Amino acid dipepetide frequency for Marinobacter lutaoensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.176AlaAla: 11.176 ± 0.157	1.114AlaCys: 1.114 ± 0.033	5.844AlaAsp: 5.844 ± 0.085	6.982AlaGlu: 6.982 ± 0.091	3.751AlaPhe: 3.751 ± 0.058	9.35AlaGly: 9.35 ± 0.104	2.114AlaHis: 2.114 ± 0.046	5.219AlaIle: 5.219 ± 0.075	2.696AlaLys: 2.696 ± 0.054	13.217AlaLeu: 13.217 ± 0.15	2.929AlaMet: 2.929 ± 0.052	2.643AlaAsn: 2.643 ± 0.054	4.736AlaPro: 4.736 ± 0.076	3.831AlaGln: 3.831 ± 0.062	8.708AlaArg: 8.708 ± 0.105	5.778AlaSer: 5.778 ± 0.07	5.076AlaThr: 5.076 ± 0.064	7.412AlaVal: 7.412 ± 0.094	1.636AlaTrp: 1.636 ± 0.04	2.45AlaTyr: 2.45 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.839CysAla: 0.839 ± 0.026	0.141CysCys: 0.141 ± 0.011	0.548CysAsp: 0.548 ± 0.023	0.552CysGlu: 0.552 ± 0.025	0.317CysPhe: 0.317 ± 0.018	0.88CysGly: 0.88 ± 0.033	0.32CysHis: 0.32 ± 0.02	0.361CysIle: 0.361 ± 0.02	0.226CysLys: 0.226 ± 0.013	1.034CysLeu: 1.034 ± 0.031	0.164CysMet: 0.164 ± 0.012	0.223CysAsn: 0.223 ± 0.012	0.56CysPro: 0.56 ± 0.024	0.416CysGln: 0.416 ± 0.019	0.795CysArg: 0.795 ± 0.028	0.486CysSer: 0.486 ± 0.022	0.436CysThr: 0.436 ± 0.018	0.63CysVal: 0.63 ± 0.023	0.132CysTrp: 0.132 ± 0.01	0.258CysTyr: 0.258 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.7AspAla: 5.7 ± 0.08	0.477AspCys: 0.477 ± 0.021	3.534AspAsp: 3.534 ± 0.076	3.833AspGlu: 3.833 ± 0.06	2.131AspPhe: 2.131 ± 0.041	4.673AspGly: 4.673 ± 0.073	1.391AspHis: 1.391 ± 0.045	2.995AspIle: 2.995 ± 0.053	1.643AspLys: 1.643 ± 0.042	6.238AspLeu: 6.238 ± 0.081	1.353AspMet: 1.353 ± 0.037	1.672AspAsn: 1.672 ± 0.036	3.193AspPro: 3.193 ± 0.05	2.309AspGln: 2.309 ± 0.042	4.393AspArg: 4.393 ± 0.06	2.712AspSer: 2.712 ± 0.05	3.217AspThr: 3.217 ± 0.055	3.815AspVal: 3.815 ± 0.058	0.988AspTrp: 0.988 ± 0.029	1.807AspTyr: 1.807 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.561GluAla: 7.561 ± 0.1	0.454GluCys: 0.454 ± 0.02	3.312GluAsp: 3.312 ± 0.052	3.532GluGlu: 3.532 ± 0.064	2.0GluPhe: 2.0 ± 0.038	4.272GluGly: 4.272 ± 0.066	1.654GluHis: 1.654 ± 0.042	3.11GluIle: 3.11 ± 0.061	2.178GluLys: 2.178 ± 0.053	6.757GluLeu: 6.757 ± 0.092	1.337GluMet: 1.337 ± 0.036	1.729GluAsn: 1.729 ± 0.045	3.149GluPro: 3.149 ± 0.058	3.446GluGln: 3.446 ± 0.064	5.463GluArg: 5.463 ± 0.075	2.986GluSer: 2.986 ± 0.055	3.4GluThr: 3.4 ± 0.061	4.461GluVal: 4.461 ± 0.07	0.733GluTrp: 0.733 ± 0.024	1.435GluTyr: 