0.063	6.946GluLeu: 6.946 ± 0.08	1.952GluMet: 1.952 ± 0.04	3.082GluAsn: 3.082 ± 0.047	2.137GluPro: 2.137 ± 0.046	2.938GluGln: 2.938 ± 0.051	3.226GluArg: 3.226 ± 0.051	2.969GluSer: 2.969 ± 0.044	3.099GluThr: 3.099 ± 0.045	4.539GluVal: 4.539 ± 0.058	0.616GluTrp: 0.616 ± 0.02	2.085GluTyr: 2.085 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	2.978PheAla: 2.978 ± 0.044	0.54PheCys: 0.54 ± 0.018	2.03PheAsp: 2.03 ± 0.036	2.084PheGlu: 2.084 ± 0.038	1.834PhePhe: 1.834 ± 0.042	2.961PheGly: 2.961 ± 0.045	0.701PheHis: 0.701 ± 0.021	3.102PheIle: 3.102 ± 0.051	2.271PheLys: 2.271 ± 0.041	3.824PheLeu: 3.824 ± 0.062	1.068PheMet: 1.068 ± 0.031	2.032PheAsn: 2.032 ± 0.041	1.585PhePro: 1.585 ± 0.034	1.144PheGln: 1.144 ± 0.029	1.657PheArg: 1.657 ± 0.028	2.631PheSer: 2.631 ± 0.043	2.262PheThr: 2.262 ± 0.037	2.452PheVal: 2.452 ± 0.046	0.476PheTrp: 0.476 ± 0.02	1.519PheTyr: 1.519 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.973GlyAla: 5.973 ± 0.065	1.209GlyCys: 1.209 ± 0.03	3.616GlyAsp: 3.616 ± 0.054	4.702GlyGlu: 4.702 ± 0.063	3.201GlyPhe: 3.201 ± 0.045	6.045GlyGly: 6.045 ± 0.081	1.403GlyHis: 1.403 ± 0.027	6.069GlyIle: 6.069 ± 0.069	4.936GlyLys: 4.936 ± 0.059	7.847GlyLeu: 7.847 ± 0.075	2.339GlyMet: 2.339 ± 0.041	3.062GlyAsn: 3.062 ± 0.052	2.295GlyPro: 2.295 ± 0.042	2.727GlyGln: 2.727 ± 0.047	3.918GlyArg: 3.918 ± 0.064	4.317GlySer: 4.317 ± 0.059	4.193GlyThr: 4.193 ± 0.072	5.78GlyVal: 5.78 ± 0.069	0.872GlyTrp: 0.872 ± 0.026	3.033GlyTyr: 3.033 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.182HisAla: 1.182 ± 0.034	0.291HisCys: 0.291 ± 0.014	0.867HisAsp: 0.867 ± 0.026	0.954HisGlu: 0.954 ± 0.026	0.773HisPhe: 0.773 ± 0.022	1.387HisGly: 1.387 ± 0.032	0.428HisHis: 0.428 ± 0.018	1.196HisIle: 1.196 ± 0.032	0.875HisLys: 0.875 ± 0.026	1.755HisLeu: 1.755 ± 0.033	0.452HisMet: 0.452 ± 0.015	0.823HisAsn: 0.823 ± 0.022	0.985HisPro: 0.985 ± 0.029	0.656HisGln: 0.656 ± 0.021	1.004HisArg: 1.004 ± 0.026	0.98HisSer: 0.98 ± 0.025	0.891HisThr: 0.891 ± 0.026	0.982HisVal: 0.982 ± 0.025	0.217HisTrp: 0.217 ± 0.012	0.682HisTyr: 0.682 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.113IleAla: 6.113 ± 0.081	0.919IleCys: 0.919 ± 0.028	3.813IleAsp: 3.813 ± 0.055	4.395IleGlu: 4.395 ± 0.063	2.979IlePhe: 2.979 ± 0.054	5.042IleGly: 5.042 ± 0.066	1.145IleHis: 1.145 ± 0.03	5.974IleIle: 5.974 ± 0.076	5.0IleLys: 5.0 ± 0.063	6.541IleLeu: 6.541 ± 0.071	1.97IleMet: 1.97 ± 0.037	3.975IleAsn: 3.975 ± 0.052	3.351IlePro: 3.351 ± 0.051	