Amino acid dipepetide frequency for Campylobacter sp. FMV-PI01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.865AlaAla: 2.865 ± 0.1
0.639AlaCys: 0.639 ± 0.049
2.453AlaAsp: 2.453 ± 0.072
1.956AlaGlu: 1.956 ± 0.072
3.197AlaPhe: 3.197 ± 0.091
3.449AlaGly: 3.449 ± 0.098
0.846AlaHis: 0.846 ± 0.046
6.026AlaIle: 6.026 ± 0.132
6.721AlaLys: 6.721 ± 0.133
6.257AlaLeu: 6.257 ± 0.124
1.546AlaMet: 1.546 ± 0.053
3.961AlaAsn: 3.961 ± 0.105
1.391AlaPro: 1.391 ± 0.052
1.413AlaGln: 1.413 ± 0.057
1.969AlaArg: 1.969 ± 0.065
3.715AlaSer: 3.715 ± 0.085
2.937AlaThr: 2.937 ± 0.087
3.29AlaVal: 3.29 ± 0.088
0.362AlaTrp: 0.362 ± 0.029
2.278AlaTyr: 2.278 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.661CysAla: 0.661 ± 0.038
0.089CysCys: 0.089 ± 0.015
0.868CysAsp: 0.868 ± 0.048
0.854CysGlu: 0.854 ± 0.055
0.576CysPhe: 0.576 ± 0.041
0.96CysGly: 0.96 ± 0.048
0.189CysHis: 0.189 ± 0.03
0.885CysIle: 0.885 ± 0.054
0.86CysLys: 0.86 ± 0.048
0.874CysLeu: 0.874 ± 0.05
0.244CysMet: 0.244 ± 0.023
0.429CysAsn: 0.429 ± 0.028
0.331CysPro: 0.331 ± 0.034
0.211CysGln: 0.211 ± 0.019
0.242CysArg: 0.242 ± 0.023
0.634CysSer: 0.634 ± 0.044
0.311CysThr: 0.311 ± 0.026
0.716CysVal: 0.716 ± 0.043
0.071CysTrp: 0.071 ± 0.011
0.403CysTyr: 0.403 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.896AspAla: 2.896 ± 0.071
0.531AspCys: 0.531 ± 0.034
4.049AspAsp: 4.049 ± 0.136
6.44AspGlu: 6.44 ± 0.135
4.008AspPhe: 4.008 ± 0.097
3.799AspGly: 3.799 ± 0.111
0.512AspHis: 0.512 ± 0.033
6.223AspIle: 6.223 ± 0.131
6.367AspLys: 6.367 ± 0.129
5.409AspLeu: 5.409 ± 0.106
1.255AspMet: 1.255 ± 0.049
2.924AspAsn: 2.924 ± 0.112
1.273AspPro: 1.273 ± 0.056
0.885AspGln: 0.885 ± 0.042
1.851AspArg: 1.851 ± 0.069
3.349AspSer: 3.349 ± 0.111
2.316AspThr: 2.316 ± 0.118
2.884AspVal: 2.884 ± 0.084
0.348AspTrp: 0.348 ± 0.027
2.355AspTyr: 2.355 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
3.644GluAla: 3.644 ± 0.102
0.679GluCys: 0.679 ± 0.042
3.042GluAsp: 3.042 ± 0.085
3.514GluGlu: 3.514 ± 0.11
4.523GluPhe: 4.523 ± 0.107
2.265GluGly: 2.265 ± 0.072
0.744GluHis: 0.744 ± 0.037
9.249GluIle: 9.249 ± 0.168
6.493GluLys: 6.493 ± 0.141
6.097GluLeu: 6.097 ± 0.128
1.389GluMet: 1.389 ± 0.054
5.918GluAsn: 5.918 ± 0.12
1.385GluPro: 1.385 ± 0.063
1.415GluGln: 1.415 ± 0.061
1.724GluArg: 1.724 ± 0.066
2.853GluSer: 2.853 ± 0.09
1.977GluThr: 1.977 ± 0.061
3.488GluVal: 3.488 ± 0.091
0.421GluTrp: 0.421 ± 0.029