1.435 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.314PheAla: 3.314 ± 0.066	0.409PheCys: 0.409 ± 0.02	2.369PheAsp: 2.369 ± 0.049	2.259PheGlu: 2.259 ± 0.043	1.408PhePhe: 1.408 ± 0.04	3.084PheGly: 3.084 ± 0.057	0.787PheHis: 0.787 ± 0.024	1.623PheIle: 1.623 ± 0.042	0.962PheLys: 0.962 ± 0.029	3.67PheLeu: 3.67 ± 0.061	0.795PheMet: 0.795 ± 0.025	1.149PheAsn: 1.149 ± 0.029	1.574PhePro: 1.574 ± 0.039	1.288PheGln: 1.288 ± 0.03	2.605PheArg: 2.605 ± 0.052	2.26PheSer: 2.26 ± 0.048	1.871PheThr: 1.871 ± 0.038	2.536PheVal: 2.536 ± 0.048	0.54PheTrp: 0.54 ± 0.022	1.027PheTyr: 1.027 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.188GlyAla: 7.188 ± 0.088	0.881GlyCys: 0.881 ± 0.029	4.529GlyAsp: 4.529 ± 0.066	4.986GlyGlu: 4.986 ± 0.065	3.311GlyPhe: 3.311 ± 0.059	5.964GlyGly: 5.964 ± 0.087	2.072GlyHis: 2.072 ± 0.046	4.326GlyIle: 4.326 ± 0.07	2.74GlyLys: 2.74 ± 0.059	8.986GlyLeu: 8.986 ± 0.106	2.128GlyMet: 2.128 ± 0.047	2.159GlyAsn: 2.159 ± 0.048	2.91GlyPro: 2.91 ± 0.049	3.448GlyGln: 3.448 ± 0.06	5.783GlyArg: 5.783 ± 0.082	3.981GlySer: 3.981 ± 0.073	3.988GlyThr: 3.988 ± 0.065	6.001GlyVal: 6.001 ± 0.077	1.294GlyTrp: 1.294 ± 0.037	2.475GlyTyr: 2.475 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.999HisAla: 1.999 ± 0.043	0.298HisCys: 0.298 ± 0.016	1.238HisAsp: 1.238 ± 0.042	1.225HisGlu: 1.225 ± 0.036	0.911HisPhe: 0.911 ± 0.027	1.96HisGly: 1.96 ± 0.046	0.689HisHis: 0.689 ± 0.027	1.026HisIle: 1.026 ± 0.03	0.578HisLys: 0.578 ± 0.025	2.531HisLeu: 2.531 ± 0.051	0.468HisMet: 0.468 ± 0.02	0.617HisAsn: 0.617 ± 0.021	1.621HisPro: 1.621 ± 0.034	1.051HisGln: 1.051 ± 0.03	1.927HisArg: 1.927 ± 0.044	1.175HisSer: 1.175 ± 0.036	1.106HisThr: 1.106 ± 0.029	1.308HisVal: 1.308 ± 0.034	0.467HisTrp: 0.467 ± 0.02	0.801HisTyr: 0.801 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.155IleAla: 5.155 ± 0.07	0.48IleCys: 0.48 ± 0.02	3.054IleAsp: 3.054 ± 0.055	3.398IleGlu: 3.398 ± 0.058	1.344IlePhe: 1.344 ± 0.036	3.996IleGly: 3.996 ± 0.069	1.123IleHis: 1.123 ± 0.034	2.072IleIle: 2.072 ± 0.048	1.45IleLys: 1.45 ± 0.041	4.543IleLeu: 4.543 ± 0.079	0.903IleMet: 0.903 ± 0.034	1.597IleAsn: 1.597 ± 0.033	2.4IlePro: 2.4 ± 0.042	1.752IleGln: 1.752 ± 0.036	4.021IleArg: 4.021 ± 0.058	2.573IleSer: 2.573 ± 0.051	2.595IleThr: 2.595 ± 0.049	3.262IleVal: 3.262 ± 0.059	0.494IleTrp: 0.494 ± 0.019	1.068IleTyr: 1.068 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.519LysAla: 