2.077IleGln: 2.077 ± 0.039	3.259IleArg: 3.259 ± 0.046	4.647IleSer: 4.647 ± 0.061	4.399IleThr: 4.399 ± 0.07	4.679IleVal: 4.679 ± 0.063	0.626IleTrp: 0.626 ± 0.021	2.385IleTyr: 2.385 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.563LysAla: 4.563 ± 0.059	0.643LysCys: 0.643 ± 0.026	3.232LysAsp: 3.232 ± 0.048	4.662LysGlu: 4.662 ± 0.06	1.858LysPhe: 1.858 ± 0.038	3.711LysGly: 3.711 ± 0.05	1.043LysHis: 1.043 ± 0.029	4.699LysIle: 4.699 ± 0.056	4.513LysLys: 4.513 ± 0.062	5.65LysLeu: 5.65 ± 0.067	1.792LysMet: 1.792 ± 0.033	3.078LysAsn: 3.078 ± 0.053	2.406LysPro: 2.406 ± 0.041	2.318LysGln: 2.318 ± 0.046	2.674LysArg: 2.674 ± 0.043	2.998LysSer: 2.998 ± 0.052	3.316LysThr: 3.316 ± 0.053	4.292LysVal: 4.292 ± 0.05	0.573LysTrp: 0.573 ± 0.018	2.241LysTyr: 2.241 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	9.627LeuAla: 9.627 ± 0.1	1.123LeuCys: 1.123 ± 0.032	5.163LeuAsp: 5.163 ± 0.064	6.482LeuGlu: 6.482 ± 0.076	3.776LeuPhe: 3.776 ± 0.056	7.5LeuGly: 7.5 ± 0.085	1.691LeuHis: 1.691 ± 0.037	6.798LeuIle: 6.798 ± 0.082	6.097LeuLys: 6.097 ± 0.073	10.158LeuLeu: 10.158 ± 0.117	2.45LeuMet: 2.45 ± 0.041	4.348LeuAsn: 4.348 ± 0.052	4.66LeuPro: 4.66 ± 0.062	3.491LeuGln: 3.491 ± 0.045	4.667LeuArg: 4.667 ± 0.061	5.997LeuSer: 5.997 ± 0.072	5.512LeuThr: 5.512 ± 0.061	7.27LeuVal: 7.27 ± 0.074	0.924LeuTrp: 0.924 ± 0.027	2.832LeuTyr: 2.832 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.591MetAla: 2.591 ± 0.042	0.264MetCys: 0.264 ± 0.014	1.435MetAsp: 1.435 ± 0.03	1.874MetGlu: 1.874 ± 0.035	0.905MetPhe: 0.905 ± 0.022	2.082MetGly: 2.082 ± 0.04	0.464MetHis: 0.464 ± 0.019	1.765MetIle: 1.765 ± 0.036	1.572MetLys: 1.572 ± 0.031	2.897MetLeu: 2.897 ± 0.047	0.716MetMet: 0.716 ± 0.023	1.112MetAsn: 1.112 ± 0.027	1.255MetPro: 1.255 ± 0.029	1.059MetGln: 1.059 ± 0.026	1.288MetArg: 1.288 ± 0.029	1.601MetSer: 1.601 ± 0.031	1.365MetThr: 1.365 ± 0.029	2.102MetVal: 2.102 ± 0.033	0.182MetTrp: 0.182 ± 0.012	0.652MetTyr: 0.652 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.023AsnAla: 3.023 ± 0.045	0.628AsnCys: 0.628 ± 0.021	1.994AsnAsp: 1.994 ± 0.04	2.5AsnGlu: 2.5 ± 0.045	1.674AsnPhe: 1.674 ± 0.04	3.066AsnGly: 3.066 ± 0.048	0.773AsnHis: 0.773 ± 0.022	3.565AsnIle: 3.565 ± 0.055	2.767AsnLys: 2.767 ± 0.041	4.385AsnLeu: 4.385 ± 0.064	1.231AsnMet: 1.231 ± 0.028	2.29AsnAsn: 2.29 ± 0.043	2.248AsnPro: 2.248 ± 0.042	1.65AsnGln: 1.65 ± 0.035	2.279AsnArg: 2.279 ± 0.041	2.529AsnSer: 2.529 ± 0.052	2.153AsnThr: 2.153 ± 0.039	2.834AsnVal: 2.834 ± 0.044	0.526AsnTrp: 0.526 ± 0.022	1.628AsnTyr: 1.628 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.649ProAla: 3.649 ± 0.061	0.431ProCys: 0.431 ± 0.017	2.59ProAsp: 2.59 ± 0.044	3.532ProGlu: 3.532 ± 0.054	1.615ProPhe: 1.615 ± 0.035	4.157ProGly: 4.157 ± 0.058	0.727ProHis: 0.727 ± 0.022	2.109ProIle: 2.109 ± 0.037	1.818ProLys: 1.818 ± 0.03	3.824ProLeu: 3.824 ± 0.054	0.925ProMet: 0.925 ± 0.028	1.441ProAsn: 1.441 ± 0.034	1.65ProPro: 1.65 ± 0.039	1.405ProGln: 1.405 ± 0.031	1.829ProArg: 1.829 ± 0.034	1.926ProSer: 1.926 ± 0.035	1.768ProThr: 1.768 ± 0.036	4.173ProVal: 4.173 ± 0.051	0.434ProTrp: 0.434 ± 0.015	1.332ProTyr: 1.332 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.148GlnAla: 3.148 ± 0.051	0.344GlnCys: 0.344 ± 0.016	1.662GlnAsp: 1.662 ± 0.033	2.488GlnGlu: 2.488 ± 0.046	1.131GlnPhe: 1.131 ± 0.029	2.367GlnGly: 2.367 ± 0.035	0.607GlnHis: 0.607 ± 0.02	2.499GlnIle: 2.499 ± 0.044	2.46GlnLys: 2.46 ± 0.045	3.456GlnLeu: 3.456 ± 0.052	1.012GlnMet: 1.012 ± 0.027	1.645GlnAsn: 1.645 ± 0.037	1.326GlnPro: 1.326 ± 0.032	1.64GlnGln: 1.64 ± 0.043	1.722GlnArg: 1.722 ± 0.039	1.722GlnSer: 1.722 ± 0.034	1.686GlnThr: 1.686 ± 0.034	2.745GlnVal: 2.745 ± 0.049	0.362GlnTrp: 0.362 ± 0.016	1.092GlnTyr: 1.092 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	3.712ArgAla: 3.712 ± 0.052	0.609ArgCys: 0.609 ± 0.021	2.684ArgAsp: 2.684 ± 0.049	4.31ArgGlu: 4.31 ± 0.063	1.946ArgPhe: 1.946 ± 0.036	3.277ArgGly: 3.277 ± 0.054	0.974ArgHis: 0.974 ± 0.025	3.382ArgIle: 3.382 ± 0.048	3.054ArgLys: 3.054 ± 0.047	5.149ArgLeu: 5.149 ± 0.07	1.361ArgMet: 1.361 ± 0.034	1.967ArgAsn: 1.967 ± 0.033	1.875ArgPro: 1.875 ± 0.032	2.092ArgGln: 2.092 ± 0.04	2.93ArgArg: 2.93 ± 0.048	2.523ArgSer: 2.523 ± 0.036	2.165ArgThr: 2.165 ± 0.037	3.737ArgVal: 3.737 ± 0.054	0.564ArgTrp: 0.564 ± 0.021	1.71ArgTyr: 1.71 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.159SerAla: 4.159 ± 0.056	0.735SerCys: 0.735 ± 0.021	2.628SerAsp: 2.628 ± 0.047	3.107SerGlu: 3.107 ± 0.042	2.489SerPhe: 2.489 ± 0.043	5.146SerGly: 5.146 ± 0.074	0.958SerHis: 0.958 ± 0.025	3.957SerIle: 3.957 ± 0.06	2.857SerLys: 2.857 ± 0.049	5.626SerLeu: 5.626 ± 0.065	1.556SerMet: 1.556 ± 0.034	2.219SerAsn: 2.219 ± 0.041	2.362SerPro: 2.362 ± 0.042	1.774SerGln: 1.774 ± 0.036	2.903SerArg: 2.903 ± 0.043	3.202SerSer: 3.202 ± 0.051	2.729SerThr: 2.729 ± 0.043	3.806SerVal: 3.806 ± 0.054	0.638SerTrp: 0.638 ± 0.022	1.804SerTyr: 1.804 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.647ThrAla: 