2.345GluTyr: 2.345 ± 0.073
0.002GluXaa: 0.002 ± 0.002
Phe
3.327PheAla: 3.327 ± 0.108
0.911PheCys: 0.911 ± 0.052
4.102PheAsp: 4.102 ± 0.096
3.984PheGlu: 3.984 ± 0.101
3.376PhePhe: 3.376 ± 0.115
3.945PheGly: 3.945 ± 0.095
0.679PheHis: 0.679 ± 0.041
6.105PheIle: 6.105 ± 0.158
5.592PheLys: 5.592 ± 0.12
6.367PheLeu: 6.367 ± 0.152
1.56PheMet: 1.56 ± 0.059
3.604PheAsn: 3.604 ± 0.098
0.988PhePro: 0.988 ± 0.053
1.096PheGln: 1.096 ± 0.045
1.674PheArg: 1.674 ± 0.059
4.478PheSer: 4.478 ± 0.105
2.333PheThr: 2.333 ± 0.066
3.231PheVal: 3.231 ± 0.099
0.468PheTrp: 0.468 ± 0.033
2.772PheTyr: 2.772 ± 0.092
0.0PheXaa: 0.0 ± 0.0
Gly
3.915GlyAla: 3.915 ± 0.108
0.734GlyCys: 0.734 ± 0.045
3.616GlyAsp: 3.616 ± 0.128
3.61GlyGlu: 3.61 ± 0.08
3.74GlyPhe: 3.74 ± 0.113
4.334GlyGly: 4.334 ± 0.13
0.917GlyHis: 0.917 ± 0.039
5.464GlyIle: 5.464 ± 0.127
4.958GlyLys: 4.958 ± 0.119
5.259GlyLeu: 5.259 ± 0.125
1.326GlyMet: 1.326 ± 0.063
3.014GlyAsn: 3.014 ± 0.152
0.783GlyPro: 0.783 ± 0.046
1.157GlyGln: 1.157 ± 0.052
1.897GlyArg: 1.897 ± 0.07
3.878GlySer: 3.878 ± 0.136
2.343GlyThr: 2.343 ± 0.087
4.74GlyVal: 4.74 ± 0.118
0.447GlyTrp: 0.447 ± 0.027
2.756GlyTyr: 2.756 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
0.763HisAla: 0.763 ± 0.041
0.185HisCys: 0.185 ± 0.022
0.569HisAsp: 0.569 ± 0.032
0.671HisGlu: 0.671 ± 0.038
0.826HisPhe: 0.826 ± 0.048
0.834HisGly: 0.834 ± 0.048
0.344HisHis: 0.344 ± 0.047
1.409HisIle: 1.409 ± 0.058
1.312HisLys: 1.312 ± 0.056
1.328HisLeu: 1.328 ± 0.061
0.325HisMet: 0.325 ± 0.027
0.838HisAsn: 0.838 ± 0.044
0.632HisPro: 0.632 ± 0.035
0.445HisGln: 0.445 ± 0.029
0.415HisArg: 0.415 ± 0.033
1.003HisSer: 1.003 ± 0.046
0.787HisThr: 0.787 ± 0.04
0.409HisVal: 0.409 ± 0.028
0.075HisTrp: 0.075 ± 0.013
0.616HisTyr: 0.616 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.592IleAla: 5.592 ± 0.128
1.438IleCys: 1.438 ± 0.067
5.826IleAsp: 5.826 ± 0.134
5.686IleGlu: 5.686 ± 0.129
6.107IlePhe: 6.107 ± 0.166
5.434IleGly: 5.434 ± 0.152
1.129IleHis: 1.129 ± 0.049
8.183IleIle: 8.183 ± 0.169
10.231IleLys: 10.231 ± 0.155
10.731IleLeu: 10.731 ± 0.199
1.895IleMet: 1.895 ± 0.074
6.776IleAsn: 6.776 ± 0.154
2.648IlePro: 2.648 ± 0.07
2.08IleGln: 2.08 ± 0.066
2.361IleArg: 2.361 ± 0.072
7.856IleSer: 7.856 ± 0.134
4.23IleThr: 4.23 ± 0.105
4.72IleVal: 4.72 ± 0.103
0.62IleTrp: 0.62 ± 0.036
4.419IleTyr: 4.419 ± 0.103
0.0IleXaa: 0.0 ± 0.0
Lys
5.273LysAla: 5.273 ± 0.13