3.519 ± 0.072	0.168LysCys: 0.168 ± 0.012	1.663LysAsp: 1.663 ± 0.046	1.748LysGlu: 1.748 ± 0.048	0.75LysPhe: 0.75 ± 0.027	2.242LysGly: 2.242 ± 0.046	0.665LysHis: 0.665 ± 0.026	1.374LysIle: 1.374 ± 0.037	1.268LysLys: 1.268 ± 0.042	3.07LysLeu: 3.07 ± 0.064	0.65LysMet: 0.65 ± 0.024	0.828LysAsn: 0.828 ± 0.028	1.72LysPro: 1.72 ± 0.045	1.23LysGln: 1.23 ± 0.034	2.198LysArg: 2.198 ± 0.05	1.558LysSer: 1.558 ± 0.044	1.764LysThr: 1.764 ± 0.043	2.403LysVal: 2.403 ± 0.049	0.301LysTrp: 0.301 ± 0.015	0.713LysTyr: 0.713 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.42LeuAla: 14.42 ± 0.153	1.068LeuCys: 1.068 ± 0.03	6.755LeuAsp: 6.755 ± 0.088	6.994LeuGlu: 6.994 ± 0.095	3.838LeuPhe: 3.838 ± 0.07	8.557LeuGly: 8.557 ± 0.116	2.159LeuHis: 2.159 ± 0.042	4.995LeuIle: 4.995 ± 0.076	3.793LeuLys: 3.793 ± 0.065	11.637LeuLeu: 11.637 ± 0.169	2.63LeuMet: 2.63 ± 0.058	3.266LeuAsn: 3.266 ± 0.053	5.851LeuPro: 5.851 ± 0.08	3.658LeuGln: 3.658 ± 0.06	7.569LeuArg: 7.569 ± 0.101	6.768LeuSer: 6.768 ± 0.093	6.102LeuThr: 6.102 ± 0.083	8.435LeuVal: 8.435 ± 0.108	1.407LeuTrp: 1.407 ± 0.035	2.495LeuTyr: 2.495 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.093MetAla: 3.093 ± 0.056	0.144MetCys: 0.144 ± 0.011	1.252MetAsp: 1.252 ± 0.034	1.21MetGlu: 1.21 ± 0.033	0.65MetPhe: 0.65 ± 0.025	1.708MetGly: 1.708 ± 0.042	0.43MetHis: 0.43 ± 0.02	1.103MetIle: 1.103 ± 0.035	1.024MetLys: 1.024 ± 0.037	2.368MetLeu: 2.368 ± 0.056	0.576MetMet: 0.576 ± 0.023	0.821MetAsn: 0.821 ± 0.031	1.285MetPro: 1.285 ± 0.039	0.771MetGln: 0.771 ± 0.026	1.374MetArg: 1.374 ± 0.036	1.477MetSer: 1.477 ± 0.035	1.668MetThr: 1.668 ± 0.039	1.7MetVal: 1.7 ± 0.038	0.141MetTrp: 0.141 ± 0.011	0.399MetTyr: 0.399 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.736AsnAla: 2.736 ± 0.057	0.265AsnCys: 0.265 ± 0.015	1.484AsnAsp: 1.484 ± 0.038	1.502AsnGlu: 1.502 ± 0.036	0.908AsnPhe: 0.908 ± 0.029	2.347AsnGly: 2.347 ± 0.052	0.671AsnHis: 0.671 ± 0.025	1.379AsnIle: 1.379 ± 0.032	0.751AsnLys: 0.751 ± 0.027	3.253AsnLeu: 3.253 ± 0.058	0.571AsnMet: 0.571 ± 0.023	0.792AsnAsn: 0.792 ± 0.026	1.989AsnPro: 1.989 ± 0.045	1.138AsnGln: 1.138 ± 0.032	2.321AsnArg: 2.321 ± 0.05	1.241AsnSer: 1.241 ± 0.032	1.457AsnThr: 1.457 ± 0.039	1.767AsnVal: 1.767 ± 0.043	0.399AsnTrp: 0.399 ± 0.018	0.789AsnTyr: 0.789 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.63ProAla: 5.63 ± 0.075	