4.647 ± 0.06	0.584ThrCys: 0.584 ± 0.018	2.525ThrAsp: 2.525 ± 0.042	2.955ThrGlu: 2.955 ± 0.048	2.01ThrPhe: 2.01 ± 0.036	5.44ThrGly: 5.44 ± 0.065	0.864ThrHis: 0.864 ± 0.026	3.625ThrIle: 3.625 ± 0.058	2.302ThrLys: 2.302 ± 0.043	4.932ThrLeu: 4.932 ± 0.065	1.234ThrMet: 1.234 ± 0.027	1.905ThrAsn: 1.905 ± 0.037	2.415ThrPro: 2.415 ± 0.038	1.268ThrGln: 1.268 ± 0.032	2.445ThrArg: 2.445 ± 0.04	2.649ThrSer: 2.649 ± 0.048	2.677ThrThr: 2.677 ± 0.053	4.378ThrVal: 4.378 ± 0.067	0.513ThrTrp: 0.513 ± 0.02	1.546ThrTyr: 1.546 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.178ValAla: 6.178 ± 0.072	0.918ValCys: 0.918 ± 0.029	3.994ValAsp: 3.994 ± 0.056	4.754ValGlu: 4.754 ± 0.065	3.035ValPhe: 3.035 ± 0.044	4.953ValGly: 4.953 ± 0.069	1.126ValHis: 1.126 ± 0.029	5.605ValIle: 5.605 ± 0.064	4.397ValLys: 4.397 ± 0.056	7.505ValLeu: 7.505 ± 0.084	1.972ValMet: 1.972 ± 0.037	3.263ValAsn: 3.263 ± 0.048	3.175ValPro: 3.175 ± 0.051	2.323ValGln: 2.323 ± 0.035	3.428ValArg: 3.428 ± 0.053	4.182ValSer: 4.182 ± 0.055	4.098ValThr: 4.098 ± 0.067	5.68ValVal: 5.68 ± 0.065	0.621ValTrp: 0.621 ± 0.023	2.26ValTyr: 2.26 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.735TrpAla: 0.735 ± 0.025	0.118TrpCys: 0.118 ± 0.009	0.547TrpAsp: 0.547 ± 0.02	0.683TrpGlu: 0.683 ± 0.02	0.44TrpPhe: 0.44 ± 0.018	0.782TrpGly: 0.782 ± 0.027	0.216TrpHis: 0.216 ± 0.013	0.571TrpIle: 0.571 ± 0.019	0.494TrpLys: 0.494 ± 0.016	1.227TrpLeu: 1.227 ± 0.028	0.268TrpMet: 0.268 ± 0.012	0.444TrpAsn: 0.444 ± 0.015	0.43TrpPro: 0.43 ± 0.017	0.525TrpGln: 0.525 ± 0.02	0.517TrpArg: 0.517 ± 0.021	0.58TrpSer: 0.58 ± 0.021	0.397TrpThr: 0.397 ± 0.021	0.692TrpVal: 0.692 ± 0.022	0.151TrpTrp: 0.151 ± 0.011	0.332TrpTyr: 0.332 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.384TyrAla: 2.384 ± 0.042	0.482TyrCys: 0.482 ± 0.018	1.805TyrAsp: 1.805 ± 0.037	1.838TyrGlu: 1.838 ± 0.04	1.524TyrPhe: 1.524 ± 0.032	2.579TyrGly: 2.579 ± 0.045	0.719TyrHis: 0.719 ± 0.023	2.279TyrIle: 2.279 ± 0.048	1.788TyrLys: 1.788 ± 0.039	3.603TyrLeu: 3.603 ± 0.056	0.757TyrMet: 0.757 ± 0.027	1.548TyrAsn: 1.548 ± 0.039	1.494TyrPro: 1.494 ± 0.032	1.305TyrGln: 1.305 ± 0.029	2.008TyrArg: 2.008 ± 0.041	1.878TyrSer: 1.878 ± 0.035	1.641TyrThr: 1.641 ± 0.032	1.951TyrVal: 1.951 ± 0.035	0.38TyrTrp: 0.38 ± 0.016	1.351TyrTyr: 1.351 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5051 proteins (1486842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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