0.708LysCys: 0.708 ± 0.043
7.199LysAsp: 7.199 ± 0.176
7.299LysGlu: 7.299 ± 0.152
7.565LysPhe: 7.565 ± 0.154
4.46LysGly: 4.46 ± 0.104
1.214LysHis: 1.214 ± 0.051
10.851LysIle: 10.851 ± 0.17
9.529LysLys: 9.529 ± 0.174
6.747LysLeu: 6.747 ± 0.145
2.379LysMet: 2.379 ± 0.075
10.119LysAsn: 10.119 ± 0.215
2.396LysPro: 2.396 ± 0.075
2.725LysGln: 2.725 ± 0.091
2.928LysArg: 2.928 ± 0.084
6.42LysSer: 6.42 ± 0.126
4.85LysThr: 4.85 ± 0.115
4.031LysVal: 4.031 ± 0.101
0.535LysTrp: 0.535 ± 0.035
3.461LysTyr: 3.461 ± 0.085
0.0LysXaa: 0.0 ± 0.0
Leu
5.993LeuAla: 5.993 ± 0.123
0.931LeuCys: 0.931 ± 0.047
5.956LeuAsp: 5.956 ± 0.116
6.66LeuGlu: 6.66 ± 0.13
4.736LeuPhe: 4.736 ± 0.129
5.666LeuGly: 5.666 ± 0.125
1.177LeuHis: 1.177 ± 0.054
8.37LeuIle: 8.37 ± 0.159
10.969LeuLys: 10.969 ± 0.173
7.665LeuLeu: 7.665 ± 0.17
2.152LeuMet: 2.152 ± 0.073
8.751LeuAsn: 8.751 ± 0.168
2.743LeuPro: 2.743 ± 0.095
2.243LeuGln: 2.243 ± 0.078
2.924LeuArg: 2.924 ± 0.081
7.305LeuSer: 7.305 ± 0.127
3.996LeuThr: 3.996 ± 0.085
4.793LeuVal: 4.793 ± 0.116
0.553LeuTrp: 0.553 ± 0.036
3.156LeuTyr: 3.156 ± 0.099
0.0LeuXaa: 0.0 ± 0.0
Met
1.629MetAla: 1.629 ± 0.065
0.22MetCys: 0.22 ± 0.023
1.224MetAsp: 1.224 ± 0.054
1.025MetGlu: 1.025 ± 0.047
1.039MetPhe: 1.039 ± 0.046
1.527MetGly: 1.527 ± 0.061
0.39MetHis: 0.39 ± 0.033
2.115MetIle: 2.115 ± 0.086
2.249MetLys: 2.249 ± 0.071
2.099MetLeu: 2.099 ± 0.07
0.586MetMet: 0.586 ± 0.039
1.108MetAsn: 1.108 ± 0.051
0.891MetPro: 0.891 ± 0.048
0.956MetGln: 0.956 ± 0.052
0.746MetArg: 0.746 ± 0.035
1.578MetSer: 1.578 ± 0.064
0.689MetThr: 0.689 ± 0.038
1.163MetVal: 1.163 ± 0.05
0.136MetTrp: 0.136 ± 0.018
0.48MetTyr: 0.48 ± 0.034
0.002MetXaa: 0.002 ± 0.002
Asn
3.752AsnAla: 3.752 ± 0.109
0.482AsnCys: 0.482 ± 0.03
4.0AsnAsp: 4.0 ± 0.146
4.976AsnGlu: 4.976 ± 0.106
4.84AsnPhe: 4.84 ± 0.118
4.057AsnGly: 4.057 ± 0.11
1.088AsnHis: 1.088 ± 0.051
6.27AsnIle: 6.27 ± 0.151
5.999AsnLys: 5.999 ± 0.176
10.729AsnLeu: 10.729 ± 0.174
1.167AsnMet: 1.167 ± 0.053
3.764AsnAsn: 3.764 ± 0.172
2.097AsnPro: 2.097 ± 0.068
2.105AsnGln: 2.105 ± 0.065
1.916AsnArg: 1.916 ± 0.068
5.788AsnSer: 5.788 ± 0.17
2.865AsnThr: 2.865 ± 0.098
2.69AsnVal: 2.69 ± 0.086
0.368AsnTrp: 0.368 ± 0.028
2.648AsnTyr: 2.648 ± 0.08
0.0AsnXaa: 0.0 ± 0.0
Pro
1.269ProAla: 1.269 ± 0.051
0.242ProCys: 0.242 ± 0.02
1.232ProAsp: 1.232 ± 0.05
1.302ProGlu: 1.302 ± 0.052
1.647ProPhe: 1.647 ± 0.064
1.308ProGly: 1.308 ± 0.057