0.36ProCys: 0.36 ± 0.017	3.998ProAsp: 3.998 ± 0.058	4.876ProGlu: 4.876 ± 0.078	1.749ProPhe: 1.749 ± 0.04	4.593ProGly: 4.593 ± 0.064	0.977ProHis: 0.977 ± 0.029	1.932ProIle: 1.932 ± 0.036	1.357ProLys: 1.357 ± 0.035	5.1ProLeu: 5.1 ± 0.076	1.159ProMet: 1.159 ± 0.033	1.224ProAsn: 1.224 ± 0.036	2.28ProPro: 2.28 ± 0.048	1.596ProGln: 1.596 ± 0.04	2.944ProArg: 2.944 ± 0.055	2.505ProSer: 2.505 ± 0.051	2.137ProThr: 2.137 ± 0.043	4.774ProVal: 4.774 ± 0.085	0.811ProTrp: 0.811 ± 0.028	1.18ProTyr: 1.18 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.37GlnAla: 5.37 ± 0.073	0.297GlnCys: 0.297 ± 0.017	1.891GlnAsp: 1.891 ± 0.046	2.134GlnGlu: 2.134 ± 0.059	1.231GlnPhe: 1.231 ± 0.032	3.161GlnGly: 3.161 ± 0.055	0.866GlnHis: 0.866 ± 0.027	1.7GlnIle: 1.7 ± 0.038	1.213GlnLys: 1.213 ± 0.036	4.236GlnLeu: 4.236 ± 0.071	0.845GlnMet: 0.845 ± 0.031	0.956GlnAsn: 0.956 ± 0.029	2.239GlnPro: 2.239 ± 0.045	1.93GlnGln: 1.93 ± 0.049	3.263GlnArg: 3.263 ± 0.057	1.889GlnSer: 1.889 ± 0.044	1.859GlnThr: 1.859 ± 0.041	3.269GlnVal: 3.269 ± 0.054	0.676GlnTrp: 0.676 ± 0.025	0.928GlnTyr: 0.928 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.151ArgAla: 7.151 ± 0.086	0.695ArgCys: 0.695 ± 0.027	4.264ArgAsp: 4.264 ± 0.06	5.134ArgGlu: 5.134 ± 0.077	3.176ArgPhe: 3.176 ± 0.053	4.43ArgGly: 4.43 ± 0.06	2.113ArgHis: 2.113 ± 0.047	3.926ArgIle: 3.926 ± 0.057	2.473ArgLys: 2.473 ± 0.053	9.164ArgLeu: 9.164 ± 0.116	1.792ArgMet: 1.792 ± 0.037	2.193ArgAsn: 2.193 ± 0.051	3.64ArgPro: 3.64 ± 0.063	3.969ArgGln: 3.969 ± 0.073	6.079ArgArg: 6.079 ± 0.091	3.518ArgSer: 3.518 ± 0.059	3.385ArgThr: 3.385 ± 0.058	5.441ArgVal: 5.441 ± 0.08	1.213ArgTrp: 1.213 ± 0.033	2.369ArgTyr: 2.369 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.255SerAla: 5.255 ± 0.075	0.425SerCys: 0.425 ± 0.021	2.994SerAsp: 2.994 ± 0.062	3.265SerGlu: 3.265 ± 0.06	1.935SerPhe: 1.935 ± 0.041	5.064SerGly: 5.064 ± 0.076	1.316SerHis: 1.316 ± 0.034	2.337SerIle: 2.337 ± 0.049	1.351SerLys: 1.351 ± 0.039	6.1SerLeu: 6.1 ± 0.088	1.216SerMet: 1.216 ± 0.029	1.366SerAsn: 1.366 ± 0.038	2.746SerPro: 2.746 ± 0.047	2.074SerGln: 2.074 ± 0.038	4.047SerArg: 4.047 ± 0.065	2.642SerSer: 2.642 ± 0.051	2.446SerThr: 2.446 ± 0.056	4.016SerVal: 4.016 ± 0.068	0.706SerTrp: 0.706 ± 0.027	1.29SerTyr: 1.29 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.0ThrAla: 5.0 ± 0.058	0.46ThrCys: 0.46 ± 0.019	2.94ThrAsp: 2.94 ± 0.047	3.044ThrGlu: 3.044 ± 0.051	1.807ThrPhe: 1.807 ± 0.043	5.01ThrGly: 5.01 ± 0.071	1.062ThrHis: 1.062 ± 0.029	2.165ThrIle: 2.165 ± 0.044	1.026ThrLys: 1.026 ± 0.031	7.084ThrLeu: 7.084 ± 0.08	0.96ThrMet: 0.96 ± 0.03	1.132ThrAsn: 1.132 ± 0.033	3.339ThrPro: 3.339 ± 0.062	1.571ThrGln: 1.571 ± 0.042	3.709ThrArg: 3.709 ± 0.059	2.412ThrSer: 2.412 ± 0.044	2.538ThrThr: 2.538 ± 0.057	4.165ThrVal: 4.165 ± 0.061	0.719ThrTrp: 0.719 ± 0.025	1.197ThrTyr: 1.197 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.279ValAla: 8.279 ± 0.094	0.756ValCys: 0.756 ± 0.025	4.196ValAsp: 4.196 ± 0.065	4.283ValGlu: 4.283 ± 0.067	2.773ValPhe: 2.773 ± 0.057	4.889ValGly: 4.889 ± 0.07	1.524ValHis: 1.524 ± 0.035	3.974ValIle: 3.974 ± 0.068	2.1ValLys: 2.1 ± 0.046	8.029ValLeu: 8.029 ± 0.095	1.921ValMet: 1.921 ± 0.046	2.259ValAsn: 2.259 ± 0.045	3.802ValPro: 3.802 ± 0.071	2.285ValGln: 2.285 ± 0.05	5.296ValArg: 5.296 ± 0.079	4.552ValSer: 4.552 ± 0.066	4.438ValThr: 4.438 ± 0.059	6.038ValVal: 6.038 ± 0.094	0.852ValTrp: 0.852 ± 0.027	1.752ValTyr: 1.752 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.094TrpAla: 1.094 ± 0.033	0.169TrpCys: 0.169 ± 0.012	0.666TrpAsp: 0.666 ± 0.025	0.551TrpGlu: 0.551 ± 0.024	0.571TrpPhe: 0.571 ± 0.024	0.851TrpGly: 0.851 ± 0.028	0.42TrpHis: 0.42 ± 0.02	0.65TrpIle: 0.65 ± 0.025	0.377TrpLys: 0.377 ± 0.019	2.253TrpLeu: 2.253 ± 0.054	0.346TrpMet: 0.346 ± 0.015	0.393TrpAsn: 0.393 ± 0.02	0.717TrpPro: 0.717 ± 0.027	0.897TrpGln: 0.897 ± 0.026	1.192TrpArg: 1.192 ± 0.033	0.811TrpSer: 0.811 ± 0.027	0.621TrpThr: 0.621 ± 0.026	0.98TrpVal: 0.98 ± 0.033	0.223TrpTrp: 0.223 ± 0.016	0.35TrpTyr: 0.35 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.185TyrAla: 2.185 ± 0.039	0.258TyrCys: 0.258 ± 0.016	1.543TyrAsp: 1.543 ± 0.045	1.459TyrGlu: 1.459 ± 0.038	0.97TyrPhe: 0.97 ± 0.034	2.12TyrGly: 2.12 ± 0.043	0.645TyrHis: 0.645 ± 0.027	1.014TyrIle: 1.014 ± 0.033	0.624TyrLys: 0.624 ± 0.027	3.126TyrLeu: 3.126 ± 0.051	0.45TyrMet: 0.45 ± 0.019	0.741TyrAsn: 0.741 ± 0.024	1.432TyrPro: 1.432 ± 0.041	1.292TyrGln: 1.292 ± 0.036	2.438TyrArg: 2.438 ± 0.051	1.27TyrSer: 1.27 ± 0.037	1.234TyrThr: 1.234 ± 0.033	1.584TyrVal: 1.584 ± 0.036	0.399TyrTrp: 0.399 ± 0.018	0.735TyrTyr: 0.735 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3411 proteins (1153080 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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