0.478ProHis: 0.478 ± 0.033
2.225ProIle: 2.225 ± 0.078
2.701ProLys: 2.701 ± 0.086
2.568ProLeu: 2.568 ± 0.075
0.462ProMet: 0.462 ± 0.03
2.225ProAsn: 2.225 ± 0.071
0.657ProPro: 0.657 ± 0.035
0.818ProGln: 0.818 ± 0.043
0.677ProArg: 0.677 ± 0.042
1.605ProSer: 1.605 ± 0.061
1.426ProThr: 1.426 ± 0.051
1.466ProVal: 1.466 ± 0.061
0.193ProTrp: 0.193 ± 0.016
1.171ProTyr: 1.171 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
1.324GlnAla: 1.324 ± 0.065
0.179GlnCys: 0.179 ± 0.02
1.419GlnAsp: 1.419 ± 0.056
1.56GlnGlu: 1.56 ± 0.07
0.801GlnPhe: 0.801 ± 0.042
1.216GlnGly: 1.216 ± 0.045
0.26GlnHis: 0.26 ± 0.022
3.024GlnIle: 3.024 ± 0.073
3.378GlnLys: 3.378 ± 0.093
1.385GlnLeu: 1.385 ± 0.05
0.543GlnMet: 0.543 ± 0.032
3.187GlnAsn: 3.187 ± 0.089
0.582GlnPro: 0.582 ± 0.037
0.551GlnGln: 0.551 ± 0.038
0.846GlnArg: 0.846 ± 0.044
1.501GlnSer: 1.501 ± 0.053
1.462GlnThr: 1.462 ± 0.06
1.021GlnVal: 1.021 ± 0.039
0.142GlnTrp: 0.142 ± 0.017
0.614GlnTyr: 0.614 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
1.891ArgAla: 1.891 ± 0.058
0.285ArgCys: 0.285 ± 0.026
2.003ArgAsp: 2.003 ± 0.067
1.891ArgGlu: 1.891 ± 0.068
1.629ArgPhe: 1.629 ± 0.057
1.729ArgGly: 1.729 ± 0.063
0.472ArgHis: 0.472 ± 0.032
2.485ArgIle: 2.485 ± 0.087
2.217ArgLys: 2.217 ± 0.074
2.928ArgLeu: 2.928 ± 0.088
0.728ArgMet: 0.728 ± 0.036
1.796ArgAsn: 1.796 ± 0.058
0.724ArgPro: 0.724 ± 0.039
0.881ArgGln: 0.881 ± 0.051
1.092ArgArg: 1.092 ± 0.047
1.615ArgSer: 1.615 ± 0.07
1.025ArgThr: 1.025 ± 0.045
2.28ArgVal: 2.28 ± 0.069
0.23ArgTrp: 0.23 ± 0.023
1.428ArgTyr: 1.428 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
3.457SerAla: 3.457 ± 0.092
0.685SerCys: 0.685 ± 0.043
4.02SerAsp: 4.02 ± 0.113
3.486SerGlu: 3.486 ± 0.091
4.1SerPhe: 4.1 ± 0.093
4.643SerGly: 4.643 ± 0.105
1.114SerHis: 1.114 ± 0.048
6.192SerIle: 6.192 ± 0.141
7.154SerLys: 7.154 ± 0.147
6.398SerLeu: 6.398 ± 0.13
1.279SerMet: 1.279 ± 0.053
4.637SerAsn: 4.637 ± 0.14
1.621SerPro: 1.621 ± 0.06
2.03SerGln: 2.03 ± 0.065
1.916SerArg: 1.916 ± 0.064
4.897SerSer: 4.897 ± 0.132
2.721SerThr: 2.721 ± 0.077
4.027SerVal: 4.027 ± 0.091
0.476SerTrp: 0.476 ± 0.031
2.739SerTyr: 2.739 ± 0.086
0.0SerXaa: 0.0 ± 0.0
Thr
2.43ThrAla: 2.43 ± 0.078
0.334ThrCys: 0.334 ± 0.029
1.879ThrAsp: 1.879 ± 0.072
1.487ThrGlu: 1.487 ± 0.056
2.025ThrPhe: 2.025 ± 0.058
2.609ThrGly: 2.609 ± 0.086
0.927ThrHis: 0.927 ± 0.039
4.23ThrIle: 4.23 ± 0.128
4.649ThrLys: 4.649 ± 0.102
4.48ThrLeu: 4.48 ± 0.112
0.832ThrMet: 0.832 ± 0.042
3.006ThrAsn: 3.006 ± 0.09
1.983ThrPro: 1.983 ± 0.065
1.617ThrGln: 1.617 ± 0.062
1.314ThrArg: 1.314 ± 0.055
2.812ThrSer: 2.812 ± 0.082
2.444ThrThr: 2.444 ± 0.085
1.497ThrVal: 1.497 ± 0.071
0.234ThrTrp: 0.234 ± 0.023
1.596ThrTyr: 1.596 ± 0.064
0.002ThrXaa: 0.002 ± 0.002
Val
3.86ValAla: 3.86 ± 0.112
0.716ValCys: 0.716 ± 0.042
3.126ValAsp: 3.126 ± 0.078
3.374ValGlu: 3.374 ± 0.089
3.059ValPhe: 3.059 ± 0.1
3.831ValGly: 3.831 ± 0.094
0.529ValHis: 0.529 ± 0.037
4.763ValIle: 4.763 ± 0.112
4.893ValLys: 4.893 ± 0.112
4.899ValLeu: 4.899 ± 0.106
1.236ValMet: 1.236 ± 0.058
3.03ValAsn: 3.03 ± 0.082
1.287ValPro: 1.287 ± 0.051
0.852ValGln: 0.852 ± 0.045
1.56ValArg: 1.56 ± 0.06
3.524ValSer: 3.524 ± 0.091
1.836ValThr: 1.836 ± 0.062
3.882ValVal: 3.882 ± 0.113
0.362ValTrp: 0.362 ± 0.03
1.727ValTyr: 1.727 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.447TrpAla: 0.447 ± 0.031
0.087TrpCys: 0.087 ± 0.015
0.427TrpAsp: 0.427 ± 0.03
0.338TrpGlu: 0.338 ± 0.027
0.319TrpPhe: 0.319 ± 0.027
0.476TrpGly: 0.476 ± 0.031
0.161TrpHis: 0.161 ± 0.019
0.616TrpIle: 0.616 ± 0.044
0.362TrpLys: 0.362 ± 0.032
0.702TrpLeu: 0.702 ± 0.04
0.207TrpMet: 0.207 ± 0.021
0.293TrpAsn: 0.293 ± 0.025
0.085TrpPro: 0.085 ± 0.014
0.344TrpGln: 0.344 ± 0.026
0.185TrpArg: 0.185 ± 0.02
0.342TrpSer: 0.342 ± 0.029
0.193TrpThr: 0.193 ± 0.018
0.34TrpVal: 0.34 ± 0.026
0.073TrpTrp: 0.073 ± 0.012
0.301TrpTyr: 0.301 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.282TyrAla: 2.282 ± 0.073
0.334TyrCys: 0.334 ± 0.028
2.662TyrAsp: 2.662 ± 0.08
3.056TyrGlu: 3.056 ± 0.081
2.479TyrPhe: 2.479 ± 0.084
2.347TyrGly: 2.347 ± 0.069
0.614TyrHis: 0.614 ± 0.034
3.278TyrIle: 3.278 ± 0.09
4.053TyrLys: 4.053 ± 0.103
3.819TyrLeu: 3.819 ± 0.093
0.74TyrMet: 0.74 ± 0.038
2.223TyrAsn: 2.223 ± 0.078
1.173TyrPro: 1.173 ± 0.045
1.171TyrGln: 1.171 ± 0.057
1.09TyrArg: 1.09 ± 0.052
2.438TyrSer: 2.438 ± 0.072
1.643TyrThr: 1.643 ± 0.058
1.678TyrVal: 1.678 ± 0.058
0.183TyrTrp: 0.183 ± 0.019
1.489TyrTyr: 1.489 ± 0.072
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.002XaaCys: 0.002 ± 0.002
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.002XaaLys: 0.002 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.002XaaThr: 0.002 ± 0.002
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1625 proteins (491741 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski